Metpure AR 5mg Tablet 10'S
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Introduction About METPURE AR 5MG TABLET
METPURE AR 5MG TABLET is a combination of Atorvastatin, Metoprolol and Ramipril which belongs to the group of medicines called Antihypertensives and Antihyperlipidemics respectively. It is used to manage hypertension (high blood pressure) and hyperlipidemia (high blood cholesterol levels) in patients who have both co-existing medical conditions.
It can also be used to manage the risk of heart attack, stroke, angina and other heart problems. It also protects the function of kidneys particularly in patients who have both hypertension and type II diabetes mellitus.
Along with the management, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results. Avoid consuming alcohol or grapefruit juice while taking METPURE AR 5MG TABLET as it may make this medicine less effective.
Before taking METPURE AR 5MG TABLET inform your doctor if you have any liver, kidney or heart problems apart from hypertension, angina and heart failure. You must also inform your doctor if you have asthma, COPD, diabetes, thyroid problems, severe dehydration due to any recent sickness (such as vomiting or diarrhea), psoriasis or muscle problems before taking METPURE AR 5MG TABLET as a precaution.
METPURE AR 5MG TABLET is not recommended for use in patients with severe hypotension (low blood pressure). It is also not suitable for use in women who are pregnant or breastfeeding due to increased risk of side effects.
The most common side effects of taking METPURE AR 5MG TABLET are dizziness, swelling of ankles or other body parts, headache, sleepiness, tiredness, indigestion, constipation and muscle cramps. Contact your doctor if any of these side effects trouble you.
Uses Of METPURE AR 5MG TABLET
- Manage hypertension (high blood pressure)
- Manage hyperlipidemia (high blood cholesterol levels)
- Prevents the risk of heart attack, stroke, angina or related health problems
- Protects kidney functions in patients with hypertension and diabetes
How METPURE AR 5MG TABLET Works
METPURE AR 5MG TABLET contains three medicines namely atorvastatin, metoprolol and ramipril. Metoprolol is a beta-blocker. It blocks the effects of certain chemical messengers in the body (such as adrenaline) that increases heart rate and blood pressure.
Ramipril is an ACE inhibitor. It blocks the effects of certain enzymes in the body (such as angiotensin converting enzyme (ACE)) that causes narrowing of blood vessels and increase in blood pressure.
Atorvastatin is a lipid-lowering medicine. It blocks the release of certain enzymes (HMG-CoA reductase) in the body that is involved in cholesterol formation. It also reduces the amount of cholesterol produced by the liver and improves the excretion of lipids from the body via faeces.
Collectively, this medicine reduces blood pressure and blood cholesterol levels and manages you from their associated risks.
How to use METPURE AR 5MG TABLET
Take METPURE AR 5MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Continue to take METPURE AR 5MG TABLET for the stipulated duration instructed by your doctor to achieve better results.
Side Effects Of METPURE AR 5MG TABLET
Common
- headache, tiredness, dizziness
- feeling faint or dizzy while standing up
- dry cough, inflammation of sinus
- stomach pain, nausea, vomiting, constipation, diarrhea, indigestion
- skin rash
- chest pain
- increased potassium levels in blood
- slow heart rate
- throat pain, nose bleeds
- allergic reactions
- increase in blood sugar levels
- joint pain, muscle pain and back pain
- liver problems
Uncommon
- anxiety, depression
- insomnia (sleeplessness)
- changes in taste
- tingling sensation in limbs, loss of pain sensation
- blocked nose
- heartburn, constipation, dry mouth, loss of appetite
- increased urination
- increased sweating
- swollen arms and legs (oedema)
- flushing (skin redness and warmth)
- blurred vision
- inability to obtain an erection, enlargement of the breasts in men
- anorexia (loss of appetite)
- weight gain
- loss of memory
- ringing in the ears followed by vomiting
- fatigue, feeling unwell, weakness, chest pain
- raised temperature
Rare
- confusion
- red, swollen tongue
- loosening or separation of a nail from its bed
- skin rash, itching, redness
- red, itchy, swollen or watery eyes
- unexpected bleeding or bruising
- cholestasis (yellowish discoloration of the skin and whites of the eyes)
- tendon injury
Stop taking METPURE AR 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath (signs of heart attack)
- inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
- signs of liver problems (such as fever, muscle pain, rashes, itching, stomach pain, diarrhea, discoloration of eyes, skin and urine)
- increased bleeding or bruising, fever, chills, red spots under the skin, tiredness, dizziness, pale skin (signs of low blood cells counts)
- unexplained muscle pain or weakness, especially if accompanied by fever, weakness or reddish-brown urine (rhabdomyolysis)
How To Manage Side Effects
Nausea:
Take METPURE AR 5MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
METPURE AR 5MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, inform your doctor before taking this medicine if you are pregnant, think you may be pregnant or planning to have a baby. If you accidentally become pregnant while undergoing therapy with METPURE AR 5MG TABLET, inform your doctor immediately.
