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Introduction About METAFOLATE TABLET
METAFOLATE TABLET contains a combination of Metformin and Myo Inositol, which belong to groups of medicines called antidiabetic agents and nutritional supplements, respectively. It is used in the management of polycystic ovarian syndrome (PCOS) in women. Polycystic ovarian syndrome is a hormonal disorder among women of reproductive age that causes the ovaries to enlarge, which manages the release of eggs at regular intervals. The symptoms may include menstrual irregularity, excess hair growth, acne, weight gain etc.
While taking METAFOLATE TABLET, your doctor will monitor your blood sugar level and kidney functions at regular intervals. During the course of management with METAFOLATE TABLET, your doctor may advise regular monitoring of blood sugar levels and kidney function. Before taking METAFOLATE TABLET, inform your doctor if you have liver, kidney, lung or heart problems or should undergo any surgery. Do not consume alcohol while taking METAFOLATE TABLET as it can worsen the side effects.
Inform your doctor if you are pregnant or breastfeeding before taking this medicine. METAFOLATE TABLET is not recommended for use by children. The most common side effects of taking METAFOLATE TABLET are nausea, changes in taste, diarrhoea, dizziness, stomach pain and loss of appetite.
Uses Of METAFOLATE TABLET
- Manage polycystic ovarian syndrome (PCOS) in women
How METAFOLATE TABLET Works
METAFOLATE TABLET is a drug that combines metformin and myo-inositol. Metformin enhances the body's sensitivity to insulin by decreasing the level of circulating insulin and producing a positive effect on the accumulated adipose (fat) tissue. Myo-inositol works by reducing insulin resistance and regulating hormonal imbalances. These types of actions aid in the control of polycystic ovarian syndrome symptoms and the regulation of the menstrual cycle.
How to use METAFOLATE TABLET
Take METAFOLATE TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
Side Effects Of METAFOLATE TABLET
Common
- taste change
- dizziness
- stomach pain
- nausea
- diarrhea
- loss of appetite
Rare
Stop taking METAFOLATE TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of lactic acidosis (vomiting, stomachache, muscle cramps, tiredness, difficulty breathing, reduced body temperature) as this condition may lead to coma
- changes in liver function tests or signs of inflamed liver hepatitis (tiredness, loss of appetite, weight loss, with or without yellowing of the skin or whites of the eyes)
How To Manage Side Effects
Nausea :
Stick to simple meals. Avoid eating oily or spicy foods. If your symptoms do not improve, consult your doctor.
Diarrhea:
Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Consult your doctor if your symptoms don’t improve.
Stomach pain:
Try to have smaller and more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, consult your doctor.
Loss of appetite:
Eat when you are hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If your symptoms do not improve, see your doctor.
Warning & Precautions
Pregnancy
The safety and effectiveness of METAFOLATE TABLET for use by pregnant women are not established. Consult your doctor before taking it.
Breastfeeding
METAFOLATE TABLET is not recommended for use by breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Avoid driving or using heavy machines if you feel weak, dizzy, have profuse sweating, faster heartbeat, have vision problems or have concentrating difficulties after taking METAFOLATE TABLET.
Alcohol
Do not consume alcohol while taking METAFOLATE TABLET as it can increase the impact of side effects.
Kidney
METAFOLATE TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney disease. Consult your doctor before taking it.
Liver
METAFOLATE TABLET is not recommended for use in patients with severe liver diseases. METAFOLATE TABLET should be used with caution in patients with mild to moderate liver disease. Consult your doctor before taking it.
Allergy
Do not take METAFOLATE TABLET if you are allergic to Metformin or Myo Inositol.
Lungs
METAFOLATE TABLET is not recommended for use in patients with a severe lung infection. Consult your doctor before taking it.
Heart Disease
METAFOLATE TABLET is not recommended for use in patients with acute heart failure, who recently had a heart attack, severe problems with circulation (such as shock) or who have breathing difficulties. Consult your doctor before taking it.
