NAXDOM 250 Tablet 15's

Introduction About NAXDOM 250 TABLET

NAXDOM 250 TABLET manages the symptoms of migraine, menstrual migraine, and chronic daily headaches associated with nausea and vomiting. It is a combination of Domperidone and Naproxen, which belong to the groups of medicines called antiemetics and NSAIDs (non-steroidal anti-inflammatory drugs), respectively.

NAXDOM 250 TABLET is not recommended in patients with severe liver, kidney, or heart problems, stomach ulcers, bleeding in the stomach or intestine, intestinal tears, or pituitary gland tumours. N

AXDOM 250 TABLET should be taken with caution in patients with lung disease, diabetes, high cholesterol, systemic lupus erythematosus, a blood clotting disorder, a history of gastrointestinal diseases, and a habit of drinking or smoking.

NAXDOM 250 TABLET is not recommended for use during pregnancy, while breastfeeding, or in children less than 5 years old. It should be used with caution in elderly patients (those over the age of 60). The common side effect of taking NAXDOM 250 TABLET may include dry mouth. Consult your doctor immediately if your symptoms get worse or persist.

Uses Of NAXDOM 250 TABLET

Manage symptoms of

• migraine
• menstrual migraine
• chronic daily headache

Benefits of NAXDOM 250 TABLET

Provides Effective Relief from Pain

• Naproxen is a strong NSAID (non-steroidal anti-inflammatory drug) that reduces pain, inflammation, and swelling.
• Offers longer pain relief compared to many other NSAIDs.

Helps Prevent Nausea and Vomiting

• Domperidone reduces stomach upset, queasiness, and vomiting that may occur along with pain or due to NSAID use.

Useful in Migraine Episodes

• The combination is particularly effective in migraine attacks where:
  • Pain is intense
  • Nausea/vomiting worsen symptoms
• Domperidone helps improve gastric emptying, which enhances absorption of Naproxen, giving faster relief.

Reduces Gastric Discomfort

• Domperidone counters the gastric irritation caused by NSAIDs, improving tolerance.

Long-Lasting Pain Control

• Naproxen has a longer duration of action (8–12 hours), reducing the need for frequent re-dosing.

Multi-Symptom Relief

Targeted benefit in conditions such as:

• Migraine with nausea
• Tension headache
• Menstrual pain
• Musculoskeletal pain
• Post-injury pain

How NAXDOM 250 TABLET Works

Naxdom works through a dual-action mechanism due to its two active ingredients:

A. Naproxen – Anti-inflammatory & Pain-Relief Action

Naproxen blocks the COX-1 and COX-2 enzymes, which are essential for producing prostaglandins.

Prostaglandins normally cause:

• Pain
• Swelling
• Inflammation
• Fever

By inhibiting prostaglandin production, Naproxen:

• Reduces pain severity
  Controls inflammation
  Lowers swelling
  Improves mobility in muscle/joint-related conditions

Pharmacological Highlights

• Provides long-lasting analgesia
• Has strong anti-inflammatory potency
• Faster absorption when combined with Domperidone due to improved gastric motility

Domperidone – Anti-nausea & Prokinetic Action

Domperidone works by blocking dopamine D2 receptors present in:

1. Chemoreceptor Trigger Zone (CTZ) – the brain area that controls nausea
2. Stomach and upper intestine

This leads to:

• Reduced nausea & vomiting
• Improved stomach emptying
• Faster absorption of pain-relief medicine
• Relief from heaviness, bloating, and indigestion symptoms

Unique Advantage

During a migraine attack, stomach motility decreases. Domperidone counteracts this, allowing better absorption of Naproxen → resulting in quicker symptom relief.

How to use NAXDOM 250 TABLET

Recommended Administration

• Take before meals for faster absorption especially useful for migraine episodes.
• Swallow the tablet whole with a full glass of water.
• Do not chew or crush.

General Dosing Guidance

Typically taken:

• At the onset of pain or migraine symptoms
• Can be repeated based on medical advice, but usually not more than 2–3 tablets per day

Special Directions for Migraine Relief

For migraine, effectiveness improves when:

• Taken as early as possible during the aura or at the start of pain
• Avoiding delay helps prevent escalation of headache intensity

Hydration & Dietary Guidance

• Drink sufficient water to avoid dehydration during migraines.
• Avoid alcohol as it may worsen gastric irritation.

Missed Dose

• For scheduled use: take when remembered unless close to next dose.
• Do not double the dose.

Duration of Use

• Use the lowest effective dose for the shortest duration.
• Prolonged or excessive use of NSAIDs should be avoided unless medically supervised.

