New Revised MRP, 100% GST benefit passed NEOPRATE 500MG INJECTION 5ML
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Introduction About NEOPRATE 500MG INJECTION 5ML
NEOPRATE 500MG INJECTION 5ML contains Sodium valproate, which belongs to the group of medicines called Anti-convulsant. It is used in the management of epilepsy (fits). Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness. Symptoms include temporary confusion, staring spells, stiff muscles, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness, fear, anxiety or déjà vu.
NEOPRATE 500MG INJECTION 5ML is not recommended for use if you have porphyria (affecting metabolism), liver problems or Alpers-Huttenlocher syndrome. Before receiving NEOPRATE 500MG INJECTION 5ML inform your doctor if you have kidney, brain problems, carnitine palmitoyl transferase type II deficiency, diabetes, systemic lupus erythematosus, urea cycle disorder, a genetic problem caused by a mitochondrial disorder in your family.
Do not consume alcohol while receiving NEOPRATE 500MG INJECTION 5ML. NEOPRATE 500MG INJECTION 5ML is not recommended or used in pregnant women, inform your doctor if you are breastfeeding. NEOPRATE 500MG INJECTION 5ML should be used with caution in children and the elderly. The most common side effects of receiving NEOPRATE 500MG INJECTION 5ML are stomach pain, diarrhea, headache, feeling tired and weight gain. Consult your doctor if any of your symptoms become worse while taking NEOPRATE 500MG INJECTION 5ML.
Uses Of NEOPRATE 500MG INJECTION 5ML
- Manage epilepsy (fits)
How NEOPRATE 500MG INJECTION 5ML Works
NEOPRATE 500MG INJECTION 5ML increases concentrations of gamma-aminobutyric acid (GABA) which reduces neuronal excitability by inhibiting nerve transmission in the brain, probably due to inhibition of the enzymes responsible for the breakdown of GABA.
How to use NEOPRATE 500MG INJECTION 5ML
NEOPRATE 500MG INJECTION 5ML will be given to you only by a doctor or a nurse as a slow infusion into the veins (intravenously). Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
Side Effects Of NEOPRATE 500MG INJECTION 5ML
Common
- stomach pain, feeling or being sick
- diarrhea
- dry or sore mouth or swollen gums
- shakes (tremors) in a part of your body or unusual eye movements
- feeling tired or sleepy
- headache
- weight gain
- thinning hair or changes to the color or texture of your hair
- irregular or delayed periods
- pain at the injection site
Rare
Stop receiving NEOPRATE 500MG INJECTION 5ML and contact your doctor immediately if you experience any of the following side effects:
- thoughts of harming or killing yourself
- an allergic reaction (rash, joint pain, fever (systemic lupus erythematosus), swallowing or breathing problems, swelling of your lips, face, throat or tongue, lymph node enlargement and possible impairment of other organs
- liver problems and problems of the pancreas may show as a sudden illness (feeling and being sick many times; being very tired, sleepy and weak, stomach pain, jaundice, loss of appetite, swelling of legs, worsening of fits
- skin rash or skin lesions with a pink/red ring and a pale center which may be itchy, scaly or filled with fluid (on the palms or soles of your feet, can be erythema multiforme)
- blistering or bleeding of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever (Stevens-Johnson syndrome)
- severe blistering rash where layers of the skin may peel off to leave large areas of raw exposed skin over the body, unwell, fever, chills and aching muscles (toxic epidermal necrolysis)
- bruising more easily and getting more infections than usual (thrombocytopenia), blood clotting problems
- changes in mood, loss of memory, lack of concentration and coma
- hypothyroidism, which may cause tiredness or weight gain
- breathing difficulty and pain due to inflammation of the lungs
- changes in behavior including being very alert and sometimes also aggressive, hyperactive and unusual or inappropriate behavior
- changes in the amount of ammonia in the blood (being sick, problems with balance and co-ordination, feeling lethargic or less alert)
- feeling shaky (tremor), sleepy or unsteady when walking or jerky muscle movements.
