Nexpro 40mg(L)
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Introduction About NEXPRO 40MG(L)
NEXPRO 40MG(L) contains Esomeprazole which belongs to the group of medicines called Proton pump inhibitors. It is used for the management of Gastroesophageal reflux disease (GERD) heartburn in adults and in adolescents above 12 years of age. NEXPRO 40MG(L) also helps in managing stomach ulcers or upper part of the gut (intestine) that are infected with Helicobacter pylori bacteria and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) medicines in adults and in adolescents above 12 years of age. It is also used to manage Zollinger-Ellison syndrome (too much acid produced in the stomach caused by a growth in the pancreas).
GERD is a disease where acid from the stomach escapes into the tube which connects your throat to your stomach (oesophagus) causing pain and inflammation.
NEXPRO 40MG(L) is not recommended to be taken in patients with severe kidney and liver failure. NEXPRO 40MG(L) should be taken only if considered clearly necessary by your doctor in pregnant women. It is not recommended for use in breast-feeding women. Consult your doctor for advice before taking the medicine.
NEXPRO 40MG(L) is not recommended for children and adolescents aged less than 12 years. Consult your doctor for advice before taking the medicine.
The most common side effects of taking NEXPRO 40MG(L) are headache, diarrhoea, stomach pain, constipation, flatulence, nausea and vomiting. Contact your physician if any of the above symptoms worsens with time.
Uses Of NEXPRO 40MG(L)
Used to manage:
- Gastroesophageal reflux disease (GERD)
- Stomach ulcers and intestinal ulcers caused by helicobacter pylori infection and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
- Zollinger-Ellison syndrome
How NEXPRO 40MG(L) Works
NEXPRO 40MG(L) is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of enzymes in the stomach cell. It hence reduces gastric acidity by blocking the final step in acid production and helps in relief of acid related indigestion and heartburn.
How to use NEXPRO 40MG(L)
Take NEXPRO 40MG(L) as advised by your doctor. It can be taken with or without food. Swallow NEXPRO 40MG(L) with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of NEXPRO 40MG(L)
Common
- headache
- diarrhoea
- stomach pain
- constipation
- flatulence
- nausea
- vomiting
- benign polyps in the stomach (masses of cells that form on the lining inside your stomach)
Uncommon
- swelling of the feet and ankles
- troubled sleep
- dizziness
- tingling sensations (pins and needles)
- sleepiness
- dry mouth
- skin rash, bumpy rash (hives) and itchy skin
- fracture of joints such as hip, wrist or spine
Rare
- weakness, bruising or make infections due to reduced number of white cells or platelets
- due to low levels of sodium in the blood causing weakness, being sick (vomiting) and cramps
- agitation, confused or depressed
- taste changes
- blurred vision
- suddenly feeling wheezy, short of breath (bronchospasm)
- oral inflammation
- fungal infection affecting the gut- thrush
- yellow skin, dark urine, and tiredness (liver problem)
- hair loss (alopecia)
- skin rash on exposure to sunshine
- pain in joints (arthralgia) or muscle (myalgia)
- lack of energy and feeling unwell and lacking energy
- increased sweating
Stop taking NEXPRO 40MG(L) and consult your doctor immediately if you experience any of the following side effects:
- sudden wheezing, swelling of lips, tongue and throat or body, rashes, fainting or difficulty in swallowing (severe allergic reaction)
- reddening of the skin with blisters or peeling in the lips, eyes, mouth, nose and genitals indicative of Stevens-Johnson syndrome or toxic epidermal necrolysis
- yellow skin, dark-coloured urine and tiredness indicative of liver problems
- fever with a severely reduced general condition or fever with symptoms of a local infection such as pain in the neck, throat or mouth or difficulties in urinating
How To Manage Side Effects
Headache:
Rest and relax. Frequently hydrate yourself by drinking plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if needed. Do not consume too much of alcohol. Consult your doctor if symptom worsens.
Diarrhea:
Drink plenty of liquids such as water, fruit juices or electrolytes to avoid loss of water (dehydration) in your body. Consult your doctor if the symptom persists for long time.
Nausea and Vomiting:
Try to take NEXPRO 40MG(L) with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food.
Warning & Precautions
Pregnancy
NEXPRO 40MG(L) should be used during pregnancy only if considered clearly necessary. Consult your doctor before taking NEXPRO 40MG(L).
Breastfeeding
NEXPRO 40MG(L) is not recommended for use in breast feeding women as it is unclear whether it passes through the breast milk. Consult your doctor before taking NEXPRO 40MG(L).
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you experience dizziness and blurred vision after taking NEXPRO 40MG(L). Consult your doctor before taking NEXPRO 40MG(L).
Alcohol
Avoid or limit the consumption of alcohol while taking NEXPRO 40MG(L) because it might increase the amount of acid in your stomach than normal which can irritate your stomach lining and worsen your symptoms.
Kidney
NEXPRO 40MG(L) should be used with caution in patients with severe kidney problems. Consult your doctor before taking NEXPRO 40MG(L).
Liver
[GBNKWEYWORD] should be used with caution in patients with severe liver problems. Consult your doctor before taking NEXPRO 40MG(L).
Allergy
Do not take NEXPRO 40MG(L) if you are allergic to Esomeprazole or to any other proton pump inhibitor medicines.