Breastfeeding
METPURE AR 5MG TABLET is not recommended for use in breast-feeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you feel dizzy after taking METPURE AR 5MG TABLET.
Alcohol
Avoid consumption of alcohol while taking METPURE AR 5MG TABLET as it may severely decrease your blood pressure and make you feel dizzier or faint.
Kidney
METPURE AR 5MG TABLET is not recommended for use in patients with severe kidney impairment (including dialysis or narrowing or renal arteries). It should be used with caution in patients with other kidney problems (including kidney transplantation). Therefore, consult your doctor before taking it.
Liver
METPURE AR 5MG TABLET is not recommended for use in patients with liver failure. It should be used with caution in patients with other minor liver problems (such as liver cirrhosis). Therefore, consult your doctor before taking it.
Allergy
Do not take METPURE AR 5MG TABLET if you are allergic to Atorvastatin, Metoprolol, Ramipril or to any other beta-blockers (such as propranolol, atenolol) or ACE inhibitors (such as captopril, enalapril, lisinopril).
Lungs
METPURE AR 5MG TABLET is not recommended for use in patients with severe lung problems (such as asthma, COPD or any form of breathing difficulties). Therefore, consult your doctor before taking it.
Heart Disease
METPURE AR 5MG TABLET is not recommended for use in patients with severe heart problems (such as slow or irregular heartbeat, severe heart failure, recent heart attack). It should be used with caution in patients with other minor heart problems. Therefore, consult your doctor before taking it.
Others
METPURE AR 5MG TABLET is not recommended for use if you:
- have diabetes with impaired kidney functions
- are in shock
- have unmanageed phaeochromocytoma (a tumor of adrenal gland)
- have metabolic acidosis (increased acidity in blood)
- have problems in blood circulation (such as Raynaud’s disease)
- have block in blood vessels
- have a type of angina called Prinzmetal’s angina
- have severe low blood pressure
- suffer from frequent episodes of low blood sugar levels
Before taking METPURE AR 5MG TABLET, inform your doctor if you:
- have a history of allergic reaction to insects
- have diabetes
- have psoriasis (an auto-immune skin disorder)
- have dry eyes
- have myasthenia gravis (severe muscle weakness)
- are scheduled for any upcoming surgery
- are severely dehydrated due to any recent sickness such as vomiting or diarrhea
- have any autoimmune disease that affects the skin or collagen (Ex. lupus erythematosus, rheumatoid arthritis or scleroderma)
- have any desensitization management (used to reduce the effect of an allergy to bee or wasp stings)
- have high blood potassium levels
- have an unexplained muscle pain
- had any muscle problems in the past
- have improper functioning of thyroid gland
- have personal or family history of muscle problems
- are alcoholic
- are overweight
- have a previous history of stroke with bleeding the brain
Use in Paediatrics:
METPURE AR 5MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before consumption.
