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Introduction About METHYCOBAL INJ 1ML(L)
METHYCOBAL INJ 1ML(L) contains Mecobalamin which belongs to the group of medicines called Vitamins. METHYCOBAL INJ 1ML(L) is used to manage diabetic neuropathy (nerve damage caused by diabetes), peripheral neuropathy (peripheral nerve damage that affects hands, feet and arms) and megaloblastic anaemia (blood disorder) caused by vitamin B12 deficiency in affected individuals.
METHYCOBAL INJ 1ML(L) is also used to manage sciatica pain (leg pain), back pain and general weakness in affected individuals.
METHYCOBAL INJ 1ML(L) is not recommended for use in patients allergic to mecobalamin and/or other B12 containing medicines.
Before receiving METHYCOBAL INJ 1ML(L), inform your doctor if you have Leber's disease (inherited form of vision loss) and/or suffering from low potassium level (with associated signs such as muscle twitches/cramps, low blood pressure), optic nerve disease (swelling and nerve damage to the eyes), kidney and/or liver problems.
METHYCOBAL INJ 1ML(L) is not recommended for use during pregnancy and in breastfeeding women. It should be used with caution in children & adolescents (aged 6 months to 18 years) and in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of receiving METHYCOBAL INJ 1ML(L) are headache, nausea, vomiting, diarrhoea, loss of appetite, skin rash and/or hot flushes. Consult your doctor if any of these side effects worsens.
Uses Of METHYCOBAL INJ 1ML(L)
- Manage diabetic and peripheral neuropathies
- Manage megaloblastic anaemia (caused by vitamin B12 deficiency)
- Manage sciatica pain (leg pain), back pain and general weakness in affected individuals.
How METHYCOBAL INJ 1ML(L) Works
METHYCOBAL INJ 1ML(L) works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from diabetic & peripheral neuropathy, sciatica pain and back pain in affected individuals. It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus managing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.
How to use METHYCOBAL INJ 1ML(L)
METHYCOBAL INJ 1ML(L) will be given to you only by a doctor or a nurse into a vein as an intravenous injection or into the muscle as an intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of METHYCOBAL INJ 1ML(L)
Common
- headache
- nausea, vomiting, diarrhoea, loss of appetite
- skin rash, hot flushes.
Rare
Stop receiving METHYCOBAL INJ 1ML(L) and contact your doctor immediately if you experience any of the following side effects:
- signs of severe allergic reaction such as wheezing, chest tightness, fever; itching, bad cough, blue/grey skin colour, seizures, swelling of face/lips/tongue/throat and/or swelling/pain in the leg/arm.
How To Manage Side Effects
Headache:
If METHYCOBAL INJ 1ML(L) causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving METHYCOBAL INJ 1ML(L). If it lasts more than a week or severe, inform your doctor.
Nausea and vomiting:
Receive METHYCOBAL INJ 1ML(L) with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Talk with your doctor if the condition worsens.
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult your doctor and inform them if the symptom gets worse.
Warning & Precautions
Pregnancy
METHYCOBAL INJ 1ML(L) is not recommended for use in pregnant women. Consult your doctor before receiving METHYCOBAL INJ 1ML(L).
Breastfeeding
METHYCOBAL INJ 1ML(L) is not recommended for use in breastfeeding women. Consult your doctor before receiving METHYCOBAL INJ 1ML(L).
Kidney
METHYCOBAL INJ 1ML(L) should be received with caution in patients with kidney problems. Consult your doctor before receiving the medicine.
Liver
METHYCOBAL INJ 1ML(L) should be received with caution in patients with liver problems. Consult your doctor before receiving the medicine.
Allergy
Do not receive METHYCOBAL INJ 1ML(L) if you are allergic to mecobalamin, other B12 containing medicines and/or any other ingredients of this medicine.
Others
Before receiving METHYCOBAL INJ 1ML(L), inform your doctor if you:
- have Leber's disease (inherited form of vision loss)
- have signs of low potassium level in blood such as muscle twitches/cramps, low blood pressure, faintness and/or excessive urination/thirst
- are suffering from optic nerve disease (swelling and nerve damage to the eyes).
Use in Paediatrics:
METHYCOBAL INJ 1ML(L) should be used with caution in children and adolescents (aged 6 months to 18 years). Consult your doctor before receiving METHYCOBAL INJ 1ML(L).
Use in Geriatrics:
METHYCOBAL INJ 1ML(L) should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving the medicine.
