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Sun Pharmaceutical Industries Ltd

Oxetol 300mg Tablet 10'S

Epilepsy/Convulsion
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    Introduction About OXETOL 300MG TABLET

    Uses of Oxetol 300mg Tablet:

    Oxetol 300mg is primarily prescribed for managing epilepsy by reducing seizures. It works by reducing nerve impulses that cause seizures.

    Oxetol 300mg should be taken as per the doctor’s prescription. Usually, it is taken once or twice daily with or without food.

    Avoid alcohol while taking Oxetol 300mg. Inform your doctor if you have kidney or liver issues.

    Oxetol 300mg Tablet is not recommended for pregnant or breastfeeding women without consultation.

    The most common side effects of Oxetol 300mg are dizziness, drowsiness, headache, nausea or fatigue. Consult your doctor if any of the above side effects worsen or persists for a longer duration.

    Uses Of OXETOL 300MG TABLET

    • Used to manage epilepsy by reducing seizures

    Benefits of OXETOL 300MG TABLET

    1. Effective seizure control - helps in managing partial seizures and generalized tonic-clonic seizures

    2. Mood stabilization - helps in managing manic episodes in bipolar patients

    3. Improves quality of life - helps patients regain control over daily activities by reducing seizure episodes

    How OXETOL 300MG TABLET Works

    How Oxetol 300mg works: Explain its mechanism of action in controlling seizures

    1. Blocks overactive nerve signals:

    • Oxcarbazepine inhibits voltage-gated sodium (Na?) channels in neurons, preventing excessive electrical activity that leads to seizures

    2. Enhances GABA Activity:

    • May have a mild effect in enhancing GABAergic neurotransmission, promoting a calming effect on nerve cells

    3. Reduces excitatory signals:

    • Decreases glutamate release, a key excitatory neurotransmitter, lowering seizure risk

    Who should take it: Conditions it manages (e.g., epilepsy, neuropathic pain)

    1. Epilepsy: Used to manage partial (focal) seizures and generalized tonic-clonic seizures

    2. Neuropathic pain: Used to relieve trigeminal neuralgia (nerve pain in the face) and diabetic neuropathy (off-label use)

    3. Bipolar disorder (Off-label use): May help stabilize mood swings in manic episodes

    How to use OXETOL 300MG TABLET

    Oxetol 300mg Tablet is a prescription medicine which needs to be taken under medical supervision. Always consult your doctor or pharmacist if you have any questions or concerns about taking this medication.

    How to take Oxetol 300mg Tablet:

    • Take Oxetol 300mg as advised by your physician
    • Swallow the medicine with a glass of water. Do not crush or chew the medicine
    • Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition

    Recommended dosage for Oxetol 300mg Tablet:

    • Usually, Oxetol 300mg is taken once or twice daily with or without food
    • Starting dose: 300 mg twice daily (600 mg/day)
    • Maintenance dose: can be increased by 600 mg every week based on response
    • Typical dose range: 600 mg to 2400 mg per day, divided into two doses

    Oxetol 300mg Tablet dosage for adults:

    1. For Epilepsy (seizure control)

    • Starting dose: 300 mg twice daily (600 mg/day)
    • Titration: can be increased by 600 mg every week, based on response
    • Maintenance dose: 600 mg to 2400 mg per day, divided into two doses
    • Maximum dose: 2400 mg/day in severe cases

    2. For neuropathic pain (Off-label use)

    • Starting dose: 300 mg once or twice daily
    • Increase gradually by 300 mg every 3-7 days, based on response
    • Usual dose: 900 mg to 1800 mg per day, in two divided doses.\
    • Maximum dose: 2100 mg/day, if well tolerated

    What if I forgot to take OXETOL 300MG TABLET

    Missed dose instructions for Oxetol 300mg:

    • Take it as soon as you remember, unless it is almost time for your next dose
    • Do not double the dose to make up for a missed one

    Discontinuation:

    • Do not stop taking Oxetol 300mg Tablet suddenly without consulting your doctor
    • Abrupt cessation can worsen seizures or cause withdrawal symptoms.
    • Your doctor may gradually reduce the dose to safely discontinue the medication.

