Melapik Evernew Cream 20gm
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Introduction About MELAPIK EVERNEW CREAM
MELAPIK EVERNEW CREAM contains Allantoin, Tretinoin, Hydroquinone which belongs to the group of medicines called skin protectants, retinoids, demelanizing agents respectively. It is used in adults for the management of melasma (hyperpigmentation (excess melanin production) disorder with symptoms of symmetrical brown patches on sun exposed areas mainly on the face).
It is advised to reduce sun exposure during management with MELAPIK EVERNEW CREAM for better results. It is recommended to apply sunscreens and wear fully covering clothes while going out. Avoid smoking, exposing to open fire as MELAPIK EVERNEW CREAM contains ingredients that may flame and cause severe burns.
It is not advised to use MELAPIK EVERNEW CREAM if you have eczema, redness on the cheeks, nose, chin, or forehead (acne rosacea), sunburn or skin irritation with redness, sensitivity to sunlight, peeling or itching, irritation of skin around mouth, using any skin peeling agents, and allergic to any of the ingredients.
MELAPIK EVERNEW CREAM should be used with caution in patients with a personal or family history of skin cancer, inflammatory skin disorders along with acne (pimples), photo allergy, fair complexion, or sensitive skin. MELAPIK EVERNEW CREAM is not recommended to use in pregnant or breastfeeding women.
It is not recommended for use in elderly patients above 65 years of age and children below 18 years of age. Most common side effects of MELAPIK EVERNEW CREAM are skin dryness, itching, peeling, burning with pain, redness, and numbness. Consult your doctor if any of the symptoms are worsening.
Uses Of MELAPIK EVERNEW CREAM
- It is used to manage melasma
How MELAPIK EVERNEW CREAM Works
MELAPIK EVERNEW CREAM contains allantoin, hydroquinone, tretinoin. Hydroquinone is a skin bleaching agent that blocks enzyme tyrosinase which is responsible for the production of melanin that causes pigmentation. Thus, it helps in fading of dark spots in skin. Tretinoin helps to recover the damage to the skin caused by sun exposure (photodamage) by thickening skin layer and loss of keratinized cells. Allantoin also has keratolytic action that helps to remove excess keratinized skin layer and a moisturizing effect that helps to get rid of irritations caused by tretinoin.
How to use MELAPIK EVERNEW CREAM
Apply MELAPIK EVERNEW CREAM as advised by your physician. It is for external use only. Wash your hands before applying MELAPIK EVERNEW CREAM. Wash your face with a mild soap and dry properly. Apply MELAPIK EVERNEW CREAM as a thin layer on the affected area.
For better results do not apply any other fairness products for 1 hour after applying MELAPIK EVERNEW CREAM. It’s advised to use moisturizer on your face at least everyday morning to avoid dryness caused by medicine. Avoid contact with your eyes, nose, mouth, mucous membrane.
Reduce exposure to sunlight while using MELAPIK EVERNEW CREAM. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of MELAPIK EVERNEW CREAM
Common
- pain
- burning sensation
- tenderness
- skin peeling
- dry skin
- redness, numbness and irritation at applied area
Rare
Stop using MELAPIK EVERNEW CREAM and consult your doctor immediately if you experience any of the following side effects:
- rash, itchy skin, swelling of the lips, eyes, tongue, or difficulty in breathing may be signs of an allergic reaction
- blistering of skin
- feeling of bump or swelling in skin
- swelling or irritation in one eye or both eyes
- severe reddening of skin and peeling at the site of application
- increased sensitivity to sunlight
How To Manage Side Effects
Dry Skin
Drink plenty of water, milk, honey and stay hydrated. Apply sunflower oil, coconut oil ,aloe vera or petroleum jelly to moisturize skin. Take an oatmeal bath. Contact the doctor if it doesn't improve.
Skin Sensitivity
Apply cool compress or wet cloth over the burned area. Apply moisturizers if required. Contact the doctor if it is not subsiding.
Warning & Precautions
Pregnancy
ContraindicatedMELAPIK EVERNEW CREAM is not recommended to use if you are pregnant or planning to get pregnant as it may affect the unborn baby. Consult your doctor before using MELAPIK EVERNEW CREAM.
Breastfeeding
ContraindicatedMELAPIK EVERNEW CREAM is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before using MELAPIK EVERNEW CREAM to decide whether to discontinue nursing or to discontinue the medicine considering the benefit of breastfeeding to the child and the benefit of the MELAPIK EVERNEW CREAM to the mother.
Allergy
ContraindicatedDo not use MELAPIK EVERNEW CREAM if you are allergic to allantoin, hydroquinone, tretinoin or any other constituents of this medicine. Consult your doctor before using MELAPIK EVERNEW CREAM.