Use in Geriatrics:
METPURE AR 5MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking METPURE AR 5MG TABLET inform your doctor, if you are taking any of the following medicines such as:
- medicines used to manage stomach ulcers (such as cimetidine)
- medicines used to manage high blood pressure (such as hydralazine, clonidine, prazosin, aliskiren, sacubitril/valsartan, verapamil or diltiazem)
- medicines used to manage irregular heart rhythm (such as amiodarone, procainamide, digoxin and propafenone)
- medicines used to manage depression (such as moclobemide, paroxetine, fluoxetine isocarboxazid, phenelzine, selegiline, tranylcypromine, lithium)
- medicines used to manage epilepsy (such as phenobarbital, phenytoin)
- anaesthetics (used to causes numbness of body parts or loss of consciousness) such as lidocaine, cyclopropane or trichloroethylene
- medicines used to manage some cancers (such as aldesleukin)
- medicines used to manage erectile dysfunction (such as alprostadil)
- medicines used to reduce anxiety and to induce sleep (such as temazepam, nitrazepam, diazepam)
- non-steroidal anti-inflammatory drugs (used for pain relief) Ex. indomethacin, ibuprofen, aspirin
- rifampicin (a medicine used to manage tuberculosis infection)
- terbinafine (a medicine used to manage fungal infections)
- contraceptive pills (birth control pills) such as ethinyl Estradiol
- hormone replacement therapy (used to manage menstrual problems) such as estrogens
- corticosteroids (used to manage pain and inflammation) such as hydrocortisone, prednisolone
- anti-diabetic medicines and insulin (used to lower the blood glucose level) Ex. vildagliptin, metformin
- timolol eye drops (used to manage glaucoma)
- sympathomimetic drugs (used to manage low blood pressure, asthma, allergies or heart failure) such as ephedrine, noradrenaline or adrenaline
- moxisylyte (a medicine used in Raynaud’s syndrome)
- medicines used to manage asthma (such as aminophylline or theophylline)
- medicines to manage migraines (such as ergotamine)
- medicines used to manage rheumatoid arthritis (such as hydroxychloroquine)
- diphenydramine (an allergic medicine)
- medicines used to manage graft rejection (Ex. ciclosporin, sirolimus, everolimus)
- medicines that supplement potassium to the body (Ex. spironolactone, triamterene or amiloride)
- trimethoprim, co-trimoxazole (used to manage bacterial infections)
- heparin (a medicine used to manage blood clots)
- allopurinol (a medicine used to manage gout)
- racecadotril (a medicine used to manage diarrhea)
- medicines used to manage bacterial infection (such as fusidic acid, erythromycin, clarithromycin, telithromycin)
- medicines used to manage fungal infection (such as ketoconazole, itraconazole, voriconazole, fluconazole, posaconazole)
- rifampin (a medicine used to manage tuberculosis infection)
- other medicines used to reduce blood cholesterol levels (such as gemfibrozil, fenofibrate, colestipol or ezetimibe)
- medicines used to manage heart problems (Ex. amlodipine, diltiazem, digoxin, verapamil, amiodarone)
- medicines used to manage viral infections such as HIV or Hepatitis C (Ex. letermovir, ritonavir, lopinavir, atazanavir, indinavir, darunavir, the combination of tipranavir/ritonavir, telaprevir, boceprevir and the combination of elbasvir/grazoprevir, ledipasvir/sofosbuvir)
- warfarin (a medicine used to manage blood clots)
- oral contraceptives (used to manage pregnancy) Ex. levonorgestrel
- stiripentol (a medicine used to control epilepsy)
- antacids (used to neutralize stomach acid and to reduce heartburn) Ex. aluminium hydroxide or magnesium hydroxide
- phenazone (a medicine used for pain relief)
- colchicine (a medicine used to manage gout)
- St John’s wort (a herbal preparation used to manage depression)
B. Drug-Food interactions:
Avoid consumption of grapefruit while taking METPURE AR 5MG TABLET as it may reduce its effectiveness.
Overdosage:
If you or anyone else accidentally took more METPURE AR 5MG TABLET, consult your doctor immediately. Symptoms of overdose might include low blood pressure, tiredness, dizziness, slow pulse, shortness of breath, nausea, vomiting, blue colouring of the skin, low blood sugar levels and high levels of potassium in the blood.
Synopsis
| Drug | : | Atorvastatin, Metoprolol, Ramipril |
| Pharmacological Category | : | HMG-CoA reductase inhibitors, Beta Blockers, ACE inhibitors |
| Therapeutic Indication | : | Hypertension, Hyperlipidemia |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep METPURE AR 5MG TABLET out of the sight and reach of children
- Store METPURE AR 5MG TABLET at room temperature
FAQs About METPURE AR 5MG TABLET
Q: How METPURE AR 5MG TABLET works?
A: METPURE AR 5MG TABLET relaxes the blood vessels supplying the heart and the kidneys. This reduces the strain on the heart and improves blood flow and oxygen supply to them which reduces blood pressure and kidney damage. It also reduces blood cholesterol levels and removes the excess fats from the body via faeces.
Q: What are the dietary restrictions that I need to follow while taking METPURE AR 5MG TABLET?
