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Introduction About OLMESAR AV TABLET
OLMESAR AV TABLET is a combination of Atorvastatin and Olmesartan which belongs to the group of medicines called Antihyperlipidemics and Antihypertensives respectively. It is used to manage hypertension (high blood pressure) and hyperlipidemia (high blood cholesterol levels) in patients who have both co-existing medical conditions. It can also be used to manage the risk of heart attack, stroke and other heart problems.
Before taking OLMESAR AV TABLET inform your doctor if you have any lung, liver, kidney or heart problems (apart from hypertension such as heart failure). You must also inform your doctor if you have diabetes, thyroid disorders, muscle problems, alcoholism or severe dehydration as a precaution.
OLMESAR AV TABLET is not recommended for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby or the nursing baby. The most common side effects of taking OLMESAR AV TABLET are dizziness, headache, nausea, constipation, high blood potassium levels and high blood sugar levels. Consult your doctor if any of these side effect worsens.
Uses Of OLMESAR AV TABLET
It is used to:
- Manage high blood pressure
- Manage high blood cholesterol levels
- Prevent the risk of heart attack or stroke
How OLMESAR AV TABLET Works
OLMESAR AV TABLET effectively reduces high blood pressure and high blood cholesterol levels. It contains two medicines namely, olmesartan and atorvastatin. Olmesartan relaxes the blood vessels supplying the heart and other vital organs of the body. As a result, it improves blood flow and oxygen supply to the heart which reduces strain on the heart and improves heart functions.
Atorvastatin is a lipid-lowering medicine. It blocks the release of certain enzymes (HMG-CoA reductase) that is involved in cholesterol formation within the body. It also reduces the amount of cholesterol produced by the liver and improves the excretion of lipids from the body via faeces.
Collectively, this medicine reduces blood pressure and blood cholesterol levels and manages you from their associated risks.
How to use OLMESAR AV TABLET
Take OLMESAR AV TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. OLMESAR AV TABLET can be taken with or without meals. Try to take OLMESAR AV TABLET at the same time each day.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Continue to take OLMESAR AV TABLET for the stipulated duration instructed by your doctor without interruption to achieve better results.
Side Effects Of OLMESAR AV TABLET
Common
- low blood pressure
- nausea, vomiting, stomach pain, constipation, diarrhea, indigestion
- headache, dizziness
- joint pain, muscle pain or back pain
- high blood sugar levels (causing frequent urination, excessive thirst, or hunger)
- high blood potassium levels (causing muscle weakness, irregular heartbeat, chest pain)
- stuffy nose, sore throat, nose bleeds, sinus inflammation
- inflammation of the bronchus
- cough, flu-like symptoms
- urinary tract infection
- swelling of body parts
- high blood uric acid levels
Uncommon
- loss of appetite
- weight gain
- difficulty in sleeping
- tingling or numbness in fingers or toes, loss of pain or touch sensation
- altered taste sensation, loss of memory
- blurred vision
- ringing sound in the ears
- hair loss
- neck pain, muscle tiredness
- vertigo (spinning sensation)
Rare
- tendon injury (bone injury)
- high potassium levels in blood
Stop taking OLMESAR AV TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as peeling and swelling of the skin, blistering of skin around mouth, eyes, genitals, and fever, skin rash with red raised lump on palms of hands or sole of the feet)
- muscle weakness, tenderness or pain with fever, tiredness, red-brown discoloration of urine (signs of rhabdomyolysis)
- signs of liver problem (such as unusual bleeding or bruising)
- lupus-like disease syndrome (such as joint disorders, rash and altered count of blood cells)
- sepsis (infection of blood)
How To Manage Side Effects
Nausea and vomiting:
Take OLMESAR AV TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
OLMESAR AV TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, inform your doctor before taking OLMESAR AV TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with OLMESAR AV TABLET, stop taking it and consult your doctor immediately.