Overdose

If you or anyone else accidentally takes too much NAXDOM 250 TABLET, consult your doctor immediately or visit the nearby hospital. Overdoes of NAXDOM 250 TABLET can cause headaches, nausea, vomiting, sleepiness, confusion, heartburn, fainting, diarrhoea, disorientation, stomach or intestine bleeding, unconsciousness, drowsiness, dizziness, ringing or buzzing sensation in the ears, fits and excitation, unusual eye movements, unusual tongue movements, or abnormal posture (such as a twisted neck). 

Side Effects Of NAXDOM 250 TABLET

Common

• dry mouth

When to consult  a doctor?

• swelling of the hands, feet, ankles, face, lips or throat which may lead to difficulty in swallowing or breathing
• an itchy, lumpy rash (hives) or nettle rash (urticaria)
• any uncontrolled movements which include unusual movements of the tongue, irregular eye movements, and abnormal posture such as a twisted neck, muscle stiffness, and trembling
• very fast or unusual heartbeat
• a fit or seizure

Warning & Precautions

Pregnancy

Contraindicated

NAXDOM 250 TABLET is not recommended for use in pregnant women during the first 6 months of pregnancy. NAXDOM 250 TABLET must not be used during the last 3 months of pregnancy. Consult your doctor before taking it.

Breastfeeding

Contraindicated

NAXDOM 250 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel drowsy, dizzy, tired or have blurred vision after taking NAXDOM 250 TABLET.

Kidney

Contraindicated

NAXDOM 250 TABLET is not recommended in patients with severe kidney disease. Consult your doctor before taking.

Liver

Contraindicated

NAXDOM 250 TABLET is not recommended in patients with severe liver disease. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take NAXDOM 250 TABLET if you are allergic to Domperidone or Naproxen.

Lungs

Use with Caution

NAXDOM 250 TABLET should be used with caution in patients with lung diseases such as asthma, other breathing problems or nasal polyps. Consult your doctor before taking it.

Heart Disease

Consult your doctor

NAXDOM 250 TABLET not recommended in patients with severe heart disease such as heart failure, prolonged QT corrected interval. It should be used with caution in patients having a stroke or high blood pressure. Consult your doctor before taking NAXDOM 250 TABLET.

Use In Pediatrics

Contraindicated

NAXDOM 250 TABLET is not recommended for use in children under 5 years of age. Consult your doctor before taking NAXDOM 250 TABLET.

Use In Geriatrics

Use with Caution

NAXDOM 250 TABLET should be used with caution in elderly patients (above 60 years of age). Consult your doctor for advice.

Other Warnings for NAXDOM 250 TABLET

Before taking NAXDOM 250 TABLET tell your doctor if you:

• have a history of disorders of the stomach or bowel (ulcerative colitis, Crohn’s disease)
• have diabetes
• have a habit of smoking
• have systemic lupus erythematosus or other connective tissue disorder
• have a blood clotting disorder

Who should not take NAXDOM 250 TABLET

NAXDOM 250 TABLET is not recommended for use if you:

• have stomach or duodenal ulcers
• have bleeding in the stomach or intestines
• have a blockage or tear in the intestine
• have a tumour of the pituitary gland

Drug - Drug interaction

1. Medicines That Increase the Risk of Gastric Bleeding (With Naproxen)

Taking Naproxen together with certain drugs may raise the risk of stomach bleeding or ulcers, such as:

• Other NSAIDs (Ibuprofen, Diclofenac, Aspirin)
• Corticosteroids (Prednisolone, Dexamethasone)
• Anticoagulants / Blood thinners (Warfarin, Acenocoumarol)
• Antiplatelet drugs (Clopidogrel, Ticagrelor)
• SSRIs / SNRIs (Sertraline, Fluoxetine, Venlafaxine)

2. Drugs That Increase Naproxen Levels or Toxicity

Some medicines can increase Naproxen concentration in the bloodstream:

• Lithium – Risk of lithium toxicity increases
• Methotrexate – Higher risk of bone marrow suppression
• Phenytoin – Altered serum levels
• Probenecid – Reduces excretion of Naproxen

3. Medicines That Reduce the Effect of Certain Drugs

Naproxen may reduce the effectiveness of:

• Antihypertensives
  • ACE inhibitors (Enalapril, Ramipril)
  • ARBs (Losartan, Telmisartan)
  • Beta-blockers (Metoprolol)
• Diuretics (Hydrochlorothiazide, Furosemide)

This may lead to reduced blood pressure control or reduced diuretic effect.