    Overdose

    Common overdose symptoms

    • extreme dizziness or drowsiness
    • confusion or disorientation
    • slurred speech
    • loss of coordination (ataxia)
    • uncontrollable muscle twitching or tremors
    • irregular heartbeat
    • low blood pressure (dizziness, fainting)

    Side Effects Of OXETOL 300MG TABLET

    Potential side effects of OXETOL 300MG TABLET:

    • dizziness
    • drowsiness
    • headache
    • nausea
    • fatigue

    Seek medical attention if any side effects persist or worsen:

    • signs of low number of white blood cells
    • signs of a blood disorder (tiredness, breathlessness when exercising, looking pale, headache, chills, dizziness, infections leading to fever, sore throat, mouth ulcer, bleeding or bruising more easily than normal, nose bleeding, reddish or purplish patches, unexplained blotches on skin)

    How To Manage Side Effects

    Dizziness Or Drowsiness

    • When getting up from a sitting or lying position, do it slowly to prevent sudden dizziness
    • Drink plenty of water throughout the day
    • If you feel dizzy, do not drive or operate machinery until symptoms improve
    • Take Oxetol at night (if prescribed), if drowsiness is persistent, ask your doctor if you can take your dose before bedtime instead of during the day
    • Drink plenty of water and eat a balanced diet to maintain energy levels
    • Exposure to natural light and fresh air can help regulate your sleep-wake cycle

    Headache

    • Drink plenty of water throughout the day to prevent dehydration, a common headache trigger
    • Apply an ice pack or a warm cloth to your forehead for relief
    • Bright lights and noise can worsen headaches. Try relaxing in a dimly lit, quiet space

    Nausea And Vomiting

    • Having medicine with meals or a light snack can help reduce nausea
    • Step outside for fresh air or practice slow, deep breathing to calm your stomach
    • Strong odors can trigger nausea, so stick to mild, non-greasy foods

    Tiredness

    • Drink plenty of water throughout the day to prevent dehydration, which can worsen fatigue
    • Maintain a balanced diet rich in proteins, whole grains, and healthy fats
    • Aim for 7-9 hours of uninterrupted sleep each night

    Warning & Precautions

    Pregnancy

    Monitoring required

    Oxetol 300mg Tablet classifies as FDA category C which means animal studies have shown adverse effects on the fetus, but limited human data is available. The drug should only be used if the benefits outweigh the risks.

    Breastfeeding

    Consult your doctor

    Oxcarbazepine & its active metabolite (MHD) may pass into breast milk in small amounts. Hence breastfed infants may show drowsiness, poor feeding, or irritability, but most studies report no serious adverse effects. Breastfeeding is generally considered safe if the baby is monitored for drowsiness or feeding difficulties.

    Driving and Using Machines

    Use with Caution

    Oxetol 300mg Tablet may cause drowsiness, dizziness, and tiredness. It is advisable to avoid such activities until they are sure of how the medication affects them.

    Alcohol

    Consult your doctor

    Combining Oxetol 300mg Tablet with alcohol can increase dizziness and sleepiness. Patients are advised to avoid alcohol during treatment.

    Kidney

    Use with Caution

    Oxetol 300mg Tablet sshould be used with caution in patients with kidney problems (especially associated with low sodium levels in the blood). Your doctor may initiate the management with the lowest effective dose and may gradually increase the dose of this medicine.

    Liver

    Use with Caution

    Oxetol 300mg should be used with caution in patients with liver problems or who develop liver problems during management and in serious liver problems your doctor may adjust the dose.  

    Allergy

    Contraindicated

    Do not take Oxetol 300mg Tablet if you are allergic to Oxcarbazepine or any other ingredients of this medicine.

