Opiprime 50mg Tablet 10'S

Introduction About OPIPRIME 50MG TABLET

OPIPRIME 50MG TABLET contains Opipramol which belongs to the group of medicines called Antidepressants. OPIPRIME 50MG TABLET is used to manage generalised anxiety disorder and somatic disturbances (a mental health condition in which a person feels significantly distressed about physical symptoms such as pain or fatigue and has abnormal thoughts, feelings and behaviours in response to them). Generalised anxiety disorder is a mental health disorder that produces fear, worry, and a constant feeling of being overwhelmed. It is characterized by symptoms such as excessive, persistent, and unrealistic worry about everyday things.

Opipramol works by binding to certain receptors (sigma receptor) in the brain and spinal cord, as a result it works in the N-methyl-D-aspartate (NMDA) receptor system and influences the neurotransmitters glutamate and dopamine (messenger substances in the brain) and produces a calming and anxiety-relieving effect followed by enhancement of mood.

OPIPRIME 50MG TABLET should be used during first trimester of pregnancy unless clearly advised by your doctor and it is not recommended for use in breastfeeding women. Contact your doctor before taking it. OPIPRIME 50MG TABLET is not recommended for use in patients with liver or kidney disease, heart problems such as pre-existing high-grade atrioventricular block or supraventricular or ventricular conduction disturbances, acute urinary retention, unmanageed glaucoma, brain damage and fits.

OPIPRIME 50MG TABLET should be used with caution in children (above 6 years of age) and child’s doctor may adjust the dose depending upon body weight. The most common side effects of taking OPIPRIME 50MG TABLET are fatigue, dry mouth, stuffy nose and low blood pressure. Contact your physician if any of the symptoms worsen.

Uses Of OPIPRIME 50MG TABLET

Manage:

• generalised anxiety disorder
• somatic disturbances

How OPIPRIME 50MG TABLET Works

OPIPRIME 50MG TABLET works by binding to certain receptors (sigma receptor) in the brain and spinal cord, as a result it works in the N-methyl-D-aspartate (NMDA) receptor system and influences the neurotransmitters glutamate and dopamine (messenger substances in the brain) and produces a calming and anxiety-relieving effect followed by enhancement of mood.

How to use OPIPRIME 50MG TABLET

Take OPIPRIME 50MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of OPIPRIME 50MG TABLET

How To Manage Side Effects

Constipation

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.

Dizziness Or Drowsiness

Lie down until dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids. Consult your doctor if the symptom does not improve or worsens.

Headache

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Take this medicine with, or just after, a meal or snack and stick to simple meals and do not eat oil rich or spicy food. Consult your doctor if the symptom does not improve.

Tiredness

Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Monitoring required

OPIPRIME 50MG TABLET can be used with caution in pregnancy, especially in the first trimester of pregnancy only if considered clearly necessary. Contact your doctor before taking OPIPRIME 50MG TABLET.

Breastfeeding

Contraindicated

OPIPRIME 50MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk in small amounts. Contact your doctor before taking OPIPRIME 50MG TABLET.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines after taking OPIPRIME 50MG TABLET as it may change responsiveness of normal functions.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking OPIPRIME 50MG TABLET as it may cause drowsiness.

Kidney

Contraindicated

OPIPRIME 50MG TABLET is not recommended for use in patients with kidney disease. Contact your doctor before taking OPIPRIME 50MG TABLET.

Liver

Contraindicated

OPIPRIME 50MG TABLET is not recommended for use in patients with liver disease. Contact your doctor before taking OPIPRIME 50MG TABLET.

Allergy

Contraindicated

Do not take OPIPRIME 50MG TABLET if you are allergic to opipramol or to other ingredients of this medicine.

Heart Disease

Contraindicated

OPIPRIME 50MG TABLET is not recommended for use in patients with pre-existing high-grade AV block or supraventricular or ventricular conduction disturbances. Contact your doctor before taking OPIPRIME 50MG TABLET.

Use In Pediatrics

Use with Caution

OPIPRIME 50MG TABLET should be used with caution in children above 6 years of age and dose may be adjusted depending upon body weight. Consult child’s doctor for advice.

