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Introduction About MOXAM 400MG INFUSION
MOXAM 400MG INFUSION contains Moxifloxacin which belongs to the group of medicines called Antibiotics. It is used to manage acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, community acquired pneumonia, uncomplicated skin and skin structure infection in adults of age 18 years and above.
MOXAM 400MG INFUSION is not recommended for use in patients having liver and heart problems. MOXAM 400MG INFUSION is not recommended for use in pregnant or breastfeeding mothers. Consult your doctor before receiving the medicine.
Before receiving MOXAM 400MG INFUSION inform your doctor if you have or had myasthenia gravis, diabetes, epilepsy or any mental disorders.
MOXAM 400MG INFUSION is not recommended for use in children and adolescents below 18 years of age. MOXAM 400MG INFUSION should be used with caution in elderly patients with renal impairment. Consult your doctor before receiving the medicine.
The common side effects of receiving MOXAM 400MG INFUSION are headache, dizziness, nausea, vomiting and stomach pain. Consult your doctor if the above symptoms do not improve.
Uses Of MOXAM 400MG INFUSION
It is used to manage:
- acute bacterial sinusitis
- acute bacterial exacerbation of chronic bronchitis
- community acquired pneumonia
- uncomplicated skin and skin structure infection
How MOXAM 400MG INFUSION Works
MOXAM 400MG INFUSION works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV which are required for DNA replication and transcription resulting in cell death. This manages the bacterial cells from dividing and repairing and destroys them.
How to use MOXAM 400MG INFUSION
MOXAM 400MG INFUSION will be administered intravenously (in the vein) by your doctor or nurse. Your doctor will administer the right dose depends on your age, body weight and severity of the infection.
Side Effects Of MOXAM 400MG INFUSION
Common
- nausea
- diarrhoea
- pain or inflammation at the injection site
- dizziness
- stomach and abdominal pain
- vomiting
- headache
- abdominal pain, dark urine, fatigue, itching (signs of an increase in liver transaminases enzymes)
- infections caused by resistant bacteria or fungi (Ex. oral and vaginal infections caused by candida)
- changes of the heart rhythm (low blood potassium level)
Uncommon
- sleep problems
- signs of a low number of white blood cells like fever, infections, mouths sores
- constipation
- decreased appetite and food intake
- aches and pains such as the back, chest, pelvic and extremities pains, joint pain
- signs of increase or decrease in blood cells necessary for blood clotting (Ex. weakness, bleeding, tingling in the hands and feet)
- sweating, anxiety, restlessness, agitation, confusion, disorientation, shaking
- palpitations, signs of angina pectoris like pressing, squeezing, or crushing pain
- difficulty in breathing (asthma)
- increase of a special digestive enzyme in the blood (amylase)
- visual disturbances like double and blurred vision
- weight gain
- muscle pain
- signs of increase of bilirubin abdominal pain or swelling, chills, fever
- dehydration or dry skin
Rare
- hallucination, abnormal dreams
- disturbed concentration
- high or low blood pressure
- difficulty in swallowing
- balance disorder and poor coordination
- partial or total loss of memory
- hearing impairment including deafness (usually reversible)
- signs of high uric acid in the blood such as intense joint pain, inflammation, redness
- emotional instability
- impaired speech
- fainting
Stop receiving MOXAM 400MG INFUSION and contact your doctor immediately if you experience any of the following side effects:
- abnormal fast heart rhythm
- signs of liver inflammation such as feeling unwell or yellowing of the whites of the eyes, dark urine, itching of the skin, a tendency to bleed or disturbances of thought or wakefulness
- serious skin rashes including Stevens-Johnson syndrome and toxic epidermal necrolysis characterized by reddish target-like macules or circular patches, skin peeling, ulcers of mouth, throat, nose, genitals, and eyes and can be preceded by fever and flu-like symptoms
- a red, scaly widespread rash with bumps under the skin and blisters accompanied by fever (acute generalized exanthematous pustulosis)
- syndrome associated with impaired water excretion and low levels of sodium (SIADH)
- severe, sudden generalized allergic reaction (Ex. difficulty in breathing, drop of blood pressure, fast pulse)
- swelling of the airway
- convulsions (fits)
- problems with the nervous system such as pain, burning, tingling, numbness and/or weakness in extremities
- depression, insanity (such as suicidal ideations/thoughts, or suicide attempts)
- severe diarrhoea containing blood and/or mucus
- pain and swelling of the tendons (tendonitis)
- muscle weakness, tenderness or pain and particularly with a feeling of unwell, high temperature or dark urine
How To Manage Side Effects
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Try to avoid oil-rich or spicy foods, sugary snacks, and drinks. Try to drink liquid slowly along with your meals or between meals. Consult your doctor if your symptom is not improving.
Constipation:
Eat fibre-rich foods like fresh fruit, vegetables, and cereals. Drink plenty of water. Exercise more regularly.
Dizziness:
Lie, or sit down immediately when you feel dizzy. Try to avoid vehicle driving. Discuss with your doctor if the symptom worsens.
Headache:
Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage on scalp or head with mild pressure. Consult your doctor for advice.
Stomach pain:
Try to rest and relax. Have smaller and more frequent meals. Keep a heating pad on your stomach. Take your physician's advice.
Warning & Precautions
Pregnancy
MOXAM 400MG INFUSION is not recommended for use in pregnant women or if you think you might become pregnant. Consult your doctor before receiving the medicine.
Breastfeeding
MOXAM 400MG INFUSION is not recommended for use in breastfeeding women. Consult your doctor before receiving the medicine.
