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Introduction About OLMEZEST AZ 20 TABLET
OLMEZEST AZ 20 TABLET is used to manage severe hypertension and chronic heart failure. It contains a combination of medicines called Azelnidipine and Olmesartan, which belong to the group of medicines called Antihypertensives. Azelnidipine works by blocking calcium channels in blood vessels, which helps them relax and lower blood pressure. Olmesartan blocks a hormone that narrows blood vessels, also helping to reduce blood pressure.
Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (Ex. potassium) in your blood at regular intervals.
OLMEZEST AZ 20 TABLET is not recommended for use if you have impaired kidney function, jaundice (yellowing of the skin and eyes), or problems with drainage of the bile from the gallbladder (biliary obstruction, Ex. gallstones).
Inform your doctor if you have kidney disease, liver disease, heart failure, or problems with your heart valves or heart muscle before taking this medicine. It is not recommended for use in pregnant and breastfeeding women.
The safety and effectiveness of OLMEZEST AZ 20 TABLET in newborns, infants, and children is not established. This medicine should be used with caution in elderly patients aged over 65 years of age. Consult your doctor before taking it.
The most common side effects of taking OLMEZEST AZ 20 TABLET are dizziness, tiredness, headache, nausea, indigestion, diarrhea, stomachache, gastroenteritis, sore throat, runny or stuffy nose, bronchitis, flu-like symptoms, cough, pain, pain in the chest, back, bones or joints, infection of the urinary tract, blood in the urine, and swelling of ankles, feet, legs, hands, or arms. Consult your doctor if any of the side effects worsen.
How OLMEZEST AZ 20 TABLET Works
Azelnidipine is a calcium channel blocker. It works by relaxing the blood vessels, making it easier for blood to flow. This helps lower high blood pressure. Olmesartan is an angiotensin II receptor blocker (ARB). It prevents a substance called angiotensin II from tightening the blood vessels. By blocking its action, olmesartan helps to lower blood pressure.
How to use OLMEZEST AZ 20 TABLET
- Take this medicine as advised by your doctor.
- Swallow the tablet with a glass of water and do not crush or chew the medicine.
- Your doctor will decide the correct dose and duration for you depending on your age, condition, and body weight.
- Continue to take this medication unless your doctor tells you to stop.
Side Effects Of OLMEZEST AZ 20 TABLET
COMMON
- dizziness, tiredness
- headache
- nausea, indigestion, diarrhea, stomachache
- gastroenteritis
- sore throat
- runny or stuffy nose
- bronchitis
- flu-like symptoms, cough
- pain
- pain in the chest, back, bones, or joints
- infection of the urinary tract, blood in the urine
- swelling of ankles, feet, legs, hands, or arms
Stop taking OLMEZEST AZ 20 TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions such as rash, itching, swelling of the face, mouth, and/or larynx, severe lightheadedness, or fainting.
Warning & Precautions
Pregnancy
ContraindicatedOLMEZEST AZ 20 TABLET is not recommended for use in pregnancy as it may cause serious harm to your baby.
Breastfeeding
ContraindicatedOLMEZEST AZ 20 TABLET is not recommended for use in breastfeeding women. Your doctor may choose an alternative if you wish to breastfeed, especially if your baby is newborn or was born prematurely.
Driving and Using Machines
Use with CautionDo not drive or operate machinery if you feel dizzy or sleepy after taking OLMEZEST AZ 20 TABLET.
Kidney
ContraindicatedOLMEZEST AZ 20 TABLET is not recommended for use if you have impaired kidney function. Inform your doctor if you have kidney disease before taking this medicine.
Liver
Consult your doctorOLMEZEST AZ 20 TABLET is not recommended for use if you suffer from jaundice (yellowing of the skin and eyes) or problems with drainage of the bile from the gallbladder (biliary obstruction, Ex. gallstones). It should be used with caution in patients with liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take OLMEZEST AZ 20 TABLET if you are allergic to Azelnidipine, olmesartan, or any of the other ingredients in this medicine.
Heart Disease
Use with CautionOLMEZEST AZ 20 TABLET should be used with caution in patients with heart failure or problems with your heart valves or heart muscle. Consult your doctor for advice.
Use In Pediatrics
Consult your doctorThe safety and effectiveness of OLMEZEST AZ 20 TABLET in newborns, infants, and children is not established.
Use In Geriatrics
Use with CautionOLMEZEST AZ 20 TABLET should be used with caution in elderly patients aged over 65 years of age. Consult your doctor before taking it.
