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Introduction About MIDACIP NASAL SPRAY
MIDACIP NASAL SPRAY contains Midazolam, which belongs to the group of medicines called benzodiazepines (sedatives). MIDACIP NASAL SPRAY is used to manage sudden repetitive attacks of fits (epilepsy). Epilepsy (fits) is a central nervous system (neurological) disorder which affects the brain creating a disturbance in nerve cells and electrical activity leading to sudden, uncontrolled body movements. Epilepsy can be triggered by sleep deprivation, stress, missing medications, illness with fever or using alcohol and other nonmedical drugs.
Before using MIDACIP NASAL SPRAY, inform your doctor if you have chronic respiratory problems, myasthenia gravis (muscle weakness), a history of drug abuse or depression, narrow-angle glaucoma, sleep apnoea syndrome (sleep disorder in which breathing stops and starts repeatedly), kidney, heart, liver problems.
MIDACIP NASAL SPRAY is generally not recommended during pregnancy especially in the last trimester and breastfeeding, unless deemed necessary. MIDACIP NASAL SPRAY should be used with caution in elderly patients and children. MIDACIP NASAL SPRAY has a few side effects like nausea, vomiting, headache, drowsiness, runny nose, throat irritation, nasal discomfort and dizziness in some cases. If any of these symptoms worsen, contact your doctor for advice.
Uses Of MIDACIP NASAL SPRAY
MIDACIP NASAL SPRAY nasal spray is used for emergencies to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to manage epilepsy (seizures).
How MIDACIP NASAL SPRAY Works
MIDACIP NASAL SPRAY contains midazolam which works by increasing a particular chemical messenger in the brain that acts as a natural nerve-calming agent (GABA) resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant and muscle relaxant properties. Hence MIDACIP NASAL SPRAY helps manage fits by stabilizing the altered, electrical activity of nerve cells in the brain.
How to use MIDACIP NASAL SPRAY
Use MIDACIP NASAL SPRAY as advised by your physician. MIDACIP NASAL SPRAY is for nasal use only. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Side Effects Of MIDACIP NASAL SPRAY
Common
- nausea
- vomiting
- headache
- drowsiness
- runny nose
- throat irritation
- nasal discomfort
Uncommon
- hypersensitivity reactions
- feeling confused
- feeling very happy or excited (euphoria)
- loss of libido
- feeling depressed
- restlessness, agitation, irritability, aggression, delusion, anger, nightmares, hallucinations, psychosis, or inappropriate behaviour
- feeling tired or sleepy or being sedated for a long time
- difficulty co-ordinating muscles
- temporary loss of memory
- seeing double
- stomach upsets
- skin reactions including rash
- muscle weakness
- fatigue
- an increased risk of falling and fractures in the elderly
Rare
Stop using MIDACIP NASAL SPRAY and contact your doctor immediately if you experience any of the following side effects:
- signs of heart attack symptoms like include chest pain
- breathing problems, sometimes causing the breathing to stop
- excessive sleepiness (sedation)
How To Manage Side Effects
Nasal discomfort:
Try to take steam inhalation. Do not take any other medication without consulting your doctor.
Nausea:
Try to relax and rest. Eat and drink slowly or try to have smaller and more frequent meals. If symptoms do not improve, contact your doctor.
Headache:
Try a cold pack or use a heating pad or hot compress. Ease pressure on your scalp or head. Dim the lights. Hydrate yourself and practice relaxation.
Warning & Precautions
Pregnancy
MIDACIP NASAL SPRAY is generally not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before using it.
Breastfeeding
MIDACIP NASAL SPRAY is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before using it.
Driving and Using Machines
Do not drive or operate any machines if you feel dizzy after using MIDACIP NASAL SPRAY.
Alcohol
Do not drink alcohol if you are using MIDACIP NASAL SPRAY. This is because alcohol may make you feel very sleepy and cause problems with your breathing.
Kidney
MIDACIP NASAL SPRAY should be used with caution in patients with kidney diseases. Consult your doctor before using MIDACIP NASAL SPRAY.
Liver
MIDACIP NASAL SPRAY should be used with caution in patients with liver diseases. Consult your doctor before using MIDACIP NASAL SPRAY.
Allergy
Do not use MIDACIP NASAL SPRAY if you are allergic to midazolam. Allergic reactions to MIDACIP NASAL SPRAY are rare but may show as an itchy rash. Very rarely, a severe allergic reaction may occur causing a sudden onset of swelling of the face and neck, and shortness of breath.
Lungs
MIDACIP NASAL SPRAY should be used with caution in patients with respiratory diseases. Consult your doctor before using MIDACIP NASAL SPRAY.