Breastfeeding
OLMESAR AV TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking OLMESAR AV TABLET.
Alcohol
Avoid consumption of alcohol while taking OLMESAR AV TABLET as it might make you feel dizzier and drowsier.
Kidney
OLMESAR AV TABLET should be used with caution in patients with kidney problems (such as recent kidney transplant, renal artery stenosis (narrowing of blood vessels leading to kidneys) or dialysis)). Therefore, consult your doctor before taking it.
Liver
OLMESAR AV TABLET is not recommended for use in patients with severe liver problems (such as jaundice, cholestasis or biliary obstruction). It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take OLMESAR AV TABLET if you are allergic to Atorvastatin and Olmesartan.
Lungs
OLMESAR AV TABLET should be used with caution in patients with severe respiratory failure (breathing problem). Therefore, consult your doctor before taking.
Heart Disease
OLMESAR AV TABLET should be used with caution in patients with heart problems (such as heart failure or problems in heart valves). Therefore, consult your doctor before taking it.
Others
OLMESAR AV TABLET is not recommended for you, if you:
- have diabetes related kidney problems
Before taking OLMESAR AV TABLET, inform your doctor if you:
- have low blood pressure or are severely dehydrated (due to diarrhea, vomiting or excess sweating)
- are on a low-salt diet
- have primary hyperaldosteronism (problems in adrenal gland)
- have diabetes
- have hyperkalemia (high blood potassium levels)
- have or previously had stroke (bleeding in the brain)
- have hypothyroidism (thyroid deficiency)
- have a history of hereditary muscular disorders
- previously had any muscle problems after taking statins (such as rosuvastatin)
- are an alcoholic
- are overweight
- are undergoing any major surgery
Use in pediatrics:
OLMESAR AV TABLET should be used in children (aged 10 years or above) only if prescribed by the physician. Therefore, consult your doctor before taking it.
Use in geriatrics:
OLMESAR AV TABLET should be used with caution in elderly patients (aged 70 years or older) especially who have muscle related problems. Therefore, consult your doctor before taking.
Interactions
A. Drug-Drug interactions:
Before taking OLMESAR AV TABLET inform your doctor, if you are taking any of the following medicines such as:
- other medicines used to manage elevated blood pressure (such as aliskiren, captopril, enalapril, lisinopril, losartan, valsartan)
- other medicines used to reduce blood cholesterol levels (Ex. gemfibrozil, ezetimibe, colestipol, colesevelam)
- medicines used to manage angina or other heart problems (Ex. amlodipine, diltiazem, verapamil, amiodarone, and digoxin)
- lithium, St. John’s wort (medicines used to manage depression)
- potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
- non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
- medicines to manage graft rejection (Ex. cyclosporin, tacrolimus, sirolimus)
- medicines used to manage Hepatitis C infection (Ex. telaprevir, boceprevir and combination of elbasvir/grazoprevir)
- medicines used to manage fungal infection (Ex. ketoconazole, itraconazole, voriconazole, fluconazole, posaconazole)
- medicines used to manage bacterial infections (Ex. fusidic acid, erythromycin, clarithromycin, telithromycin, trimethoprim)
- medicines used to manage HIV infection (Ex. ritonavir, lopinavir, atazanavir, indinavir, darunavir)
- warfarin, heparin (used to manage or manage blood clots)
- letermovir (a medicine used to manage cytomegalovirus)
- phenazone (a pain killer)
- oral contraceptives (birth control pill) Ex. levonorgestrel, ethinylestradiol
- cimetidine (a medicine used to manage heartburn and stomach ulcers)
- colchicine (a medicine used to manage gout)
- antacids (used to neutralize stomach acid) Ex. aluminium hydroxide, milk of magnesia
- stiripentol (a medicine used to manage fits)
B. Drug-Food interactions:
While taking OLMESAR AV TABLET, avoid drinking grapefruit juice as it may interact with OLMESAR AV TABLET and reduce its effectiveness.