Others
MELAPIK EVERNEW CREAM is not recommended to use if you have:
- redness on the cheeks, nose, chin, or forehead (acne rosacea)
- sensitivity to sunlight
- peeling or itching , irritation of skin around mouth
- using any skin peeling agents
- inherited sensitivity to sunlight
- sunburns
- eczema or other chronic skin conditions of the face
- hypersensitivity to retinoids
Before using MELAPIK EVERNEW CREAM inform your doctor if you have:
- personal or family history of skin cancer
- inflammation of skin along with acne
- sensitive skin
- fair complexion
- photo allergy or hypersensitivity
Use in Paediatrics:
MELAPIK EVERNEW CREAM is not recommended to use in children and adolescents under 18 years of age. Consult your doctor before using MELAPIK EVERNEW CREAM.
Use in Geriatrics:
MELAPIK EVERNEW CREAM is not recommended in elderly people above 65 years of age as safety data has not been established yet. Consult your doctor before using MELAPIK EVERNEW CREAM.
Interactions
A. Drug – Drug interactions:
Before using MELAPIK EVERNEW CREAM inform your doctor if you are taking any of following medicines:
- medicines used to manage blood pressure (Ex. thiazides such as chlorthalidone, indapamide)
- medicines used to manage infections (Ex. tetracyclines, ciprofloxacin, ofloxacin, sulfadiazine etc)
- medicines used to manage emotional problems (Ex. phenothiazines like chlorpromazine, promazine etc)
- medicines used to manage skin infections (Ex. ketoconazole, fluconazole)
- medicine used to manage pimples (Ex. benzoyl peroxide)
- medicated soaps (Ex. triclosan, trichlor carbamide etc)
- permanent wave solutions (Ex. Thioglycolic acid)
- cleansers, shampoos, or cosmetics with a strong drying effect (sulphate, resorcinol, salicylic acid containing products)
- products with alcohol, spices, astringents, or lime
- chemical hair removers or waxes
- products that irritate skin (detergents, nail polish etc)
Overdosage:
If you or anyone else accidentally apply to much of MELAPIK EVERNEW CREAM, consult your doctor immediately. Symptoms include marked redness, peeling, or discomfort.
Synopsis
| Drug | : | Allantoin, Tretinoin, Hydroquinone |
| Pharmacological Category | : | Skin protectants, Retinoids, Demelanizing agents |
| Therapeutic Indication | : | Melasma |
| Dosage Forms | : | Cream, gel |
More Information
- Keep MELAPIK EVERNEW CREAM out of reach of children
- Store MELAPIK EVERNEW CREAM at room temperature
- Protect MELAPIK EVERNEW CREAM from light and moisture
FAQs About MELAPIK EVERNEW CREAM
Q. What is MELAPIK EVERNEW CREAM used for?
A. MELAPIK EVERNEW CREAM is used in adults for the management of melasma. Melasma is one of the most frequently acquired hyperpigmentation (excess melanin production) disorders with symptoms of symmetrical brown patches on sun exposed areas mainly on the face. The occurrence of melasma is more common in women at time of pregnancy or menopause. Consult a doctor before using MELAPIK EVERNEW CREAM.
Q. What are the common side effects of using MELAPIK EVERNEW CREAM?
A. Common side effects of MELAPIK EVERNEW CREAM are skin dryness, itching, peeling, burning with pain, redness, and numbness. Consult your doctor if any of the symptoms are worsening while using MELAPIK EVERNEW CREAM.
Q. How MELAPIK EVERNEW CREAM works?
A. MELAPIK EVERNEW CREAM contains allantoin, hydroquinone, tretinoin. Hydroquinone is a skin bleaching agent that blocks enzyme tyrosinase which is responsible for the production of melanin that causes pigmentation. Thus, it helps for the fading of dark spots in skin. Tretinoin helps to recover the damage to the skin caused by sun exposure (photodamage) by thickening skin layer and loss of keratinized cells. Allantoin also has keratolytic action that helps to remove excess keratinized skin layer. It has a moisturizing effect that helps to get rid of irritations caused by tretinoin.
Q. How to use MELAPIK EVERNEW CREAM?
A. Apply MELAPIK EVERNEW CREAM as advised by your physician. It is for external use only. Wash your hands before applying MELAPIK EVERNEW CREAM. Wash your face with a mild soap and dry properly. Apply as a thin layer on the affected area. For better results do not apply any other fairness products for 1 hour after applying MELAPIK EVERNEW CREAM. It’s advised to use moisturizer on your face at least everyday morning to avoid dryness caused by medicine. Avoid contact with your eyes, nose, mouth, mucous membrane. Reduce exposure to sunlight while using MELAPIK EVERNEW CREAM.