- rapid, uncontrollable movement of the eyes
- increase in the number and severity of convulsions
- liver damage, inflammation of the pancreas, bedwetting, renal dysfunction, overgrowth of gum tissue, aggression, agitation, disturbance in attention, abnormal behavior, hyperactivity and learning disorder in children
- kidney disease or kidney problems (renal failure, tubulointerstitial nephritis and Fanconi syndrome) which may manifest as reduced urinary output or blood in the urine
- confusion, which could be due to decreased levels of sodium in your blood (Syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion)
How To Manage Side Effects
Stomach pain:
Try to rest and relax. Eat and drink slowly. Keep a heating pad. Consult your doctor if any of your symptoms get worse.
Diarrhea:
Drink lots of water or fruit juice to keep yourself hydrated. Consult your doctor if any of your symptoms get worse.
Feeling or being sick:
Stick to simple meals. Avoid eating oily or spicy meals. Consult your doctor if any of your symptoms get worse.
Headache:
Avoid bright lights, take enough rest and drink more water. Consult your doctor if any of your symptoms get worse.
Warning & Precautions
Pregnancy
NEOPRATE 500MG INJECTION 5ML is not recommended for use in pregnant women or if you are planning to have a baby as it can cause birth defects and behavioral/learning problems in the baby. if you are a woman able to have a baby, you must not take it unless you use an effective method of birth control (contraception) during your entire> management. Do not stop taking this medicine or contraception, until you have discussed this with your doctor. Consult your doctor before receiving NEOPRATE 500MG INJECTION 5ML.
Breastfeeding
Inform your doctor if you are breastfeeding before receiving NEOPRATE 500MG INJECTION 5ML as very little medicine might pass through the breastmilk. Consult your doctor if you can breastfeed or not receive the medicine during the> management.
Driving and Using Machines
Do not drive or use machines while receiving NEOPRATE 500MG INJECTION 5ML as it can make you sleepy.
Alcohol
Do not consume alcohol while receiving NEOPRATE 500MG INJECTION 5ML as it can worsen the side effects.
Kidney
NEOPRATE 500MG INJECTION 5ML should be used with caution in patients with kidney disease. The dose will be adjusted by your doctor. Consult your doctor before receiving NEOPRATE 500MG INJECTION 5ML.
Liver
NEOPRATE 500MG INJECTION 5ML is not recommended for patients with liver problems or with a family history of liver disease. Consult your doctor before receiving NEOPRATE 500MG INJECTION 5ML.
Allergy
Do not receive NEOPRATE 500MG INJECTION 5ML if you are allergic to Sodium valproate or any other ingredients of this medicine.
Others
NEOPRATE 500MG INJECTION 5ML is not recommended for use if you:
- have a rare illness called porphyria which affects metabolism
- have a known metabolic disorder, i.e., a urea cycle disorder
- have a genetic problem caused by a mitochondrial disorder (Alpers-Huttenlocher syndrome)
- are a woman of birth-giving age and not using contraceptives (birth control)
Before receiving NEOPRATE 500MG INJECTION 5ML, inform your doctor if you:
- have diabetes
- have a carnitine palmitoyl transferase type II deficiency
- have a brain disease or a metabolic condition affecting the brain
- have a ‘urea cycle disorder’ where too much ammonia builds up in the body.
- have an illness called systemic lupus erythematosus (SLE) (an immune system which affects skin, bones, joints and internal organs)
- genetic problem caused by a mitochondrial disorder in your family
Use in pediatrics:
NEOPRATE 500MG INJECTION 5ML should be used with caution in children only if recommended by your doctor. Consult your doctor for advice.
Use in geriatrics:
NEOPRATE 500MG INJECTION 5ML should be used with caution in the elderly only if recommended by your doctor. Consult your doctor for advice.
Interactions
A. Drug-Drug interactions:
Before receiving NEOPRATE 500MG INJECTION 5ML, inform your doctor if you are taking any of the following medicine:
- medicines used for pain and inflammation (salicylates) (Ex. aspirin)
- other medicines used to manage fits (Ex. phenobarbital, primidone, phenytoin, carbamazepine, rufinamide, topiramate, acetazolamide, lamotrigine and felbamate)
- medicines used for thinning the blood (Ex. warfarin).
