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Introduction About NEBIMAX H 5MG TABLET
NEBIMAX H 5MG TABLET is a combination of Hydrochlorothiazide and Nebivolol which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure).
Hypertension (also known as high blood pressure) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high and as a result it may lead to severe damage to the blood vessels supplying several vital organs, such as heart, kidney or brain. If left unmanageed, it may cause serious complications such as heart attack, heart failure, stroke or even blindness.
By lowering blood pressure, NEBIMAX H 5MG TABLET can also reduce the risk of heart attack (myocardial infarction) or stroke. During management with NEBIMAX H 5MG TABLET your doctor will constantly monitor your kidney functions, blood pressure, electrolyte levels and blood sugar levels to avoid the risk of unwanted side effects.
Before taking NEBIMAX H 5MG TABLET inform your doctor if you have any liver, kidney or heart problems (such as angina). You must also inform your doctor if you have asthma, diabetes, thyroid problems, poor blood circulation, psoriasis or dehydration as a precaution.
NEBIMAX H 5MG TABLET is not recommended for use in patients with severe heart problems (such as heart failure or heart block). Consult your doctor before taking this medicine if you are pregnant or breastfeeding.
The most common side effects of taking this medicine are headache, dizziness, tiredness, tingling sensation, diarrhoea, constipation, shortness of breath and swollen hands or feet. Consult your doctor if any of these side effect worsens.
Uses Of NEBIMAX H 5MG TABLET
- Manage Hypertension (high blood pressure)
- Prevents the risk of heart attack or stroke
How NEBIMAX H 5MG TABLET Works
NEBIMAX H 5MG TABLET is an antihypertensive medicine. It contains two medicines namely, nebivolol and hydrochlorothiazide. Nebivolol works by blocking the actions of certain chemical messengers (such as adrenaline) in the body that increases heart rate and blood pressure.
Hydrochlorothiazide works by reducing the thickness of the blood by removing excess fluids from the body in the form of urine. Collectively, these actions improve blood flow, reduce the strain on the heart and helps the heart to pump more blood with less pressure.
How to use NEBIMAX H 5MG TABLET
Take NEBIMAX H 5MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Try to take NEBIMAX H 5MG TABLET at the same time each day. NEBIMAX H 5MG TABLET can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
Continue to take NEBIMAX H 5MG TABLET for the stipulated duration instructed by your doctor without any interruption to achieve better results.
Side Effects Of NEBIMAX H 5MG TABLET
Common
- headache, dizziness
- tiredness
- tingling sensation or unusual itching in the body
- diarrhoea, constipation
- nausea
- shortness of breath
- swollen hands or feet
Uncommon
- low blood pressure
- slow heartbeat
- leg pain or cramps
- abnormal vision
- impotency (problems in reaching orgasm)
- depression
- indigestion, bloating
- vomiting
- skin rash or itching
- throat tightness
- nightmare
Rare
Stop taking NEBIMAX H 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
How To Manage Side Effects
Nausea and vomiting:
Take NEBIMAX H 5MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
NEBIMAX H 5MG TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Breastfeeding
NEBIMAX H 5MG TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle any heavy tools or machines if your ability is affected by NEBIMAX H 5MG TABLET.
Alcohol
Avoid consumption of alcohol while taking NEBIMAX H 5MG TABLET as it might make you feel dizzier and drowsier.
Kidney
NEBIMAX H 5MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
NEBIMAX H 5MG TABLET is not recommended for use in patients with severe liver impairment. Therefore, consult your doctor before taking it.
Allergy
Do not take NEBIMAX H 5MG TABLET if you are allergic to Nebivolol or Hydrochlorothiazide.
Lungs
NEBIMAX H 5MG TABLET is not recommended for use in patients with asthma or other breathing problems. It should be used with caution in patients with chronic bronchitis (inflammation of the airways). Therefore, consult your doctor before taking it.
Heart Disease
NEBIMAX H 5MG TABLET is not recommended for use in patients with slow heartbeat, serious heart rhythm problems or recent heart failure. It should be used with caution in patients having angina (chest pain) or heart block. Therefore, consult your doctor before taking it.
