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Introduction About MIGACE INJECTION
MIGACE INJECTION contains Aceclofenac which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs (NSAIDs). It is used for the short-term management of pain due to post operative and post-traumatic cases.
MIGACE INJECTION is not recommended for use in patients with active or suspected peptic ulcer, intestinal haemorrhage and with severe renal impairment.
Before receiving MIGACE INJECTION inform your doctor if you have impaired kidney, liver or heart function and gastrointestinal disorders like ulcerative colitis or with crohn's disease, bleeding diathesis (increased tendency to bleed or bruise) or haematological abnormalities.
MIGACE INJECTION is not recommended for use in pregnant or breast-feeding women. It is not recommended for use in children and should be used with caution in elderly patients due to increased risk of serious side effects.
The most common side effects of receiving MIGACE INJECTION are dizziness, nausea, diarrhoea and stomach pain. Inform your doctor if any of the side effects worsen.
Uses Of MIGACE INJECTION
Used as short-term management:
- For pain due to post-operative or post-traumatic cases
How MIGACE INJECTION Works
MIGACE INJECTION works by exhibiting anti-inflammatory and painkiller properties by blocking the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins which are responsible for causing pain and inflammation (swelling).
How to use MIGACE INJECTION
MIGACE INJECTION will be given to you only by a doctor or a nurse into a muscle (as an intramuscular injection). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of MIGACE INJECTION
Common
- indigestion, abdominal pain, nausea, diarrhea
- dizziness
- elevated hepatic enzymes
Uncommon
- flatulence, gastritis, constipation, vomiting
- ulcerative stomatitis, vertigo
- itching, rash, dermatitis
Rare
- pancreatitis, melena (dark stools)
- stomatitis (sore or inflammation inside of the mouth)
- burning or prickling sensation usually in hands or feet, tremor
- depression, abnormal dreaming, sleepiness, insomnia
- eczema, flushing, purpura (purple-colored spots and patches that occur on the skin)
- odema (fluid retention), palpitation, cramps legs
- shortness of breath, stridor (noisy breathing)
- nephrotic syndrome
- headache, fatigue, facial oedema, weight gain and allergic reactions such as anaphylactic shock
- abnormal vision, abnormal taste
How To Manage Side Effects
Nausea or vomiting:
Take regular sips of cold drink. Stick to simple meals. Avoid eating oily, fried, or spicy foods. Do not lie down or sleep immediately after eating. If the symptoms does not improve, inform your doctor.
Constipation:
Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals and drink plenty of fluids. Exercise more regularly (such as daily walk) and stay active. Inform your doctor if the symptom does not improve.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Inform your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Inform your doctor if the symptom did not improve on its own.
Warning & Precautions
Pregnancy
MIGACE INJECTION is not recommended for use in pregnant women or women planning for pregnancy. Consult your doctor before receiving it.
Breastfeeding
MIGACE INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving it.
Driving and Using Machines
Do not drive or operate any machines if you feel dizziness, vertigo or other central nervous system disorders after receiving MIGACE INJECTION.
Kidney
MIGACE INJECTION is not recommended for use in patients with severe renal impairment. It should be used with caution in patients with impaired renal function. Consult your doctor before receiving it.
Liver
MIGACE INJECTION should be used with caution in patients with severe hepatic impairment. It should be used with caution in patients with hepatic porphyria (rare genetic disease). Consult your doctor before receiving it.
Allergy
Do not receive MIGACE INJECTION if you are allergic to Aceclofenac or aspirin or any other nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen, naproxen or diclofenac).
Lungs
MIGACE INJECTION is not recommended for use in patients with asthma due to the use of nonsteroidal anti-inflammatory drugs. Consult your doctor before receiving it.
Heart Disease
MIGACE INJECTION should be used with caution in patients with impaired cardiac function. Consult your doctor before receiving it.