    Heart Disease

    Use with Caution

    Oxetol 300mg Tablet should be used with caution in patients with heart failure (signs include breathlessness, swelling of the feet or legs due to fluid build-up) or heart rhythm disorder.

    Use In Pediatrics

    Consult your doctor

    Oxetol 300mg Tablet is generally prescribed for children. Hence, your doctor will give the right dose depends on your child’s age, body weight and disease condition.

    Use In Geriatrics

    Use with Caution

    Oxetol 300mg Tablet should be used with caution in elderly patients (aged 65 years and above), especially in patients with kidney impairment and your doctor may adjust the dose.

    Other Warnings for OXETOL 300MG TABLET

    Before taking Oxetol 300mg Tablet, inform your doctor if you:

    • have low blood levels of sodium
    • intolerance to certain sugars

    Diet and Lifestyle Advice

    How to minimize side effects (lifestyle adjustments, dietary tips):

    Lifestyle Adjustments:

    • Stay Hydrated
    • Maintain a Regular Sleep Schedule  
    • Avoid Alcohol
    • Rise Slowly from Sitting or Lying Down
    • Exercise Regularly
    • Monitor Sodium Levels

    Dietary Tips

    • Eat Magnesium-Rich Foods (Spinach, nuts, whole grains, bananas)
    • Increase Vitamin B12 & Folate (Eggs, dairy, leafy greens, fortified cereals)
    • Protein-Rich Diet (Chicken, fish, beans, tofu)
    • Limit Caffeine & Sugary Foods (Ginger or Peppermint Tea)

    Drug - Drug interaction

    Oxetol 300mg Tablet drug interactions:

    1. Anti-Seizure medications (Antiepileptics)

    • Carbamazepine – increases the risk of side effects (drowsiness, dizziness, nausea)
    • Phenytoin & Phenobarbital – Oxetol may increase or decrease their levels, requiring dose adjustments
    • Valproate & Lamotrigine – Oxetol reduces their effectiveness, leading to poor seizure control
    • What to do? – monitor seizure control closely and adjust doses if needed

    2. Blood thinners (anticoagulants)

    • Warfarin - Oxetol may alter blood clotting, increasing the risk of bleeding or clot formation
    • What to do? – Regularly monitor INR levels (blood clotting tests) if taking warfarin

    3. Psychiatric medications (Antidepressants & Antipsychotics)

    • SSRIs (e.g., Fluoxetine, Sertraline) – may increase the risk of low sodium levels (hyponatremia)
    • Benzodiazepines (e.g., Diazepam, Lorazepam) – Increases sedation and dizziness
    • What to do? – monitor for symptoms of excessive drowsiness or confusion

    4. Immunosuppressants (used for organ transplants & autoimmune diseases)

    • Cyclosporine & Tacrolimus – Oxetol reduces their effectiveness, increasing the risk of organ rejection
    • What to do? – Doctors may adjust immunosuppressant doses as needed

    5. Painkillers & Anti-Inflammatory Drugs (NSAIDs)

    • Ibuprofen & Diclofenac – May increase blood pressure or kidney stress
    • Opioids (e.g., Morphine, Tramadol) – Enhances sedation and dizziness
    • What to Do? – Use painkillers cautiously and consult a doctor before combining

    Oxetol 300mg and Birth control pills

    Birth control pills (oral contraceptives)

    • Oxetol reduces the effectiveness of hormonal contraceptives, increasing the risk of pregnancy
    • What to Do? – Use non-hormonal birth control methods (e.g., condoms, IUD) while on Oxetol

    Drug - Food interaction

    Foods to avoid while taking Oxetol 300mg:

    1. Grapefruit & Grapefruit Juice

    • Why? It may increase Oxetol levels in the blood, leading to excessive drowsiness and side effects.
    • Alternative: Choose orange juice or other citrus fruits instead

    2. Caffeine & energy drinks

    • Why? High caffeine intake may worsen anxiety, restlessness, or affect sleep, which can be side effects of Oxetol.
    • Alternative: Opt for decaffeinated coffee, herbal tea, or water

    3. High-Sodium & Processed Foods

    • Why? Oxetol can cause low sodium levels (hyponatremia), and eating too much sodium-rich food can disrupt electrolyte balance.