- zidovudine, lopinavir and ritonavir (to manage HIV infection)
- temozolomide (to manage cancer)
- medicines for depression (monoamine oxidase inhibitors (MAOI) such as moclobemide, selegiline, linezolid)
- selegiline (used to manage Parkinson’s disease), linezolid (used to manage infections).
- medicines used to calm emotional and mental health problems (Ex. quetiapine, diazepam and olanzapine)
- nimodipine (to manage hemorrhage)
- propofol (used for anesthesia)
- oestrogen-containing products (including some birth control pills).
- medicines to manage malaria (Ex. mefloquine and chloroquine)
- cimetidine (for stomach ulcers)
- carbapenem agents (antibiotics used to manage bacterial infections) Ex. imipenem, meropenem, rifampicin and erythromycin
- cholestyramine is used to lower blood fat (cholesterol) levels.
- metamizole (to manage pain and fever)
Overdosage:
NEOPRATE 500MG INJECTION 5ML will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like feeling sick or being sick, pupils of the eye become smaller, dizziness, loss of consciousness, weak muscles and poor reflexes, breathing problems, headaches, fits (seizures), confusion, memory loss and unusual or inappropriate behavior.
Synopsis
| Drug | : | Sodium Valproate |
| Pharmacological Category | : | Anti-convulsant |
| Therapeutic Indication | : | Epilsepsy (fits) |
| Dosage Forms | : | Tablet, Injection, Syrup, Oral solution |
More Information
- Keep NEOPRATE 500MG INJECTION 5ML out of reach from children
- Store at room temperature
FAQs About NEOPRATE 500MG INJECTION 5ML
What is NEOPRATE 500MG INJECTION 5ML used for?
NEOPRATE 500MG INJECTION 5ML is used in the management of epilepsy (fits). Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness.
Can pregnant women receive NEOPRATE 500MG INJECTION 5ML?
NEOPRATE 500MG INJECTION 5MLis not recommended for use in pregnant women or if you are planning to have a baby as it can cause birth defects and behavioral/learning problems in the baby. Consult your doctor before receiving NEOPRATE 500MG INJECTION 5ML.
How does NEOPRATE 500MG INJECTION 5ML work?
NEOPRATE 500MG INJECTION 5ML increases concentrations of gamma-aminobutyric acid (GABA) which reduces neuronal excitability by inhibiting nerve transmission in the brain, probably due to inhibition of the enzymes responsible for the breakdown of GABA.
Can I drive while receiving NEOPRATE 500MG INJECTION 5ML?
Do not drive or use machines while receiving NEOPRATE 500MG INJECTION 5ML as it can make you sleepy and weaken your ability to drive. Consult your doctor for more information on NEOPRATE 500MG INJECTION 5ML.
Can NEOPRATE 500MG INJECTION 5ML be received by kidney patients?
NEOPRATE 500MG INJECTION 5MLshould be used with caution in patients with kidney disease. The dose will be adjusted by your doctor. Consult your doctor before receiving NEOPRATE 500MG INJECTION 5ML.
References
1. KD Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 444.
2. Pubchem. Sodium Valproate. [Accessed on 15th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-valproate#:~:text=Valproate%20sodium%20is%20converted%20into,for%20the%20catabolism%20of%20GABA.
3. R. M. Pinder, R. N. Brogden, T. M. Speight & G. S. Avery. Sodium Valproate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Epilepsy. [Accessed on 15th July 2022] https://link.springer.com/article/10.2165/00003495-197713020-00001
4. Sanofi S.r.l. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 15th July 2022] https://www.medicines.org.uk/emc/files/pil.1445.pdf
5. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 15th July 2022] https://www.medicines.org.uk/emc/files/pil.1209.pdf
6. NHS. Sodium Valproate [Revised in August 2021] [Accessed on 15th July 2022] https://www.nhs.uk/medicines/sodium-valproate/
7. Mayoclinic. Sodium valproate. [Revised on October 2021] [Accessed on 15th July 2022] https://www.mayoclinic.org/diseases-conditions/epilepsy/symptoms-causes/syc-20350093#:~:text=Epilepsy%20is%20a%20central%20nervous,races%2C%20ethnic%20backgrounds%20and%20ages.
Useful Diagnostic Tests
- Blood tests
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