Natrilix SR 1.5 Tablet 10'S

Introduction About NATRILIX SR TABLET

Natrilix SR 1.5 mg Tablet is a sustained-release formulation containing Indapamide, a thiazide-like diuretic. It is commonly used to support the management of high blood pressure (hypertension), especially in patients who may benefit from fluid reduction as part of their overall blood pressure control. By helping the kidneys eliminate excess salt and water through urine, Natrilix SR reduces the volume of circulating blood, which in turn helps relax blood vessels and lower pressure within them. This tablet is ideal for individuals with salt-sensitive hypertension, elderly patients, or those who do not respond well to other classes of antihypertensives.

Natrilix SR is typically prescribed as a once-daily tablet, taken preferably in the morning to avoid increased urination during nighttime. It can be taken with or without food. The sustained-release nature of the tablet ensures a gradual and prolonged effect, promoting stable blood pressure control throughout the day. Patients are advised to take the tablet at the same time each day and not to skip or stop it without medical advice. Regular monitoring of blood pressure and blood electrolyte levels (like potassium and sodium) is usually recommended during treatment.

While generally well tolerated, certain precautions should be followed. Natrilix SR may cause dizziness, especially when standing up quickly, due to its blood pressure-lowering effect. It may also lead to low potassium or sodium levels, so your doctor may monitor your blood through periodic tests. Alcohol intake should be limited as it can amplify the risk of dizziness or fainting. Patients with severe kidney or liver problems, very low electrolyte levels, or those on lithium therapy should avoid this medicine unless carefully supervised.

Use of Natrilix SR 1.5 mg is not recommended during pregnancy or breastfeeding, as safety data in these groups is limited. Commonly reported side effects include fatigue, muscle cramps, headache, increased urination, or gastrointestinal discomfort. Any signs of severe weakness, irregular heartbeat, or allergic reaction (such as rash or swelling) should be reported immediately. As with any long-term medication, it is essential to follow medical advice closely and adopt supportive lifestyle changes like a low-salt diet, regular exercise, and stress management for optimal results. 

Uses Of NATRILIX SR TABLET

• Manage high blood pressure
• Edema (fluid retention) associated with heart, liver, or kidney disease
• To reduce risk of heart failure 

Benefits of NATRILIX SR TABLET

Natrilix SR Tablet for hypertension

Natrilix SR Tablet is primarily prescribed for the treatment of hypertension (high blood pressure). Its active ingredient, indapamide, belongs to the thiazide-like diuretic class and works by promoting the excretion of excess salt and water through the kidneys, which lowers blood volume and, consequently, reduces blood pressure. Clinical studies have shown that Natrilix SR effectively lowers diastolic blood pressure to below 90 mmHg in a significant percentage of patients and offers particular benefit in elderly patients with isolated systolic hypertension. Maintaining controlled blood pressure with Natrilix SR helps reduce long-term risks of complications such as stroke, heart attack, and kidney damage.

Natrilix SR Tablet to reduce fluid retention

Natrilix SR is also indicated for reducing fluid retention (edema). It acts as a diuretic, increasing urine production and facilitating the removal of extra fluid and electrolytes from the body. This effect is beneficial for patients experiencing swelling due to heart, kidney, or liver conditions. By effectively reducing fluid overload, Natrilix SR helps relieve symptoms such as swelling in the legs, ankles, or abdomen and supports better cardiovascular and organ function. It is important to take the medication during the day to minimize nighttime urination, and regular monitoring of kidney function and electrolytes is advised during ongoing therapy.

How NATRILIX SR TABLET Works

Natrilix SR 1.5 mg Mechanism of Action

Natrilix SR 1.5 mg contains Indapamide, a thiazide-like diuretic. It works by acting on the kidneys to remove excess sodium and water from the body through urine. This process reduces the volume of fluid in blood vessels, helping them relax and widen. As a result, it lowers blood pressure and eases the workload on the heart.

 How Does Natrilix SR 1.5 mg Control Blood Pressure

Natrilix SR helps control high blood pressure by reducing the amount of fluid in your blood vessels. It removes extra salt and water, which decreases the pressure inside the arteries. Over time, it also improves the elasticity of blood vessels, making it easier for blood to flow. This combined effect helps keep blood pressure within a healthy range.