A: While taking METPURE AR 5MG TABLET, follow a low-cholesterol diet as instructed by your doctor and avoid excessive alcohol intake. Avoid eating oil rich or deep-fried foods or foods rich in potassium such as bananas, oranges and green leafy vegetables. Limit your sugar intake by avoid eating biscuits, cakes, soft drinks or pastries. Stick to a simple nutritious diet. Avoid consumption of grapefruit while taking METPURE AR 5MG TABLET as it may lead to unwanted side effects.
Q: What are the uses of METPURE AR 5MG TABLET?
A: METPURE AR 5MG TABLET is used to manage hypertension (high blood pressure) and hyperlipidemia (high blood cholesterol levels) in patients who have both co-existing medical conditions. It can also be used to manage the risk of heart attack, stroke, angina and other heart problems.
Q: Can the use of METPURE AR 5MG TABLET cause diabetes?
A: Yes. METPURE AR 5MG TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension. Therefore, consult your doctor before taking this medicine if you are diabetic, obese or have hypertension. Your doctor will closely monitor your blood sugar levels while undergoing therapy with METPURE AR 5MG TABLET to avoid any unwanted side effects.
Q: What is the best time to take METPURE AR 5MG TABLET?
A: Take METPURE AR 5MG TABLET as advised by your physician. Your doctor will decide the best time for you to take METPURE AR 5MG TABLET. Try to take this medicine at the same time each day. It can be taken with or without food.
Q: What are the side effects of taking METPURE AR 5MG TABLET?
A: The most common side effects of taking METPURE AR 5MG TABLET are dizziness, swelling of ankles or other body parts, headache, sleepiness, tiredness, indigestion, constipation and muscle cramps. Contact your doctor if any of these side effects trouble you.
Q: Can I consume alcohol along with METPURE AR 5MG TABLET?
A: METPURE AR 5MG TABLET should be used with caution in patients who consume large amounts of alcohol. It is advisable to avoid alcohol consumption while taking this medicine to achieve maximum benefits.
Q: Can the use of METPURE AR 5MG TABLET make me feel more tired?
A: Yes. The use of METPURE AR 5MG TABLET can make you feel more tired, because it acts by reducing the supply of energy to the muscles present in your body. However, you may also feel tired due to other reasons such as severe liver damage. Consult your doctor if you experience excessive tiredness with muscle pain.
Q: Who should not take METPURE AR 5MG TABLET?
A: METPURE AR 5MG TABLET is not recommended for use in patients with severe liver damage. It is also not suitable for use in patients having muscle problems and in women in who are pregnant or breastfeeding. Before taking METPURE AR 5MG TABLET inform your doctor if you have diabetes or any kidney or heart problems. Do not take this medicine if you are undergoing therapy with antibiotics such as fusidic acid.
Q: What should I do if I forget to take a dose of METPURE AR 5MG TABLET?
A: If you forget to take a dose of METPURE AR 5MG TABLET, take it as soon as you remember. However, if it is time to take the next dose of METPURE AR 5MG TABLET, skip the missed dose and take the next one at regular times. Do not take a double dose of METPURE AR 5MG TABLET to compensate the missed dose, as it could lead to toxicity.
Q: Can I stop taking METPURE AR 5MG TABLET once my symptom subsides?
A: Do not stop taking this medicine without consulting your doctor, as it could once again increase your blood pressure and cholesterol levels once again. METPURE AR 5MG TABLET can only control your hypertension and blood cholesterol levels and cannot manage them completely, therefore, it is important to take this medicine until your doctor advises you to stop.
Q: Can I take METPURE AR 5MG TABLET if I am diabetic?
A: METPURE AR 5MG TABLET may increase blood sugar levels in some patients. This is most predominantly seen in patients who already have diabetes along with obesity and/or hypertension. Therefore, consult your doctor before taking METPURE AR 5MG TABLET if you are diabetic, obese or have hypertension.
Q: Does METPURE AR 5MG TABLET cause muscle pain?
A: METPURE AR 5MG TABLET may cause a rare but serious side effect of unexplained muscle pain or weakness called rhabdomyolysis. Therefore, consult your doctor if you experience any signs of muscle problems after taking METPURE AR 5MG TABLET. Also, talk to your doctor before taking METPURE AR 5MG TABLET if you already have weak muscles or have a family history of any muscle disorders.
