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Introduction About METORAL 5MG TABLET
METORAL 5MG TABLET contains Metolazone which belongs to the group of medicines called Diuretics. It is used for the management of hypertension. Hypertension is defined as persistently increased blood pressure, that can show symptoms like headache, sweating, fast heartbeat, or throbbing sensation.
METORAL 5MG TABLET is also used to manage oedema accompanying congestive heart failure and renal failure. Fluid regularly drains into body tissues from the blood. When this fluid isn’t removed from the tissue, fluid retention (oedema) occurs, causing symptoms like swelling and aching of affected body parts such as feet, ankles, or hands.
Prior to the management, your doctor may want you to take several blood tests to understand your existing condition.
Avoid consumption of alcohol with METORAL 5MG TABLET as it may drop your blood pressure. METORAL 5MG TABLET is not recommended for patients who have an inability to urinate or electrolyte disbalance and have comatose condition due to liver cirrhosis.
Before taking METORAL 5MG TABLET inform your doctor if you have kidney disorder, rheumatism, diabetes, infection, eye problems, or you are about to have any surgery. METORAL 5MG TABLET is not recommended for use in pregnant and breast-feeding women. Consult with your doctor for advice.
Safety and effectiveness of METORAL 5MG TABLET in children have not been established. It should be used with caution in elderly with reduced kidney function. The most common side effects of taking METORAL 5MG TABLET are nausea, vomiting, congestion, diarrhoea, muscle cramps, headache, dizziness, and tiredness. Contact your doctor if any of the symptoms worsen.
Uses Of METORAL 5MG TABLET
To manage:
- fluid retention (oedema) in heart failure and kidney diseases
- hypertension
How METORAL 5MG TABLET Works
METORAL 5MG TABLET works by inhibiting sodium transport across the kidney resulting in a decrease in sodium reabsorption and an increase in sodium, chloride, and water excretion. This causes a decrease in the volume of fluid in the body and diuresis (increased urinary excretion) resolves fluid retention and contributing to the antihypertensive effect.
How to use METORAL 5MG TABLET
Take METORAL 5MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of METORAL 5MG TABLET
Common
- nausea, vomiting, congestion and diarrhea
- muscle cramps
- headache
- dizziness and tiredness
- low levels of potassium, sodium and chloride in the blood
- high levels of uric acid, urea and creatinine and sugar in the blood
- glucose in the urine
Uncommon
- reduced number of white blood cells (leukopenia)
- skin rash
- inflammation in the blood vessels
- gout
Rare
- reduced number of red blood cells and platelets in the blood
- high levels of calcium in the blood
- low levels of magnesium in the blood
- hepatitis, intrahepatic cholestasis (build up of bile in liver)
- kidney failure
Stop taking METORAL 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- reduced white blood cell count (flu-like symptoms, sore throat/pharynx/mouth, extreme tiredness, or urinary problems)
- a severe skin reaction (painful red area developing into large blisters then peeling of layers of skin)
How To Manage Side Effects
Diarrhea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Ask for your doctor’s advice if diarrhea doesn’t improve.
Nausea:
Take this medicine with or after meals. Stick to simple meals while taking this medicine. Avoid eating rich or spicy food. Do not take any medication on your own. Ask for your doctor’s advice if nausea doesn’t improve.
Headache:
Try to take rest and don’t involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your doctor’s advice if headache doesn’t improve
Vomiting:
Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, oily, or sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting doesn’t improve.
Dizziness:
Lie, or sit down immediately when you feel dizzy. If you're feeling severe episode of spinning(vertigo), lie in a dark and quite place with eyes closed. Try to avoid vehicle driving. Discuss with your doctor if the symptom worsens.
Warning & Precautions
Pregnancy
METORAL 5MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
METORAL 5MG TABLET is not recommended for use in breastfeeding women as it appears in breast milk. Consult your doctor before taking it.
Driving and Using Machines
The effects of METORAL 5MG TABLET on the ability to drive and use machines have not been studied. However, do not drive or operate any machines if you feel drowsy, dizzy or tired after taking it.
Alcohol
Avoid consumption of alcohol while taking METORAL 5MG TABLET as it may further drop your blood pressure and make you feel dizzy, feeble, and extremely tired.
Kidney
METORAL 5MG TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking it.
