Norper Sugar Free Syrup 200ml

Introduction About NORPER SYRUP

NORPER SYRUP contains Domperidone, Magaldrate, Simethicone and Sorbitol which belong to the group of medicines called antiemetics, antacids, gastrointestinal agents and sugar alcohols, respectively. It is used in adults and children above the age of 12 (who weigh 35 kg or more) for the management of gastric problems such as nausea, vomiting, burping, stomach pain, acidity and excess gas. NORPER SYRUP is also used in the management of peptic ulcers.

A peptic ulcer (stomach ulcer) develops on the lining of the oesophagus, stomach and small intestine and may occur due to excess intake of spicy foods, alcohol, acidic foods, increased caffeine intake, pain-relieving medicines, etc. Symptoms of this disease include stomach pain and discomfort, indigestion, heartburn, nausea, vomiting, excess gas, loss of appetite, etc.

Avoid consuming alcohol, carbonated drinks, citrus fruit juices and caffeine to reduce acidity and gas problems. Maintaining a healthy diet plan with adequate sleep is recommended to get effective results.

NORPER SYRUP is not recommended for use in patients suffering from stomach or intestinal bleeding, stomach pain with black stools, gut problems, pituitary gland tumours, moderate to severe liver disease, heart diseases like prolonged QT interval, heart failure or altered potassium and magnesium levels in the blood.

Before taking NORPER SYRUP, inform your doctor if you have or have had liver diseases, kidney problems, heart problems, appendicitis, stomach pain, bowel blockage, rectal bleeding, nausea, diarrhoea and vomiting, are following a low magnesium diet or have had bowel surgery in the past.

Inform your doctor about your pregnancy status before taking this medicine. Breastfeeding women and children below the age of 12 (who weigh less than 35 kg) are not recommended to take NORPER SYRUP. Dry mouth, headache, diarrhoea, bone pain, muscle weakness, hyperacidity, constipation, intestinal problems and other common side effects of NORPER SYRUP include: Consult your doctor if any of the symptoms are worsening.

Uses Of NORPER SYRUP

• Manage nausea, vomiting, burping, excess gas, stomach pain
• Manage peptic ulcer (stomach ulcer), stomach acidity

How NORPER SYRUP Works

NORPER SYRUP contains domperidone, magaldrate, simethicone and sorbitol. Domperidone is an antiemetic that manages nausea and vomiting by blocking the messages between the brain (vomiting centre and chemoreceptor trigger zone) and the digestive system. It also causes tightening at the entrance of the stomach muscles and loosens the muscles at the stomach exit, which also helps reduce the chance to vomit.

Magaldrate is an antacid that works by neutralising stomach acid and increasing the pH of the stomach. It protects gastric mucosa and reduces stomach ulcers. It dissolves in the stomach acid and envelopes the ulcer area, leading to the process of stomach repair.

Simethicone is an anti-flatulent that manages excess gas production by breaking up the gas bubbles in the stomach. Sorbitol is an artificial sweetener added to the combination for better flavour and texture.

How to use NORPER SYRUP

Take NORPER SYRUP as advised by your physician. Shake well before use. Your doctor will decide the management dose and duration of management for you depending on your age, body weight and disease condition.

Side Effects Of NORPER SYRUP

How To Manage Side Effects

Dry mouth:

Drink plenty of water to make your mouth moist. Take ginger water, which stimulates saliva production. Eat chewing gums. Contact your doctor if it is not subsiding.

Headache:

Drink plenty of fluids and stay hydrated. Try to be tension free and relaxed. Take adequate sleep and rest. Avoid consumption of alcohol. Apply pain balm if required. Consult your doctor if it is getting worse.

Loose stools

Keep yourself hydrated by drinking plenty of fluids and electrolytes. Consult your doctor before taking any medication.

Warning & Precautions

Pregnancy

NORPER SYRUP must be taken with caution if you are pregnant. Consult your doctor and inform them about your pregnancy status before taking it.

Breastfeeding

NORPER SYRUP is generally not recommended in breastfeeding mothers unless clearly necessary as it may pass through breast milk. Consult your doctor before taking NORPER SYRUP.

Driving and Using Machines

Do not drive or operate machines if you feel sleepy, an irregular heartbeat after taking NORPER SYRUP. Consult your doctor before taking NORPER SYRUP.

Alcohol

Avoid alcohol consumption while taking NORPER SYRUP to avoid worsening of side effects such as sleepiness or irregular heartbeat.  Consult your doctor before taking NORPER SYRUP.

Kidney

NORPER SYRUP should be used with caution in patients with kidney diseases such as kidney failure or loss of kidney function. Consult your doctor before taking NORPER SYRUP.

Liver

NORPER SYRUP should be used with caution in patients with moderate to severe liver diseases. Consult your doctor before taking NORPER SYRUP.

Allergy

Do not take NORPER SYRUP if you are allergic to Domperidone, Magaldrate, Simethicone or Sorbitol. Consult your doctor before taking NORPER SYRUP.

Heart Disease

NORPER SYRUP is not recommended in patients suffering from cardiac failure (heart failure to pump blood to body parts) and in patients with ECG variation such as prolonged QT interval. Consult your doctor before taking NORPER SYRUP.