 Natrilix SR 1.5 mg Diuretic Effect

As a diuretic or "water pill," Natrilix SR increases the amount of urine your body makes. It promotes the removal of salt and water from your bloodstream through the kidneys. This helps reduce swelling in certain conditions and supports long-term blood pressure control. Unlike strong loop diuretics, its diuretic effect is mild and steady, making it suitable for daily use in hypertension.

How to use NATRILIX SR TABLET

Administration Instructions – Natrilix SR 1.5 mg

• Take one tablet once daily, or as directed by your doctor.
• It is usually recommended to take the dose in the morning to avoid nighttime urination.
• Swallow the tablet whole with a glass of water. Do not crush or chew it.
• Try to take it at the same time every day to maintain consistent blood levels.
• Do not skip doses or stop taking the medicine without medical advice.
• Follow all instructions given by your doctor, especially regarding diet, fluid intake, and monitoring.

 Can I Take Natrilix SR with Breakfast?

•  Yes, Natrilix SR can be taken with or without food, including with breakfast.
• Taking it with breakfast may help reduce stomach discomfort in sensitive individuals.
• It’s best to avoid taking it late in the day, as it may cause frequent urination at night.
• If your doctor has not specified otherwise, taking it with a light morning meal is ideal.
• Always follow your doctor’s guidance on how and when to take the medicine.

What if I forgot to take NATRILIX SR TABLET

• If you forget to take Natrilix SR Tablet, take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose.
• If your next dose is less than 6 hours away, skip the missed dose and take the next dose at the usual time—do not take two doses together.
• Do not take a double dose to make up for a forgotten dose.
• Continue your regular dosing schedule going forward.
• If you have any concerns or miss doses frequently, consult your doctor or pharmacist for advice.

Overdose

If you or anyone else accidentally take too much of NATRILIX SR1.5mg TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea or vomiting, low blood pressure, cramps, dizziness, drowsiness, confusion and changes in the amount of urine produced by the kidneys due to severe dehydration.

Side Effects Of NATRILIX SR TABLET

Common side effects of NATRILIX SR1.5mg TABLET

• skin rash
• allergic reactions in the form of skin rashes (especially patients who are more prone to allergic and asthmatic reactions)
• signs of low potassium in blood (constipation, skipped heartbeat feeling, muscle weakness or spasms)

When to Seek Medical Attention?

• Severe dizziness or fainting, especially after standing up may indicate a sharp drop in blood pressure.
• Muscle weakness, cramps, or irregular heartbeat can be a sign of low potassium or another electrolyte imbalance.
• Unusual tiredness or confusion could point to low sodium or dehydration.
• Reduced or no urine output may signal kidney problems.
• Severe skin rash, itching, or swelling may suggest an allergic reaction.
• Sudden weight gain or swelling in legs/ankles could indicate fluid retention or heart issues.
• Persistent nausea, vomiting, or diarrhoea increases the risk of dehydration and salt imbalance.
• Signs of liver issues like yellowing of skin/eyes or dark urine.
• Extreme thirst, dry mouth, or sunken eyes signs of dehydration, especially in hot weather.
• Visual changes or eye pain very rare but should be reported immediately.

How To Manage Side Effects

Skin rash Or Itching

• Apply a clean, soft cloth soaked in cold water to the rash for 10–15 minutes.
• Helps reduce inflammation, itching, and redness quickly.
• If the symptom does not improve, contact your doctor immediately.

Warning & Precautions

Pregnancy

Contraindicated

NATRILIX SR1.5mg TABLET is not recommended for use in pregnant women. Consult your doctor before taking this medicine.

Breastfeeding

Contraindicated

NATRILIX SR1.5mg TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking this medicine. 

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy or tired after taking NATRILIX SR 1.5mg TABLET.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking NATRILIX SR1.5mg TABLET because it might make you dizzier.

Kidney

Consult your doctor

NATRILIX SR 1.5mg TABLET is not recommended in patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney problems. Consult your doctor before taking this medicine.

Liver

Consult your doctor

NATRILIX SR1.5mg TABLET is not recommended in patients with severe liver disease or hepatic encephalopathy (liver problems affect your brain and central nervous system). It should be used with caution in patients with mild to moderate liver problems. Consult your doctor before taking the medicine.

Allergy

Contraindicated

Do not take NATRILIX SR 1.5mg TABLET if you are allergic to Indapamide or any other ingredients of this medicine.

