NEFOSAR Injection 5X1ml

Introduction About NEFOSAR INJECTION

NEFOSAR INJECTION contains Nefopam which belongs to the group of medicines called Painkillers. It is used for the symptomatic management of acute painful conditions, especially post-operative pains.

NEFOSAR INJECTION is not recommended for use in patients with cardiovascular diseases, acute angle glaucoma, fits, urinary retention. NEFOSAR INJECTION should be used with caution in patients with liver, kidney disease. Consult your doctor before receiving it.

NEFOSAR INJECTION is not recommended for use in pregnant and breastfeeding women. NEFOSAR INJECTION is not recommended for use in children below 12 years of age and in elderly patients. Consult your doctor before receiving it.

The most common side effects of receiving NEFOSAR INJECTION are vertigo, nausea, vomiting, sweats and pain at the injection site. Consult your doctor if any of the symptoms worsen.

Uses Of NEFOSAR INJECTION

• To manage acute painful conditions

How NEFOSAR INJECTION Works

NEFOSAR INJECTION interrupts the pain messages being sent to the brain and it also stops pain messages being felt in the brain. It does not stop the pain from happening, but you will not be able to feel the pain as much.

How to use NEFOSAR INJECTION

NEFOSAR INJECTION will be given to you only by a doctor or a nurse into the muscle as intramuscular injection (IM) or into a vein as intravenous injection (IV). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Side Effects Of NEFOSAR INJECTION

How To Manage Side Effects

Dry mouth:

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying. Consult your doctor if the dry mouth gets worse.

Nausea and vomiting:

Receive NEFOSAR INJECTION, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting did not improve.

Warning & Precautions

Pregnancy

NEFOSAR INJECTION is not recommended for use in pregnant women. Consult your doctor before receiving it.

Breastfeeding

NEFOSAR INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving it.

Driving and Using Machines

NEFOSAR INJECTION can cause vertigo (reeling sensation). Hence, do not drive or use machines after receiving this medicine.

Kidney

NEFOSAR INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving it.

Liver

NEFOSAR INJECTION should be used with caution in patients with liver disease. Consult your doctor before receiving it.

Allergy

Do not receive NEFOSAR INJECTION if you are allergic to Nefopam or any of the other ingredients of this medicine.

Heart Disease

NEFOSAR INJECTION is not recommended for use in patients with cardiovascular diseases. Consult your doctor before receiving it.

Interactions

A. Drug - Drug interactions:

Before receiving NEFOSAR INJECTION, inform your doctor if you are taking any of the following medicine:

• morphine (used to manage severe pain)
• medicines used to manage depression (Ex.  isocarboxazid, phenelzine, amitriptyline)
• anticholinergics Ex. hyoscine butylbromide, propantheline bromide (for relief of stomach cramps or spasms, overactive bladder)
• sympathomimetic agents Ex. pseudoephedrine (used to manage nasal congestion)

Overdosage:

NEFOSAR INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like heart problems, convulsions, hallucinations.

Synopsis

More Information

• Keep NEFOSAR INJECTION out of reach of children
• Store NEFOSAR INJECTION below 30°C

FAQs About NEFOSAR INJECTION

Q: How often can I use NEFOSAR INJECTION?

A: Receive NEFOSAR INJECTION as advised by your physician. Generally, it can be renewed every 6 hours (IM route) or every 4 hours (IV route). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Q: Can I become addicted to this medicine?

A: Some people have become addicted to NEFOSAR INJECTION after using it for a long time. If this happens to you, you might have withdrawal symptoms if you suddenly stop using this medicine. Symptoms include feeling anxious, restlessness, difficulty sleeping. Do not suddenly stop using this medicine. If you’ve using this medicine for a long time, talk to your doctor if you want to stop using it. Your doctor will reduce your dose gradually, to avoid side effects.

Q: How long will I take it for?

A: You may only need to use this medicine for a short time (Ex. For acute painful conditions, especially post-operative pains). It’s best to receive this medicine for the shortest time to control your symptoms. If you need to use this medicine for longer time, your doctor will monitor how well it is working for you and whether you still need it. Contact your doctor if you are unaware how long you need to use NEFOSAR INJECTION.

Q: How do you administer NEFOSAR INJECTION?

A: NEFOSAR INJECTION can be administered by deep intramuscular route (IM) or slow intravenous route (IV) (more than 15 minutes). Patient must lie down before and after administration of this medicine for 15-20 minutes to avoid some side effects such as nausea, dizziness, sweats.

Q: What are the side effects of NEFOSAR INJECTION?

A: The most common side effects of receiving NEFOSAR INJECTION are vertigo, nausea, vomiting, sweats and pain at the injection site. Consult your doctor if any of the symptoms worsen.

References

1. KD Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page –224.

2. Young Min Kim Byung Gun Lim, Heezoo Kim, Myoung Hoon Kong, Mi Kyoung Lee & II Ok Lee. Slow injection of nefopam reduces pain intensity associated with intravenous injection: a prospective randomized trial. Journal of Anesthesia. November 2013. [Accessed on 30th May 2022]. https://link.springer.com/article/10.1007/s00540-013-1744-z

3. Alfonsi P, Adam F, Passard A, Guignard B, Sessler DI, Chauvin M. Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. January 2004. [Accessed on 30th May 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283107/

4. BIOCODEX. Food and Drug Administration. [Revised in July 2017] [Accessed on 30th May 2022]. https://fdaghana.gov.gh/img/pils/ACUPAN%2020%20mg%20per%202%20ml%20(Nefopam%20hydrochloride).pdf

5. Square Pharma. Nefopam. [Accessed on 30th May 2022]. http://www.squarepharma.com.bd/downloads/Xripa.pdf

6. Central Drugs Standard Control Organization. Nefopam. [Revised in April 1991] [Accessed on 30th May 2022]. https://cdscoonline.gov.in/CDSCO/Drugs

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 13 Jan 2023 | 12:15 PM(IST)