Natrilam 1.5mg/5mg Tablet 10'S

Introduction About NATRILAM 5MG TABLET

NATRILAM 5MG TABLET is a combination of Amlodipine and Indapamide, which belong to the group of medicines called Calcium-channel blockers and Thiazide diuretics. It is used in the management of high blood pressure (hypertension), which is a condition in which the force of the blood is consistently high against the walls of the arteries, which can increase the risk of heart disease, kidney disease and stroke.

Inform your doctor if you are pregnant or breastfeeding before taking this medicine. Inform your doctor if you have any problems related to the kidney, liver or heart. If you are elderly and younger than 18 years old, you should consult with a doctor before taking the medicine.

Before taking NATRILAM 5MG TABLET, inform your doctor if you have any conditions such as diabetes, low blood pressure, gout, low levels of potassium in the blood (hypokalaemia) and symptoms of fluid accumulation around the eye that present with visual disturbances or eye pain. The most common side effects of taking NATRILAM 5MG TABLET are headache, nausea, dizziness and tiredness.

Uses Of NATRILAM 5MG TABLET

• Manage hypertension (high blood pressure)

How NATRILAM 5MG TABLET Works

NATRILAM 5MG TABLET helps to reduce high blood pressure, where amlodipine works by inhibiting the movement of calcium ions into both vascular smooth muscle and cardiac muscle, resulting in lower blood pressure by relaxing the blood vessels and improving the flow of blood to the heart muscles. Indapamide reduces blood pressure by promoting the excretion of extra fluid and certain salts (sodium) from the body by increasing the amount of urine produced by the kidneys.

How to use NATRILAM 5MG TABLET

Always take NATRILAM 5MG TABLET as instructed by your doctor. Take NATRILAM 5MG TABLET with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Do not stop taking the medicine without informing your doctor.

Side Effects Of NATRILAM 5MG TABLET

How To Manage Side Effects

Diarrhoea:

Drink plenty of fluids, such as water, fruit juices or electrolytes (ORS), to avoid dehydration in your body. Consult your doctor if the symptoms do not improve.

Nausea:

Try to take NATRILAM 5MG TABLET with or just after, a meal or snack, stick to simple meals and do not eat oil-rich or spicy food. Consult your doctor if the symptoms do not improve.

Dizziness:

Lie down until the dizziness passes away and then move slowly and carefully. Take plenty of rest and drink plenty of fluids. Consult your doctor if the symptoms do not improve.

Stomach pain:

Take some time to rest and relax. Eat and drink slowly or try to have smaller, more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.

Headache:

Apply a hot or cold-water bag to your head. Try taking a rest in a quiet and dark room. Drink tea or coffee. Consult your doctor if the symptoms do not improve.

Warning & Precautions

Pregnancy

NATRILAM 5MG TABLET should not be used by pregnant women. Consult with your doctor for advice before taking the medicine.

Breastfeeding

NATRILAM 5MG TABLET is not recommended for use by breastfeeding women. Consult with your doctor for advice before taking the medicine.

Driving and Using Machines

NATRILAM 5MG TABLET may cause side effects such as dizziness or tiredness due to low blood pressure, so use caution while driving or operating heavy machinery.

Alcohol

Consumption of alcohol is not recommended during management with NATRILAM 5MG TABLET.

Kidney

NATRILAM 5MG TABLET should be used with caution in patients with kidney disease undergoing dialysis and it is not recommended for use in patients with severe kidney disease. Consult with your doctor for advice before taking NATRILAM 5MG TABLET.

Liver

NATRILAM 5MG TABLET should be used with caution in liver disease patients and it is not recommended for use in patients with severe liver disease. Consult with your doctor for advice before taking NATRILAM 5MG TABLET.

Allergy

Do not take this medicine if you are allergic to Amlodipine and Perindopril or other inactive preparations of this medicine.

Heart Disease

NATRILAM 5MG TABLET should not be used in patients with heart problems such as heart failure, recent heart attack, narrowing of the aortic heart valve (aortic stenosis) or cardiogenic shock (where the heart is unable to pump a sufficient amount of blood to the body).

