Nicip 100mg Tablet 10'S

Introduction About NICIP 100MG TABLET

Nicip 100mg Tablet contains nimesulide, a non-steroidal anti-inflammatory drug (NSAID) commonly used for short-term management of pain and inflammation. It works by reducing substances in the body that cause pain, swelling, and discomfort. Nicip 100mg Tablet is often prescribed for conditions such as acute pain, dental pain, musculoskeletal pain, and menstrual discomfort.  

Nimesulide acts by inhibiting cyclooxygenase enzymes, thereby reducing the production of prostaglandins responsible for pain and inflammation. The medicine provides effective relief from pain while also helping reduce swelling. It is generally intended for short-term use and should always be taken under medical supervision.

Caution is required in individuals with liver problems, as prolonged or excessive use may affect liver function. It is not recommended for children, pregnant women, or breastfeeding mothers unless advised by a doctor. Common side effects may include nausea, stomach discomfort, dizziness, or heartburn.

Uses Of NICIP 100MG TABLET

• Reduces joint pain caused by arthritis or injuries.
• Provides relief from short-term pain such as dental, muscle, or post-surgical discomfort.
• Effectively brings down fever.
• Alleviates menstrual pain and headaches.

Benefits of NICIP 100MG TABLET

Nicip 100mg Tablet for Arthritis

Nicip 100mg contains nimesulide, a non-steroidal anti-inflammatory medicine that may be prescribed to help manage pain, stiffness, and joint discomfort associated with rheumatoid arthritis. In this condition, ongoing inflammation within the joints can lead to swelling and reduced mobility. Nicip works by lowering the production of certain inflammatory mediators, which can help ease daily joint pain and improve comfort during movement. It is generally advised for short-term, symptom-focused use, alongside other long-term medicines recommended by the doctor for rheumatoid arthritis care.

Nicip 100mg for Postoperative Painful Condition

After surgery, the body’s natural healing response often leads to pain, swelling, and tenderness around the operated area. Nicip 100mg may be advised to relieve postoperative pain and inflammation, helping patients feel more comfortable during the recovery phase. By reducing inflammatory signals at the surgical site, it can support easier movement and rest in the initial days following a procedure. The medicine is usually prescribed for a limited duration, with dose and length of use carefully decided by the healthcare provider to suit the individual’s recovery needs.

Nicip 100mg for Fever

Nicip 100mg may be prescribed to help reduce fever associated with infections or inflammatory conditions. Fever occurs when the body releases chemicals that raise body temperature as part of the immune response. Nicip works by inhibiting substances responsible for this temperature rise, helping bring the fever down and improving overall comfort. It is usually recommended for short-term use, especially when fever is accompanied by pain or inflammation.

How NICIP 100MG TABLET Works

Inhibition of Prostaglandin Synthesis

Nicip 100mg contains nimesulide, which works by inhibiting the cyclooxygenase (COX) pathway involved in the production of prostaglandins. Prostaglandins are chemical messengers responsible for causing pain, inflammation, and fever at injury or infection sites. By reducing their formation, nimesulide helps control pain and inflammatory responses.

Anti-Inflammatory Effect

By lowering prostaglandin levels, Nicip helps reduce inflammation-related symptoms such as swelling, redness, warmth, and stiffness. This action is particularly beneficial in conditions involving joint and soft-tissue inflammation, allowing improved mobility and comfort.

Analgesic Action

Nimesulide interferes with pain signal transmission both at the site of inflammation and within the central nervous system. This dual action helps lessen pain intensity, providing effective relief from acute and short-term pain conditions such as musculoskeletal, dental, and post-operative pain.

Selective Action

Nicip shows relatively selective inhibition of inflammatory pathways, which may help reduce irritation to the stomach lining when used at the prescribed dose and duration. However, appropriate use and medical supervision remain essential to minimize gastrointestinal and liver-related risks.

Short-Term Symptom Control

Nicip 100mg is primarily intended for short-term management of pain, inflammation, and fever. It provides symptomatic relief rather than treating the underlying cause, making it suitable for acute conditions when used for the shortest effective duration as advised by a healthcare professional.