Liver
METORAL 5MG TABLET is not recommended in patients with liver diseases such as in cases of coma or comatose state which is due to liver cirrhosis. Consult your doctor before taking it.
Allergy
Do not take METORAL 5MG TABLET if you are allergic to Metolazone or any other ingredient of this medicine.
Others
METORAL 5MG TABLET is not recommended for use if you:
- are not able to urinate
- have a serious electrolyte imbalance in your blood
Before taking METORAL 5MG TABLET, inform your doctor if you:
- have diabetes or rheumatism
- have an infection (fever and serious deterioration of your general condition, or fever with sore throat/pharynx/mouth or urinary problems)
- are about to have any surgery
- reduced vision or eye pain
Use in pediatrics:
Safety and effectiveness of METORAL 5MG TABLET in children have not been established. Consult your doctor child’s before giving it to your child.
Use in geriatrics:
METORAL 5MG TABLET should be used with caution in elderly patients with kidney, liver or heart problems. Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking METORAL 5MG TABLET, inform your doctor if you are taking any of the following medicine:
- lithium (used to manage mood disorders)
- digoxin (used to manage heart insufficiency)
- medicines used to manage pain, fever, and inflammation (Ex. aspirin, naproxen)
- ciclosporin (used after organ transplantation)
- medicines used to manage heart problems like high blood pressure, heart failure (Ex. furosemide, hydrochlorothiazide, chlorthalidone, enalapril, captopril, sotalol, valsartan, telmisartan)
- warfarin (used to manage blood clotting)
- medicines used to manage high blood sugar levels (Ex. insulin, metformin, glyburide)
- medicines used to manage inflammation (Ex. prednisolone, hydrocortisone)
- Adrenocorticotropic Hormone (ACTH) (a pituitary hormone used to manage infections)
- medicines used to manage insomnia, anxiety, fits (Ex. phenobarbital, pentobarbital)
- medicines used to manage severe pain (Ex. codeine, morphine)
- medicines used to manage low blood pressure, asthma, glaucoma, and other diseases (Ex. amphetamine, ephedrine)
- methenamine (used to manage urinary tract infections)
- medicines used to manage infections (Ex. penicillin, sulfasalazine)
Overdosage:
If you or anyone else accidentally take too much of METORAL 5MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are thirst, nausea, vomiting, disorientation, dizziness, drowsiness, muscle cramps, low blood pressure and irregular heart rate (in severe cases).
Synopsis
| Drug | : | Metolazone |
| Pharmacological Category | : | Thiazide diuretics |
| Therapeutic Indication | : | Fluid retention, hypertension |
| Dosage Forms | : | Tablet |
More Information
- Keep METORAL 5MG TABLET out of reach of children
- Store METORAL 5MG TABLET below 30°C
FAQs About METORAL 5MG TABLET
What is METORAL 5MG TABLET used for?
METORAL 5MG TABLET is used to manage fluid retention (oedema) in heart failure and kidney diseases patients and to manage hypertension. It works by increasing the flow of urine by acting on the kidneys. This causes a decrease in the volume of fluid in the body as a result it resolves fluid retention and contributing to the blood pressure lowering effect.
Is METORAL 5MG TABLET used for hypertension?
Yes, METORAL 5MG TABLET reduces blood pressure by decreasing the amount of water present in the body by acting on the kidneys. This causes a decrease in the volume of fluid in the body, offering the antihypertensive effect.
What are the common side effects of METORAL 5MG TABLET?
The common side effects of METORAL 5MG TABLET include muscle or joint pain; numbness or tingly feeling in the limbs; nausea, stomach pain, loss of appetite; or. diarrhoea, constipation. Consult your doctor immediately if any of the symptoms worsen.
How often can I take METORAL 5MG TABLET?
Take METORAL 5MG TABLET as advised by doctor. Your doctor may adjust the dose based on the medical condition. Do not stop taking the medicine unless your doctor advice you to stop.
How long does the effect of METORAL 5MG TABLET last?
METORAL 5MG TABLET is slowly and incompletely absorbed from the gastrointestinal tract. When this medicine is given, its effect usually begins within one hour and may persist for 24 hours or more. For most patients, the duration of effect can be varied by adjusting the dose. High doses may prolong the effect. If you any have doubt, please consult your doctor for advice.