Others
METAFOLATE TABLET is not recommended for use if you:
- uncontrolled diabetes
Before taking METAFOLATE TABLET, inform your doctor if you:
- are undergoing any major surgery
Use in Pediatrics:
METAFOLATE TABLET is not recommended for use by children. Consult your doctor before taking it.
Use in Geriatrics:
Your doctor will decide the right dose depending on your kidney tests and disease condition. Consult your doctor before taking [GBNKEYORD].
Interactions
A. Drug-Drug interactions:
Before taking METAFOLATE TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to manage high blood pressure (Ex. propranolol, metoprolol)
- Medicines used in depression management (Ex. fluoxetine, amitriptyline)
- cholesterol-lowering agents (Ex. cholestyramine)
- fluorouracil (used in cancer management)
- sulfasalazine (used to manage stomach or duodenum ulcers)
- medicines used to relieve pain and inflammation (Ex. ibuprofen, celecoxib)
- medicine used to manage heart conditions (Ex. digoxin, digitalis)
- medicines used to provide relief from inflammation (Ex. prednisone, hydrocortisone)
Overdosage:
If you or anyone else accidentally take too much of METAFOLATE TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are lactic acidosis (vomiting, stomachache, muscle cramps, tiredness, difficulty breathing, reduced body temperature and heartbeat) as this condition may lead to coma.
Synopsis
| Drug | : | Metformin, Myo Inositol |
| Pharmacological Category | : | Biguanides, Nutraceutical products |
| Therapeutic Indication | : | Polycystic Ovarian Syndrome (PCOS) |
| Dosage Forms | : | Tablet |
More Information
- Keep METAFOLATE TABLET out of reach from children
- Store below 25°C
FAQs About METAFOLATE TABLET
What is METAFOLATE TABLET used for?
METAFOLATE TABLET is used to manage polycystic ovarian syndrome (PCOS) in women. Polycystic ovary syndrome (PCOS) is a hormonal disorder in women where the ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs.
Can METAFOLATE TABLET be used in patients with kidney disease?
No, METAFOLATE TABLET is not recommended for use in patients with severe kidney disease. Patients with mild to moderate disease should take this medicine with caution and regular monitoring of kidney function is needed, especially in the elderly.
How does METAFOLATE TABLET work?
METAFOLATE TABLET helps your body to utilise insulin and regulate menstrual cycles. Metformin decreases glucose production in the liver and improves insulin sensitivity. Myo-inositol increases insulin sensitivity (body cells utilise insulin effectively to produce glucose) and decreases hyperandrogenism (levels of the male hormone androgen are reduced).
What if I take more of METAFOLATE TABLET?
If you or anyone else takes more METAFOLATE TABLET, consult your doctor right away because you could develop lactic acidosis (vomiting, stomachache, muscle cramps, tiredness, difficulty breathing, reduced body temperature and decreased heartbeat) and end up in a coma.
Can I consume alcohol or drive while taking METAFOLATE TABLET?
No, do not consume alcohol while taking METAFOLATE TABLET as it can increase the side effects and do not drive or use machines as it can make you feel dizzy or sleepy, which affects your ability to drive.
References
1. KD Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of medical pharmacology. Eighth Edition. 2019. Page –299-300.
2. Philippe Merviel, Pandora James, Sarah Bouée, Mathilde Le Guillou, Camille Rince, Charlotte Nachtergaele & Véronique Kerlan. Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies [Revised in January 2021] [Accessed on 21st June 2022] https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-021-01073-3
3. R Dumitrescu, C Mehedintu, I Briceag, VL Purcarea and D Hudita. Metformin-Clinical Pharmacology in PCOs. [Accessed on 21st June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392089/
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 21st June 2022] https://www.medicines.org.uk/emc/files/pil.594.pdf
5. Myo inositol. Drugs.com. [Accessed on 27th June 2022] https://www.drugs.com/ingredient/inositol.html
Useful Diagnostic Tests
- Blood tests
- Kidney function test
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