Heart Disease
MIDACIP NASAL SPRAY should be used with caution in patients with heart diseases. Consult your doctor before using MIDACIP NASAL SPRAY.
Others
MIDACIP NASAL SPRAY is not recommended for use if you:
- have acute narrow-angle glaucoma
Before using MIDACIP NASAL SPRAY, inform your doctor if you:
- regularly take recreational drugs or drink large amounts of alcohol or have had problems with alcohol or drug abuse in the past
- suffer from mental disorders including depression, psychosis, or schizophrenia
Use in paediatrics:
MIDACIP NASAL SPRAY is used with caution for use in children and adolescents. Consult your doctor before using it.
Use in geriatrics:
MIDACIP NASAL SPRAY should be used with caution in elderly (65 years and above) patients. Consult your doctor for advice.
Interactions
A. Drug-Drug interactions:
Before using MIDACIP NASAL SPRAY, inform your doctor if you are taking any of the following medicine:
- medicines for depression (Ex. citalopram)
- hypnotic medicines, to make you sleep (Ex. zopiclone)
- sedatives to make you feel calm or sleepy (Ex. barbiturates, benzodiazepines)
- tranquilliser medicines for anxiety or to help you sleep (Ex. pentobarbital)
- carbamazepine or phenytoin (these may be used for fits or seizures)
- rifampicin to manage tuberculosis
- medicines for HIV called protease inhibitors (Ex. saquinavir)
- antibiotics to manage infection (Ex. erythromycin or clarithromycin)
- medicines to manage fungal infections (Ex. ketoconazole, voriconazole, fluconazole, itraconazole,)
- strong pain killers (Ex. ketorolac)
- antihistamines to manage allergic reactions (Ex. cetirizine)
- any kind of herbal medicine for depression
- medicines for high blood pressure (Ex. diltiazem)
Overdosage:
If you or anyone else accidentally used too much of MIDACIP NASAL SPRAY, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose may include feeling sick (nausea), vomiting, dizziness, slowing of breathing, drowsiness or coma, slurred speech, loss of balance, and slow reactions.
Synopsis
| Drug | : | Midazolam |
| Pharmacological Category | : | Benzodiazepines |
| Therapeutic Indication | : | General anaesthesia, conscious sedation |
| Dosage Forms | : | Tablet, nasal spray, injection, syrup |
More Information
- Keep MIDACIP NASAL SPRAY out of reach from children
- Store at room temperature
FAQs About MIDACIP NASAL SPRAY
What are the uses of MIDACIP NASAL SPRAY?
MIDACIP NASAL SPRAY contains Midazolam which belongs to the group of medicines called benzodiazepines (sedatives). MIDACIP NASAL SPRAY is used to manage sudden repetitive attacks of fits (epilepsy). Epilepsy (fits) is a central nervous system (neurological) disorder which affects the brain creating a disturbance in nerve cells and electrical activity leading to sudden, uncontrolled body movements. Epilepsy can be triggered by sleep deprivation, stress, missing medications, illness with fever, or using alcohol or other nonmedical drugs.
How to use MIDACIP NASAL SPRAY?
Use MIDACIP NASAL SPRAY as advised by your physician. MIDACIP NASAL SPRAY is for nasal use only. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Does MIDACIP NASAL SPRAY has any side effects?
MIDACIP NASAL SPRAY has few side effects like any other medicine. The symptoms include nausea, vomiting, headache, drowsiness, runny nose, throat irritation, and nasal discomfort. If any of these symptoms become worsen, contact your doctor for advice.
Can we use MIDACIP NASAL SPRAY for pregnant women?
If you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor for advice before using MIDACIP NASAL SPRAY. It is generally not recommended during pregnancy and breastfeeding. Consult your doctor for advice.
How does MIDACIP NASAL SPRAY work?
MIDACIP NASAL SPRAY contains midazolam which works by increasing a particular chemical messenger in the brain that acts as a natural nerve-calming agent (GABA) resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties. Hence MIDACIP NASAL SPRAY helps manage fits by stabilizing the altered, electrical activity of nerve cells in the brain.
References
1. KD Tripathi. Sedative-Hypnotics Essentials of medical pharmacology. seventh edition. 2017. Page – 397-411.
2. Dundee, J.W., Halliday, N.J., Harper, K.W. et al. Midazolam. Drugs. [Revised in Oct 2012] [Accessed in August 2022] https://doi.org/10.2165/00003495-198428060-00002
3. Proximagen, LLC. U.S. Food and Drug Administration. [Revised in May 2019] [Accessed in August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211321s000lbl.pdf
4. NAYZILAM. Patient Leaflet. [Accessed in August 2022] https://www.nayzilam.com/patient-brochure.pdf
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