Name: OXRAMET G XR 10/1/1000 Tablet 7's
Brand: Netmeds
SKU: 8477701
Price: 94.87 INR
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OXRAMET G XR 10/1/1000 Tablet 7's - Diabetes-Ant

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Introduction About OXRAMET G XR 10/1/1000 TABLET

OXRAMET G XR 10/1/1000 TABLET is a combination of Dapagliflozin, Glimepiride, and Metformin, which belongs to the group of medicines called Antidiabetic agents. It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus when management with single agents does not result in adequate response.

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.

Before taking OXRAMET G XR 10/1/1000 TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished or starved on an irregular diet as a precaution.

OXRAMET G XR 10/1/1000 TABLET is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis, severe low blood pressure, or severe dehydration. It is also not suitable for use in pregnant or breastfeeding women.

Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking OXRAMET G XR 10/1/1000 TABLET, as it may aggravate your existing condition. During therapy with OXRAMET G XR 10/1/1000 TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects.

The most common side effects of taking OXRAMET G XR 10/1/1000 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness, genital infections, back pain, and passing more urine. Consult your doctor if any of these side effects worsen.

Uses Of OXRAMET G XR 10/1/1000 TABLET

It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus.

How OXRAMET G XR 10/1/1000 TABLET Works

OXRAMET G XR 10/1/1000 TABLET contains three medicines, namely, metformin, glimepiride, and dapagliflozin. Metformin and glimepiride stimulate the pancreas to secrete more insulin (a hormone involved in glucose metabolism). They also make our body more sensitive to insulin, which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, metformin can also reduce the glucose produced by the liver and reduce its absorption in the body.

Dapagliflozin is an SGLT-2 inhibitor. It works by blocking the action of a protein called SGLT-2 in the kidneys. This action manages the reabsorption of glucose and sodium ions in the kidneys. As a result, it excretes excess glucose from the body in the form urine.

How to use OXRAMET G XR 10/1/1000 TABLET

Take OXRAMET G XR 10/1/1000 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Do not stop taking OXRAMET G XR 10/1/1000 TABLET unless your doctor advises you to stop.

Side Effects Of OXRAMET G XR 10/1/1000 TABLET

Common

hypoglycemia (low blood sugar levels)
nausea, vomiting
diarrhea, stomach pain, loss of appetite, flatulence
changes in taste, metallic taste
headache, dizziness
joint pain, back pain, muscle pain
impotence
sinus infection, sore throat
fungal infections of the genital (thrush) causing itching, irritation, unusual discharge, odour
passing more urine, increased urine frequency
skin rash
changes in blood cholesterol levels
changes in RBC in blood

Uncommon

difficulty in sleeping (insomnia)
proteins in urine
spinning sensation (vertigo)
dehydration, thirst, constipation, dry mouth
weight loss

Rare

Stop taking OXRAMET G XR 10/1/1000 TABLET and contact your doctor immediately if you experience any of the following side effects:

signs of diabetic ketoacidosis or lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting, a sweet smell to breath, a sweet or metallic taste in the mouth or a different odor to urine or sweat, and rapid weight loss)
symptoms of heart failure (such as unusual shortness of breath or trouble breathing, rapid increase in weight or localized swelling (oedema), especially in the ankles or legs, unusual tiredness)
blurred vision, urinary tract infections
pain, swelling, redness, or tenderness of the genitals or the areas between the genitals and the anus accompanied by a high fever or a feeling generally unwell (a sign of necrotizing fasciitis of the perineum)

How To Manage Side Effects

Constipation

Taking OXRAMET G XR 10/1/1000 TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if constipation persists.

Diarrhea

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not manage diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Hypoglycemia

Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If you have not gained the optimum level, take another sugary snack or drink and check the blood sugar again. Consult your doctor if there is no improvement in your condition.

Nausea And Vomiting

Take OXRAMET G XR 10/1/1000 TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.

Skin Conditions

OXRAMET G XR 10/1/1000 TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.