Heart Disease

Use with Caution

NATRILIX SR1.5mg TABLET should be taken with caution in patients with heart rhythm problems. Consult your doctor before this medicine.

Use In Pediatrics

Contraindicated

NATRILIX SR 1.5mg TABLET is generally not recommended for use in children. Consult your doctor before taking this medicine.

Use In Geriatrics

Use with Caution

NATRILIX SR 1.5mg TABLET should be used with caution in elderly patients, especially in those with impaired kidney function. Consult your doctor before taking this medicine. 

Other Warnings for NATRILIX SR TABLET

Before taking NATRILIX SR 1.5mg TABLET, inform your doctor if you:

• experience a decrease in vision or eye pain due to choroidal effusion (fluid collection in the vascular layer of the eye)
• have muscle disorders  
• have diabetes
• have gout
• have or had photosensitivity reactions
• are an athlete  

Who should not take [GBNKEYWORD

NATRILIX SR 1.5mg TABLET is not recommended for use if you:

• have hypokalaemia (low levels of potassium in blood)

Safety Advice

• Take the medicine exactly as prescribed by your doctor, usually once daily in the morning.
• Do not stop or change the dose without consulting your healthcare provider.
• Rise slowly from sitting or lying down to avoid dizziness due to a sudden drop in blood pressure.
• Drink enough water throughout the day unless your doctor restricts fluid intake.
• Avoid alcohol as it can worsen dizziness or lower blood pressure further.
• Inform your doctor about all other medicines you are taking, including over-the-counter drugs or supplements.
• Regularly monitor your blood pressure, kidney function, and blood electrolyte levels as advised.
• Do not use Natrilix SR if you have severe kidney problems, liver disease, or very low sodium or potassium levels.
• Report any unusual symptoms like muscle cramps, irregular heartbeat, extreme fatigue, or confusion to your doctor immediately.

Diet and Lifestyle Advice

Diet Tips

• Limit salt (sodium) intake – Avoid processed foods, salty snacks, pickles, and canned items to support better blood pressure control.
• Include potassium-rich foods like bananas, oranges, tomatoes, spinach, and coconut water (if your doctor allows), as the medicine may lower potassium levels.
• Stay hydrated – Drink enough water unless your doctor advises fluid restriction to avoid dehydration and maintain kidney health.
• Eat a heart-friendly diet – Focus on fruits, vegetables, whole grains, lean proteins, and low-fat dairy products.
• Limit caffeine (tea, coffee, energy drinks) as excessive amounts can slightly raise blood pressure or increase urination.
• Avoid alcohol or keep it to a minimum to reduce the risk of low blood pressure and dizziness.
• Avoid licorice – Natural or candy forms may worsen potassium loss and increase blood pressure.

 Lifestyle Tips

• Exercise regularly – Aim for 30 minutes of moderate activity like walking, yoga, or cycling most days of the week (after consulting your doctor).
• Get enough sleep – Poor sleep can affect your blood pressure. Try to maintain a regular sleep schedule.
• Manage stress – Use relaxation techniques like meditation, breathing exercises, or light hobbies to reduce stress levels.
• Monitor your blood pressure at home if advised, and keep a record for your doctor.
• Stand up slowly – To prevent dizziness or fainting, especially in the morning or after sitting for long periods.
• Avoid overheating – Take extra care in hot weather, as sweating and fluid loss may increase the risk of dehydration.
• Keep regular doctor appointments for checkups, blood pressure tracking, and blood tests to monitor electrolytes and kidney function.

1. How is Natrilix SR 1.5 mg different from Lasix 40 mg?

2. Is Natrilix SR better than Telma H for blood pressure control?

Drug - Drug interaction

1. Lithium

• Interaction: Natrilix SR may reduce the body’s ability to eliminate lithium, leading to increased lithium levels in the blood.
• Management: Lithium levels should be closely monitored if used together. Dose adjustments may be necessary, or an alternative approach may be considered.

2. NSAIDs (e.g., Ibuprofen, Diclofenac)

• Interaction: Using nonsteroidal anti-inflammatory drugs (NSAIDs) with Indapamide may reduce its effect on fluid balance and may stress kidney function.
• Management: Use NSAIDs with caution. Ensure proper hydration and consider periodic kidney function tests during prolonged use. 

