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Introduction About MINADO 250 TABLET
MINADO 250 TABLET is a combination of Domperidone and Naproxen, which belong to the groups of medicines called antiemetics and NSAIDs (non-steroidal anti-inflammatory drugs), respectively. It is used to manage the symptoms of migraine, menstrual migraine, and chronic daily headaches associated with nausea and vomiting.
A migraine is a recurring headache that often involves one side of the head and causes severe pain that is pulsating or throbbing and is accompanied by nausea, weakness, and sensitivity to sound and light.
MINADO 250 TABLET is not recommended in patients with severe liver, kidney, or heart problems, stomach ulcers, bleeding in the stomach or intestine, intestinal tears, or pituitary gland tumours. MINADO 250 TABLET should be taken with caution in patients with lung disease, diabetes, high cholesterol, systemic lupus erythematosus, a blood clotting disorder, a history of gastrointestinal diseases, and a habit of drinking or smoking.
MINADO 250 TABLET is not recommended for use during pregnancy, while breastfeeding, or in children less than 5 years old. It should be used with caution in elderly patients (those over the age of 60). The common side effect of taking MINADO 250 TABLET may include dry mouth. Consult your doctor immediately if your symptoms get worse or persist.
Uses Of MINADO 250 TABLET
Manage symptoms of
- migraine
- menstrual migraine
- chronic daily headache
How MINADO 250 TABLET Works
MINADO 250 TABLET effectively manages migraine, which is commonly associated with nausea and vomiting, by blocking the centres in the brain and stomach that regulate nausea and vomiting. It also increases the contractions and movements in the stomach. MINADO 250 TABLET stops the pain pathways and reduces the release of substances (prostaglandins) that cause inflammation, thus decreasing pain and inflammation.
How to use MINADO 250 TABLET
Take MINADO 250 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of MINADO 250 TABLET for you depending on your age, body weight and disease condition.
Side Effects Of MINADO 250 TABLET
Common
- dry mouth
Uncommon
- decreased sexual drive in men
- feeling anxious, drowsy and weak
- headache
- diarrhoea
- itchy skin
- pain or tenderness in breasts
Rare
Stop taking MINADO 250 TABLET and talk to your doctor if you experience any of the following side effects:
- swelling of the hands, feet, ankles, face, lips or throat which may lead to difficulty in swallowing or breathing
- an itchy, lumpy rash (hives) or nettle rash (urticaria)
- any uncontrolled movements which include unusual movements of the tongue, irregular eye movements, and abnormal posture such as a twisted neck, muscle stiffness, and trembling
- very fast or unusual heartbeat
- a fit or seizure
How To Manage Side Effects
Headache:
Try to rest and relax. Do not involve yourself in exertive activities. Apply a pain-relieving balm on your forehead.
Diarrhoea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Drowsiness:
Take adequate sleep. Do not involve in rigorous activities. Do not interfere with your sleep cycle. Talk to your doctor if the symptom doesn’t improve.
Warning & Precautions
Pregnancy
MINADO 250 TABLET is not recommended for use in pregnant women during the first 6 months of pregnancy. MINADO 250 TABLET must not be used during the last 3 months of pregnancy. Consult your doctor before taking it.
Breastfeeding
MINADO 250 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel drowsy, dizzy, tired or have blurred vision after taking MINADO 250 TABLET.
Kidney
MINADO 250 TABLET is not recommended in patients with severe kidney disease. Consult your doctor before taking MINADO 250 TABLET.
Liver
MINADO 250 TABLET is not recommended in patients with severe liver disease. Consult your doctor before taking it.
Allergy
Do not take MINADO 250 TABLET if you are allergic to Domperidone or Naproxen.
Lungs
MINADO 250 TABLET should be used with caution in patients with lung diseases such as asthma, other breathing problems or nasal polyps. Consult your doctor before taking it.
Heart Disease
MINADO 250 TABLET not recommended in patients with severe heart disease such as heart failure, prolonged QT corrected interval. It should be used with caution in patients having a stroke or high blood pressure. Consult your doctor before taking MINADO 250 TABLET.
