OBPARP 150 Tablet 8's
Netmeds First Membership
Quick Links
Introduction About OBPARP 150 TABLET
OBPARP 150 TABLET is used in the management of various types of cancer such as ovarian cancer, breast cancer, pancreatic cancer and prostate cancer that is caused or relapsed due to certain gene mutations (like BRCA, HER-2 negative genes). It can be used as a single agent or in combination with other anticancer agents for effective management.
It contains a medicine called Olaparib which is an anticancer agent. It works by blocking the actions of certain enzymes which is required for the cancer cells to grow and multiply.
OBPARP 150 TABLET should be used under careful medical supervision. It can be taken with or without food. Do not stop taking OBPARP 150 TABLET without consulting your doctor.
During therapy with OBPARP 150 TABLET, your doctor will schedule blood tests regularly in order to evaluate the effectiveness of this medicine and to avoid side effects. Make sure you take all the blood test recommended by your doctor. Do not drink grapefruit juice along with this medicine, as it may affect the way this medicine works.
OBPARP 150 TABLET should not be used in pregnant or breastfeeding women, as it could harm the unborn baby or nursing infant. Women of childbearing potential must use a very effective contraceptive (hormone medicines and condoms) to avoid pregnancy while on therapy with Olaparib. Men must also use condoms to avoid sexual exposure of Olaparib to their female partners even if they are pregnant.
Before taking OBPARP 150 TABLET inform your doctor if you have any liver or kidney problems. The most common side effects of taking OBPARP 150 TABLET are nausea, vomiting, tiredness, weakness, indigestion or heartburn, loss of appetite, diarrhea, upper stomach pain, low RBC, WBC and platelet levels, headache, Changes in taste of foods, skin rashes and mouth ulcers. Consult your doctor if any of these side effects troubles you.
Uses Of OBPARP 150 TABLET
Management of following types of cancer such as:
- Ovarian cancer
- Breast cancer
- Pancreatic cancer
- Prostate cancer
How OBPARP 150 TABLET Works
OBPARP 150 TABLET contains Olaparib which is an effective anticancer agent. It works by blocking the actions of an enzyme called PARP (poly ADP-ribose polymerase) within the cells, which is responsible for repairing damaged genetic material (DNA) in both normal and cancerous cells.
Since cancers originated due to gene mutations (like BRCA or HER-2 negative gene mutation) contains damaged DNAs in the cells, PARP is required by the cancer cells to repair the damaged DNA and for subsequent proliferation. By blocking the actions of PARP, Olaparib stops cancer cells from repairing their DNA, causing them to die while leaving normal cells less affected.
How to use OBPARP 150 TABLET
Take OBPARP 150 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy based on your age, body weight and severity of the disease. Do not stop taking OBPARP 150 TABLET without consulting your doctor.
Side Effects Of OBPARP 150 TABLET
Common
- Nausea, vomiting
- Tiredness, weakness
- Indigestion or heartburn, loss of appetite, diarrhea, upper stomach pain
- Headache, Changes in taste of foods
- Dizziness, cough, shortness of breath
- low white blood cell counts which may be associated with fever
- Skin rashes
- Mouth ulcers (stomatitis)
- Low blood platelet counts causing bleeding or bruising
- Increase in blood creatinine - this test is used to check how your kidneys are working
- Abnormal liver function tests
Uncommon
- increase in the size of red blood cells (not associated with any symptoms)
Rare
- facial swelling (angioedema)
- pain and inflammation of fatty tissue under the skin
Stop taking OBPARP 150 TABLET and consult your doctor immediately if you experience any of the following side effects:
- Pneumonitis (signs include shortness of breath, coughing and wheezing)
- Signs of blood clots such as pain or swelling in an extremity (blood clot in legs), shortness of breath, chest pain, breathing that is more rapid than normal or heart beats faster than normal (pulmonary embolism)
- Signs of liver problems (such as unexplained nausea, vomiting, yellowing of your skin or the whites of your eyes, abnormally dark or brown urine, pain at right side of the stomach area (abdomen), tiredness, less hunger)
- Signs of anemia (such as shortness of breath, feeling very tired, pale skin or fast heartbeat)
- Severe allergic reactions (such as skin rashes, itching, difficulty in breathing or swallowing, dizziness)
- Itchy rash or swollen, reddened skin (dermatitis)
- Bone marrow problems (such as myelodysplastic syndrome or acute myeloid leukaemia)
How To Manage Side Effects
Dizziness Or Drowsiness
Stay hydrated and avoid sudden movements like standing up quickly, which can worsen the dizziness. Try to move slowly and sit down if you feel lightheaded. Resting with your head elevated can also help. Eating small, balanced meals throughout the day can keep your blood sugar stable, reducing dizziness. Ensure your home is free of tripping hazards and keep a stable object nearby to hold onto if needed. If dizziness persists or worsens, consult your healthcare provider for further guidance.
