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Introduction About MAHAGABA MNT TABLET
MAHAGABA MNT TABLET is a combination of Methylcobalamin, Nortriptyline and Pregabalin which belongs to the group of medicines called Vitamins, Antidepressants and Anticonvulsants respectively. It is used to manage diabetic peripheral neuropathic pain with coexistent vitamin B12 deficiency.
Neuropathic pain is a form of pain where there is a damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body.
Patients taking MAHAGABA MNT TABLET may have thoughts of harming or killing themselves. If at any time you have these thoughts, immediately consult your physician. Avoid consumption of alcohol during management with MAHAGABA MNT TABLET as it may cause dizziness.
Before taking MAHAGABA MNT TABLET, inform your physician if you have liver or kidney problems, diabetes and angioedema. MAHAGABA MNT TABLET is not recommended for use in pregnant women unless advised by the doctor and not recommended for breast-feeding women.
Elderly patients above 65 years of age always should consult the physician before taking it. The most common side effect of MAHAGABA MNT TABLET are dry mouth, dizziness, sleepiness, blurred vision and weight gain. Consult your doctor if any of the side effects worsen over the time.
Uses Of MAHAGABA MNT TABLET
- Manage diabetic peripheral neuropathic pain with coexistent vitamin B12 deficiency
How MAHAGABA MNT TABLET Works
MAHAGABA MNT TABLET is a combination of methylcobalamin, nortriptyline and pregabalin, where methylcobalamin is a form of vitamin B that helps in the production of myelin (a substance that protects nerve fibers) and regenerates damaged nerve cells. Nortriptyline is a tricyclic antidepressant that increases the chemical messenger levels (serotonin and noradrenaline) that stops the movement of pain signals in the brain. Pregabalin is an anticonvulsant (alpha 2 delta ligand) that decreases pain by altering the calcium channel activity of the nerve cells. Together, methylcobalamin, nortriptyline and pregabalin helps to relieve neuropathic pain (pain from damaged nerves).
How to use MAHAGABA MNT TABLET
Always take MAHAGABA MNT TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of MAHAGABA MNT TABLET for you depending upon your age, body weight and disease condition. Do not stop taking MAHAGABA MNT TABLET without informing your doctor.
Overdose
If you or anyone else accidentally takes too much of MAHAGABA MNT TABLET, consult your physician immediately or visit the nearby hospital.
Side Effects Of MAHAGABA MNT TABLET
Common side effects of MAHAGABA MNT TABLET:
- dizziness, sleepiness
- trouble concentrating, blurry vision
- dry mouth
- weight gain
- swelling of your hands or feet
Stop taking MAHAGABA MNT TABLET and contact your physician immediately if you experience any of the following side effects:
- hypersensitivity or allergic reactions (symptoms include skin redness, blisters, hives, rash, dyspnoea and wheezing)
- have feelings of harming or killing themselves
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom does not improve.
Dry Mouth
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
Consult your doctorMAHAGABA MNT TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it.
Breastfeeding
ContraindicatedMAHAGABA MNT TABLET is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your physician before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate heavy machines if you experience dizziness while taking MAHAGABA MNT TABLET. Consult with your physician for advice before taking the medicine.
Alcohol
ContraindicatedConsumption of alcohol is not recommended during management with MAHAGABA MNT TABLET as it may cause dizziness.
Kidney
Use with CautionMAHAGABA MNT TABLET should be used with caution in patients with kidney problems. Consult with your doctor for advice before taking MAHAGABA MNT TABLET.
Liver
Use with CautionMAHAGABA MNT TABLET should be used with caution in patients with liver problems. Consult with your doctor for advice before taking MAHAGABA MNT TABLET.
Allergy
ContraindicatedDo not take MAHAGABA MNT TABLET if you are allergic to Methylcobalamin, Nortriptyline, Pregabalin or any other ingredients of this medicine.
Use In Geriatrics
Use with CautionMAHAGABA MNT TABLET should be used with caution in elderly patients above 65 years of age. Consult with your physician for advice before taking MAHAGABA MNT TABLET.