How to use NICIP 100MG TABLET

How to Take Nicip 100mg Tablet

• Take Nicip 100mg Tablet exactly as prescribed by your doctor.
• Swallow the tablet whole with a glass of water.
• It is usually taken after food to reduce stomach irritation.
• Do not crush or chew the tablet.
• Follow the prescribed dose and duration strictly.
• Do not use for longer than advised.

What if I forgot to take NICIP 100MG TABLET

• Take the missed dose as soon as you remember.
• Skip the missed dose if it is almost time for the next dose.
• Resume your regular dosing schedule.
• Do not take a double dose.
• Consult your doctor if doses are missed frequently.

Overdose

Seek immediate medical attention in case of overdose. severe stomach pain, nausea, vomiting, dizziness, liver-related symptoms, or extreme weakness.

Side Effects Of NICIP 100MG TABLET

Common side effects of Nicip 100mg Tablet

• Nausea
• Stomach pain or discomfort
• Heartburn
• Dizziness
• Diarrhoea
• Fatigue

When to Seek Medical Attention?

Stop taking Nicip 100mg Tablet and contact your doctor immediately if you experience

• Severe abdominal pain
• Yellowing of skin or eyes
• Dark urine or persistent nausea
• Severe allergic reactions
• Unusual fatigue or weakness

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or lie down immediately: If you feel dizzy, sit or lie down right away to avoid falls. Rest until the feeling passes.
• Stay hydrated: Drink enough water during the day. Dehydration is a common cause of dizziness, especially in hot weather.
• Eat on time: Low blood sugar can lead to light-headedness. Have small, balanced meals at regular intervals.
• Move slowly: Avoid sudden changes in position. Get up slowly from sitting or lying down to reduce the risk of dizziness.
• Try deep breathing: Slow, steady breathing may help if dizziness is related to anxiety or stress.
• Ginger tea: Ginger may help ease dizziness linked with nausea. Sip it slowly for comfort.
• Ensure proper sleep: Lack of rest can worsen dizziness. Maintain a consistent sleep routine.

Nausea And Vomiting

• Sip ginger tea or chew a small piece of fresh ginger: Ginger is commonly used to ease stomach discomfort. Warm ginger tea or ginger candy may help settle the feeling of nausea.
• Drink small sips of clear fluids: Water, coconut water, clear soups, or oral rehydration fluids can help prevent dehydration. Take small, frequent sips instead of drinking large amounts at once.
• Try lemon or citrus aroma: Smelling fresh lemon or adding a few drops of lemon juice to warm water may help reduce queasiness.
• Eat light, bland foods: Choose simple foods like plain rice, toast, crackers, bananas, or curd. Avoid spicy, oily, or heavy meals until you feel better.
• Peppermint tea: Peppermint has a soothing effect on the stomach. A warm cup of peppermint tea may help relieve the uneasy feeling.
• Rest in an upright position: Sit upright or keep your head elevated after eating. Lying flat may worsen nausea.
• Get fresh air: Open a window or take a short walk in fresh air. Strong smells and stuffy rooms can trigger nausea.

Warning & Precautions

Pregnancy

Use with Caution

Nicip 100mg Tablet should be used with caution during pregnancy and only if the doctor considers it necessary. Pregnant women should consult a healthcare professional before using this medicine, as safety depends on individual risk assessment.

Breastfeeding

Consult your doctor

Use of Nicip 100mg during breastfeeding is generally not recommended unless clearly advised by a doctor. Medical guidance is important to evaluate potential risks to the nursing infant before use.

Driving and Using Machines

Use with Caution

Nicip 100mg may cause dizziness in some individuals. Avoid driving or operating heavy machinery if you feel light-headed or unwell after taking the tablet.

Alcohol

Contraindicated

Consuming alcohol while taking Nicip 100mg may increase the risk of stomach irritation and liver-related side effects. It is advisable to avoid or strictly limit alcohol intake during use.

Kidney

Use with Caution

Patients with kidney-related conditions should use Nicip 100mg cautiously. A doctor’s consultation is necessary before starting the medicine, and monitoring may be required during use.

Liver

Consult your doctor

Nicip 100mg should be used with extreme caution in individuals with liver disorders. It is generally avoided or used only under strict medical supervision, as liver monitoring may be needed.

