Metaspan Tablet 10'S

Introduction About METASPAN TABLET

METASPAN TABLET is a combination of L-Methylfolate, Methylcobalamin, and Pyridoxal Phosphate, which belongs to the group of medicines called Vitamins. It is used to manage endothelial dysfunction (large blood vessels on the heart's surface narrow instead of widening) or hyperhomocysteinemia (high levels of an amino acid called homocysteine) in patients who present with lower extremity ulceration.

METASPAN TABLET can also be used to promote optimum health and protect nerve cells in diabetic peripheral neuropathy. Diabetic neuropathy is nerve damage that occurs over time because of high sugar and fat levels in the blood due to diabetes. Symptoms depend on the type of neuropathy, such as pain and numbness in your feet or problems with organ functions like those of your heart and bladder.

Avoid smoking and drinking during management with METASPAN TABLET. METASPAN TABLET has not been proven safe or effective in children, so consult your doctor before using it.

Before taking METASPAN TABLET, inform your doctor if you have any other conditions or if you are taking any medicines. In pregnant and breastfeeding women, METASPAN TABLET should be used with caution.

The most common side effects of taking METASPAN TABLET are allergic reactions, acne, skin reactions, light sensitivity, nausea, vomiting, abdominal pain, loss of appetite, mild diarrhea, tingling or pricking sensation, sleepiness, headaches, polycythemia vera (a type of blood cancer), itching, temporary skin rash accompanied by fever, and swelling of the entire body. Consult your doctor if you experience any side effects or if your symptoms worsen.

Uses Of METASPAN TABLET

• Manage endothelial dysfunction or hyperhomocysteinemia
• Promotes optimum health
• Promotes nerve cells in diabetic peripheral neuropathy

How METASPAN TABLET Works

METASPAN TABLET helps protect nerve cells where L-methyl folate is a form of folate that increases levels of nitric oxide vasodilator, thus increasing blood flow to the peripheral nerves, methylcobalamin participates in many processes like the production of red and white blood cells, regeneration of RNA and DNA, synthesis of proteins, nerve cell and sheath maintenance, and maintenance of bone marrow, and pyridoxal-5-phosphate takes part in a wide range of biochemical reactions like the metabolism of amino acids and glycogen, the synthesis of nucleic acids, haemoglobin, and certain neurotransmitters.

How to use METASPAN TABLET

Take METASPAN TABLET as advised by your physician. Swallow with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of METASPAN TABLET for you according to your age, body weight, and disease condition.

Side Effects Of METASPAN TABLET

How To Manage Side Effects

Diarrhea

Drink lots of fluids, like water or fruit juice, to keep yourself hydrated. Ask your doctor before taking any medicine for diarrhea. If diarrhea does not improve, contact your doctor.

Headache

Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for headaches. If the headache does not improve, contact your doctor.loss

Loss Of Appetite

Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If your appetite does not improve, contact your doctor.

Nausea And Vomiting

Take METASPAN TABLET with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If nausea does not improve, contact your doctor.

Skin rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Warning & Precautions

Pregnancy

Use with Caution

METASPAN TABLET should be used with caution in pregnant women. Consult your doctor before taking it.

Breastfeeding

Consult your doctor

There is no information available about the distribution of METASPAN TABLET in breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or use any machines if you feel disturbed mental alertness and motor coordination after taking METASPAN TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking METASPAN TABLET.

Kidney

Consult your doctor

There is no information available about the use of METASPAN TABLET in patients with kidney failure. Consult your doctor before taking it.

Liver

Consult your doctor

There is no information available about the use of METASPAN TABLET in patients with liver impairment. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take METASPAN TABLET if you are allergic to L-Methylfolate, Methylcobalamin, Pyridoxal Phosphate, or any of the other ingredients of this medicine.

Use In Pediatrics

Consult your doctor

The safety and effectiveness of METASPAN TABLET in children have not been established. Consult your doctor before taking it.

Use In Geriatrics

Consult your doctor

The safety and effectiveness of METASPAN TABLET in elderly patients have not been established. Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking METASPAN TABLET, inform your doctor if you are taking any of the following medicines:

• pyrimethamine, pentamidine (used to manage parasitic infection)
• medicines used to manage fits (Ex. carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid, valproate, lamotrigine)
• levodopa (used for Parkinson’s disease)
• medicines used to manage bacterial infections (Ex erythromycin, cefixime)
• cholestyramine, colestipol (used to control blood cholesterol levels)
• colchicine (used to manage gout)
• metformin (used to manage diabetes)
• potassium chloride (used to manage potassium deficiency)
• nitrous oxide (used as general anaesthesia)
• methotrexate (used in certain types of cancer)
• sulfasalazine (used to manage inflammatory diseases like Crohn’s)
• pancreatic enzymes (pancrelipase, pancreatin)
• triamterene (used to manage fluid retention)
• trimethoprim (used to manage bacterial infections)
• warfarin (used to thin blood)

Overdosage:

If you or anyone else accidentally took too much of METASPAN TABLET, contact your doctor immediately.