Q. When is MELAPIK EVERNEW CREAM not recommended?
A. MELAPIK EVERNEW CREAM is not recommended to use if you are pregnant, planning to get pregnant, breastfeeding. It is not advised to use MELAPIK EVERNEW CREAM if you have eczema, redness on the cheeks, nose, chin, or forehead (acne rosacea) , sunburn or skin irritation with redness, sensitivity to sunlight, peeling or itching , irritation of skin around mouth, using any skin peeling agents, and allergic to any of the ingredients. Consult a doctor before using.
Q. Can I smoke while using MELAPIK EVERNEW CREAM?
A. To avoid risk of severe burns it’s better to avoid smoking while using MELAPIK EVERNEW CREAM as it contains ingredients which are easily flammable.
References
1. Schwartz, Chelsea, Arif Jan, and Patrick M. Zito. Hydroquinone. In StatPearls [Internet]. StatPearls Publishing, 2022.[Revised in May 2022] [Accessed on 14th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK539693/
2. Pillaiyar, Thanigaimalai, Manoj Manickam, and Vigneshwaran Namasivayam. Skin whitening agents: Medicinal chemistry perspective of tyrosinase inhibitors.Journal of enzyme inhibition and medicinal chemistry. NIH, National library of medicine, National center for biotechnology information. Pubmed central. January 2017. [Accessed on 14th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010116/
3. T., F. Al-Niaimi, and F. R. Ali. Hydroquinone: myths and reality. Clinical and Experimental Dermatology [Revised in November 2020] [Accessed on 14th September 2022]. https://onlinelibrary.wiley.com/doi/abs/10.1111/ced.14480
4. LilyTalakoub, Isaac M.Neuhaus, Siegrid S.Yu. Cosmeceuticals .Cosmetic Dermatology The Requisites in Dermatology [Published in 2009 ][Accessed on 14th September 2022] https://www.sciencedirect.com/science/article/pii/B9780702031434100023, https://www.sciencedirect.com/topics/medicine-and-dentistry/allantoin
5. Szymanska, E.Allantoin-healing and anti-inflammatory properties. Pediatria i Medycyna Rodzinna [Accessed on 14th September 2022] https://www.researchgate.net/publication/289628507_Allantoin_-_Healing_and_anti-inflammatory_properties
6. KowichiJimbow, HirokoObata, Madhu A.Pathak,Thomas B.Fitzpatrick. Mechanism of depigmentation by hydroquinone. Journal of investigative dermatology [Accessed on 14th September 2022] https://www.sciencedirect.com/science/article/pii/S0022202X15442642
7. Nanda, Soni, Chander Grover, and Belum SN Reddy. Efficacy of hydroquinone (2%) versus tretinoin (0.025%) as adjunct topical agents for chemical peeling in patients of melasma.Dermatologic surgery [Revised in March 2004][Accessed on 14th September 2022] https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4725.2004.30106.x
8. Noble, Stuart, and Antona J. Wagstaff. Tretinoin.Drugs & Aging.[Revised in October 2012][Accessed on 14th September 2022] https://link.springer.com/article/10.2165/00002512-199506060-00008
9. Kang, Sewon. The mechanism of action of topical retinoids. Cutis. [Revised in February 2005][Accessed on 14th September 2022] https://europepmc.org/article/med/15773538
10. Ortho Pharmaceuticals, United States Food and Drug Administration (USFDA) [Revised in July 2012] [Accessed on 14th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021108s015lbl.pdf
11. Dailymed. hydroquinone 2%. [Revised in October 2020] [Accessed on 14th September 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2e53471e-ad03-4d6b-9384-4af374bb5f74
12. Dailymed. Tretinoin [Revised in January 2021] [Accessed on 14th September 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=745cc3ce-60b4-4479-a055-316817567949
13. Akema fine chemicals. Allantoin [Revised in March 2006] [Accessed on 14th September 2022] https://chemistscorner.com/cosmeticsciencetalk/uploads/editor/d0/7wqj5gds7r75.pdf
14. Akema fine chemicals. Allantoin [Revised in January 2019] [Accessed on 14th September 2022] https://www.akema.it/pdf/ALLANTOIN.pdf
15. GlaxoSmithKline Inc. Tretinoin [Revised in February 2021] [Accessed on 14th September 2022] https://ca.gsk.com/media/6123/stieva-a.pdf
16. Janssen Pharmaceutica NV. Tretinoin [Revised in March 2010] [Accessed on 14th September 2022] https://www.medical-specialists.co.uk/private-prescription/downloads/retin-a-PIL.16192.5.pdf
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