Others
MIGACE INJECTION is not recommended for use if you have:
- intestinal haemorrhage, active or suspected peptic ulcer
- acute rhinitis or urticaria (due to the use of nonsteroidal anti-inflammatory drugs)
Before receiving MIGACE INJECTION, inform your doctor:
- gastrointestinal disorders like gastro-intestinal ulceration, ulcerative colitis or Crohn's disease, bleeding diathesis or haematological abnormalities
- gastro-intestinal bleeding or ulcerative perforation, hematemesis and melena
Use in pediatrics:
MIGACE INJECTION is not recommended for use in children. Consult your child’s doctor for advice.
Use in geriatrics:
MIGACE INJECTION should be used with caution in elderly patients due to increased risk of serious side effects. Consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving MIGACE INJECTION, inform your doctor if you are taking any of the following medicines:
- lithium (used to manage depression)
- medicines used to manage heart failure and irregular heartbeats (Ex. digoxin)
- medicines that stop blood clotting (anticoagulants) Ex. warfarin, heparin
- glibenclamide, glicazide, tolbutamide (medicines used to manage diabetes)
- aspirin, ibuprofen and naproxen (used to manage pain and inflammation)
- drugs used to increase the rate of urine excretion (Ex. thiazides such as indapamide, furosemide and amiloride)
- medicines used to suppress the immune system after organ transplant to manage rejection (Ex. cyclosporin)
- methotrexate (used to manage cancer)
Overdosage:
MIGACE INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms.
Synopsis
| Drug | : |
Aceclofenac |
| Pharmacological Category | : |
Non-steroidal Anti-inflammatory drugs |
| Therapeutic Indication | : |
Post operative and post-traumatic pain for short-term |
| Dosage Forms | : | Tablet, Dispersible tablet, Capsule, Injection |
More Information
- Store MIGACE INJECTION below 30°C
FAQs About MIGACE INJECTION
What is MIGACE INJECTION used for?
MIGACE INJECTION contains Aceclofenac which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs (NSAIDs). It is used for the short-term management of pain due to post operative and post-traumatic cases.
Can MIGACE INJECTION be used in elderly patients?
MIGACE INJECTION should be used with caution in elderly patients due to increased risk of serious side effects. Your doctor will initiate the management with the lowest effective dose for shorter duration. Consult your doctor before receiving MIGACE INJECTION.
What are the common side effects of MIGACE INJECTION?
The most common side effects of receiving MIGACE INJECTION are indigestion, dizziness, nausea, diarrhoea and stomach pain. Inform your doctor immediately if any of the side effects worsen.
Is MIGACE INJECTION safe to use in patients with kidney disease?
MIGACE INJECTION is not recommended for use in patients with severe renal impairment. It should be used with caution in patients with impaired renal function. Consult your doctor before receiving MIGACE INJECTION.
Can MIGACE INJECTION be used in pregnant women?
MIGACE INJECTION is not recommended for use in pregnant women or women planning for pregnancy. Consult your doctor for advice to select a suitable alternative management for the pain management.
References
1. K.D Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 204.
2. Parvati B. Patel and Tejas K. Patel. Efficacy and safety of aceclofenac in osteoarthritis: A meta-analysis of randomized controlled trials. NIH. National Library of Medicine, National centre for biotechnology information. PubMed Central. March 2017. [Accessed on 16th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335881/
3. Daewon Pharmaceutical Co., Ltd. Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patients With Osteoarthritis of the Knee. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in October 2016] [Accessed on 16th April 2022] https://clinicaltrials.gov/ct2/show/NCT02682524
4. Themis Medicare Limited. National Agency for Food and Drug Administration and Control (NAFDAC). [Accessed on 16th April 2022] https://www.nafdac.gov.ng/wp-content/uploads/Files/SMPC/V1_2022/Aceclofenac-Injection-150-mg-per-ml.pdf
5. Aceclofenac injection. Rewine Pharmaceuticals. [Accessed on 16th April 2022] https://m.rewinepharmaceutical.com/aceclofenac-injection-7158247.html
Useful Diagnostic Tests
- Kidney function tests
- Liver function tests
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