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INTRODUCTION
MAGNEX FORTE 3.0GM INJECTION is a combination of Cefoperazone and Sulbactam which belongs to the group of medicines called Antibiotics. It is used to treat various bacterial infections such as respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicemia (serious bloodstream infection), meningitis (inflammation of brain and spinal cord membranes, typically caused by an infection), skin and soft tissue infections.
It is also used to treat bone and joint infections, gonorrhea (sexually transmitted bacterial infection), endometritis (inflammation of the uterine lining due to infection), pelvic inflammatory disease (infection of the female reproductive organs) and other infections of the genital tract.
Bacterial infections are caused by multiplication of specific harmful strain of bacteria anywhere in the body. It is characterized by symptoms such as fever, nausea, vomiting, headache tiredness and swollen lymph nodes in the neck, armpits, groin or elsewhere.
Before receiving MAGNEX FORTE 3.0GM INJECTION, inform your doctor if you have impaired kidney function, severe biliary obstruction (blockage of the bile ducts), severe liver disease, malabsorption conditions and have schedule for laboratory tests (such as measuring glucose in the urine).
MAGNEX FORTE 3.0GM INJECTION should be used with caution in pregnant and breastfeeding women only if advised by the doctor. Also, it should be used with caution in children and elderly patients.
The most common side effects of receiving MAGNEX FORTE 3.0GM INJECTION are diarrhea, nausea and vomiting. Inform your doctor if any of these side effects bothers you.
USES OF MAGNEX FORTE 3.0GM INJECTION
Treats bacterial infections such as:
- respiratory tract infections
- urinary tract infections (upper and lower)
- intra-abdominal infections
- septicemia
- meningitis
- skin and soft tissue infections
- bone and joint infections
- pelvic inflammatory disease
- endometritis
- gonorrhea
- other infections of the genital tract
HOW MAGNEX FORTE 3.0GM INJECTION WORKS
MAGNEX FORTE 3.0GM INJECTION contains cefoperazone and sulbactam. Cefoperazone works by stopping the formation of bacterial cell coverings, which makes the bacteria susceptible for killing. Sulbactam works by reducing bacterial resistance and enhancing the activity of cefoperazone against the bacteria. Together, they helps to treat various bacterial infections.
DIRECTIONS FOR USE
MAGNEX FORTE 3.0GM INJECTION will be given to you only by a doctor or a nurse, either into the vein (intravenously) or muscle (intramuscularly). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of the infection.
SIDE EFFECTS OF MAGNEX FORTE 3.0GM INJECTION
COMMON
- diarrhea
- nausea, vomiting
- coagulopathy (impairment in the blood's ability to clot)
UNCOMMON
- headache
- itching
- raised red rashes (urticaria)
- pain or inflammation of a vein at the site of injection
- fever, chills
RARE
Inform your doctor immediately if you experience any of the following side effects after receiving MAGNEX FORTE 3.0GM INJECTION:
- allergic reactions
- skin reactions such as toxic epidermal necrolysis, stevens-johnson syndrome, dermatitis exfoliative (signs include blistering and peeling of the skin)
- persistent bleeding
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take regular sips of cold drink. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. If nausea does not improve, inform your doctor.
Headache:
Apply hot or cold-water bag on your head. Drink plenty of fluids. Try taking rest in a quiet and dark room. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the headache does not reduce.
Diarrhea:
Keep yourself hydrated by drinking lot of fluids such as water or fruit juices. If the symptom does not improve, inform your doctor.
WARNING & PRECAUTIONS
PREGNANCY
MAGNEX FORTE 3.0GM INJECTION should be used during pregnancy only if considered clearly necessary Consult your doctor before receiving MAGNEX FORTE 3.0GM INJECTION.
BREASTFEEDING
MAGNEX FORTE 3.0GM INJECTION should be used with caution in breast-feeding women as small amount of this medicine is excreted in the breast milk. Consult your doctor before receiving MAGNEX FORTE 3.0GM INJECTION.
DRIVING AND USING MACHINES
MAGNEX FORTE 3.0GM INJECTION does not affect your ability to drive or use machinery.
ALCOHOL
Avoid consuming alcohol while receiving MAGNEX FORTE 3.0GM INJECTION because it may cause flushing, sweating, headache and increase in the heartbeat.