Should I drink more water while taking METORAL 5MG TABLET?
No, there is no need to alter the amount of fluid that you normally drink while taking METORAL 5MG TABLET. The normal amount of fluid intake is approximately 1.5 to 2 litres of fluid per day is sufficient to handle the water depletion caused by this medicine.
Can I change the dose of METORAL 5MG TABLET?
No, you should not change the prescribed dose of METORAL 5MG TABLET on your own. If you think the prescribed dose is not working effectively for you, please consult your doctor immediately. The doctor may alter it according to the condition.
What if I forget to take a dose of METORAL 5MG TABLET?
If you forget to take a dose of METORAL 5MG TABLET, take it as soon as you remember and do not take if it is almost time for your next dose schedule. Do not take the medicine twice to make up for the forgotten dose.
Can METORAL 5MG TABLET cause diarrhea?
Yes. Diarrhea is a common side effect of METORAL 5MG TABLET. Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine other than METORAL 5MG TABLET without asking your doctor. Inform your doctor if you have persistent diarrhea.
Will METORAL 5MG TABLET lower blood potassium levels?
Yes, METORAL 5MG TABLET might lower potassium level when larger doses are used, when there is a rapid increase in urine flow, in severe liver diseases, when corticosteroids are given together, and the oral intake is inadequate due to vomiting or diarrhea. To avoid this, blood potassium level should be determined at regular and appropriate intervals, and dose may be adjusted, also potassium supplementation can be used whenever needed as advised by your doctor.
Do I need to be monitored while taking METORAL 5MG TABLET?
Yes, while taking METORAL 5MG TABLET your doctor will monitor your kidney function and level of salts such as potassium and sodium in your blood to make sure that you are not losing too much water and electrolytes. They may advise you to adjust the doses of METORAL 5MG TABLET based on the results of these tests.
How does METORAL 5MG TABLET help for swollen ankles?
METORAL 5MG TABLET is thiazide diuretic or a water tablet. If your heart or kidneys are not functioning properly, the water might build up in your body (in legs) and cause swollen ankles. This medicine helps to get rid of the extra water from your body for better functioning of your heart and kidneys.
Will I feel dizzy after taking METORAL 5MG TABLET?
METORAL 5MG TABLET can cause sudden decrease in blood pressure. During such episodes you might feel dizzy when you first stand up from sitting or lying position. If you experience dizziness lie down until dizziness passes away and then move slowly and carefully. Consult your doctor immediately if your symptom worsens or does not improve.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Hypertension. Pharmacotherapy Handbook. Ninth edition. Page- 87.
2. Gretchen Bond; Ghufran Adnan; Anterpreet Dua; Karampal Singh; Cassie M. Crew. Metolazone. NIH National Library of Medicine, National center for biotechnology information. Nih.gov. February 2022. [Accessed on 12th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK534203/
3. G T McInnes, J R Shelton, R M Perkins, I R Harrison, J M Clarke. Use of a bioassay in healthy men to evaluate diuretic-spironolactone combinations. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 1983. [Accessed on 12th May 2022] https://pubmed.ncbi.nlm.nih.gov/6860532/
4. Metolazone. Formula Pharmazeutische und chemische Entwicklungs GmbH. [Revised in August 2021] [Accessed on 12th May 2022] https://docetp.mpa.se/LMF/Metolazon%20Abcur%20tablet%20ENG%20PL_09001bee807a5529.pdf
5. Lannett Company, Inc. U.S. Food & Drug Administration. [Revised in May 2019] [Accessed on 12th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/017386s043lbl.pdf
6. Eon Labs, Inc. Metolazone Tablets. Dailymed. [Revised in March 2022]. [Accessed on 12th May 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0b619826-2567-49d7-8972-b6da5e4467df
7. Centaur Pharma. Metolazone. [Revised in January 2021] [Accessed on 12th May 2022] https://www.centaurpharma.com/downloads/2021/nephrology/METOZ.pdf
8. Fluid retention (oedema). Better Health Channel. [Accessed on 12th May 2022] https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/Fluid-retention-oedema
Useful Diagnostic Tests
- Complete Blood Count (CBC)
- ECG
- Liver function test (LFT)
- Kidney function test (KFT)
- Serum electrolyte test
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