Allergy

Contraindicated

Nicip 100mg should not be used by individuals who are allergic to nimesulide or any other component of the formulation. Inform your doctor about any known drug allergies before use.

Heart Disease

Use with Caution

People with existing heart conditions should use Nicip 100mg carefully. Medical advice is essential, especially in those with cardiovascular risk factors.

Use In Pediatrics

Contraindicated

Nicip 100mg is generally not recommended for use in children. Always seek medical guidance before considering this medicine for paediatric patients.

Use In Geriatrics

Monitoring required

Elderly patients may be more sensitive to the effects of Nicip 100mg. Closer medical monitoring and dose considerations may be advised to ensure safe use.

Other Warnings for NICIP 100MG TABLET

Before taking NICIP 100MG TABLET, inform your doctor if you

• have peptic ulcer, ulcerative colitis, or Crohn's diseas

Who should not take NICIP 100MG TABLET

NICIP 100MG TABLET is not recommended for use if you

• have drug addiction problems
• have cerebrovascular bleeding or other active bleeding or bleeding disorders
• have severe clotting disorders
• have an active or history of gastric or duodenal ulcers or gastrointestinal bleeding
• have signs of flu or fever

Safety Advice

• Use for the shortest duration advised: Nicip 100mg is generally recommended for short-term pain relief. Avoid prolonged use unless your doctor specifically advises it.
• Monitor liver health: Inform your doctor if you notice symptoms like persistent nausea, dark urine, yellowing of the eyes/skin, or unusual tiredness, as these may need medical review.
• Watch for stomach discomfort: Report symptoms such as severe abdominal pain, indigestion, black stools, or vomiting, which may indicate stomach irritation.
• Avoid combining with similar pain medicines: Do not take other NSAIDs or pain relievers alongside Nicip unless approved by your healthcare provider.
• Caution in existing conditions: Tell your doctor if you have a history of liver, kidney, heart, or stomach problems before starting the medicine.
• Inform before surgery or procedures: Let your doctor or dentist know you are taking Nicip 100mg, as it may affect bleeding tendency.
• Do not exceed the prescribed dose: Taking more than recommended does not improve relief and may increase the risk of side effects.
• Store properly: Keep the tablets in a cool, dry place away from direct sunlight and out of reach of children.
• Avoid sharing medication: This medicine should only be used by the person it is prescribed for, under medical supervision.

Diet and Lifestyle Advice

• Use for the shortest duration advised: Nicip 100mg is generally recommended for short-term pain relief. Avoid prolonged use unless your doctor specifically advises it.
• Monitor liver health: Inform your doctor if you notice symptoms like persistent nausea, dark urine, yellowing of the eyes/skin, or unusual tiredness, as these may need medical review.
• Watch for stomach discomfort: Report symptoms such as severe abdominal pain, indigestion, black stools, or vomiting, which may indicate stomach irritation.
• Avoid combining with similar pain medicines: Do not take other NSAIDs or pain relievers alongside Nicip unless approved by your healthcare provider.
• Caution in existing conditions: Tell your doctor if you have a history of liver, kidney, heart, or stomach problems before starting the medicine.
• Inform before surgery or procedures: Let your doctor or dentist know you are taking Nicip 100mg, as it may affect bleeding tendency.
• Do not exceed the prescribed dose: Taking more than recommended does not improve relief and may increase the risk of side effects.
• Store properly: Keep the tablets in a cool, dry place away from direct sunlight and out of reach of children.
• Avoid sharing medication: This medicine should only be used by the person it is prescribed for, under medical supervision.

Nicip 100 mg Tablet vs Drotin DS Tablet – Abdominal Pain

Drug - Drug interaction

1.Anticoagulants and Antiplatelet Medicines (e.g., warfarin, aspirin, clopidogrel)
Interaction: Using Nicip with blood-thinning medicines may increase the risk of bleeding, especially in the stomach or intestines.
Management: This combination should be used cautiously. Your doctor may monitor for signs of bleeding and adjust doses or suggest an alternative pain-relief option.

2.Other NSAIDs and Pain Relievers (e.g., ibuprofen, diclofenac)
Interaction: Taking Nicip along with other NSAIDs can increase the chances of stomach irritation, ulcers, or kidney strain.
Management: Avoid combining similar pain medicines unless specifically advised. Use only one NSAID at a time under medical guidance.