Q: How METPURE AR 5MG TABLET controls cholesterol levels in the body?
A: METPURE AR 5MG TABLET is a lipid-lowering medicine. It blocks the release of certain enzymes (HMG-CoA reductase) that is involved in cholesterol formation within the body. It also reduces the amount of cholesterol produced by the liver and improves the excretion of lipids from the body via faeces.
Q: How long should I take METPURE AR 5MG TABLET to manage high cholesterol?
A: You should take METPURE AR 5MG TABLET as long as your doctor advises you to take. Because METPURE AR 5MG TABLET will only help you in managing your blood pressure and cholesterol levels and cannot completely manage them. If you stop using METPURE AR 5MG TABLET, your symptoms may raise once again.
Q: Can METPURE AR 5MG TABLET be taken by pregnant or breast-feeding women?
A: METPURE AR 5MG TABLET is not recommended for use in pregnant or breast-feeding women. Therefore, consult your doctor before taking it. Women of childbearing age must use a reliable contraceptive method to avoid pregnancy while undergoing therapy with this medicine. However, if you accidentally become pregnant while taking this medicine, stop taking it and consult your doctor immediately.
Q: Can I take METPURE AR 5MG TABLET daily?
A: Take METPURE AR 5MG TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take METPURE AR 5MG TABLET every day or not.
Q: Can METPURE AR 5MG TABLET cause ankle swelling?
A: METPURE AR 5MG TABLET may cause edema or swelling of ankles in few patients. If you experience ankle swelling, keep your legs on a table or slightly elevated from the ground level. If this symptom bothers you, contact your doctor.
Q: Can the use of METPURE AR 5MG TABLET affect the liver?
A: Yes. METPURE AR 5MG TABLET may affect the way your liver work. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Q: Can METPURE AR 5MG TABLET cause erectile dysfunction?
A: METPURE AR 5MG TABLET may cause problems in erection in few individuals. Consult your doctor if it bothers you.
References
1. KD. Tripathi. Anti-adrenergic drugs and Drugs for Glaucoma. Drugs affecting Renin-angiotensin system. Insulin, Hypolipidemic Drugs and Plasma Expanders. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 148, 503 & 637.
2. Martin H. Strauss, Alistair S. Hall & Krzysztof Narkiewicz. The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases. Cardiovascular Drugs and Therapy. SpringerLink. September 2021. [Accessed on 7th January 2023]. https://link.springer.com/article/10.1007/s10557-021-07248-1
3. Lindsey A. McIver, Momin S. Siddique. Statpearls. Mechanism of Action of Atorvastatin. National Institute of Health, National Library of Medicine, National center for biotechnology information. Pubmed.gov. September 2021. [Accessed on 7th January 2023]. https://www.ncbi.nlm.nih.gov/books/NBK430779/#:~:text=Go%20to%3A-,Mechanism%20of%20Action,cholesterol%20production%20in%20the%20liver
4. Zentiva k.s. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed on 7th January 2023]. https://www.medicines.org.uk/emc/files/pil.12971.pdf
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in March 2019] [Accessed on 7th January 2023]. https://www.medicines.org.uk/emc/files/pil.5345.pdf
6. Mylan Pharmaceuticals Inc. Metoprolol succinate tablet, film coated, extended release. Dailymed.com. [Revised in August 2022] [Accessed on 7th January 2023]. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c50e8e36-42df-406b-8e63-eb8bf3f07e89
7. Accord. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 7th January 2023]. https://www.medicines.org.uk/emc/files/pil.5890.pdf
8. Sun Pharmaceutical Industries. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 7th January 2023]. https://www.medicines.org.uk/emc/files/pil.4339.pdf
9. Sanofi Ltd. Cardace Meto. Ramipril & Metoprolol Succinate Extended-Release Tablets. [Revised in October 2021] [Accessed on 7th January 2023]. https://www.sanofi.in/dam/jcr:dc1286a7-0e3d-4b7d-942d-14f37c6c3b70/CARDACE%20Meto-%20PI.pdf
10. Centrals Drugs Standard Control Organization. Metoprolol 50/50/25 mg + Atorvastatin20/10/10 mg + Ramipril 10/5/2.5 mg capsules. July 2009. [Accessed on 7th January 2023]. https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Kidney Function Test
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