Interactions

A. Drug-Drug interactions:

Inform your doctor, if you are taking any of the following medicines

• ketoconazole, itraconazole, amphotericin B (used to manage fungal infections)
• verapamil, diltiazem (used to manage low blood pressure)
• phenobarbital, phenytoin, carbamazepine (used to manage seizures)
• erythromycin, clarithromycin, rifampicin (used to manage bacterial infections)
• nefazodone (used to manage depression)
• dantrolene infusion (used to manage body temperature abnormalities)
• tacrolimus (used to alter the immune system response)
• simvastatin (used to manage high cholesterol)
• St. john’s wort (herbal preparation used to manage depression)
• ritonavir, nelfinavir, indinavir (used to manage HIV)
• sildenafil (used to manage impotence)
• metformin (used to manage diabetes)
• allopurinol (used to manage gout)
• quinidine, amiodarone, hydroquinidine (used to manage heart rhythm disorder)
• bepridil (used to manage chest pain)
• diphemanil, cisapride (used to manage stomach ulcers)
• pentamidine (used to manage malaria)
• halofantrine (manages certain types of malaria)
• ibuprofen (used to manage swelling and pain)
• calcium supplements
• potassium-sparing diuretics such as spironolactone and amiloride (used to manage high blood pressure or heart failure)

B. Drug-Food interactions:

Do not eat grapefruit or drink grapefruit juice while taking this medicine as it increases the level of this medicine in the blood, resulting in blood pressure-lowering effects. Consult your doctor before taking NATRILAM 5MG TABLET.

Overdosage:

If you or anyone else accidentally takes too much of NATRILAM 5MG TABLET, consult your doctor immediately. Overdosage may cause side effects such as dizziness, light-headedness, nausea, cramps, flushing (redness of the skin), fainting, low blood pressure, urinary problems, drowsiness and confusion.

Synopsis

More Information

• Keep NATRILAM 5MG TABLET medicine out of reach from children
• Store at normal room temperature below 25°C

FAQs About NATRILAM 5MG TABLET

Can I take NATRILAM 5MG TABLET with grapefruit?

No, do not drink grapefruit or its juice while taking NATRILAM 5MG TABLET, as it can alter the therapeutic effect of this medicine, resulting in an increased lowering of blood pressure, which can lead to dizziness, shakiness, nausea and blurred vision.

Can I stop taking NATRILAM 5MG TABLET when my blood pressure is controlled?

No, you should follow the instructions of your doctor while taking NATRILAM 5MG TABLET. When abruptly stopped, it causes an increase in blood pressure. If you experience very low blood pressure while taking NATRILAM 5MG TABLET, consult your doctor immediately.

For how long should I take NATRILAM 5MG TABLET?

You should continue taking NATRILAM 5MG TABLET unless your doctor tells you to stop taking it. Blood pressure medicines will usually be taken for a lifetime to manage complications due to high blood pressure. Your doctor may change your management with another hypertension drug if you do not achieve any therapeutic effect with NATRILAM 5MG TABLET.

Can NATRILAM 5MG TABLET cause dizziness?

Yes, NATRILAM 5MG TABLET can cause dizziness or drowsiness due to severely low blood pressure. Alcohol consumption during management can alter the effect of medicine and increase the risk of dizziness. Do not drive or operate machines if you experience dizziness or drowsiness.

References

1. KD Tripathi. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 558 & 561.

2. Uday Jadhav, Jagdish Hiremath, Deepak J Namjoshi, Vinod K Gujral, Kamlakar K Tripathi, Mohammad Siraj, Paramesh Shamanna, Michel Safar. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 2014. [Accessed 24th March 2022] https://pubmed.ncbi.nlm.nih.gov/24714044/

3. Zh. D. Kobalava, Eteri L. Kolesnik, E. K. Shavarova, L. A. Goreva & L. V. Karapetyan. Effectiveness of indapamide/amlodipine single-pill combination in patients with isolated systolic hypertension: a posthoc analysis of the ARBALET study. BMC Cardiovascular Disorders. March 2022. [Accessed 24th March 2022] https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-022-02514-y

4. Bricout-Hennel. S, Zelveian. P, Nedogoda. S, Safety and efficacy of indapamide sustained release/amlodipine fixed-dose combination in essential hypertension. Journal of Hypertension. June 2018. [Accessed 24th March 2022] https://journals.lww.com/jhypertension/Abstract/2018/06001/SAFETY_AND_EFFICACY_OF_INDAPAMIDE_SUSTAINED.128.aspx

5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed 24th March 2022] https://www.medicines.org.uk/emc/files/pil.6068.pdf

6. Balkanpharma. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed 24th March 2022] https://www.medicines.org.uk/emc/files/pil.6528.pdf

7. Athlone Pharmaceuticals Limited, Health Products Regulatory Authority (HPRA). [Revised in February 2019] [Accessed 24th March 2022] https://www.hpra.ie/img/uploaded/swedocuments/9489d761-46b7-4af5-b8d9-d00564ccea84.pdf

8. Pfizer Labs. Food & Drug Administration. [Revised in May 2011] [Accessed 24th March 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019787s047lbl.pdf

Useful Diagnostic Tests

• Kidney Function Test

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 17 Dec 2022 | 10:27 AM(IST)