Others
NEBIMAX H 5MG TABLET is not recommended for use if you:
- have low blood pressure
- have poor blood circulation in the arms and legs
- have metabolic acidosis (too much acidity in blood)
- have unmanageed phaeochromocytoma
Before taking NEBIMAX H 5MG TABLET inform your doctor if you:
- have a slow heartbeat with shortness of breath and dizziness
- have Raynaud’s disease (poor blood circulation to fingers and toes)
- have leg pain, tension or weakness (intermittent claudication)
- have diabetes
- have overactivity of thyroid gland
- have psoriasis (white scaly patches on the skin)
- are going to undergo an operation
- are severely dehydrated
- have low sodium, potassium or magnesium levels in the blood
Use in Pediatrics:
NEBIMAX H 5MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Use in Geriatrics:
NEBIMAX H 5MG TABLET should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking NEBIMAX H 5MG TABLET inform to your doctor, if you are taking any of the following medicines such as:
- medicines that can depress the brain such as barbiturates (Ex. phenobarbital)
- narcotic drugs (used for pain relief) such as morphine, fentanyl, pethidine
- medicines used to reduce blood cholesterol levels (such as cholestyramine, colestipol)
- corticosteroids (used to manage inflammation) Ex. prednisolone
- corticotropin (a medicine used to correct hormone problems)
- noradrenaline (a medicine used to increase blood pressure)
- tubocurarine, dantrolene (medicines used to relax muscles)
- medicines used for pain and inflammation (such as ibuprofen or indomethacin)
- calcium channel blockers (used to manage heart problems) such as verapamil, diltiazem, amlodipine, felodipine, lacidipine, nifedipine, nicardipine, nimodipine and nitrendipine
- other medicines used to manage high blood pressure (such as clonidine, guanfacine, moxonidine, methyldopa, rilmenidine, Aliskiren, captopril, enalapril, ramipril, losartan, valsartan)
- medicines used to manage uneven heartbeat (such as digoxin, quinidine, hydroquinidine, amiodarone, cibenzoline, ecainide, disopyramide, lidocaine, mexiletine and propafenone)
- medicines used to manage anxiety (such as phenobarbital, chlorpromazine)
- medicines used to manage depression (such as lithium, amitriptyline, trazodone, paroxetine, fluoxetine and thioridiazine)
- medicines used to manage asthma (such as salbutamol, salmeterol, budesonide)
- medications used to manage cough and cold (such as pseudoephedrine)
- medicines used to manage glaucoma (such as timolol, pindolol)
- medicines used to manage diabetes (such as insulin, metformin, gliclazide, glibenclamide)
- anaesthetics (used to cause numbness or loss of sensation) such as lidocaine, sevoflurane, halothane
- cimetidine (a medicine used to manage stomach ulcers)
- antacids (medicines used to neutralise stomach acid) such as aluminium hydroxide, magaldrate
- medicines used for pain and inflammation (such as aspirin, ibuprofen, diclofenac)
- baclofen (a medicine used for relaxing muscles)
- amifostine (a kidney protectant used along with chemotherapeutic agents)
Overdosage:
If you or anyone else accidentally took excessive amount of this medicine, consult your doctor immediately or visit the nearby hospital straight away. Symptoms of overdosage might include low blood pressure, fast or slow heart rate, dizziness, kidney problems and shortness of breath.
Synopsis
| Drug | : | Nebivolol, Hydrochlorothiazide |
| Pharmacological Category | : | Beta-Blockers, Thiazide like diuretic |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet |
More Information
- Keep NEBIMAX H 5MG TABLET out of reach to children
- Store NEBIMAX H 5MG TABLET at normal room temperature
FAQs About NEBIMAX H 5MG TABLET
Q: What are the uses of NEBIMAX H 5MG TABLET?
A: NEBIMAX H 5MG TABLET is used to manage hypertension. It can also be used to manage the risk of heart attack or stroke.
Q: What type of a medicine is NEBIMAX H 5MG TABLET?
A: NEBIMAX H 5MG TABLET is an antihypertensive medicine. It slows down your heartbeat and reduces the force of contraction of the heart. It also reduces the thickness of the blood by removing excess fluids from the body in the form of urine. Collectively, these actions reduce the strain on the heart and helps the heart to pump blood more smoothly with less pressure.
Q: What happens when I stop taking NEBIMAX H 5MG TABLET?
A: Do not stop taking NEBIMAX H 5MG TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take NEBIMAX H 5MG TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
Q: What is the best time to take NEBIMAX H 5MG TABLET?