Others
Before taking NEXPRO 40MG(L), inform your doctor if you:
- have ever had a skin reaction after taking medicine to manage acidity
- are going to have a specific blood test (Chromogranin A)
- are losing a lot of weight without reason
- have problems swallowing
- have stomach pain or indigestion
- pass black stools (blood-stained faeces)
- skin rashes especially after getting exposed in sun
- have joint pains
Use in pediatrics:
NEXPRO 40MG(L) is not recommended to be taken in children and adolescents below 12 years of age. Your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking NEXPRO 40MG(L).
Use in geriatrics:
NEXPRO 40MG(L) should be taken with caution in elderly patients (65 years and above). Consult your doctor before taking NEXPRO 40MG(L).
Interactions
A. Drug-Drug interactions:
Before taking NEXPRO 40MG(L) inform your doctor if you are taking any of these medicines:
- antibiotics used to manage ulcers caused by Helicobacter pylori infection (Ex. amoxicillin, clarithromycin)
- medicines used to manage HIV infection (Ex. nelfinavir, atazanavir)
- medicines used to manage blood clots (clopidogrel, warfarin)
- anti-fungal medicines (Ex. ketoconazole, itraconazole or voriconazole)
- medicine used to manage cancer (Ex. erlotinib)
- anti-depressants used to manage depression (Ex. citalopram, imipramine, clomipramine or St. John’s wort (Hypericum perforatum)
- medicines used to manage anxiety, relax muscles or in epilepsy (Ex. diazepam)
- medicine used in epilepsy (Ex. phenytoin)
- medicines used to manage intermittent pain in your legs while walking caused by an insufficient blood supply (Ex. cilostazol)
- medicines used for indigestion and heartburn (Ex. cisapride)
- digoxin (medicine used for heart problems)
- methotrexate (a chemotherapy medicine used in high doses to manage cancer)
- immunosuppressants for organ transplantation (Ex. tacrolimus)
- medicines used for management of tuberculosis (Ex. rifampicin)
- medicines that increase magnesium such as diuretics (Ex. hydrochlorothiazide, chlorthalidone)
Overdosage:
If you or anyone else accidentally take more of NEXPRO 40MG(L), consult your doctor immediately or visit the nearby hospital. Symptoms of overdose may include reduced physical (motor) activity, changes in respiratory rate, tremor, coordination-balance-speech disorders (ataxia) and intermittent fits (clonic convulsions).
Synopsis
| Drug | : | Esomeprazole |
| Pharmacological Category | : | Proton Pump Inhibitors |
| Therapeutic Indication | : | Gastroesophageal reflux disease (GERD), Stomach ulcers, Intestinal ulcers caused by NSAID’s, Manages rebleeding following therapeutic endoscopic procedures done for acute bleeding stomach (gastric) or intestinal (duodenal) ulcers |
| Dosage Forms | : | Tablet, Capsule, Injection, Infusion, Sachet, Granules |
More Information
- Keep NEXPRO 40MG(L) out of reach of children
- Store at room temperature
FAQs About NEXPRO 40MG(L)
Can NEXPRO 40MG(L) used to manage heartburn?
Yes. NEXPRO 40MG(L) contains Esomeprazole used to manage symptoms of stomach acid reflux such as heartburn and indigestion. Consult your doctor regarding the symptoms before taking it.
Can I take an antacid along with NEXPRO 40MG(L)?
Yes. It is safe to take NEXPRO 40MG(L) with antacids as there is no known interaction. However, consult your doctor before taking it together.
Is NEXPRO 40MG(L) addictive in nature?
No, NEXPRO 40MG(L) is not addictive in nature and you can continue NEXPRO 40MG(L) to take as long as it is of benefit to you. Consult your doctor to assess your management on a regular basis.
How and when NEXPRO 40MG(L) should be taken?
Take NEXPRO 40MG(L) as advised by your doctor and can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Can NEXPRO 40MG(L) be taken in pregnant women?
NEXPRO 40MG(L) should be taken in pregnant women only if considered clearly necessary by your doctor. If you think you may be pregnant or planning to become pregnant, consult your doctor for advice before taking NEXPRO 40MG(L).
Can NEXPRO 40MG(L) cause headache?
Yes, headache is one of the most common side effects of taking NEXPRO 40MG(L). In case if you are experiencing a headache after taking NEXPRO 40MG(L), try to rest and relax. Keep drinking plenty of fluids such as water. Apply a pain-relieving balm on the forehead if needed. Consult your doctor if headache persists for a long time.
References
1. KD Tripathi. Drugs for Peptic Ulcer and G.E.R.D. Essentials of Medical Pharmacology. seventh edition. 2013. Page – 649, 653, 657.
2. Franke, Andreas, Caroline Hepp, Hermann Harder, Christoph Beglinger, and Manfred V. Singer. Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers. Scandinavian journal of gastroenterology. NIH National Library of Medicines, National Library of Medicine. 2008. [Accessed on 11th June 2022] https://pubmed.ncbi.nlm.nih.gov/18924018/
3. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 11th June 2022] https://www.medicines.org.uk/emc/files/pil.2326.pdf
4. Astra Zeneca Pharmaceuticals LP. U.S. Food & Drug Administration. [Revised in December 2014] [Accessed on 11th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022101s014021957s017021153s050lbl.pdf
5. AstraZeneca Pharmaceuticals (Ptd) Limited. [Revised in October 2020] [Accessed on 11th June 2022] https://www.sahpra.org.za/wp-content/uploads/2020/08/Nexium-Sachets_PIL_AstraZeneca_MCC-Format-02-October-2020.pdf
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