Others
MINADO 250 TABLET is not recommended for use if you:
- have stomach or duodenal ulcers
- have bleeding in the stomach or intestines
- have a blockage or tear in the intestine
- have a tumour of the pituitary gland
Before taking MINADO 250 TABLET tell your doctor if you:
- have a history of disorders of the stomach or bowel (ulcerative colitis, Crohn’s disease)
- have diabetes
- have a habit of smoking
- have systemic lupus erythematosus or other connective tissue disorder
- have a blood clotting disorder
Use in paediatrics:
MINADO 250 TABLET is not recommended for use in children under 5 years of age. Consult your doctor before taking MINADO 250 TABLET.
Use in geriatrics:
MINADO 250 TABLET should be used with caution in elderly patients (above 60 years of age). Consult your doctor for advice.
Interactions
A. Drug–Drug Interactions:
Inform your physician if you are taking any of the following drugs before taking MINADO 250 TABLET:
- medicines used to manage heart problems, high blood pressure (Ex. amiodarone, dronedarone, quinidine, disopyramide, captopril, ramipril, losartan, candesartan, dofetilide, sotalol, diltiazem, verapamil)
- medicines used in the management of psychoses (Ex. haloperidol, pimozide, sertindole), depression (Ex. citalopram, escitalopram), mental illness (Ex. lithium), epilepsy (Ex. phenytoin)
- medicines used to manage gastrointestinal disorders (Ex. cisapride, dolasetron, prucalopride), antacids (Ex. aluminium hydroxide gel)
- medicines used to manage bacterial infections (Ex. erythromycin, clarithromycin, ciprofloxacin, telithromycin, moxifloxacin, pentamidine)
- medicines used in the management of cancer (Ex. toremifene, methotrexate, vandetanib, vincamine)
Overdosage:
If you or anyone else accidentally takes too much MINADO 250 TABLET, consult your doctor immediately or visit the nearby hospital. Overdoes of MINADO 250 TABLET can cause headaches, nausea, vomiting, sleepiness, confusion, heartburn, fainting, diarrhoea, disorientation, stomach or intestine bleeding, unconsciousness, drowsiness, dizziness, ringing or buzzing sensation in the ears, fits and excitation, unusual eye movements, unusual tongue movements, or abnormal posture (such as a twisted neck).
Synopsis
| Drug | : | Domperidone, Naproxen |
| Pharmacological Category | : | NSAIDs, Antiemetics |
| Therapeutic Indication | : | Migraine, Menstrual migraine and Chronic daily headache |
| Dosage Forms | : | Tablet |
More Information
- Keep MINADO 250 TABLET out of reach of children
- Store below 25°C
FAQs About MINADO 250 TABLET
Does MINADO 250 TABLET make you feel sleepy?
Yes. MINADO 250 TABLET may cause sleepiness, dizziness, fatigue, or blurring of your vision. Therefore, it is advised not to drive or use any machines if you feel any of the above side effects.
Is MINADO 250 TABLET safe for use by pregnant and breastfeeding women?
MINADO 250 TABLET is not recommended for pregnant women in the first 6 months of pregnancy, and it must not be taken during the last 3 months. MINADO 250 TABLET is not advised for breastfeeding women as it may pass through the milk. Consult with your doctor.
Does MINADO 250 TABLET help with migraines?
There is no permanent manage for migraine. MINADO 250 TABLET is used to manage the symptoms of migraine, which could be nausea, weakness, and sensitivity to sound and light. Consult with your doctor.
References
1. KD Tripathi. Gastrointestinal Drugs & NSAIDs and Antipyretic Analgesics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 666 & 201.
2. Joseph C. Brutzkus, Mahsa Shahrokhi, Matthew Varacallo. Naproxen. NIH National Library of Medicine, National center for biotechnology information. Feb 2022. [Accessed on 23rd May 2022] https://www.ncbi.nlm.nih.gov/books/NBK525965/
3. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 23rd May 2022] https://www.medicines.org.uk/emc/files/pil.556.pdf
4. Accord Healthcare. Electronic Medicines Compendium (EMC). [Revised in Jan 2021] [Accessed on 23rd May 2022] https://www.medicines.org.uk/emc/files/pil.5812.pdf
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