Interactions
A. Drug - Drug interactions:
Before receiving METHYCOBAL INJ 1ML(L), inform your doctor if you are receiving any of the following medicine:
- neomycin (used to prevent/manage bacterial skin infections)
- amino salicylic acid (used to manage tuberculosis)
- histamine H2-antagonists (used to manage recurrence of duodenal ulcers) Ex. ranitidine, famotidine
- colchicine (used in the management of gout)
- oral contraceptives (used to manage pregnancy) Ex. ethinyl estradiol and norethindrone
- chloramphenicol (used to manage bacterial infections)
- cimetidine (used to manage ulcers of stomach and intestines)
Overdosage:
METHYCOBAL INJ 1ML(L) will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Mecobalamin |
| Pharmacological Category | : | Vitamin B12 |
| Therapeutic Indication | : | Diabetic neuropathy, Peripheral neuropathy, Megaloblastic anaemia, General weakness, Sciatica pain, back pain |
| Dosage Forms | : | Tablet, Oral disintegrating strip, Injection, Prefilled Syringe, Nasal spray |
More Information
- Keep METHYCOBAL INJ 1ML(L) out of reach of children
- Store METHYCOBAL INJ 1ML(L) below 30°C
FAQs About METHYCOBAL INJ 1ML(L)
What is METHYCOBAL INJ 1ML(L) used for?
METHYCOBAL INJ 1ML(L) is used to manage diabetic neuropathy (nerve damage caused by diabetes), peripheral neuropathy (peripheral nerve damage that affects hands, feet and arms) and megaloblastic anaemia (blood disorder) caused by vitamin B12 deficiency. It is also used to manage sciatica pain (leg pain), back pain and general weakness in affected individuals.
How METHYCOBAL INJ 1ML(L) is received?
METHYCOBAL INJ 1ML(L) will be given to you only by a doctor or a nurse into a vein as an intravenous injection or into the muscle as an intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
What are the side effects of METHYCOBAL INJ 1ML(L)?
The most common side effects of receiving METHYCOBAL INJ 1ML(L) are headache, nausea, vomiting, diarrhoea, loss of appetite, skin rash and/or hot flushes. Consult your doctor if any of these side effects worsens.
How METHYCOBAL INJ 1ML(L) works?
METHYCOBAL INJ 1ML(L) works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from diabetic & peripheral neuropathy, sciatica pain and back pain in affected individuals. It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus managing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.
Does METHYCOBAL INJ 1ML(L) cause headache?
Yes, METHYCOBAL INJ 1ML(L) causes headache as it is the commonest side effect associated with the use of METHYCOBAL INJ 1ML(L). If such side effect experienced after receiving the medicine, then try to take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving METHYCOBAL INJ 1ML(L). If it lasts more than a week or severe, then inform your doctor.
References
1. KD. Tripathi. Drugs affecting blood and blood formation, Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 606.
2. Rabia G Sezer, Abdulkadir Bozaykut, Handan A Akoglu, Gül N Özdemir. The Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 Deficiency. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. March 2018. [Accessed on 4th November 2022] https://pubmed.ncbi.nlm.nih.gov/29189512/
3. Emmanuel Andrès, Thomas Vogel, Laure Federici, Jacques Zimmer, Ecaterina Ciobanu and Georges Kaltenbach. Cobalamin Deficiency in Elderly Patients: A Personal View. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. May 2008. [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672039/
4. Getz Pharma (Pvt) Ltd. Nervon. [Accessed on 4th November 2022] https://getzpharma.com/wp-content/uploads/2016/08/Nervon-Range-Leaflet-Export-GA.pdf
5. Cradle Life Science Pvt. Ltd. MUST Injection. [Accessed on 4th November 2022] https://cradlelifesciences.com/product.php
6. KINESIS BIOCARE. Vitkin-1500 INJECTION. [Accessed on 4th November 2022] https://www.kinesisbiocare.in/vitkin-1500-injection-methylcobalamin-1500mcg-injection--4429240.html
7. KINESIS BIOCARE. Vitkin-1500 INJECTION. [Accessed on 4th November 2022] https://www.kinesisbiocare.in/vitkin-1500-injection-methylcobalamin-1500mcg-injection--4429240.html
8. Integrated Laboratories Pvt Ltd. Methylcobalamin Injection. [Accessed on 4th November 2022] https://integratedlaboratories.in/methylcobalamin-injection-intebion-2500/#
Useful Diagnostic Tests
- Nerve conduction test
- Complete blood count
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