Overdosage:
If you or anyone else accidentally take too much of this medicine, consult your doctor immediately. Overdosage may cause side effects such as low blood pressure, increased or decreased heartbeat, low blood pressure and dizziness.
Synopsis
| Drug | : | Atorvastatin, Olmesartan |
| Pharmacological Category | : | HMG-CoA reductase inhibitors, Anginotensin-II receptor blockers |
| Therapeutic Indication | : | High blood pressure, High blood cholesterol levels, Management of heart attack or stroke |
| Dosage Forms | : | Tablet |
More Information
- Keep OLMESAR AV TABLET out of reach of children
- Store OLMESAR AV TABLET at room temperature
FAQs About OLMESAR AV TABLET
Q: What are the uses of OLMESAR AV TABLET?
A: OLMESAR AV TABLET is used to manage hypertension (high blood pressure) and hyperlipidemia (high blood cholesterol levels) in patients who have both co-existing medical conditions. It can also be used to manage the risk of heart attack, stroke, angina and other heart problems.
Q: Can the use of OLMESAR AV TABLET cause diabetes?
A: Yes. OLMESAR AV TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension. Therefore, consult your doctor before taking this medicine if you are diabetic, obese or have hypertension. Your doctor will closely monitor your blood sugar levels while undergoing therapy with OLMESAR AV TABLET to avoid any unwanted side effects.
Q: What is the best time to take OLMESAR AV TABLET?
A: Take OLMESAR AV TABLET as advised by your physician. Your doctor will decide the best time for you to take OLMESAR AV TABLET. Try to take this medicine at the same time each day. It can be taken with or without food.
Q: What are the side effects of taking OLMESAR AV TABLET?
A: The most common side effects of taking OLMESAR AV TABLET are dizziness, headache, nausea, constipation, high blood potassium levels and high blood sugar levels. Consult your doctor if any of these side effect worsens.
Q: Can I consume alcohol along with OLMESAR AV TABLET?
A: OLMESAR AV TABLET should be used with caution in patients who consume large amounts of alcohol. It is advisable to avoid alcohol consumption while taking this medicine to achieve maximum benefits.
Q: Can the use of OLMESAR AV TABLET make me feel more tired?
A: Yes. The use of OLMESAR AV TABLET can make you feel more tired, because it acts by reducing the supply of energy to the muscles present in your body. However, you may also feel tired due to other reasons such as severe liver damage. Consult your doctor if you experience excessive tiredness with muscle pain.
Q: Who should not take OLMESAR AV TABLET?
A: OLMESAR AV TABLET is not recommended for use in patients with severe liver damage. It is also not suitable for use in patients having muscle problems and in women in who are pregnant or breastfeeding. Before taking OLMESAR AV TABLET inform your doctor if you have diabetes or any kidney or heart problems. Do not take this medicine if you are undergoing therapy with antibiotics such as fusidic acid.
Q: What are the dietary restrictions that I need to follow while taking OLMESAR AV TABLET?
A: While taking OLMESAR AV TABLET, follow a low-cholesterol diet as instructed by your doctor and avoid excessive alcohol intake. Avoid eating oil rich or deep-fried foods. Limit your sugar intake by avoid eating biscuits, cakes, soft drinks, or pastries. Stick to a simple nutritious diet. Avoid consumption of grapefruit while taking OLMESAR AV TABLET as it may reduce its effectiveness.
Q: What should I do if I forget to take a dose of OLMESAR AV TABLET?
A: If you forget to take a dose of OLMESAR AV TABLET, take it as soon as you remember. However, if it is time to take the next dose of OLMESAR AV TABLET, skip the missed dose and take the next one at regular times. Do not take a double dose of OLMESAR AV TABLET to compensate the missed dose, as it could lead to toxicity.
Q: Can I stop taking OLMESAR AV TABLET once my symptom subsides?
