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Introduction About MEROKWIK S 1000/500MG INJECTION
MEROKWIK S 1000/500MG INJECTION is a combination of Meropenem and Sulbactam which belong to the group of medicines called Antibiotics. It is used to manage serious bacterial infections of the respiratory tract (Ex. pneumonia, cystic fibrosis), urinary tract (Ex. cystitis), stomach, genital tract (Ex. postpartum infections), skin and soft tissues (Ex. abscess, cuts, wounds), brain (Ex. meningitis) and blood (Ex. sepsis). It can also be used to reduce fever and chills that is suspected to be a bacterial infection in patients with a weak immune system.
MEROKWIK S 1000/500MG INJECTION should be used under careful medical supervision. It will be given to you only by a doctor or a nurse into the vein. Make sure to receive therapy with MEROKWIK S 1000/500MG INJECTION for the stipulated duration instructed by your doctor. Stopping therapy or skipping doses in between therapy may not control infection effectively.
Before receiving MEROKWIK S 1000/500MG INJECTION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you previously experienced diarrhea after taking any antibiotics as a precaution.
Inform your doctor before receiving MEROKWIK S 1000/500MG INJECTION if you are pregnant, think you may be pregnant or planning to have a baby or breastfeeding. The most common side effects of receiving MEROKWIK S 1000/500MG INJECTION are stomach pain, nausea, vomiting, diarrhoea, headache, skin rash, pain or inflammation at the site of injection. Consult your doctor if any of these side effect worsens.
Uses Of MEROKWIK S 1000/500MG INJECTION
It is used to manage the following serious bacterial infections:
- Respiratory tract infections (Ex. bronchitis and pneumonia)
- Urinary tract infections (Ex. cystitis, cystourethritis, pyelonephritis)
- Genital tract infections (Ex. postpartum infections)
- Stomach infections
- Brain infections (Ex. meningitis)
- Blood infections (Ex. sepsis)
- Skin and soft tissue infections (Ex. abscess, cuts, wounds)
How MEROKWIK S 1000/500MG INJECTION Works
MEROKWIK S 1000/500MG INJECTION contains two medicines namely meropenem and sulbactam. Meropenem is a powerful antibiotic. It kills the susceptible bacteria by interfering with the bacterial cell wall synthesis. It is effective against a wide range of bacteria (including both gram-positive and gram-negative bacteria).
Sulbactam is a beta-lactamase inhibitor. It sustains the anti-bacterial activity of meropenem against the toxic bacterial proteins (such as beta lactamases). Collectively, these actions destroy the susceptible bacteria, manage their further growth and multiplication which in turn reduces the severity of the infection.
How to use MEROKWIK S 1000/500MG INJECTION
MEROKWIK S 1000/500MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of infection.
Side Effects Of MEROKWIK S 1000/500MG INJECTION
Common
- stomach pain
- nausea, vomiting
- diarrhoea
- headache
- skin rash, itchy skin
- injection site reactions (pain and inflammation)
Uncommon
- increased numbers of platelets
- tingling sensation
- fungal infection of mouth or vagina (a condition called thrush)
- bowel inflammation with diarrhoea
- swelling at injection site
- fever, sore throat
Rare
- fits
- delirium
Contact your doctor immediately if you experience any of the following side effects:
- signs of severe allergic reactions (such as skin rash, itching, swelling of the face, lips, throat or tongue causing difficulty in breathing or swallowing)
- severe skin reactions (such as widespread skin rash, blistering, peeling or bleeding on any part of the skin with fever, chills, enlarged lymph nodes and malaise or pink or reddish skin lesions on palms or soles)
- fever, skin rash, liver problems, increase in WBC count, enlarged lymph nodes
- breathlessness, red or brown urine
How To Manage Side Effects
Diarrhea
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Injection Site Reactions
Place an ice pack at the site of injection. Do not move the affected area. Consult your doctor if the symptom worsens.