A: NEBIMAX H 5MG TABLET can be taken with or without meals. Your doctor will decide the best time for you to take NEBIMAX H 5MG TABLET based on your age, body weight and disease condition.
Q: What to do if I forgot to take a dose of NEBIMAX H 5MG TABLET?
A: If you forgot to take a dose of NEBIMAX H 5MG TABLET, take it as soon as you remember. However, if it is time for the next dose of NEBIMAX H 5MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of NEBIMAX H 5MG TABLET to compensate the missed ones.
Q: What precautions should be followed while taking NEBIMAX H 5MG TABLET?
A: Before taking NEBIMAX H 5MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, thyroid problems, asthma, poor blood circulation, dehydration or low sodium, potassium or magnesium levels in the blood as a precaution. Consult your doctor before taking this medicine if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Q: Can I consume alcohol while taking NEBIMAX H 5MG TABLET?
A: Avoid consumption of alcohol while taking NEBIMAX H 5MG TABLET as it might make you feel dizzier and drowsier.
Q: What happens if I accidentally take more NEBIMAX H 5MG TABLET?
A: If you or anyone else accidentally took excessive amount of this medicine, consult your doctor immediately or visit the nearby hospital straight away. Symptoms of overdosage might include low blood pressure, fast or slow heart rate, dizziness, kidney problems and shortness of breath.
Q: Can I take NEBIMAX H 5MG TABLET daily?
A: Take NEBIMAX H 5MG TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take NEBIMAX H 5MG TABLET every day or not.
Q: Is NEBIMAX H 5MG TABLET safe to use in diabetic patients?
A: NEBIMAX H 5MG TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking NEBIMAX H 5MG TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
Q: What are the side effects of NEBIMAX H 5MG TABLET?
A: The most common side effects of taking this medicine are headache, dizziness, tiredness, tingling sensation, diarrhoea, constipation, shortness of breath and swollen hands or feet. Consult your doctor if any of these side effect worsens.
Q: Can I stop taking NEBIMAX H 5MG TABLET once my symptoms subside?
A: No. Do not stop taking NEBIMAX H 5MG TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take NEBIMAX H 5MG TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.
Q: Can NEBIMAX H 5MG TABLET be taken during pregnancy?
A: NEBIMAX H 5MG TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Q: Is NEBIMAX H 5MG TABLET safe to use in kidney disease?
A: NEBIMAX H 5MG TABLET should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.
Q: Can the use of NEBIMAX H 5MG TABLET affect the liver?
A: Yes. NEBIMAX H 5MG TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Q: Does NEBIMAX H 5MG TABLET cause frequent urination?
A: Yes. NEBIMAX H 5MG TABLET may cause frequent urination. It is because NEBIMAX H 5MG TABLET contains a medicine called hydrochlorothiazide which is a diuretic (water pill). It excretes the excess water from the body in the form of urine. Therefore, it is advised to take NEBIMAX H 5MG TABLET at least 5 hours before bedtime to avoid the urge at night to urinate.
Q: Can I take potassium supplements along with NEBIMAX H 5MG TABLET?
A: Yes. Potassium supplements can be taken along with NEBIMAX H 5MG TABLET. However, consult your doctor before taking it.
References
1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 149 & 559.
2. E Malacco. Nebivolol/hydrochlorothiazide (HCTZ) combination in patients with essential hypertension: a pooled analysis from five non-interventional studies with a focus on diabetic and elderly patients. NIH. National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2010. [Accessed on 30th December 2022]. https://pubmed.ncbi.nlm.nih.gov/20556921/
3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 30th December 2022]. https://www.medicines.org.uk/emc/files/pil.5828.pdf
4. Mylan Pharmaceuticals Inc. U.S. Food and Drug Administration. [Revised in May 2011] [Accessed on 30th December 2022]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/040735s004,040770s003lbl.pdf
5. Torrent Pharmaceuticals Ltd. Nebicard H. [Revised in January 2022] [Accessed on 30th December 2022]. https://www.torrentian.com/pisheet/Upload/PI_Sheet/2011.pdf
6. Central Drugs Standard Control Organization. Nebivolol 5mg + HCTZ 12.5mg tablets. December 2004. [Accessed on 30th December 2022]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- Kidney Function Test
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