Others

OXRAMET G XR 10/1/1000 TABLET is not recommended for use if you:

have type I diabetes mellitus (insulin-dependent diabetes)
have lactic acidosis (buildup of lactic acid in the body)
have diabetic ketoacidosis (a diabetic complication causing episodes of fatigue, nausea, frequent urination, and muscular stiffness)
have bladder cancer
pass bloody urine

Before taking OXRAMET G XR 10/1/1000 TABLET, inform your doctor if you:

are recovering from any injury, operation, infection, or from any form of stress
have G6PD deficiency
are on fating or malnourished, starved, on an irregular diet, or feeling weak
perform extreme physical exercises without proper carbohydrate intake
are severely dehydrated
have hormonal problems (Ex. disorders of the pituitary gland, adrenal cortex, or thyroid gland)
are an alcoholic
have edema (swelling of body parts)
have a habit of smoking
have cysts on your ovaries (polycystic ovarian syndrome)
previously had stroke
have anemia (low RBC in blood)
have diabetes-related kidney problems

Interactions

Before taking OXRAMET G XR 10/1/1000 TABLET, inform your doctor if you are taking any of the following medicines:

Other medicines used to regulate blood sugar levels (such as teneligliptin, rosiglitazone, insulin, and gliclazide)
Medicines used in pain management (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone, prednisolone, betamethasone)
Medicines for managing urinary infections (amikacin, nitrofurantoin, sulfamethoxazole)
Antibiotics (such as tetracyclines, chloramphenicol, ciprofloxacin, and clarithromycin); antifungals (fluconazole, miconazole, and isuvaconazole)
medicines used for blood thinning (Ex. warfarin)
Hormones (Ex. testosterone, estradiol)
Medicines used in the management of mental illnesses (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, chlorpromazine, prochlorperazine, and lithium)
Antihyperlipidemics (Ex. fenofibrate, nicotinic acid, colesevelam)
Antihypertensives (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine, reserpine, prazosin, doxazosin)
medicines used to manage gout (Ex. allopurinol, probenecid, sulfinpyrazone)
medicines used in the management of cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib, and olaparib)
medicines used in the management of allergic rhinitis (Ex. tritoqualine)
Water pills (Ex. hydrochlorothiazide)
Anti-asthmatics (Ex. salbutamol, terbutaline)
adrenaline (a medicine used for anaphylaxis)
Medicines used for constipation (Ex. lactulose, liquid paraffin)

Overdosage:

If you or anyone else accidentally took more OXRAMET G XR 10/1/1000 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat, and confusion). To manage this, consume any sugary food immediately. If the symptoms do not improve or worsen, contact your doctor immediately. Other symptoms of overdose might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness, and difficulty breathing.

Synopsis

Drug	:	Dapagliflozin, Glimepiride, Metformin
Pharmacological Category	:	SGLT-2 Inhibitors, Sulfonylureas, and Biguanides
Therapeutic Indication	:	Improve glycemic control
Dosage Forms	:	Tablet

More Information

Storage

Keep OXRAMET G XR 10/1/1000 TABLET out of reach of children
Store OXRAMET G XR 10/1/1000 TABLET at room temperature

FAQs About OXRAMET G XR 10/1/1000 TABLET

Q: What is OXRAMET G XR 10/1/1000 TABLET used for?

A: OXRAMET G XR 10/1/1000 TABLET is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus when management with single agents does not result in adequate response.

Q: How and when to take OXRAMET G XR 10/1/1000 TABLET?

A: Take OXRAMET G XR 10/1/1000 TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Q: How long should I take OXRAMET G XR 10/1/1000 TABLET?

A: You need to take OXRAMET G XR 10/1/1000 TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Q: What is the best time to take OXRAMET G XR 10/1/1000 TABLET?

A: OXRAMET G XR 10/1/1000 TABLET must be taken with meals to avoid gastrointestinal side effects.

Q: What to do if I forgot to take a dose of OXRAMET G XR 10/1/1000 TABLET?

A: If you forgot to take a dose of OXRAMET G XR 10/1/1000 TABLET, take it as soon as you remember. However, if it is time for the next dose of OXRAMET G XR 10/1/1000 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of OXRAMET G XR 10/1/1000 TABLET to compensate for the missed ones.

