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Introduction About NOBLOK AF DROPS
NOBLOK AF DROPS is a combination of Phenylephrine and Chlorpheniramine which belongs to the group of medicines called Nasal decongestants and Antihistamines respectively. It is used to relieve nasal and sinus congestion, allergic symptoms of the nose or throat due to upper respiratory tract allergies, sinus pain and headache. Also, it is used adjunctly with antibacterials to manage sinusitis (inflammation of the tissue lining the sinuses), tonsillitis (inflammation of the tonsils) and otitis media (middle ear infection).
Before giving NOBLOK AF DROPS to your child, inform child’s doctor if your child has kidney, liver or heart problems, diabetes, fits or severely raised blood pressure. NOBLOK AF DROPS is not recommended for use in pregnant or breast-feeding women and elderly patients as it is used only in children.
The most common side effects of NOBLOK AF DROPS are nausea, vomiting, dry mouth, dizziness and tiredness. Consult your child’s doctor if any of the side effects worsen.
Uses Of NOBLOK AF DROPS
It is used:
- to relieve nasal and sinus congestion
- to relieve allergic symptoms of the nose or throat due to upper respiratory tract allergies
- to relieve sinus pain and headache
- adjunctly with antibacterials to manage sinusitis, tonsillitis and otitis media
How NOBLOK AF DROPS Works
NOBLOK AF DROPS relieves cold symptoms where Phenylephrine decreases nasal congestion by acting on α1-adrenergic receptors in the small vessels of the nasal mucosa to produce constriction, resulting in decreased swelling and increased drainage of the sinus cavities and Chlorpheniramine binds to the histamine H1 receptor and blocks its action, resulting in temporary relief of the negative symptoms (runny nose, sneezing, watery and itchy eyes) brought on by histamine.
How to use NOBLOK AF DROPS
Give NOBLOK AF DROPS to your child as advised by the physician. Shake well before use. Use a measuring cup to properly measure the dose. Your child’s doctor will decide the correct dose and duration of NOBLOK AF DROPS for your child depending upon child’s age, body weight and disease condition.
Side Effects Of NOBLOK AF DROPS
Common
- drowsiness
- sedation
- disturbance in concentrating, un-coordination, dizziness, headache
- blurred vision
- nausea or vomiting
- dry mouth
- tiredness
Rare
- tremor, weakness
- painful urination
Stop giving NOBLOK AF DROPS to your child and contact doctor immediately if your child experiences any of the following side effects:
- develop rash, hives, itching, red or swollen or blistered or peeling skin; wheezing, tightness in the chest or throat, trouble breathing, swallowing or talking, unusual hoarseness or swelling of the mouth, face lips, tongue or throat
How To Manage Side Effects
Dry Mouth
Tell your child to sip water regularly and other sugar free liquids. Tell your child not to use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Consult child’s doctor if the symptom does not improve.
Headache
Apply hot or cold-water bag on your child’s head. Advise your child to take rest in a quiet room. Massage child’s scalp or head with mild pressure for relieving effect. Consult child’s doctor if the symptom does not improve.
Nausea And Vomiting
Follow simple meal plan for your child while administering NOBLOK AF DROPS. Avoid giving foods that are oily, fried or spicy foods. Do not let your child to lie down or sleep immediately after eating. Consult child’s doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ContraindicatedNOBLOK AF DROPS is not recommended for use in pregnant women as it is used only in children. Consult your doctor for advice.
Breastfeeding
ContraindicatedNOBLOK AF DROPS is not recommended for use in breast-feeding women as it is used only in children. Consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not let your child ride bicycles or drive other vehicles or operate any tools if your child experiences dizziness, drowsiness and sedation after taking NOBLOK AF DROPS.
Kidney
Use with CautionNOBLOK AF DROPS should be used with caution in children with kidney failure. Consult your child’s doctor for advice before administration of NOBLOK AF DROPS to your child.
Liver
Use with CautionNOBLOK AF DROPS should be used with caution in children with liver impairment. Consult your child’s doctor for advice before administration of NOBLOK AF DROPS to your child.