3. ACE Inhibitors / ARBs (e.g., Enalapril, Losartan)

• Interaction: May lead to excessive lowering of blood pressure or changes in blood potassium levels.
• Management: Start with a low dose and monitor blood pressure and electrolyte levels regularly. Inform your doctor about any dizziness or weakness.

4. Potassium-Lowering Drugs (e.g., Furosemide, Corticosteroids)

• Interaction: May increase the risk of low potassium levels (hypokalaemia).
• Management: Monitor potassium levels periodically. A potassium supplement or potassium-rich diet may be suggested.

5. Digitalis Glycosides (e.g., Digoxin)

• Interaction: Low potassium caused by Indapamide can increase the effects and toxicity risk of digoxin.
• Management: Potassium levels should be kept within the normal range. Dose adjustment of digoxin may be required under supervision.

6. Antidiabetic Medications (e.g., Metformin, Glimepiride)

• Interaction: Diuretics like Indapamide may affect blood sugar levels, influencing the effectiveness of antidiabetic drugs.
• Management: Blood glucose levels should be checked regularly. Inform your healthcare provider if there are noticeable changes in blood sugar control. 

7. Other Diuretics

• Interaction: Using multiple diuretics can lead to electrolyte imbalance or dehydration.
• Management: Use under close monitoring with regular tests to track fluid and salt levels in the body.

Drug - Food interaction

1. High-Sodium Foods

Salty foods such as processed snacks, pickles, canned soups, and ready-to-eat meals can reduce the effectiveness of Natrilix SR. These foods cause the body to retain water, which may counteract the blood pressure-lowering action of the medicine.
Management Tip: Follow a low-sodium diet. Cook fresh meals at home using herbs and spices instead of salt to flavour food.

 2. Potassium-Rich Foods

Natrilix SR may lower potassium levels in the body, which can lead to muscle weakness, fatigue, or irregular heartbeat. Foods like bananas, oranges, coconut water, spinach, and potatoes are rich in potassium and may help balance this loss.
Management Tip: Include moderate amounts of potassium-rich foods in your diet unless your doctor advises potassium supplements or dietary restrictions.

 3. Licorice (Natural or Candy)

Consuming large amounts of licorice or licorice-based products can worsen potassium loss and may even increase blood pressure opposite to the effect of Natrilix SR.
Management Tip: Avoid eating licorice in any form, especially regularly or in high amounts.

 4. Alcohol

Drinking alcohol while taking Natrilix SR may increase the risk of side effects such as dizziness, drowsiness, and a drop in blood pressure. It can also add to dehydration.
Management Tip: Limit or avoid alcohol, especially when starting the medicine or during hot weather.

 5. Caffeinated Beverages

Excessive caffeine from tea, coffee, or energy drinks can mildly raise blood pressure and increase urination, leading to dehydration and possible electrolyte imbalances when combined with Natrilix SR.
Management Tip: Limit caffeine intake to moderate levels and ensure adequate hydration throughout the day.

 6. Grapefruit or Grapefruit Juice

Although no strong interaction has been reported between grapefruit and Indapamide, caution is still advised. Grapefruit is known to affect the metabolism of several medicines, which may unpredictably alter the drug’s effect.
Management Tip: It’s safest to avoid grapefruit or consult your doctor if you regularly consume it.

Synopsis

More Information

FAQs About NATRILIX SR TABLET

References

1. KD. Tripathi. Antihypertensive drugs. Essentials of medical pharmacology. seventh edition. 2013. Page – 561.

2. Avuloglu-Yilmaz, Ece, Deniz Yuzbasioglu, and Fatma Unal. "Assessment of the genotoxic effects of antihypertensive drug active ingredient indapamide in human lymphocytes." Drug and Chemical Toxicology. [Revised on January 2022] [Accessed on 24th July 2025]

3. Robinson, Dean M. and Keri Wellington.NIH National Library of Medicine Indapamide sustained release: a review of its use in the treatment of hypertension. [Revised on January 2006] [Accessed on 24th July 2025]

4. S.C. Zentiva S.A. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 24th July 2025] 

Useful Diagnostic Tests

• Kidney Function Test (KFT)
• Cardiac Profile - Basic

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Venkatesh Poludasu - MBBS

Last updated on 25 Jul 2025 | 12:38 PM(IST)