Q: Can I stop taking OXRAMET G XR 10/1/1000 TABLET without consulting your doctor?

A: No. You should not stop taking OXRAMET G XR 10/1/1000 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using OXRAMET G XR 10/1/1000 TABLET, consult your doctor for advice.

Q: Will taking a higher dose of OXRAMET G XR 10/1/1000 TABLET be more effective?

A: No, taking a higher dose of OXRAMET G XR 10/1/1000 TABLET will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: Can I take medication for high blood pressure along with OXRAMET G XR 10/1/1000 TABLET?

A: It is not advisable to take medicines to control blood pressure while taking OXRAMET G XR 10/1/1000 TABLET without consulting your doctor, as they have known interactions with OXRAMET G XR 10/1/1000 TABLET.

Q: How to manage the side effects of OXRAMET G XR 10/1/1000 TABLET?

A: Low blood sugar is a common side effect of taking OXRAMET G XR 10/1/1000 TABLET. Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If not at the optimum level, take another sugary snack or drink and check the blood sugar levels once again. If your condition does not improve, consult your doctor immediately.

Q: Can OXRAMET G XR 10/1/1000 TABLET be taken with insulin?

A: Co-administration of OXRAMET G XR 10/1/1000 TABLET with insulin is considered risky as they can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.

Q: Can OXRAMET G XR 10/1/1000 TABLET be used in pregnant women?

A: OXRAMET G XR 10/1/1000 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.

Q: What are the side effects of taking OXRAMET G XR 10/1/1000 TABLET?

A: The most common side effects of taking OXRAMET G XR 10/1/1000 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness, genital infections, back pain, and passing more urine. Consult your doctor if any of these side effects worsen.

Q: Can OXRAMET G XR 10/1/1000 TABLET cause urinary tract infection?

A: Yes, taking OXRAMET G XR 10/1/1000 TABLET may cause urinary tract infections in few people. Not every individual gets the side effect, so it is always better to practice good hygiene. Contact your doctor for advice.

Q: Can OXRAMET G XR 10/1/1000 TABLET cause constipation?

A: Yes. Constipation is a common side effect of using OXRAMET G XR 10/1/1000 TABLET. Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals, as well as drink plenty of water and exercise more regularly while taking this medicine. Contact your doctor if this side effect bothers you.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 270, 275, 277, 278.

2. Dirk Müller-Wieland, Monika Kellerer, Katarzyna Cypryk, Dasa Skripova, Katja Rohwedder, Eva Johnsson, Ricardo Garcia-Sanchez, Raisa Kurlyandskaya, David Sjöström, Stephan Jacob, Jochen Seufert, Nalina Dronamraju, and Katalin Csomós. Efficacy and safety of dapagliflozin or dapagliflozin plus saxagliptin versus glimepiride as add-on to metformin in patients with type 2 diabetes. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2018. [Accessed on 5th September 2024]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220756/

3. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 5th September 2024]. https://www.medicines.org.uk/emc/files/pil.11951.pdf

4. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 5th September 2024]. https://www.medicines.org.uk/emc/files/pil.10742.pdf

5. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC). [Revised in November 2022] [Accessed on 5th September 2024]. https://www.medicines.org.uk/emc/files/pil.7607.pdf

6. CDSCO. Dapagliflozin… 5 mg/5 mg/10 mg/10 mg + Metformin HCL (extended release) …. 500mg/1000mg/500mg/1000mg. October 2017. [Accessed on 5th September 2024]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf

7. Centuar Pharma. Glimitab-M 1 mg/2 mg Tablets. [Accessed on 5th September 2024]. https://www.centaurpharma.com/downloads/Glimitab-M2018.pdf

Useful Diagnostic Tests

HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
Blood Glucose Fasting (FBS)
Post Prandial Blood Sugar (PPBS)
Insulin – Fasting
Netmeds Diabetic Checkup
Jaanch Diabetic Profile Basic
Advance Diabetes Monitoring (Senior Female)

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 11 Sep 2024 | 03:11 PM(IST)

Lab updated