    4. High-Fat & Fried Foods

    • Why? Fatty foods slow drug absorption and can worsen nausea (a side effect of Oxetol)
    • Alternative: Choose lean proteins, whole grains, and steamed/baked foods

    5. Excessive Sugary Foods

    • Why? High sugar intake causes energy crashes and can worsen fatigue, a common Oxetol side effect.
    • Alternative: Eat natural sugars from fruits and avoid processed sweets.

    6. Herbal Supplements & St. John’s Wort

    • Why? Some herbal supplements, especially St. John’s Wort, reduce Oxetol effectiveness and may trigger seizures
    • Alternative: Always check with your doctor before taking herbal teas or supplements

    Synopsis

    Drug :   Oxcarbazepine
    Pharmacological Category :   Anti-convulsant
    Therapeutic Indication :   It is used to manage partial seizures in adults with epilepsy as monotherapy or adjunctive therapy        
    Dosage Forms :   Tablet, Syrup, Suspension

    More Information

    Related Products:

    Myth vs. Fact blog posts:

    • Myth: "Oxetol cures epilepsy completely."
      Fact: Oxetol controls seizures but does not cure epilepsy. Long-term management is required.
    • Myth: "If I feel better, I can stop taking Oxetol."
      Fact: Stopping Oxetol suddenly can trigger seizures. Always consult your doctor before stopping.
    • Myth: "Oxetol makes everyone drowsy and weak."
      Fact: Side effects vary by person. Some may feel mild drowsiness, while others feel no effects.

    Comparing Oxetol vs. other epilepsy medications (e.g., Carbamazepine)

    Oxetol (Oxcarbazepine) vs. Carbamazepine

    Feature

    Oxetol (Oxcarbazepine)

    Carbamazepine 

    Use

    Manages epilepsy & neuropathic pain

    Manges epilepsy, trigeminal neuralgia & bipolar disorder

    Mechanism of Action

    Blocks sodium channels to stabilize nerve activity

    Similar mechanism but has a more potent effect on sodium channels

    Side Effects

    Less risk of serious skin reactions, but may cause hyponatremia (low sodium levels)

    Higher risk of rashes (Stevens-Johnson Syndrome), liver toxicity, dizziness

    Drug Interactions

    Fewer interactions, safer for multiple medications

    More interactions with antidepressants, blood thinners, birth control

    Drowsiness & Dizziness

    Milder than Carbamazepine

    More pronounced

    Effect on Sodium Levels

    Higher risk of hyponatremia (low sodium)

    Lower risk compared to Oxetol

    Liver Toxicity Risk

    Lower

    Higher

    Pregnancy Safety

    Category C – Risk exists; consult a doctor

    Category D – Higher risk of birth defects

    Effectiveness for Epilepsy

    Effective for partial seizures, fewer cognitive side effects

    Effective for partial & generalized seizures but more side effects

    Availability

    Commonly available, fewer generic versions

    More generic options available

    FAQs About OXETOL 300MG TABLET

    Q: What is Oxetol 300mg Tablet used for?

    A: Oxetol 300mg is primarily prescribed for managing epilepsy by reducing seizures. It works by reducing nerve impulses that cause seizures.

    Q: How does Oxetol 300mg work?

    A: Oxetol 300mg works by stabilizing electrical activity in the brain to reduce seizures. It belongs to the antiepileptic drug (AED) class and functions as a sodium channel blocker.

    Q: Can Oxetol 300mg Tablet be used for children?