3.Corticosteroids (e.g., prednisolone, dexamethasone)
Interaction: Concurrent use may raise the risk of gastrointestinal irritation or bleeding.
Management: Doctors may prescribe stomach-protective measures or closely monitor for digestive discomfort if both are necessary.

4.Diuretics (Water Tablets) (e.g., furosemide, hydrochlorothiazide)
Interaction: Nicip may reduce the effectiveness of diuretics and increase the risk of kidney-related effects, especially in dehydrated patients.
Management: Adequate hydration and periodic kidney function monitoring may be advised when used together.

5.Antihypertensive Medicines (e.g., ACE inhibitors, beta blockers)
Interaction: Nicip can sometimes reduce the blood pressure-lowering effect of these medicines.
Management: Blood pressure may be monitored more frequently, and dose adjustments considered if needed.

6.Lithium
Interaction: Nicip may increase lithium levels in the blood, raising the risk of toxicity.
Management: Doctors usually monitor lithium levels closely or avoid this combination where possible.

7.Methotrexate
Interaction: Using Nicip with methotrexate may increase the risk of methotrexate-related side effects due to reduced clearance.
Management: Careful timing of doses and close medical monitoring are essential if both medicines are required.

8.Cyclosporine
Interaction: Combined use may increase the risk of kidney strain.
Management: Kidney function monitoring is recommended, and alternative pain relief may be considered.

Drug - Food interaction

1.Spicy and Oily Foods
Interaction: Very spicy or oily meals may worsen stomach discomfort or acidity when taken with Nicip.
Management: Prefer light, easily digestible meals and avoid heavy or overly spicy foods to reduce gastric irritation.

2.Caffeine-Containing Beverages (coffee, strong tea, energy drinks)
Interaction: Excess caffeine may increase gastric acidity and contribute to restlessness or discomfort in some individuals.
Management: Limit caffeine intake and choose non-caffeinated beverages if you notice stomach upset.

3.Grapefruit and Grapefruit Juice
Interaction: Grapefruit products may interfere with liver enzymes involved in medicine metabolism, potentially affecting how Nicip is processed in the body.
Management: Avoid grapefruit and its juice during therapy unless your doctor confirms it is safe for you.

4.High-Fat Meals
Interaction: Very fatty foods may delay the absorption of Nicip, leading to a slower onset of pain relief.
Management: Taking the tablet with a normal or light meal, rather than a heavy fatty meal, may help maintain predictable action.

5.Herbal Supplements Affecting the Liver (e.g., herbal tonics, certain Ayurvedic or herbal products)
Interaction: Some herbal products may add to liver workload when taken with Nicip.
Management: Inform your doctor about any herbal or dietary supplements you use and avoid self-medicating with liver-affecting products.

Synopsis

Synopsis

More Information

FAQs About NICIP 100MG TABLET

References

1. KD Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh Edition, 2013. Page - 203-204.

2. H G Kress, A Baltov, A Basinski, F Berghea, J Castellsague, C Codreanu, E Copaciu, M A Giamberardino, M Hakl, L Hrazdira, M Kokavec, J Lejcko, L Nachtnebl, R Stancík, A Švec, T Tóth, M V Vlaskovska, J Woron. Acute pain: a multifaceted challenge—the role of nimesulide. NIH: National Library of Medicine, National Center of Biotechnology Information Pubmed.gov. [Accessed on 16th February 2026] 

3. A K Singla, M Chawla, A Singh. Nimesulide: some pharmaceutical and pharmacological aspects—an update. NIH: National Library of Medicine, National Center of Biotechnology Information Pubmed.gov. [Revised in May 2000]. [Accessed on 16th February 2026]

4. Pharm Evo Pvt Ltd. NICIP 100MG TABLET (Nimesulide 100mg). [Revised on May 2016] [Accessed on 16th February 2026] 

Useful Diagnostic Tests

• Liver Function Test (LFT)
• Kidney Function Test (KFT)
• Basic Arthritis Care
• Advance Bone Care
• Extended Arthritis Care Plan
• Bone Strength Package

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 13 Aug 2024 | 05:04 PM(IST)