4. Interaction With Kidney-Impacting Medicines

Combined use may increase kidney stress:

• Calcineurin inhibitors (Cyclosporine, Tacrolimus)
• Diuretics
• ACE inhibitors / ARBs

Patients with pre-existing kidney concerns should be extra cautious.

5. Domperidone Interactions (QT-Prolongation Risk)

Domperidone may cause heart rhythm changes if taken with medicines that prolong the QT interval. Notable interacting drugs include:

• Macrolide antibiotics (Azithromycin, Clarithromycin)
• Fluoroquinolone antibiotics (Levofloxacin, Ciprofloxacin)
• Antifungals (Ketoconazole, Itraconazole, Fluconazole)
• Antiarrhythmics (Amiodarone, Quinidine)
• Certain antidepressants (Citalopram, Escitalopram)
• Antipsychotics (Haloperidol, Risperidone)

6. Drugs That Increase Domperidone Levels

Domperidone is metabolized by CYP3A4, so inhibitors of this enzyme can significantly raise its levels:

• Clarithromycin / Erythromycin
• Ketoconazole / Itraconazole
• HIV protease inhibitors (Ritonavir)
• Calcium channel blockers (Diltiazem, Verapamil)

This may increase cardiac side-effect risks.

7. Interactions With Antacids or Acid-Suppressing Agents

• Antacids (containing magnesium or aluminum)
• Proton pump inhibitors (PPIs)
• H2 blockers (Ranitidine, Famotidine)

These may reduce gastric acidity and slightly alter absorption of naproxen, though the effect is usually mild.

Synopsis

More Information

1. Unique Therapeutic Positioning

Naxdom 250 Tablet offers a dual-action approach by combining an NSAID (Naproxen) with a prokinetic antiemetic (Domperidone).
This makes it particularly useful in situations where pain is often accompanied by nausea, such as:

• Migraine episodes
• Severe menstrual cramps
• Pain flares that cause gastric discomfort
• Pain-related nausea triggered by skipping meals

This dual-benefit profile differentiates it from plain analgesics.

2. Onset and Duration of Pain Relief

Naproxen in Naxdom:

• Has a longer half-life (around 12–17 hours) than many other painkillers
• Provides sustained pain-relief coverage, reducing the need for frequent re-dosing
• May be more beneficial for conditions where pain tends to return, such as musculoskeletal spasms or menstrual cramps

Domperidone starts working earlier, helping relieve nausea before or around the time pain relief begins, improving overall comfort.

3. Suitability for Patients with Episodic Pain

Naxdom 250 Tablet is often preferred for episodic or attack-like pain rather than chronic daily use due to:

• Better control of flare-ups
• Lower dosing frequency
• Longer duration of action compared to short-acting painkillers

It is not intended for long-term continuous use unless medically required.

4. Gastric Protective Role of Domperidone

Naproxen, like other NSAIDs, can cause stomach irritation in some individuals.
Domperidone in Naxdom 250 helps by:

• Enhancing gastric emptying
• Reducing nausea and vomiting
• Decreasing the likelihood of stomach discomfort during pain episodes

However, it does not replace medical advice for people with ulcers or gastric bleeding risk.

5. Impact on Daily Functioning

When taken as directed, many patients experience:

• Improved productivity during sudden pain flare-ups
• Reduced interruption of routine activities
• Better tolerance of pain episodes that usually bring nausea-driven discomfort

However, responses vary, and medical supervision is essential.

6. Food and Hydration Considerations

Taking Naxdom 250 with water and a light meal:

• Helps minimize the gastric load
• Allows smoother absorption of the NSAID
• Reduces nausea severity
• Improves tolerability, especially for those sensitive to NSAIDs

Adequate hydration supports healthier kidney function during NSAID use.

12. Why Only Prescribed Use Is Important

Both ingredients have:

• Cardiovascular considerations
• Gastric considerations
• Drug interaction profiles
• Dose-specific safety limits

Therefore, medical oversight ensures:

• Safe dose
• Suitable duration
• Prevention of complications
• Protection against drug-drug interactions

FAQs About NAXDOM 250 TABLET

References

1. KD Tripathi. Gastrointestinal Drugs & NSAIDs and Antipyretic Analgesics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 666 & 201.

2. Joseph C. Brutzkus, Mahsa Shahrokhi, Matthew Varacallo. Naproxen. NIH National Library of Medicine, National center for biotechnology information. Feb 2022. [Accessed on 24th May 2026]

3. Max Life Sciences. Propimax D Tablets (Domperidone + Naproxen). [Accessed on 24th May 2026]

4. SterisPharma. Naproxzen D Tablet (Domperidone + Naproxen). [Accessed on 24th May 2026]

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 24 Apr 2026 | 12:59 PM(IST)