Mistabron Injection 3ml (N)

INTRODUCTION ABOUT MISTABRON INJECTION

MISTABRON INJECTION contains Mesna, which belongs to a group of medicines called Cytoprotective agents. MISTABRON INJECTION is used to protect the bladder and kidneys from cancer chemotherapy involving cyclophosphamide and ifosfamide as an anticancer medicine.

MISTABRON INJECTION is also used to reduce the risk of bleeding from the bladder when Ifosfamide is used as a chemotherapy drug in affected individuals.

MISTABRON INJECTION is not recommended for use in patients allergic to Mesna.

Before receiving MISTABRON INJECTION, inform your doctor if you have liver problems (such as hepatic impairment), and/or kidney problems (such as renal impairment).

MISTABRON INJECTION is generally not recommended for use during pregnancy and in women planning for pregnancy as it is not known whether the medicine can cause harm to the unborn baby. It is also not recommended for use in breastfeeding women.

MISTABRON INJECTION should be used with caution in children and adolescents (aged below 18 years) only if necessary since it is not known whether the medicine is safe and effective in children. It is also advised to be used with caution in elderly patients (aged 65 years or older) after consulting the doctor.

The most common side effects of taking MISTABRON INJECTION are headaches, dizziness, constipation, flu-like symptoms, sore throat, fever, cough, and/or diarrhea. Consult your doctor if any of these symptoms worsen.

USES OF MISTABRON INJECTION

• Protects the bladder and kidneys from cancer chemotherapy involving cyclophosphamide and ifosfamide as an anticancer medicine
• Reduces the risk of bleeding from the bladder when Ifosfamide is used as a chemotherapy drug in affected individuals

HOW MISTABRON INJECTION WORKS

MISTABRON INJECTION works by protecting the lining of the bladder and kidney from by-products of cyclophosphamide and ifosfamide, which get formed in the body after its administration as a chemotherapy medicine in affected individuals. 

DIRECTIONS FOR USE

MISTABRON INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

SIDE EFFECTS OF MISTABRON INJECTION

HOW TO MANAGE SIDE EFFECTS

Constipation

Try to eat high-fiber foods such as vegetables, cereals, and fresh fruit, and drink plenty of water. Involve yourself in regular exercise (going for a daily walk or run), and if this does not help, consult, and inform your doctor about receiving alternate managements for constipation.

Diarrhea

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult and inform your doctor if the symptoms worsen.

Dizziness Or Drowsiness

Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit your consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptoms worsen.

Headache

If MISTABRON INJECTION causes headaches, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving MISTABRON INJECTION. If it lasts more than a week or becomes severe, then consult your doctor.

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

MISTABRON INJECTION is generally not recommended for use during pregnancy unless it is clearly necessary. Consult your doctor before receiving the medicine.

BREASTFEEDING

Contraindicated

MISTABRON INJECTION is not recommended for use by breastfeeding women. Consult your doctor before receiving the medicine.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate machines if you experience syncope, light-headedness, lethargy, drowsiness, dizziness, and/or blurred vision after receiving MISTABRON INJECTION.

KIDNEY

Use with Caution

MISTABRON INJECTION should be used with caution in patients with kidney problems, such as renal impairment. Consult your doctor before receiving the medicine.

LIVER

Use with Caution

MISTABRON INJECTION should be used with caution in patients with liver problems such as hepatic impairment. Consult your doctor before receiving the medicine.

ALLERGY

Contraindicated

Do not receive MISTABRON INJECTION if you are allergic (hypersensitive) to Mesna and/or any other ingredients of this medicine.

USE IN PEDIATRICS

Consult your doctor

MISTABRON INJECTION should be used with caution in children and adolescents (aged below 18 years) only if necessary since it is not known whether the medicine is safe and effective in children. Consult your doctor before administering the medicine to the child.

USE IN GERIATRICS

Use with Caution

MISTABRON INJECTION should be used with caution in elderly patients (aged 65 years or older). Consult your doctor before receiving the medicine.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving MISTABRON INJECTION, inform your doctor if you are taking any of the following medicines:

• oxazaphosphorine, cyclophosphamide, and ifosfamide (anticancer medicines)
• cytostatics (used to block the growth of cancer cells) Ex. adriamycin, methotrexate, and vincristine

Overdosage:

MISTABRON INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so you are unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms such as nausea, vomiting, abdominal pain, diarrhea, headache, fatigue, limb and joint pains, rash, flushing, low blood pressure, a slow or fast heart, paraesthesia (tingling or numbness in the legs or arms), fever, and/or bronchospasm.

SYNOPSIS

MORE INFORMATION

• Keep MISTABRON INJECTION out of reach of children
• Store MISTABRON INJECTION below 30°C

FAQs ABOUT MISTABRON INJECTION

Q: What is MISTABRON INJECTION used for?

A: MISTABRON INJECTION is used to protect the bladder and kidneys from cancer chemotherapy involving cyclophosphamide and ifosfamide as an anticancer medicine. It is also used to reduce the risk of bleeding from the bladder when ifosfamide is used as a chemotherapy drug in affected individuals.

Q: What are the side effects of taking MISTABRON INJECTION?

A: The most common side effects of taking MISTABRON INJECTION are headaches, dizziness, constipation, flu-like symptoms, sore throat, fever, cough, and/or diarrhea. Consult your doctor if any of these symptoms worsen.

Q: How does MISTABRON INJECTION work?

A: MISTABRON INJECTION works by protecting the lining of the bladder and kidney from by-products of cyclophosphamide and ifosfamide, which get formed in the body after its administration as a chemotherapy medicine in affected individuals. 

Q: How is MISTABRON INJECTION administered?

A: MISTABRON INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

Q: Can MISTABRON INJECTION be used for pregnant and breastfeeding women?

A: No, MISTABRON INJECTION is generally not recommended for use during pregnancy or in women planning for pregnancy since it is not known whether the medicine may cause harm to the unborn child. It is also not recommended for use by breastfeeding women. Consult your doctor before taking the medicine.

REFERENCES

1. KD Tripathi. Chemotherapy of Neoplastic Diseases. Essentials of medical pharmacology. Seventh Edition. 2013. Page – 876.

2. Vamsi Reddy; Nicole R. Winston. Mesna. NIH National Library of Medicine. National Center for biotechnology information. StatPearls [Internet]. March 2022. [Accessed on 13th February 2024] https://www.ncbi.nlm.nih.gov/books/NBK556021/

3. AdvaCare Pharma. MesnaCare. [Accessed on 13th February 2024] https://www.advacarepharma.com/en/oncology/mesna-injection

4. Taj Pharmaceuticals Limited. Mesna Injection 200mg/2ml. [Accessed on 13th February 2024] https://tajgenerics.com/portfolio-item/mesna-injection-200mg2ml-taj-pharma/

USEFUL DIAGNOSTIC TESTS

• Cancer Screening Package For Male
• Cancer Screening Package For Female
• Jaanch Tumor Panel (Female)
• Jaanch Tumor Panel (Male)
• Cancer Screening Profile-Female
• Cancer Screening Profile-Male

AUTHOR DETAILS

Written By Dr. N. Sai Swaroop - Pharm.D

Last updated on 17 Feb 2024 | 06:00 PM(IST)