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Introduction About MCBM INJECTION
MCBM INJECTION contains Mecobalamin which belongs to the group of medicines called Vitamins. MCBM INJECTION is used to manage diabetic neuropathy (nerve damage caused by diabetes), peripheral neuropathy (peripheral nerve damage that affects hands, feet and arms) and megaloblastic anaemia (blood disorder) caused by vitamin B12 deficiency in affected individuals.
MCBM INJECTION is also used to manage sciatica pain (leg pain), back pain and general weakness in affected individuals.
MCBM INJECTION is not recommended for use in patients allergic to mecobalamin and/or other B12 containing medicines.
Before receiving MCBM INJECTION, inform your doctor if you have Leber's disease (inherited form of vision loss) and/or suffering from low potassium level (with associated signs such as muscle twitches/cramps, low blood pressure), optic nerve disease (swelling and nerve damage to the eyes), kidney and/or liver problems.
MCBM INJECTION is not recommended for use during pregnancy and in breastfeeding women. It should be used with caution in children & adolescents (aged 6 months to 18 years) and in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of receiving MCBM INJECTION are headache, nausea, vomiting, diarrhoea, loss of appetite, skin rash and/or hot flushes. Consult your doctor if any of these side effects worsens.
Uses Of MCBM INJECTION
- Manage diabetic and peripheral neuropathies
- Manage megaloblastic anaemia (caused by vitamin B12 deficiency)
- Manage sciatica pain (leg pain), back pain and general weakness in affected individuals.
How MCBM INJECTION Works
MCBM INJECTION works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from diabetic & peripheral neuropathy, sciatica pain and back pain in affected individuals. It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus managing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.
How to use MCBM INJECTION
MCBM INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or into the muscle as an intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of MCBM INJECTION
Common
- headache
- nausea, vomiting, diarrhoea, loss of appetite
- skin rash, hot flushes.
Rare
Stop receiving MCBM INJECTION and contact your doctor immediately if you experience any of the following side effects:
- signs of severe allergic reaction such as wheezing, chest tightness, fever; itching, bad cough, blue/grey skin colour, seizures, swelling of face/lips/tongue/throat and/or swelling/pain in the leg/arm.
How To Manage Side Effects
Headache:
If MCBM INJECTION causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving MCBM INJECTION. If it lasts more than a week or severe, inform your doctor.
Nausea and vomiting:
Receive MCBM INJECTION with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Talk with your doctor if the condition worsens.
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult your doctor and inform them if the symptom gets worse.
Warning & Precautions
Pregnancy
MCBM INJECTION is not recommended for use in pregnant women. Consult your doctor before receiving MCBM INJECTION.
Breastfeeding
MCBM INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving MCBM INJECTION.
Kidney
MCBM INJECTION should be received with caution in patients with kidney problems. Consult your doctor before receiving the medicine.
Liver
MCBM INJECTION should be received with caution in patients with liver problems. Consult your doctor before receiving the medicine.
Allergy
Do not receive MCBM INJECTION if you are allergic to mecobalamin, other B12 containing medicines and/or any other ingredients of this medicine.
Others
Before receiving MCBM INJECTION, inform your doctor if you:
- have Leber's disease (inherited form of vision loss)
- have signs of low potassium level in blood such as muscle twitches/cramps, low blood pressure, faintness and/or excessive urination/thirst
- are suffering from optic nerve disease (swelling and nerve damage to the eyes).
Use in Paediatrics:
MCBM INJECTION should be used with caution in children and adolescents (aged 6 months to 18 years). Consult your doctor before receiving MCBM INJECTION.
Use in Geriatrics:
MCBM INJECTION should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving the medicine.
Interactions
A. Drug - Drug interactions:
Before receiving MCBM INJECTION, inform your doctor if you are receiving any of the following medicine:
- neomycin (used to prevent/manage bacterial skin infections)
- amino salicylic acid (used to manage tuberculosis)
- histamine H2-antagonists (used to manage recurrence of duodenal ulcers) Ex. ranitidine, famotidine
- colchicine (used in the management of gout)
- oral contraceptives (used to manage pregnancy) Ex. ethinyl estradiol and norethindrone
- chloramphenicol (used to manage bacterial infections)
- cimetidine (used to manage ulcers of stomach and intestines)
Overdosage:
MCBM INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Mecobalamin |
| Pharmacological Category | : | Vitamin B12 |
| Therapeutic Indication | : | Diabetic neuropathy, Peripheral neuropathy, Megaloblastic anaemia, General weakness, Sciatica pain, back pain |
| Dosage Forms | : | Tablet, Oral disintegrating strip, Injection, Prefilled Syringe, Nasal spray |
More Information
- Keep MCBM INJECTION out of reach of children
- Store MCBM INJECTION below 30°C
FAQs About MCBM INJECTION
What is MCBM INJECTION used for?
MCBM INJECTION is used to manage diabetic neuropathy (nerve damage caused by diabetes), peripheral neuropathy (peripheral nerve damage that affects hands, feet and arms) and megaloblastic anaemia (blood disorder) caused by vitamin B12 deficiency. It is also used to manage sciatica pain (leg pain), back pain and general weakness in affected individuals.
How MCBM INJECTION is received?
MCBM INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or into the muscle as an intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
What are the side effects of MCBM INJECTION?
The most common side effects of receiving MCBM INJECTION are headache, nausea, vomiting, diarrhoea, loss of appetite, skin rash and/or hot flushes. Consult your doctor if any of these side effects worsens.
How MCBM INJECTION works?
MCBM INJECTION works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from diabetic & peripheral neuropathy, sciatica pain and back pain in affected individuals. It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus managing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.
Does MCBM INJECTION cause headache?
Yes, MCBM INJECTION causes headache as it is the commonest side effect associated with the use of MCBM INJECTION. If such side effect experienced after receiving the medicine, then try to take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving MCBM INJECTION. If it lasts more than a week or severe, then inform your doctor.
References
1. KD. Tripathi. Drugs affecting blood and blood formation, Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 606.
2. Rabia G Sezer, Abdulkadir Bozaykut, Handan A Akoglu, Gül N Özdemir. The Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 Deficiency. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. March 2018. [Accessed on 4th November 2022] https://pubmed.ncbi.nlm.nih.gov/29189512/
3. Emmanuel Andrès, Thomas Vogel, Laure Federici, Jacques Zimmer, Ecaterina Ciobanu and Georges Kaltenbach. Cobalamin Deficiency in Elderly Patients: A Personal View. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. May 2008. [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672039/
4. Getz Pharma (Pvt) Ltd. Nervon. [Accessed on 4th November 2022] https://getzpharma.com/wp-content/uploads/2016/08/Nervon-Range-Leaflet-Export-GA.pdf
5. Cradle Life Science Pvt. Ltd. MUST Injection. [Accessed on 4th November 2022] https://cradlelifesciences.com/product.php
6. KINESIS BIOCARE. Vitkin-1500 INJECTION. [Accessed on 4th November 2022] https://www.kinesisbiocare.in/vitkin-1500-injection-methylcobalamin-1500mcg-injection--4429240.html
7. KINESIS BIOCARE. Vitkin-1500 INJECTION. [Accessed on 4th November 2022] https://www.kinesisbiocare.in/vitkin-1500-injection-methylcobalamin-1500mcg-injection--4429240.html
8. Integrated Laboratories Pvt Ltd. Methylcobalamin Injection. [Accessed on 4th November 2022] https://integratedlaboratories.in/methylcobalamin-injection-intebion-2500/#
Useful Diagnostic Tests
- Nerve conduction test
- Complete blood count
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