Other Warnings for MAHAGABA MNT TABLET
Before taking MAHAGABA MNT TABLET, inform your physician if you have:
- angioedema
- diabetes
- major depressive disorder
Drug - Drug interaction
Before taking MAHAGABA MNT TABLET inform your physician if you are taking any of the following medicines:
- medicines used as opioid analgesics such as oxycodone, tramadol (used to manage severe pain)
- medicine used to manage depression and anxiety (Ex. lorazepam, diazepam, MAO inhibitors like isocarboxazid)
- medicines used to manage gastroesophageal reflux (Ex. cimetidine, ranitidine)
- oral contraceptives such as desogestrel and ethinyl estradiol (used to manage pregnancy)
- medicines used for cancer chemotherapy (Ex. arsenic trioxide)
- medicines used to manage bacterial infections (Ex. chloramphenicol, azithromycin, clarithromycin and linezolid)
- reserpine (used to manage high blood pressure)
- anticholinergic drugs such as dicyclomine (used to manage the symptoms of irritable bowel syndrome)
- sympathomimetic drugs such as norepinephrine (used to raise blood pressure in emergency condition)
Synopsis
|
Drug |
Methylcobalamin, Nortriptyline, Pregabalin |
|
Pharmacological Category |
Vitamin, Tricyclic antidepressant and Anticonvulsant |
|
Therapeutic Indication |
Neuropathic Pain |
|
Dosage Forms |
Capsule, Tablet |
More Information
Storage
- Keep MAHAGABA MNT TABLET out of reach to children
- Store at room temperature
FAQs About MAHAGABA MNT TABLET
Q: When to seek medical emergency while taking MAHAGABA MNT TABLET?
A: Stop taking MAHAGABA MNT TABLET and contact your physician immediately if you experience angioedema (symptoms include swelling of the face, mouth (tongue, lips and gums) and neck (throat and larynx)) and have thoughts of harming or killing themselves.
Q: What to do If I forget to take a dose of MAHAGABA MNT TABLET?
A: You should take MAHAGABA MNT TABLET immediately when you remember. If it is time for the next dose skip the missed dose and follow the regular dose schedule. Do not double the dose to match up the missed dose.
Q: Does MAHAGABA MNT TABLET impair my ability to drive?
A: Yes, MAHAGABA MNT TABLET may cause dizziness, do not drive or operate any machines which require concentration because it can impair your ability to work. Follow appropriate precautions before driving or you may ask someone to drive for you after consulting with your physician.
Q: What is the precaution to be followed before taking MAHAGABA MNT TABLET?
A: MAHAGABA MNT TABLET is not recommended to use among women who are breast-feeding and pregnant unless advised by the doctor. Before taking MAHAGABA MNT TABLET, inform your physician if you have liver or kidney problems, diabetes and angioedema. It should be used with caution in elderly patients.
Q: Can MAHAGABA MNT TABLET be used in patients with liver or kidney problems?
A: MAHAGABA MNT TABLET should be used with caution in patients with kidney or liver problems. Your doctor may monitor your liver and kidney function test to manage the risk of any unusual effects. Consult your doctor before taking it.
References
1. KD. Tripathi. Drugs affecting blood and blood formation. Skeletal Muscle Relaxants. Drugs Used in Mental Illness: Antidepressant and Antianxiety. Antiepileptic Drugs. Drugs Essentials of medical pharmacology. Seventh edition. 2013. Page – 608, 457, 421.
2. Ram Prabhoo, Atul Panghate, Raj Pavitra Dewda, Balaji More, Tanay Prabhoo, and Rajiv Rana. Efficacy and Tolerability of a Fixed-Dose Combination of Methylcobalamin and Pregabalin in the Management of Painful Neuropathy. North American Journal of Medical Sciences. NIH. National Library of Medicine, National center for biotechnology information. Pubmed Central. November 2012. [Accessed on 21st July 2026] 
3. Sheena Derry, Philip J Wiffen, Dominic Aldington, R Andrew Moore. Nortriptyline for neuropathic pain in adults. Cochrane Database of Systematic Reviews. NIH. National Library of Medicine, National center for biotechnology information. Pubmed Central. January 2015 [Accessed on 21st July 2026] 
4. Leeford Health Care. Pregabanyl-NTM. [Accessed on 21st July 2026]
5. Akesiss Ltd. Norblend tablet. [Accessed on 21st July 2026]
6. Krishlar Pharmaceuticals. Kritpre-NP. [Accessed on 21st July 2026]
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