Interactions

A. Drug-Drug interactions:

Before taking NORPER SYRUP inform your doctor if you are taking the following medicines

• medicines used to manage fungal infections (ex. Ketoconazole, fluconazole etc)
• medicines used to manage bacterial infections (ex. Erythromycin, clarithromycin, moxifloxacin, cefaclor etc)
• medicines used to manage heart diseases (ex. Quinidine, amiodarone, disopyramide, bepidril, etc)
• medicines used to manage high blood pressure (ex. Verapamil, diltiazem etc)
• medicines used to manage mental disorders (ex. Clonazepam, haloperidol, sertindole, etc)
• medicines used to manage gastrointestinal problems (ex. Cisapride, dolasetron, prucalopride)
• medicines used to manage malaria (ex. Halofantrine)
• medicines used to manage allergies (ex. Mizolastine, mequitazine)
• medicines used to manage HIV infection (ex. Protease inhibitors like nelfinavir, indinavir etc)
• medicines used to manage cancer (ex. Toremifene, vincamine, vandetanib)
• medicine used to decrease stomach acids, saliva and sweat (ex. Diphemanil)
• medicine used to relieve pain (ex. Methadone)
• medicine used to manage blood clotting (ex. Warfarin)
• medicines that contain citrate salt (ex. Sodium citrate)
• medicine used to manage bone diseases (ex. Alendronic acid)
• medicine used to manage high potassium levels in the blood (ex. Sodium polystyrene sulfonate)
• hormonal medicines for thyroid problems (ex. Levothyroxine)

Overdosage:

If you or anyone else accidentally have taken too much of NORPER SYRUP, consult your doctor immediately. Symptoms include feeling sleepy and confused, unusual movements of the eye and tongue, abnormal posture such as a twisted neck and faster and life-threatening conditions such as irregular heartbeat.

Synopsis

More Information

• Keep NORPER SYRUP out of reach from children
• Store NORPER SYRUP at room temperature

FAQs About NORPER SYRUP

What is NORPER SYRUP used for?

NORPER SYRUP is used to manage gastric problems such as nausea, vomiting, burping, stomach pain and excess gas in adults and children (over the age of 12) weighing 35 kg or more.NORPER SYRUP is also used to manage peptic ulcers (stomach ulcers). Symptoms of a peptic ulcer include stomach pain, indigestion, heartburn, nausea, vomiting, excess gas, loss of appetite, abdominal discomfort, etc.

What precautions should I take while taking NORPER SYRUP?

NORPER SYRUP should be taken with caution by patients suffering from liver and kidney diseases to avoid unwanted side effects. Inform your doctor about your pregnancy status before starting this medicine. This medicine is not recommended for use in patients with stomach and intestinal bleeding issues or who have altered levels of potassium or magnesium in the blood.

What lifestyle modifications should I make while taking NORPER SYRUP?

It’s better to avoid alcohol consumption while taking NORPER SYRUP to avoid worsening side effects such as sleepiness or an irregular heartbeat. Apart from this, reduce your intake of citrus fruit juices, carbonated drinks and caffeine to reduce your acidity and gas problems. Also, try to maintain a healthy diet plan with adequate sleep to get better results.

Can I drive a bike or car while taking NORPER SYRUP?

Do not drive a car or bike if you are feeling sleepy or have an irregular heartbeat after taking NORPER SYRUP. Consult your doctor before taking NORPER SYRUP.

Can I give NORPER SYRUP to my 5-year-old baby?

NORPER SYRUP should not be used by children under the age of 12. Consult your doctor before taking NORPER SYRUP.

What are the most common side effects of taking NORPER SYRUP?

The most common side effects of NORPER SYRUP are dry mouth, headache, diarrhoea, bone pain, muscle weakness, sleepiness, irregular heartbeat, hyperacidity, constipation, intestinal problems, etc. Consult your doctor if any of the symptoms get worse while taking NORPER SYRUP.

References

1. Y U Torshin, Gromava, N A Kuricina, Antarite-synergistic combination of «magaldrate+ simethicone» with gastroprotective properties Torshin, I. Yu, O. A. Gromova and N. A. Kuricina. Antarite-synergistic combination of magaldrat+ simethicone with gastroprotective properties. Pharmacokinetics and Pharmacodynamics. [Published in 2018] [Accessed on 11th August 2022] https://www.pharmacokinetica.ru/jour/article/view/73?locale=en_US

2. Sorbitol. Science Direct. [Accessed on 11th August 2022] https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/sorbitol#:~:text=Sorbitol%20is%20used%20to%20provide,small%20amount%20of%20sodium%20carboxymeth

3. Sofarimex. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 11th August 2022] https://www.medicines.org.uk/emc/files/pil.3188.pdf

4. Laboratorios Dr. Esteve. Health Products Regulatory Authority (HPRA). [Published in September 2014] [Accessed on 11th August 2022] https://www.hpra.ie/img/uploaded/swedocuments/2150362.PPA0465_272_001.716eaab0-4e46-4caf-914b-808e7c255d75.000001PIL%20Motilium%2010mg%20.140919.pdf

5. NHS UK. Domperidone. [Revised on 3rd January 2020] [Accessed on 11th August 2022] https://www.nhs.uk/medicines/domperidone/

6. OTC monograph. Dailymed. Sorbitol. [Revised on 17th January 2018] [Accessed on 11th August 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae9a1c12-8662-4f5d-8435-e51dc2b45780

7. Magaldrate, Simethicone. MK Medicine. [Accessed on 11th August 2022] https://www.mkmedicine.in/magaldrate-480-mg-simethicone-20-mg-%28sugar-free%29-suspension.html#:~:text=Magaldrate%20480%20mg%20Simethicone%2020%20mg%20

Useful Diagnostic Tests

• Serum Electrolyte Tests
• Liver Function Tests
• Kidney Function Tests

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 12 Dec 2022 | 04:19 PM(IST)