NOCOHOL Tablet 4's

Introduction About NOCOHOL TABLET

NOCOHOL TABLET contains Disulfiram which belongs to the group of medicines called Aldehyde Dehydrogenase Inhibitors. It is used to manage in patients with alcohol dependence (or alcohol addiction). It helps to manage the habit of alcoholism in patients having a habit of drinking excessive alcohol (chronic alcoholism). NOCOHOL TABLET helps in reducing alcohol dependence. It creates aversion towards alcohol by creating various unpleasant symptoms (such as flushing, burning sensation, throbbing headache, increased sweating, chest tightness, dizziness, vomiting, visual disturbances and confusion).

Before taking NOCOHOL TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, high or low blood pressure, thyroid problems, brain damage, fits or any mental disorders as a precaution. NOCOHOL TABLET should not be used in patients who have already consumed alcohol. It should be used only in patients who have not drunk alcohol for at least 24 hours prior to the first dose.

It is also not suitable for use in pregnant or breastfeeding women and in children (aged below 18 years). The most common side effects of taking NOCOHOL TABLET are drowsiness, tiredness, impotence, low sex drive, headache, sleepiness and metallic taste. Consult your doctor if any of these side effect worsens.

Uses Of NOCOHOL TABLET

• Used to manage in patients with alcohol dependence (or alcohol addiction)

How NOCOHOL TABLET Works

NOCOHOL TABLET helps in reducing alcohol dependence. It acts by blocking the actions of certain enzymes (such as aldehyde dehydrogenase) within the body that helps in breaking down a substance called acetaldehyde. As a result, it leads to the accumulation of an excessive amount of acetaldehyde in the body causing unpleasant physical reactions (such as flushing, burning sensation, throbbing headache, increased sweating, chest tightness, dizziness, vomiting, visual disturbances and confusion) that can create aversion towards alcohol which will eventually help in quitting alcoholism.

How to use NOCOHOL TABLET

Take NOCOHOL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Do not consume alcohol for at least 24 hours before taking the first dose of NOCOHOL TABLET. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition.

Side Effects Of NOCOHOL TABLET

How To Manage Side Effects

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating heavy tools or machinery while you feel drowsy. Avoid the consumption of alcohol as it could aggravate your drowsiness. Contact your doctor if the condition worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Nausea And Vomiting

Try to take NOCOHOL TABLET with or just after meals. Stick to simple meals and avoid oily-rich or spicy foods. Consult your doctor if the nausea worsens.

Warning & Precautions

Pregnancy

Monitoring required

NOCOHOL TABLET is generally not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.

Breastfeeding

Monitoring required

NOCOHOL TABLET is generally not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

NOCOHOL TABLET may cause drowsiness and tiredness. Therefore, do not drive or operate any heavy tools or machinery if your ability is affected by [GBNEYWORD].

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking NOCOHOL TABLET as it may lead to serious unwanted side effects.

Kidney

Use with Caution

NOCOHOL TABLET should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.

Liver

Use with Caution

NOCOHOL TABLET should be used with caution in patients with liver diseases. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take NOCOHOL TABLET if you are allergic to Disulfiram or any other ingredients of this medicine.

Lungs

Use with Caution

[GBNEYWORD] should be used with caution in patients with lung diseases such as asthma. Therefore, consult your doctor before taking it.

Heart Disease

Contraindicated

NOCOHOL TABLET is not recommended for use in patients with severe heart diseases (such as heart failure or coronary occlusion). Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

NOCOHOL TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

NOCOHOL TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking NOCOHOL TABLET, inform your doctor if you are taking any of the following medicines such as:

• warfarin (a medicine used to reduce blood clotting)
• medicines used to manage epilepsy (ex. phenytoin and paraldehyde)
• theophylline (a medicine used to manage asthma)
• medicines used to reduce anxiety (such as chlordiazepoxide and diazepam)
• opioid analgesics (used for pain relief) such as pethidine and morphine
• medicines used to stimulate the brain (such as amphetamine, dextroamphetamine)
• medicines used for mental illness (such as pimozide and chlorpromazine)
• medicines used to manage tuberculosis (ex. isoniazid, rifampicin)
• metronidazole (a medicine used for parasite infection)
• amitriptyline (a medicine used to manage depression)
• alcohol-containing medicines (such as cough syrups)

Overdosage:

If you or anyone else accidentally took more of NOCOHOL TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include nausea, vomiting, stomach pain, diarrhoea, headache, drowsiness, fatigue, mental disorders, tiredness, rapid heartbeat, rapid breathing, high body temperature, low blood pressure, loss of muscle control and/or high blood sugar.