Driving and Using Machines
Do not drive or handle any machines while receiving MOXAM 400MG INFUSION, since it may cause dizziness, light-headedness, or transient loss of vision.
Kidney
Dosage adjustment is not required in patients with mild to severely impaired renal function or in patients on chronic dialysis. Consult your doctor before receiving MOXAM 400MG INFUSION.
Liver
MOXAM 400MG INFUSION is not recommended in patients with severe liver disease or increased liver enzymes or any active liver diseases. Consult your doctor for advice.
Allergy
Do not receive MOXAM 400MG INFUSION if you are allergic (hypersensitive) to Moxifloxacin or any other ingredients of this medicine.
Heart Disease
MOXAM 400MG INFUSION is not recommended in patients with abnormal or slow heart or abnormal heart rhythms. MOXAM 400MG INFUSION should be used with caution in patients having heart valve heart disease, aortic aneurysm or aortic dissection or congenital heart valve disease, enlargement, or bulge of a large blood or any other active heart disease. Consult your doctor before receiving the medicine.
Others
MOXAM 400MG INFUSION is not recommended for use if you:
- have tendon disease/disorder
- have electrolyte disturbances (uncorrected hypokalaemia)
Before receiving MOXAM 400MG INFUSION, inform your doctor if you:
- have hypersensitive reactions
- have epilepsy
- have any mental health problems
- have glucose- 6-phosphate dehydrogenase deficiency
- have myasthenia gravis (abnormal muscle fatigue leading to weakness and in serious cases paralysis)
- have diabetes (elderly)
Use in pediatrics:
MOXAM 400MG INFUSION is not recommended for use in children and adolescents below 18 years of age, since efficacy and safety have not been established. Consult your doctor for receiving the medicine.
Use in geriatrics:
MOXAM 400MG INFUSION should be used with caution in elderly patients. Consult your doctor before receiving the medicine.
Interactions
A. Drug - Drug interactions:
Before receiving MOXAM 400MG INFUSION inform your doctor if you are taking any of the following medicine:
- quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide (medicines used to manage heart problems)
- phenothiazines, pimozide, sertindole, haloperidol, sultopride, amitriptyline, amoxapine (medicines used to manage psychotic problems)
- saquinavir, sparfloxacin, intravenous erythromycin, pentamidine (medicine used to manage infection)
- terfenadine, astemizole, mizolastine (medicine used to manage allergies)
- intravenous vincamine, bepridil (medicines used to lower blood pressure)
- diphemanil (medicine used to manage stomach ulcers)
- medicines that lower blood potassium levels (Ex. spironolactone)
- prednisolone, betamethasone, dexamethasone, hydrocortisone
- amphotericin B (medicine used to manage fungal infections)
- cisapride, iron, zinc, didanosine (medicines used to manage stomach problems)
- warfarin (medicine used as a blood thinner)
Overdosage:
It is unlikely to receive an overdose of MOXAM 400MG INFUSION since it will be administered by the doctor or nurse. If you experience any unusual side effects, consult your doctor immediately.
Synopsis
| Drug | : | Moxifloxacin |
| Pharmacological Category | : | Fluoroquinolones |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : |
Tablet, Injection, Infusion, Eye Drops, Ophthalmic Solution, Eye Gel, Gel, Eye Ointment, Ointment |
More Information
- Keep out of reach of children
- Store at room temperature
FAQs About MOXAM 400MG INFUSION
What are the uses of MOXAM 400MG INFUSION?
MOXAM 400MG INFUSION is used to manage acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, uncomplicated skin and skin structure infection in adults of age 18 years and above.
How does MOXAM 400MG INFUSION works?
MOXAM 400MG INFUSION works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV which are required for DNA replication and transcription resulting in cell death. This manages the bacterial cells from dividing and repairing and destroys them.
Can MOXAM 400MG INFUSION be used for pregnant and breast-feeding women?
MOXAM 400MG INFUSION is not recommended for use in pregnant and breastfeeding women. Consult your doctor before receiving the medicine.
Can MOXAM 400MG INFUSION be given to children?
MOXAM 400MG INFUSION is not recommended for use in children and adolescents aged below 18 years as efficacy and safety have not been established for this age group. Consult your doctor for advice.
Does MOXAM 400MG INFUSION cause headaches?
Yes, it may cause headaches in some patients. Apply a hot or cold-water bag on your head. Try to take a rest in a quiet and dark room. Drink tea or coffee. Massage on the scalp or head with mild pressure. Consult your doctor for advice.
References
1. KD. Tripathi. Sulfonamides, Cotrimoxazole and Quinolones. Essentials of medical pharmacology. Eighth edition. 2013. Page – 764.
2. Ilija Kuzman, Alexandr Bezlepko, Irena Kondova Topuzovska, László Rókusz, Liudmyla Iudina, Hans-Peter Marschall and Thomas Petri. Efficacy and safety of moxifloxacin in community acquired pneumonia: a prospective, multicenter, observational study. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. June 2014. [Accessed 28th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105837
3. Paul M. Tulkens, Pierre Arvis, and Frank Kruesmann. Moxifloxacin Safety. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. December 2012. [Accessed 28th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585838/
4. Bayer AG. Electronic Medicines Compendium (EMC). [Revised in October 2020]. [Accessed 28th June 2022] https://www.medicines.org.uk/emc/files/pil.485.pdf
5. Torrent Pharmaceuticals Ltd. [Revised in June 2019]. [Accessed 28th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/97.pdf
Useful Diagnostic Tests
- Complete blood count
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