    A: Yes, Oxetol 300mg Tablet can be used for children, but only under a doctor’s supervision. It is commonly prescribed for pediatric epilepsy to control partial seizures.

    Q: What to do if I miss a dose of Oxetol 300mg?

    A: Take Oxetol 300mg as soon as you remember, unless it is  close to your next scheduled dose. Do not double the dose to make up for the missed one, as this may increase the risk of side effects.

    Q: How long does it take for Oxetol 300mg to show effects?

    A: Oxetol 300mg (Oxcarbazepine) typically starts working within a few hours, but full benefits may take a few weeks depending on the condition being managed.

    Q: Can I stop taking Oxetol 300mg suddenly?

    A: No, stopping Oxetol 300mg suddenly can increase the risk of seizures. Consult your doctor for guidance.

    Q: Is Oxetol 300mg safe for long-term use?

    A: Yes, but regular monitoring is necessary for Oxetol 300mg to check for any adverse effects.

    Q: Can I continue taking my oral contraceptive pill with Oxetol 300mg?

    A: No. Oxetol 300mg may stop hormonal contraceptives from working properly. Your doctor may advise you to use a different or extra (non-hormonal) method of contraception while taking this medicine.

    Q: Does Oxetol 300mg Tablet affect my ability to drive or perform any activities?

    A: Do not drive or operate any machines after taking Oxetol 300 mg if you experience dizziness, drowsiness, balance or co-ordination problems, eye problems like double or blurred vision, low blood levels of sodium causing muscle weakness or decreased consciousness, especially when starting the management or increasing the dose. You can resume your activities once if you are normal again.

    Q: Is Oxetol 300mg safe to use in patients with liver problems?

    A: It should be used with caution in patients with liver problems or who develop liver problems during management with this medicine and in serious liver problems your doctor may adjust the dose.

    Q: Is Oxetol 300mg safe?

    A: Yes, Oxetol 300mg is generally safe when taken as prescribed by a doctor. However, like all medications, it may cause side effects in some individuals.

    Q: Does Oxetol 300mg Tablet cause weight gain?

    A: Oxetol 300mg Tablet (Oxcarbazepine) is not commonly associated with weight gain, but its effects on weight may vary between individuals.

    Q: Does Oxetol 300mg cause drowsiness?

    A: Yes, Oxetol 300mg Tablet can cause drowsiness as a common side effect. Take Oxetol at the same time daily, preferably in the evening if drowsiness is strong.

    Q: Is Oxetol 300mg safe during pregnancy?

    A: Oxetol 300mg should be used during pregnancy only if the benefits outweigh the risks. It is classified as a Pregnancy Category C drug, meaning animal studies have shown potential risks, but human data is limited. Consul your doctor for advice.

    References

    1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Epilepsy. Pharmacotherapy Handbook. Ninth edition. 2015. Page-518.

    2. S M Grant, D Faulds. Oxcarbazepine. A review of its pharmacology and therapeutic potential in epilepsy, trigeminal neuralgia and affective disorders. NIH. National Center for Biotechnology Information.Pubmed.gov. June 1992. [Accessed on 28th February 2025] 

    3. Charles V. Preuss, Gagandeep Randhawa, Tom Joshua P. Wy, Abdolreza Saadabadi. Oxcarbazepine. NIH. National Library of Medicine. National Center for Biotechnology Information. May 2022. [Accessed on 28th February 2025] 

    4. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2022] [Accessed on 28th February 2025] 

    5. Torrent Pharmaceuticals Ltd. Oleptal OD (Oxcarbazepine). [Revised in July 2019] [Accessed on 28th February 2025] 

    6. Central Drugs Standard Control Organization (CDSCO). Oxcarbazepine. [Accessed on 28th February 2025] 

    Author Details

    Written By Dr. Janet.C - Pharm.D
    Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)
    Last updated on 05 Mar 2025 | 10:03 AM(IST)
    Lab updated