Allergy
ContraindicatedDo not give NOBLOK AF DROPS if your child is allergic to Phenylephrine, Chlorpheniramine or any other ingredients of this medicine.
Heart Disease
Consult your doctorNOBLOK AF DROPS is not recommended for use in children with severely high blood pressure. NOBLOK AF DROPS should be used with caution in patients with any other cardiovascular problems. Consult your child’s doctor for advice before administration of NOBLOK AF DROPS to your child.
Use In Pediatrics
Use with CautionNOBLOK AF DROPS should be used with caution in children from 1 month to 12 years of age. Consult your child’s doctor for advice before administration of NOBLOK AF DROPS.
Use In Geriatrics
ContraindicatedNOBLOK AF DROPS is not recommended for use in elderly patients as it is used only in children. Consult your doctor for advice.
Others
NOBLOK AF DROPS is not recommended for use if your child:
- has phaeochromocytoma (rare tumours that start in the inner part of the adrenal gland)
- has peripheral or mesenteric vascular thrombosis (blood clots usually in legs or major veins (one or more) that drain blood from the intestine
Before giving NOBLOK AF DROPS to your child, inform your physician if your child:
- has diabetes
- has overactive thyroid
- has closed angle glaucoma
- has history of fits
Interactions
A. Drug-Drug interactions:
Before giving NOBLOK AF DROPS to your child, inform your child’s doctor if your child is taking or receiving any of the following medicines:
- ephedrine (used to manage low blood pressure)
- phenytoin (used to manage epilepsy)
- digoxin (used to manage irregular heartbeat)
Overdosage:
If your child accidentally takes too much of NOBLOK AF DROPS, contact your doctor immediately or visit a nearby hospital. Overdosage symptoms of NOBLOK AF DROPS includes extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever and possibly seizures.
Synopsis
| Drug | : | Phenylephrine, Chlorpheniramine |
| Pharmacological Category | : | Nasal decongestant, Antihistamines |
| Therapeutic Indication | : | Relieves nasal and sinus congestion, allergic symptoms, sinus pain, sinusitis, tonsillitis, otitis media |
| Dosage Forms | : | Capsule, Tablet, Syrup, Oral drops |
More Information
Storage
- Keep NOBLOK AF DROPS out of reach of children
- Store at room temperature
FAQs About NOBLOK AF DROPS
Q: What is the use of NOBLOK AF DROPS?
A: NOBLOK AF DROPS is used to relieve nasal and sinus congestion, allergic symptoms of the nose or throat due to upper respiratory tract allergies, sinus pain and headache. Also, it is used adjunctly with antibacterials to manage sinusitis (inflammation of the tissue lining the sinuses), tonsillitis (inflammation of the tonsils) and otitis media (middle ear infection).
Q: How does NOBLOK AF DROPS work?
A: NOBLOK AF DROPS relieves cold symptoms where phenylephrine decreases nasal congestion by acting on a1-adrenergic receptors in the small vessels of the nasal mucosa to produce constriction, resulting in decreased swelling and increased drainage of the sinus cavities, and chlorpheniramine binds to the histamine H1 receptor and blocks its action, resulting in temporary relief of the negative symptoms (runny nose, sneezing, watery and itchy eyes) brought on by histamine.
Q: What are the common side effects of NOBLOK AF DROPS?
A: The most common side effects of taking NOBLOK AF DROPS are drowsiness or sedation, disturbance in concentrating, dizziness, headache, blurred vision, nausea or vomiting, and tiredness. Consult your doctor if any of the side effects worsen.
Q: What if I forget to take a dose of NOBLOK AF DROPS?
A: If you forget to take a dose of NOBLOK AF DROPS, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take medicine two times to make up for the forgotten dose.
Q: Can I stop taking NOBLOK AF DROPS on my own if my symptoms subside?
A: Continue taking NOBLOK AF DROPS until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition, or any new symptoms. In such cases, contact your doctor right away.