Others
OLMEZEST AZ 20 TABLET is not recommended for use if you:
- Have diabetes
Before taking OLMEZEST AZ 20 TABLET, inform your doctor if you:
- Suffer from severe vomiting
- Have diarrhea
- Are on a low-salt diet
- Have high levels of potassium in the blood
- Have problems with adrenal glands
- Have intolerance to sugars
- Are scheduled for blood tests
Interactions
A. Drug-Drug Interactions:
Tell your physician if you are taking any of the following medicines before taking OLMEZEST AZ 20 TABLET:
- Antihypertensives (Ex. aliskiren, enalapril, lisinopril, ramipril)
- Diuretics (Ex. spironolactone)
- Anticoagulant (Ex. heparin)
- Antimanic (Ex. lithium)
- Non-steroidal anti-inflammatory drugs (NSAIDs) (Ex. ibuprofen)
- Antihyperlipidemic (Ex. colesevelam hydrochloride)
- Antacids (Ex. aluminium hydroxide)
- Antifungals (Ex. itraconazole, miconazole)
- Antiviral (Ex. ritonavir, saquinavir, indinavir, Delavirdine mesylate)
- Cardiac glycosides (Ex. digoxin)
- H2 receptor antagonist (Ex. cimetidine)
- Tyrosine kinase inhibitor (Ex. imatinib mesylate)
- Macrolides (Ex. erythromycin, clarithromycin)
- Statins (Ex. simvastatin)
- Immunosuppressant (Ex. cyclosporin)
- Benzodiazepines (Ex. diazepam, midazolam, and triazolam)
- Oral birth control pills, follicular, and luteinizing hormones
- Anxiolytic and antidepressant (Ex. tandospirone citrate)
- Antitubercular (Ex. rifampicin)
- Anticonvulsant (Ex. phenobarbital, phenytoin)
B. Drug-food interactions:
Avoid grapefruit juice while taking this medicine due to the increased risk of low blood pressure.
Overdosage:
If you or anyone else accidentally takes too much of OLMEZEST AZ 20 TABLET, consult your doctor immediately or visit the nearby hospital. Signs and symptoms of overdosage include excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia.
Synopsis
| Drug | : | Azelnidipine, Olmesartan |
| Pharmacological Category | : | Calcium channel blocker and Angiotensin receptor blocker (ARB) |
| Therapeutic Indication | : | Severe hypertension, chronic heart failure |
| Dosage Forms | : | Tablet |
More Information
Severe hypertension is characterized by consistently high blood pressure, which can lead to serious health issues, while chronic heart failure occurs when the heart cannot pump blood effectively. Symptoms of severe hypertension include headaches and shortness of breath, whereas chronic heart failure may cause fatigue and swelling. Key causes include unhealthy lifestyle choices and conditions like coronary artery disease, which can both contribute to these cardiovascular issues.
To know more about the heart diseases:
Some lifestyle changes that will help heart health:
FAQs About OLMEZEST AZ 20 TABLET
Q: What is the use of OLMEZEST AZ 20 TABLET?
A: OLMEZEST AZ 20 TABLET is used to manage severe hypertension and chronic heart failure. It contains Azelnidipine and Olmesartan, which belong to the group of medicines called Antihypertensives.
Q: What if I forget to take a dose of OLMEZEST AZ 20 TABLET?
A: If you miss a dose of OLMEZEST AZ 20 TABLET, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Q: What are the side effects of OLMEZEST AZ 20 TABLET?
A: The most common side effects of taking OLMEZEST AZ 20 TABLET are dizziness, tiredness, headache, nausea, indigestion, diarrhea, stomachache, gastroenteritis, sore throat, runny or stuffy nose, bronchitis, flu-like symptoms, cough, pain, pain in the chest, back, bones or joints, infection of the urinary tract, blood in the urine, and swelling of ankles, feet, legs, hands, or arms. Consult your doctor if any of the side effects worsen.
Q: Can I stop taking OLMEZEST AZ 20 TABLET once my blood pressure is normal?
A: No, even if your blood pressure becomes normal, you should continue taking the medication as prescribed. Stopping it suddenly can cause a rebound increase in blood pressure, leading to serious health risks. Always consult your doctor before stopping this medication.
Q: Is OLMEZEST AZ 20 TABLET safe during pregnancy?
A: OLMEZEST AZ 20 TABLET is not recommended for use in pregnancy as it may cause serious harm to your baby. Inform your doctor if you are pregnant, think you may be pregnant, or are planning to get pregnant before taking this medication.
Q: Who should avoid OLMEZEST AZ 20 TABLET?
A: OLMEZEST AZ 20 TABLET is not recommended for use if you have diabetes, impaired kidney function, jaundice (yellowing of the skin and eyes), biliary obstruction (Ex. gallstones), or are allergic to Azelnidipine or olmesartan.
Q: What precautions must be taken while using OLMEZEST AZ 20 TABLET?
A: Before taking OLMEZEST AZ 20 TABLET, inform your doctor if you suffer from severe vomiting, diarrhea, or are on a low-salt diet, high levels of potassium in the blood, problems with adrenal glands, intolerance to sugars, kidney disease, liver disease, heart failure, or problems with your heart valves or heart muscle.
Q: Can OLMEZEST AZ 20 TABLET be used in children?
A: The safety and effectiveness of OLMEZEST AZ 20 TABLET in newborns, infants, and children is not established.
Q: What should I avoid while taking OLMEZEST AZ 20 TABLET?
A: Avoid grapefruit juice while taking this medicine due to the increased risk of low blood pressure.
Q: Is OLMEZEST AZ 20 TABLET safe for kidneys?
A: OLMEZEST AZ 20 TABLET is not recommended for use if you have impaired kidney function. Inform your doctor if you have kidney disease before taking this medicine.
References
1. K.D. Tripathi. Drugs affecting the Renin-Angiotensin System. Essentials of Medical Pharmacology. Eight Edition. 2019. Page – 535.
2. STADA M&D SRL. Electronic Medicines Compendium (EMC). [Revised in March 2024] [Accessed on 10th October 2024] click here
3. Azelnidipine. J. B. CHEMICALS & PHARMACEUTICALS LTD. [Revised in November 2022] [Accessed on 10th October 2024] click here
4. Azelnidipine, and Olmesartan. Innovative Pharmaceuticals Pvt Ltd. [Accessed on 10th October 2024] click here
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