Synopsis

More Information

FAQs About METASPAN TABLET

Q: Can I take other medicines with METASPAN TABLET?

A: Before taking METASPAN TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription, or any herbal medicine, as these might interact with each other and cause serious side effects. 

Q: Can I drive a car after taking METASPAN TABLET?

A: Activities like driving a car or operating machinery should be done cautiously after taking METASPAN TABLET, as they require complete mental alertness and motor coordination. Your doctor will tell you about these activities after assessing your response to the medicine.

Q: Does METASPAN TABLET cause vomiting?

A: Vomiting is a possible side effect of METASPAN TABLET. METASPAN TABLET. In such a case, get adequate rest and drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it; you do not need to eat or avoid any specific foods. Do not take any medicine for vomiting without asking your doctor. Tell your doctor if you have continuous vomiting.

Q: Can METASPAN TABLET be given to children?

A: The safety and efficacy of METASPAN TABLET in children have yet to be determined. Your doctor will determine the correct dose or select a suitable alternative management for your child.

Q: What if I forget to take a dose of METASPAN TABLET?

A: If you forget to take a dose of METASPAN TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take the medicine twice to make up for the forgotten dose.

Q: Can METASPAN TABLET be stopped?

A: Continue taking METASPAN TABLET until your doctor tells you to stop, unless you experience any unwanted effects, a worsening of your condition, or any new symptoms. Contact your doctor in such a case.

Q: Can METASPAN TABLET be crushed?

A: No. Do not break, crush, or chew METASPAN TABLET. Simply swallow it whole with a glass of water.

Q: What precautions do I need to follow while taking METASPAN TABLET?

A: Patients taking METASPAN TABLET must inform their doctor about their pre-existing conditions. Patients should also let their doctors know if they are pregnant, nursing, or allergic to anything. Consult your doctor if you experience anything different.

Q: Can METASPAN TABLET be taken during pregnancy?

A: In pregnant women, METASPAN TABLET should be used with caution. If you are pregnant, think you may be pregnant, or are planning to get pregnant, consult your doctor before taking this medicine. Inform your doctor immediately if you become pregnant during management with METASPAN TABLET.

Q: What is METASPAN TABLET used for?

A: METASPAN TABLET is used to manage endothelial dysfunction (large blood vessels on the heart's surface narrow instead of widening) or hyperhomocysteinemia (high levels of an amino acid called homocysteine) in patients who present with lower extremity ulceration. It can also be used to promote optimum health and protect nerve cells in diabetic peripheral neuropathy.

Q: What are the side effects of METASPAN TABLET?

A: The most common side effects of taking METASPAN TABLET are allergic reactions, acne, skin reactions, light sensitivity, nausea, vomiting, abdominal pain, loss of appetite, mild diarrhea, tingling or pricking sensation, sleepiness, headaches, polycythemia vera (a type of blood cancer), itching, temporary skin rash accompanied by fever, and swelling of the entire body. Consult your doctor if any of the side effects worsen.

References

1. KD Tripathi. Drugs Affecting Blood and Blood Formation. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 608.

2. Trippe BS, Barrentine LW, Curole MV, Tipa E. Nutritional management of patients with diabetic peripheral neuropathy with L-methyl folate-methylcobalamin-pyridoxal-5-phosphate: results of a real-world patient experience trial. NIH National Library of Medicine, National Center for Biotechnology Information. Pubmed.gov. 2016. [Accessed on 9th August 2024] https://pubmed.ncbi.nlm.nih.gov/26439233/

3. Pure and Cure Healthcare Pvt. Ltd. L-Methylfolate + Methylcobalamin + Pyridoxal phosphate. [Revised in January 2022] [Accessed on 9th August 2024] https://www.centaurpharma.com/downloads/2022/neurology/NURING%20ACTIVE.pdf

4. DM Pharma. L-Methylfolate + Methylcobalamin + Pyridoxal Phosphate + Vitamin D3. [Accessed on 9th August 2024] http://dmpharma.co.in/Methylcobalamin,%20L-Methylfolate,%20Pyridoxal-5-phosphate,%20Vitamin%20D3%20Tablet.html

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Complete Blood Count (CBC)/ Hemogram
• Liver Function Test (LFT)
• Kidney Function Test (KFT)
• Serum Electrolytes/ Electrolytes Profile
• Lipid Profile Test/Cholesterol-Total, Serum
• Healthy Midlife Checkup
• Men Health Checkup - Advanced
• Complete Women Checkup
• Full Body Checkup - Gold

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Shruthi Raikar - BDS

Last updated on 09 Aug 2024 | 05:42 PM(IST)