Synopsis

More Information

• Keep NOCOHOL TABLET out of reach of children
• Store NOCOHOL TABLET at a room temperature

FAQs About NOCOHOL TABLET

Q: What is the use of NOCOHOL TABLET?

A: It is used to manage in patients with alcohol dependence (or alcohol addiction). It helps to manage the habit of alcoholism in patients having a habit of drinking excessive alcohol (chronic alcoholism).

Q: How NOCOHOL TABLET works in the body?

A: NOCOHOL TABLET acts by blocking the actions of certain enzymes (such as aldehyde dehydrogenase) within the body that helps in breaking down a substance called as acetaldehyde. This leads to the accumulation of an excessive amount of acetaldehyde in the body causing unpleasant physical reactions which will eventually help in quitting alcoholism.

Q: Is NOCOHOL TABLET safe?

A: NOCOHOL TABLET is considered safe at doses prescribed by the physician.

Q: What are the side effects of taking NOCOHOL TABLET?

A: The most common side effects of taking NOCOHOL TABLET are drowsiness, tiredness, impotence, low sex drive, headache, sleepiness and metallic taste. Consult your doctor if any of these side effects worsen.

Q: Can I stop taking NOCOHOL TABLET once my symptoms subside?

A: No. Take NOCOHOL TABLET every day until your doctor tells you to stop. Do not stop taking this medicine abruptly or reduce the dose without consulting your doctor. Your doctor will assess your disease condition regularly and will increase or decrease the dose accordingly.

Q: Will NOCOHOL TABLET be more effective if taken at higher doses?

A: Always consume the dose prescribed for you by your physician. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and severity of the disease. Do not take a higher dose of this medicine without consulting your doctor as it could lead to unwanted side effects. If your symptoms are not relieved by the prescribed dose, consult your doctor so that he might adjust the dose according to your health condition or can suggest an alternative therapy.

Q: Can pregnant women use NOCOHOL TABLET?

A: NOCOHOL TABLET is generally not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.

Q: Can NOCOHOL TABLET be used in adolescents?

A: NOCOHOL TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Q: What happens when you forget to take NOCOHOL TABLET?

A: If you forget to take NOCOHOL TABLET, take it as soon as you remember. However, if it's time for the next dose, skip the missed dose and take the next dose. Do not take a double dose to compensate for the missed dose.

Q: Can I take NOCOHOL TABLET daily?

A: Take NOCOHOL TABLET as advised by your physician. Your doctor will evaluate your health condition and suggest whether can you take NOCOHOL TABLET every day or not.

References

1. KD. Tripathi. Ethyl and Methyl alcohol. Drugs acting on CNS. Essentials of medical pharmacology. Seventh edition. 2013. Page – 394.

2. Maranda Stokes; Sara Abdijadid. Disulfiram. StatPearls [Internet]. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. [Revised in November 2021]. [Accessed on 2nd December 2022] https://www.ncbi.nlm.nih.gov/books/NBK459340/

3. Marilyn D. Skinner,  Pierre Lahmek,  Héloïse Pham and Henri-Jean Aubin. Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. February 2014. [Accessed on 2nd December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919718/

4. Brown & Burk UK Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 2nd December 2022] https://www.medicines.org.uk/emc/files/pil.11168.pdf

5. Leeford Healthcare Pvt Ltd. Recopress 500. [Accessed on 2nd December 2022] https://www.leeford.in/product/791/recopress-500

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Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. M N Himaja - MBBS

Last updated on 17 Feb 2024 | 12:45 PM(IST)