Nausea And Vomiting
Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Skin rash Or Itching
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Warning & Precautions
Pregnancy
ContraindicatedMEROKWIK S 1000/500MG INJECTION is generally not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
Breastfeeding
Monitoring requiredMEROKWIK S 1000/500MG INJECTION may pass through the breast milk. Therefore, it should be used in breastfeeding women only if considered necessary by the physician.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by MEROKWIK S 1000/500MG INJECTION.
Kidney
Use with CautionMEROKWIK S 1000/500MG INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Liver
Use with CautionMEROKWIK S 1000/500MG INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
Allergy
Consult your doctorTalk to doctor before receiving MEROKWIK S 1000/500MG INJECTION if you are allergic to Meropenem, Sulbactam or to any other antibiotics (such as cephalosporins, penicillin antibiotics etc).
Others
Before receiving MEROKWIK S 1000/500MG INJECTION inform your doctor if you:
- previously experienced diarrhea after taking an antibiotic
- are going to undergo blood or urine tests (Coomb’s Test)
Use in Pediatrics:
MEROKWIK S 1000/500MG INJECTION is not recommended for children under the age of 3 months. Contact your doctor before receiving.
Use in Geriatrics:
There is no evidence of effects of MEROKWIK S 1000/500MG INJECTION on geriatric patients over the age of 65 years. Therefore, contact your doctor before receiving.
Interactions
A. Drug-Drug Interactions:
Before receiving MEROKWIK S 1000/500MG INJECTION, inform your doctor if you are taking any of the following medicine:
- Probenecid (medicine used to manage gout)
- Valproic acid, sodium valproate, valpromide (medicines used to manage epilepsy)
- Oral anti-coagulants such as warfarin, acenocoumarin, phenindione, dabigatran (medicines used to manage or manage blood clots)
Overdosage:
MEROKWIK S 1000/500MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, contact your doctor if you experience any unusual side effects.
Synopsis
| Drug | : | Meropenem, Sulbactam |
| Pharmacological Category | : | Carbapenems, Beta-lactamase Inhibitors |
| Therapeutic Indication | : | Serious Bacterial Infection |
| Dosage Forms | : | Injection |
More Information
- Keep MEROKWIK S 1000/500MG INJECTION out of the sight and reach of children
- Store MEROKWIK S 1000/500MG INJECTION at room temperature or in a refrigerator (2-8°C) based on the instructions given in the product label
FAQs About MEROKWIK S 1000/500MG INJECTION
Q: What is the use of MEROKWIK S 1000/500MG INJECTION?
A: MEROKWIK S 1000/500MG INJECTION is used to manage bacterial infections of the respiratory tract, urinary tract, genital tract, skin and soft tissues, stomach, biliary tract, blood and the brain. It can also be used to reduce fever and chills that is suspected to be a bacterial infection in patients with a weak immune system.
Q: How MEROKWIK S 1000/500MG INJECTION works in my body?
A: MEROKWIK S 1000/500MG INJECTION kills the susceptible bacteria by interfering with the bacterial cell wall synthesis. It is effective against a wide range of bacteria (including both gram-positive and gram-negative bacteria).
Q: Can MEROKWIK S 1000/500MG INJECTION be used in patients with kidney problems?
A: MEROKWIK S 1000/500MG INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Q: How MEROKWIK S 1000/500MG INJECTION is administered?
A: MEROKWIK S 1000/500MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously).
Q: For how long should I take MEROKWIK S 1000/500MG INJECTION?
A: Take MEROKWIK S 1000/500MG INJECTION for the stipulated duration as prescribed by your doctor. Do not skip the medicine or stop receiving it on your own as it may cause the infection to become severe.
Q: Can MEROKWIK S 1000/500MG INJECTION be given to pregnant women?
A: MEROKWIK S 1000/500MG INJECTION is generally not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
Q: What precautions should I follow while receiving MEROKWIK S 1000/500MG INJECTION?
