Minirin Nasal Spray 2.5ml
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Introduction About MINIRIN NASAL SPRAY
MINIRIN NASAL SPRAY contains Desmopressin which belongs to the group of medicines called Synthetic antidiuretic peptide. It is a synthetic analogue called 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. It is used for central or neurogenic diabetes insipidus, bleeding disorders nocturnal enuresis.
Desmopressin works by reducing the amount of water eliminated in the urine by the kidneys. It enhances the reabsorption of water in the kidneys. Avoid drinking large amounts of water or fluid while you are using this medicine. This could lead to a build-up of water which dilutes the salt in the body and may cause a serious problems or convulsions.
Before using this medicine, consult your doctor if you are pregnant or planning a pregnancy, because, blood pressure monitoring is recommended due to the increased risk of pre-eclampsia. MINIRIN NASAL SPRAY should be used with caution in breastfeeding women. Consult your doctor for advice. Do not use this medicine if you have any blood disorders or if you are aged 65 years of age. Consult your doctor before using. The most common side effects of using this medicine are headache, stomach pain and swelling of ankles.
Uses Of MINIRIN NASAL SPRAY
It is used for:
- central or neurogenic diabetes insipidus
- bleeding disorders nocturnal enuresis
How MINIRIN NASAL SPRAY Works
MINIRIN NASAL SPRAY mimics the action of endogenous anti-diuretic hormone. After intranasal administration, its acts as a selective agonist of V2 receptors present in the renal distal tubule and collecting ducts. Binding of desmopressin to V2 receptors, stimulates the production of adenylyl cyclase, which leads to increased reabsorption of water and reduced urine production.
How to use MINIRIN NASAL SPRAY
Always use this medicine as directed by your physician. It for intranasal use only. Remove the protective cap and prime the spray by pressing several times. Tilt your head backwards and insert the tip of the nozzle into your nostril. Spray into the nostril while breathing in slightly. If required, spray into other nostril in the same way. Wipe your nozzle with a clean tissue and replace the protective cap.
Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
Side Effects Of MINIRIN NASAL SPRAY
Common
- headache
- stomach pain
- blocked or runny nose, nose bleeds
Rare
- cerebral edema (water on the brain)
Stop using and consult your doctor immediately, if you experience the following:
- confusion
- convulsion
- unexplained weight gain
- ankle swelling
- nausea or vomiting
- signs of allergic reaction (such as itching, skin rashes, swelling of face, lips or throat, difficulty in breathing, chest tightness or coughing)
How To Manage Side Effects
Headache
Rest and drink plenty of fluids. Do not drink too much alcohol. Ask your doctor to recommend a painkiller.
Stomach Pain
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, consult your doctor.
Warning & Precautions
Pregnancy
Use with CautionMINIRIN NASAL SPRAY should be used with caution in pregnant women. Consult your doctor before using, because blood pressure monitoring is recommended due to the increased risk of pre-eclampsia.
Breastfeeding
Use with CautionMINIRIN NASAL SPRAY should be used with caution in breastfeeding women. Consult your doctor before using.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if your ability is affected by this medicine.
Alcohol
Consult your doctorAvoid consumption of alcohol while using this medicine.
Kidney
Use with CautionMINIRIN NASAL SPRAY should be used with caution in patients with severe kidney disease. Consult your doctor for advice.
Allergy
ContraindicatedDo not use this medicine if you are allergic (hypersensitive) to Desmopressin or any other ingredients of this medicine.
Heart Disease
Use with CautionMINIRIN NASAL SPRAY should be used with caution in patients with heart disease. Consult your doctor for advice.
Use In Geriatrics
ContraindicatedDo not use MINIRIN NASAL SPRAY if you are older than 65 years of age. Consult your doctor before using the medicine.