Nausea And Vomiting
Eat small, frequent meals instead of large ones, and avoid greasy, spicy, or strong-smelling foods. Stay hydrated by sipping clear liquids like water, ginger ale, or herbal teas throughout the day. Ginger, either in tea, candies, or as a supplement, can help reduce nausea. Resting in an upright position after eating can also minimize symptoms. If prescribed by your doctor, take anti-nausea medications as directed. Additionally, relaxation techniques such as deep breathing, meditation, or gentle distractions like listening to music can help manage nausea. Always consult your healthcare provider for personalized advice.
Warning & Precautions
Pregnancy
ContraindicatedOBPARP 150 TABLET should not be used in pregnant women as it may affect the unborn baby. Women of child-bearing potential must use effective contraceptive method to avoid pregnancy while taking OBPARP 150 TABLET and until 6 months after stopping the therapy. If you accidentally became pregnant while taking OBPARP 150 TABLET, talk to your doctor immediately.
Breastfeeding
ContraindicatedIt is not known whether OBPARP 150 TABLET passes through the breast milk. Therefore, do not breastfeed if you are taking this medicine and for 1 month after taking OBPARP 150 TABLET. Confirm with your doctor about when you can breastfeed after stopping OBPARP 150 TABLET.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machineries if you feel dizzy, weak or tired after taking OBPARP 150 TABLET.
Kidney
Use with CautionOBPARP 150 TABLET should be used with caution in patients with moderate to severe kidney disease. Therefore, consult your doctor before taking it.
Liver
Use with CautionOBPARP 150 TABLET should be used with caution in patients with liver diseases. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take OBPARP 150 TABLET if you are allergic to Olaparib.
Use In Pediatrics
Consult your doctorThere is no proper information regarding the use of OBPARP 150 TABLET in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Use In Geriatrics
Use with CautionOBPARP 150 TABLET should be used with caution in elderly patients. Therefore, consult your doctor for advice.
Others
Before taking OBPARP 150 TABLET, inform your doctor if you:
- have clots in blood vessels
- Low RBC, WBC or platelet levels in blood
Interactions
A.Drug-Drug interactions:
- Other anticancer medicines
- Vaccines or other immune suppressing agents (such as cyclosporine, sirolimus, tacrolimus)
- Antifungal agents (such as itraconazole, fluconazole)
- Antibiotics (such as telithromycin, clarithromycin, erythromycin)
- Antiviral medicines (such as ritonavir or cobicistat, boceprevir, telaprevir, nevirapine, efavirenz)
- Anti-TB agents (such as rifampicin, rifapentine, rifabutin)
- Antiepileptic agents (such as phenytoin, carbamazepine, phenobarbital)
- St John’s Wort (used for depression)
- Cardiac drugs (such as digoxin, diltiazem, furosemide, verapamil, valsartan)
- Bosentan (used for pulmonary artery hypertension)
- Antihyperlipidemic agents (such as simvastatin, pravastatin, rosuvastatin)
- Dabigatran (blood thinning agent)
- Antidiabetic agents (such as glibenclamide, metformin, repaglinide)
- Ergot alkaloids (used for migraines and headaches)
- Fentanyl (a strong pain killer)
- Antipsychotic agents (such as pimozide, quetiapine)
- Cisapride (a medicine for treat stomach problems)
- Colchicine (used for gout)
- Methotrexate (a medicine used for cancer, rheumatoid arthritis and psoriasis)
B. Drug-food interactions:
Do not drink grapefruit juice while taking OBPARP 150 TABLET, as they both may interact and cause unpleasant reactions.