Interactions

A. Drug-Drug interactions:

Before taking OPIPRIME 50MG TABLET, inform your doctor if you are taking any of the following medicines:

• neuroleptics such as chlorpromazine, haloperidol, risperidone and fluphenazine (medicines used to manage schizophrenia and other psychoses)
• barbiturates Ex. phenobarbitone, methylphenobarbital and phenytoin (medicines used for fits)
• benzodiazepines Ex. alprazolam, diazepam (medicines used to manage anxiety and panic disorders)
• anticholinergics such as trihexyphenidyl, benztropine and monoamine oxidase inhibitor (MAO) inhibitors like selegiline, rasagiline (medicines used to manage parkinson’s disease)
• fluoxetine and fluvoxamine (medicines used to manage depression and anxiety disorders)
• beta-blockers such as propranolol (medicines used to manage hypertension and heart diseases)
• propafenone, quinidine (used to manage heart rhythm disorders)
• tricyclic antidepressants Ex. imipramine, desipramine (medicines used to manage depression)
• analgesics (medicines used to manage pain) Ex. ibuprofen, diclofenac
• guanethidine, clonidine (medicines used to manage high blood pressure)
• cimetidine (medicines used to manage gastric ulcers)
• warfarin (medicines used to manage or manage blood clots)
• sympathomimetics like dobutamine (medicines used for decompensated heart failure)

Overdosage:

If you or anyone else accidentally take too much of OPIPRIME 50MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are dizziness, drowsiness, restlessness, insomnia, altered consciousness, temporary confusion, increased anxiety, impaired coordination, convulsions (fits), low urine output, low or no urine production, fast or slow heart rate, atrioventricular block (type of heart block), respiratory depression and rarely cardiac arrest.

Synopsis

More Information

• Keep OPIPRIME 50MG TABLET out of reach to children
• Store OPIPRIME 50MG TABLET at room temperature

FAQs About OPIPRIME 50MG TABLET

Q: What is OPIPRIME 50MG TABLET used for?

A: OPIPRIME 50MG TABLET is used to manage generalised anxiety disorder, and somatic disturbances. It is used in adults and in children above 6 years of age. Consult your doctor before taking OPIPRIME 50MG TABLET if you have any pre-existing disease condition or problems.

Q: What are the common side effects of taking OPIPRIME 50MG TABLET?

A: The most common side effects of taking OPIPRIME 50MG TABLET are fatigue, dry mouth, stuffy nose, low blood pressure, and orthostatic dysregulation (low blood pressure when standing up from sitting or lying position). Contact your physician if any of the symptoms worsen.

Q: Is OPIPRIME 50MG TABLET safe during pregnancy?

A: OPIPRIME 50MG TABLET should be used with caution in pregnancy, especially in the first trimester of pregnancy only if considered clearly necessary. Contact your doctor before taking OPIPRIME 50MG TABLET if you are pregnant or planning to become pregnant.

Q: Can I drive after taking OPIPRIME 50MG TABLET?

A: Do not drive or operate any machines after taking OPIPRIME 50MG TABLET as it may change responsiveness of normal functions. You may ask someone to drive for you or consult your doctor for further precautions.

Q: Can OPIPRIME 50MG TABLET be used in patients with heart problems?

A: OPIPRIME 50MG TABLET is not recommended for use in patients with heart problems such as pre-existing high-grade atrioventricular block (type of heart block) or supraventricular or ventricular conduction disturbances. Contact your doctor for advice before taking OPIPRIME 50MG TABLET.  

References

1. Christof Schaefer, Paul Peters, Richard K. Mille. Tri- and tetracyclic antidepressants. Drugs during Pregnancy and lactation. Third edition. 2015. Page – 302.

2. Maximilian Gahr , Christoph Hiemke, Bernhard J Connemann. Opipramol. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. March 2017. [Accessed on 25th June 2022] https://pubmed.ncbi.nlm.nih.gov/28320023/

3. Klaus Gerlach, Thomas Uhlig, Jasmin Plathof, Andre Klassen, Klaus-Dieter Stoll, Peter Schmucker, Michael Hueppe. Effects of opipramol as an evening anaesthesiologic premedication. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2022. [Accessed on 25th June 2022] https://pubmed.ncbi.nlm.nih.gov/12422064/

4. Torrent Pharmaceuticals Ltd. Jolivel (Opipramol Dihydrochloride Tablets). [Revised in August 2015] [Accessed on 25th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2744.pdf

Useful Diagnostic Tests

• Complete blood count
• Liver function test

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Aravindan Balachandran - MBBS, MD (Psychiatry)

Last updated on 20 Mar 2023 | 09:03 AM(IST)