Others
MINIRIN NASAL SPRAY is not recommended if you have:
- primary polydipsia (compulsive water drinking) or excessive thirst due to alcohol abuse
- hyponatremia (low levels of sodium in your blood)
- syndrome of inappropriate secretion of diuretic hormone, polyuria (producing too much urine)
- Type IIb von Willebrand’s disease (a blood disorder) or thrombotic thrombocytopenic purpura (blood disorder)
Before MINIRIN NASAL SPRAY, consult your doctor if you:
- are dehydrated due to vomiting
- have diarrhea or systemic infection or cystic fibrosis
Interactions
A. Drug-Drug Interactions:
Before using MINIRIN NASAL SPRAY inform your doctor if you are taking the following,
- medicines used for high blood pressure (e.g. captopril, propranolol, enalapril, losartan, valsartan)
- medicines used to manage depression (e.g. lithium, amitriptyline, imipramine, paroxetine, fluoxetine, sertraline)
- clofibrate (used to manage high cholesterol levels)
- chlorpromazine (used for schizophrenia)
- carbamazepine (used to manage epilepsy)
- Non-steroidal anti-inflammatory medicines (used to relieve pains and inflammatory conditions)
- glibenclamide (used to manage diabetes)
Synopsis
| Drug | : | Desmopressin |
| Pharmacological Category | : | Synthetic antidiuretic peptide, Vasopressin Analog |
| Therapeutic Indication | : | Diabetes insipidus, Primary nocturnal enuresis, Nocturia |
| Dosage Forms | : | Tablet, Nasal spray |
More Information
- Keep out of reach of children
- Do not store above 25°C
FAQs About MINIRIN NASAL SPRAY
Q: Can MINIRIN NASAL SPRAY cause SIADH?
A: No. This medicine does not cause syndrome of inappropriate secretion of diuretic hormone. Consult your doctor for advice before taking the medicine.
Q: Can MINIRIN NASAL SPRAY be used in pregnancy?
A: Consult your doctor before using this medicine, if you are pregnant, as blood pressure monitoring is recommended due to the increased risk of pre-eclampsia.
Q: Can I drink alcohol while using MINIRIN NASAL SPRAY?
A: No. Avoid alcohol consumption while using this medicine. This could lead to serious problems.
Q: Can I stop using MINIRIN NASAL SPRAY on my own?
A: Do not stop using MINIRIN NASAL SPRAY unless your doctor advice you to stop.
Q: How does MINIRIN NASAL SPRAY work?
A: MINIRIN NASAL SPRAY mimics the action of endogenous anti-diuretic hormone. After intranasal administration, its acts as a selective agonist of V2 receptors present in the renal distal tubule and collecting ducts. Binding of desmopressin to V2 receptors, stimulates the production of adenylyl cyclase, which leads to increased reabsorption of water and reduced urine production.
Q: Is MINIRIN NASAL SPRAY safe to use in patients with kidney disease?
A: MINIRIN NASAL SPRAY should be used with caution in patients with severe kidney disease. Consult your doctor for advice.
References
1. Robert F. Reilly and Edwin K. Jackson. Regulation of renal function and vascular volume. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 708-714.
2. Roger K. Long & Hakan Cakmak. Hypothalamic & Pituitary Hormones. Basic and Clinical Pharmacology. 14th Edition. New York McGarw Hill Education 2018. Page – 681-682.
3. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1085-1086.
4. Ferring Pharmaceuticals. A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on August 2012] [Accessed on January 17th, 2024] https://clinicaltrials.gov/ct2/show/NCT01280188
5. Fara M. Friedman and Jeffrey P. Weiss. Desmopressin in the treatment of nocturia: clinical evidence and experience. NCBI; PMC US National Library of Medicine, National Institute of Health. December 2013. [Accessed on January 17th, 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825109/
6. Labiana Pharmaceuticals S.L.U. Electronic Medicines Compendium (EMC). [Revised on December 2018] [Accessed on January 17th, 2024] https://www.medicines.org.uk/emc/files/pil.8020.pdf
7. Ferring GmbH. Electronic Medicines Compendium (EMC). [Revised on October 2014] [Accessed on January 17th, 2024] https://www.medicines.org.uk/emc/files/pil.5449.pdf
8. Ferring Pharmaceuticals Inc. U.S. Food & Drug Administration. [Revised on September 2002] [Accessed on January 17th, 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/21333slr001_Minirin_lbl.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Jaanch Diabetic Profile Basic
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