A: Before receiving MEROKWIK S 1000/500MG INJECTION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you previously experienced diarrhea after taking any antibiotics or if you are pregnant or breastfeeding as a precaution
Q: What are the common side effects of receiving MEROKWIK S 1000/500MG INJECTION?
A: The most common side effects of receiving MEROKWIK S 1000/500MG INJECTION are stomach pain, nausea, vomiting, diarrhoea, headache, skin rash, pain or inflammation at the site of injection. Consult your doctor if any of these side effect worsens.
Q: Can I stop receiving MEROKWIK S 1000/500MG INJECTION once my symptoms subside?
A: Do not stop receiving MEROKWIK S 1000/500MG INJECTION once your symptoms subside. It is important to take the full course of MEROKWIK S 1000/500MG INJECTION to achieve better results. Failing to complete the full course of the therapy or skipping doses in between the therapy may not result in adequate infection control. It may also cause your symptoms to reappear.
Q: Can the use of MEROKWIK S 1000/500MG INJECTION cause diarrhea?
A: MEROKWIK S 1000/500MG INJECTION may cause diarrhea in some individuals. If you experience diarrhea, drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens contact your doctor immediately.
Q: What kind of infections that MEROKWIK S 1000/500MG INJECTION can manage?
A: MEROKWIK S 1000/500MG INJECTION is an antibiotic. It is used to manage infections caused by bacteria. It kills harmful bacteria by binding to the bacterial cell and interfering with cell wall synthesis. It can manage bacterial infections of the respiratory tract, urinary tract, genital tract, stomach, brain, blood and skin or soft tissues.
Q: Is MEROKWIK S 1000/500MG INJECTION a steroid?
A: No. MEROKWIK S 1000/500MG INJECTION is an antibiotic and not a steroid medicine.
Q: Can MEROKWIK S 1000/500MG INJECTION manage viral infections?
A: No. MEROKWIK S 1000/500MG INJECTION cannot manage viral infections. It manages only bacterial infections. It acts by killing the susceptible bacteria which are responsible for causing infections, and therefore not effective against any viral infections.
References
1. KD. Tripathi. Beta-lactam Antibiotics. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 725 & 731.
2. Mohammed Ali M. Marie. Lakshmana Gowda Krishnappa. Alhusain J. Alzahrani. Murad A. Mubaraki. Abdullah A. Alyousef. A prospective evaluation of synergistic effect of sulbactam and tazobactam combination with meropenem or colistin against multidrug resistant Acinetobacter baumannii. September 2015. [Accessed on 1st February 2023]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690438/
3. Milpharm Limited. Meropenem. Electronic Medicines Compendium (EMC). [Revised in July 2020] [Accessed on 1st February 2023]. https://www.medicines.org.uk/emc/files/pil.5067.pdf
4. Alkem Labs. Merosure. Meropenem Injection. [Revised in November 2019] [Accessed on 1st February 2023]. https://www.alkemlabs.com/pdf/adverse/Merosure%20Injection-125,%20250,%20500%20mg%20&%201%20gm.pdf
5. Zuventus Healthcare Ltd. Merotec XP Inj. [Accessed on 1st February 2023] http://www.zuventus.co.in/patient_wise_products_selected.aspx?Medi_Id=84
7. La Renon Healthcare Pvt Ltd. RUAJ-S-1.5. [Accessed on 1st February 2023]. https://www.larenon.com/wp-content/uploads/2019/01/6.-Ruaj-S-1.5.pdf
8. Leeford Healthcare Pvt Ltd. Meropace S. Meropenem + Sulbactam Injection. [Accessed on 1st February 2023]. https://www.leeford.in/product/176/meropace-s
9. Central Drugs Standard Control Organization. Meropenem IP 1000mg + Sulbactam sodium USP 500mg injection. March 2011. [Accessed on 1st February 2023]. https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Complete Blood Count (CBC)
- Renal Function Tests (RFT)
- Liver Function Tests (LFT)
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