A: Do not stop taking this medicine without consulting your doctor, as it could once again increase your blood pressure and cholesterol levels once again. OLMESAR AV TABLET can only control your hypertension and blood cholesterol levels and cannot manage them completely, therefore, it is important to take this medicine until your doctor advises you to stop.
Q: Can I take OLMESAR AV TABLET if I am diabetic?
A: OLMESAR AV TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension. Therefore, consult your doctor before taking OLMESAR AV TABLET if you are diabetic, obese or have hypertension
Q: Does OLMESAR AV TABLET cause muscle pain?
A: OLMESAR AV TABLET may cause a rare but serious side effect of unexplained muscle pain or weakness called rhabdomyolysis. Therefore, consult your doctor if you experience any signs of muscle problems after taking OLMESAR AV TABLET. Also, talk to your doctor before taking OLMESAR AV TABLET if you already have weak muscles or have a family history of any muscle disorders.
Q: How OLMESAR AV TABLET controls cholesterol levels in the body?
A: OLMESAR AV TABLET is a lipid-lowering medicine. It blocks the release of certain enzymes (HMG-CoA reductase) that is involved in cholesterol formation within the body. It also reduces the amount of cholesterol produced by the liver and improves the excretion of lipids from the body via faeces.
Q: How long should I take OLMESAR AV TABLET to manage high cholesterol?
A: You should take OLMESAR AV TABLET as long as your doctor advises you to take. Because OLMESAR AV TABLET will only help you in managing your blood pressure and cholesterol levels and cannot completely manage them. If you stop using OLMESAR AV TABLET, your symptoms may raise once again.
Q: Can OLMESAR AV TABLET be taken by pregnant or breast-feeding women?
A: OLMESAR AV TABLET is not recommended for use in pregnant or in breast-feeding women. Therefore, consult your doctor before taking it. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with this medicine. However, if you accidentally become pregnant while taking this medicine, stop taking it and consult your doctor immediately.
Q: Can I take OLMESAR AV TABLET daily?
A: Take OLMESAR AV TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take OLMESAR AV TABLET every day or not.
Q: Can OLMESAR AV TABLET cause ankle swelling?
A: OLMESAR AV TABLET may cause edema or swelling of ankles in few patients. If you experience ankle swelling, keep your legs on a table or slightly elevated from the ground level. If this symptom bothers you, contact your doctor.
Q: Can the use of OLMESAR AV TABLET affect the liver?
A: Yes. OLMESAR AV TABLET may affect the way your liver work. Therefore, it is not recommended for use in patients with severe liver problems (such as jaundice, cholestasis or biliary obstruction). It should be used with caution in patients with other liver problems. Consult your doctor before taking it.
References
1. K.D. Tripathi. Drugs affecting renin angiotensin system and plasma kinins & Hypolipidaemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page –507 & 637.
2. Lindsey A. McIver; Momin S. Siddique. Atorvastatin. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2022. [Accessed on 5th January 2023] https://www.ncbi.nlm.nih.gov/books/NBK430779/
3. Xiaoshen Zhang, Han Zhang, Yuxia Ma, Wenliang Che and Michael R. Hamblin. Management of Hypertension Using Olmesartan Alone or in Combination. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. March 2017. [Accessed on 5th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446820/
4. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 5th January 2023] https://www.medicines.org.uk/emc/files/pil.4339.pdf
5. Glenmark Pharmaceuticals Europe Limited. Olmesartan medoxomil 10 mg, 20 mg and 40 mg Film-coated Tablets olmesartan medoxomil. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 5th January 2023] https://www.medicines.org.uk/emc/files/pil.9886.pdf
6. Central Drugs Standard Control Organization. Olmesartan (20/40mg )+ Atorvastatin 5/10/20mg film coated tablets. October 2009. [Accessed on 5th January 2023] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- Kidney function tests
- CBC
- Lipid Profile
- Liver Function Test
- Echocardiography
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