Q: What precautions do I need to follow while taking NOBLOK AF DROPS?
A: Patients taking NOBLOK AF DROPS must inform their doctor about their pre-existing conditions like liver, kidney disease, lung disorders, high blood pressure and heart problems, fits, problems with blood circulation (including Raynaud’s phenomenon, which makes the toes and fingers numb and pale), or allergies to foods, preservatives, or dyes.
Q: Who should not take NOBLOK AF DROPS?
A: NOBLOK AF DROPS is not recommended for use if you have a condition in which there is increased pressure inside your eye, gastrointestinal obstruction, genitourinary obstruction, stomach or duodenal ulcer, bladder and prostate problems, diabetes, high blood pressure (particularly due to a tumour near the kidney), or have an overactive thyroid gland, Peripheral or mesenteric vascular thrombosis (blood clots, usually in the legs).
Q: Can I take other medicines along with NOBLOK AF DROPS?
A: Before taking NOBLOK AF DROPS, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription, or any herbal medicines, as these might interact with each other and cause serious side effects.
Q: Can I take NOBLOK AF DROPS if I am pregnant?
A: NOBLOK AF DROPS is not recommended for use by pregnant women. If you are pregnant, think you may be pregnant, or are planning to get pregnant, consult your doctor before taking it. Inform your doctor immediately if you become pregnant during management with this medicine.
Q: Is NOBLOK AF DROPS safe to use in patients with heart problems?
A: NOBLOK AF DROPS is not recommended for use in patients with severely high blood pressure or coronary artery disease. NOBLOK AF DROPS should be used with caution in patients with high blood pressure and any other cardiovascular diseases. Consult your doctor before taking it.
Q: Can NOBLOK AF DROPS cause dizziness?
A: Dizziness is a common side effect of NOBLOK AF DROPS. In such cases, try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom does not improve.
Q: Can NOBLOK AF DROPS cause nausea and vomiting?
A: Yes. NOBLOK AF DROPS causes nausea and vomiting. Stick to simple meals while taking this medicine. Avoid eating oily, fried, or spicy foods. Do not lie down or go to sleep immediately after eating. Consult your doctor if the symptom does not improve.
Q: Can I drink alcohol while taking NOBLOK AF DROPS?
A: No, avoid consumption of alcohol while taking NOBLOK AF DROPS, as it might interfere with each other.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Allergic Rhinitis. Pharmacotherapy Handbook. Ninth edition. Page-813.
2. KD. Tripathi. Adrenergic System and Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page-135.
3. Mayuresh Kiran and Lalit Pawaskar. Study of Safety and Efficacy for the Combination of Chlorpheniramine maleate and Phenylephrine in Infants suffering from Allergic Rhinitis and Associated Symptoms. International Research of Contemporary Medical Research. March 2019. [Accessed on 20th July 2022] https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_2406_v1.pdf
4. PubChem Compound Summary for CID 2725, Chlorpheniramine. National Center for Biotechnology Information. June 2022. [Accessed on 20th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine#section=Mechanism-of-Action
5. Centaur Pharmaceuticals Pvt. Ltd. and Lab Daffodil. Sinarest AF Drops (Phenylephrine + Chlorpheniramine). [Revised in January 2022] [Accessed on 20th July 2022] https://www.centaurpharma.com/downloads/2022/pediatrics/cold/Sinarest%20AF%20oral%20drops.pdf
6. Centaur Pharmaceuticals Pvt. Ltd. and Lab Daffodil. Sinarest AF Drops/Syrups [Accessed on 20th July 2022] https://www.centaurpharma.com/downloads/Sinarest-AF-Syr-Drops2018.pdf
7. Zuventus Healthcare Limited. Maxtra Syrup (Phenylephrine + Chlorpheniramine maleate). [Accessed on 20th July 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=149
8. GlaxoSmithKline Consumer Healthcare. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 20th July 2022] https://www.medicines.org.uk/emc/files/pil.3928.pdf
Useful Diagnostic Tests
- Nasal cytology
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