Overdosage:
If you or anyone else accidentally took more OBPARP 150 TABLET, consult your doctor immediately or visit the nearby hospital straight away.
Synopsis
| Drug | : | Olaparib |
| Pharmacological Category | : | PARP inhibitor |
| Therapeutic Indication | : | Cancer |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep OBPARP 150 TABLET out of reach of children
- Store OBPARP 150 TABLET at room temperature
FAQs About OBPARP 150 TABLET
Q: What is OBPARP 150 TABLET used for?
A: OBPARP 150 TABLET is used in the management of various types of cancer such as ovarian cancer, breast cancer, pancreatic cancer and prostate cancer that is caused or relapsed due to certain gene mutations (like BRCA, HER-2 negative genes). It can be used as a single agent or in combination with other anticancer agents for effective management.
Q: Will Olaparib cure cancer?
A: OBPARP 150 TABLET will help you effectively manage cancer. It has been proven to improve overall survival and quality of life in cancer patients. Complete cure of cancer depends on the severity of the disease and how your body responds to the therapy.
Q: Is Olaparib a targeted therapy?
A: Yes. Olaparib is a targeted therapy. It works by blocking the actions of certain enzymes which is required for the cancer cells to grow and multiply.
Q: Is Olaparib approved in India?
A: Yes. Olaparib is approved in India since 2018 for cancer management.
Q: Which foods should I avoid while taking OBPARP 150 TABLET?
A: Do not drink grapefruit juice along with this medicine, as it may affect the way this medicine works.
Q: Can OBPARP 150 TABLET be used in children?
A: There is no proper information regarding the use of OBPARP 150 TABLET in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Q: What precautions must be followed while taking OBPARP 150 TABLET?
A: OBPARP 150 TABLET should be used under careful medical supervision. It can be taken with or without food. Do not stop taking OBPARP 150 TABLET without consulting your doctor.
During therapy with OBPARP 150 TABLET, your doctor will schedule blood tests regularly in order to evaluate the effectiveness of this medicine and to avoid side effects. Make sure you take all the blood test recommended by your doctor. Do not drink grapefruit juice along with this medicine, as it may affect the way this medicine works.
OBPARP 150 TABLET should not be used in pregnant or breastfeeding women, as it could harm the unborn baby or nursing infant. Women of childbearing potential must use a very effective contraceptive (hormone medicines and condoms) to avoid pregnancy while on therapy with Olaparib. Men must also use condoms to avoid sexual exposure of Olaparib to their female partners even if they are pregnant.
Before taking OBPARP 150 TABLET inform your doctor if you have any liver or kidney problems.
Q: How to take OBPARP 150 TABLET?
A: Take OBPARP 150 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It can be taken with or without food.
References
1. Olaparib. StatPearls. National Center for Biotechnology information. National Library of Medicine. [Accessed on 21st August 2024] https://www.statpearls.com/point-of-care/search?q=Olaparib
2. Olaparib. Lynparza 100 and 150 mg film-coated tablets. EMC. UK. [Revised in August 2023]. [Accessed on 21st August 2024] https://www.medicines.org.uk/emc/files/pil.9488.pdf
3. Lynparza. AstraZeneca Canada Inc. [Revised in May 2024]. [Accessed on 21st August 2024] https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/lynparza-consumer-information-leaflet-en.pdf
Useful Diagnostic Tests
- Prostate Specific Antigen-Psa (Total)
- Prostate Specific Antigen-Psa (Free)
- Breast Carcinoma Prognosis Profile
- Wbc-Total Counts Leucocytes
- Estrogen/Progesterone Receptor (ER/PR)
- Breast Carcinoma Prognosis Panel
- Cancer Screening Package For Male
- Cancer Screening Package For Female
Author Details