KIDNEY
MAGNEX FORTE 3.0GM INJECTION should be used with caution in patients with impaired kidney function. Consult your doctor before receiving MAGNEX FORTE 3.0GM INJECTION.
LIVER
MAGNEX FORTE 3.0GM INJECTION should be used with caution in patients with severe biliary obstruction (blockage of the bile ducts) and severe liver disease. Consult your doctor before receiving MAGNEX FORTE 3.0GM INJECTION.
ALLERGY
Do not receive MAGNEX FORTE 3.0GM INJECTION if you are allergic to cefoperazone, sulbactam, beta-lactam antibiotics (such as penicillins and cephalosporins (Ex. cefuroxime)) or any other ingredients of this medicine.
OTHERS
Before receiving MAGNEX FORTE 3.0GM INJECTION, inform your doctor if you:
- have poor diet and malabsorption conditions
- have any scheduled laboratory tests (such as measuring glucose in the urine)
Use in pediatrics:
MAGNEX FORTE 3.0GM INJECTION should be used with caution in children. Your child’s doctor may adjust the dose depending upon child’s body weight. Consult your child’s doctor for advice.
Use in geriatrics:
MAGNEX FORTE 3.0GM INJECTION should be used with caution in elderly patients. Consult your doctor before receiving it.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving MAGNEX FORTE 3.0GM INJECTION, inform your doctor if you are taking any of the following medicines:
- medicines used to treat bacterial infections such as aminoglycosides (Ex. gentamicin, tobramycin, amikacin and streptomycin)
- oral anti-coagulants (Ex. warfarin) (used to prevent or treat blood clots)
Overdosage:
MAGNEX FORTE 3.0GM INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms such as neurologic effects (such as fits).
SYNOPSIS
| Drug | : | Cefoperazone, Sulbactam |
| Pharmacological Category | : | Cephalosporin; Beta-lactamase inhibitors |
| Therapeutic Indication | : | Various bacterial infections |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Store below 25°C and protect from light
FAQs ABOUT MAGNEX FORTE 3.0GM INJECTION
What is MAGNEX FORTE 3.0GM INJECTION used for?
MAGNEX FORTE 3.0GM INJECTION is a combination of Cefoperazone and Sulbactam which belongs to the group of medicines called antibiotics. It is used to treat several bacterial infections such as respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicemia, meningitis, skin and soft tissue infections, bone and joint infections, gonorrhea, endometritis, pelvic inflammatory disease and other infections of the genital tract.
How does MAGNEX FORTE 3.0GM INJECTION work?
MAGNEX FORTE 3.0GM INJECTION contains cefoperazone and sulbactam. Cefoperazone works by stopping the formation of bacterial cell coverings, which makes the bacteria susceptible for killing. Sulbactam works by reducing bacterial resistance and enhancing the activity of cefoperazone against the bacteria. Together, they helps to treat various bacterial infections.
How MAGNEX FORTE 3.0GM INJECTION is administered?
MAGNEX FORTE 3.0GM INJECTION will be given to you only by a doctor or a nurse, either into the vein (intravenously) or muscle (intramuscularly). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of the infection.
Is MAGNEX FORTE 3.0GM INJECTION safe to use in patients with liver disease?
MAGNEX FORTE 3.0GM INJECTION should be used with caution in patients with severe biliary obstruction (blockage of the bile ducts) and severe liver disease. Consult your doctor for advice before receiving MAGNEX FORTE 3.0GM INJECTION.
What are the common side effects of MAGNEX FORTE 3.0GM INJECTION?
The most common side effects of receiving MAGNEX FORTE 3.0GM INJECTION are diarrhea, nausea, vomiting and coagulopathy (impairment in the blood's ability to clot). Inform your doctor if any of these side effects bothers you.
REFERENCES
1. Conan MacDougall. Penicillins, Cephalosporins and Other Beta-Lactam Antibiotics. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical, 2018. Page – 1023-1038.
2. Lan, Shao-Huan, Shen-Peng Chang, Chih-Cheng Lai, Li-Chin Lu and Hung-Jen Tang. Efficacy and safety of cefoperazone-sulbactam in empiric therapy for febrile neutropenia: A systemic review and meta-analysis. National Library of Medicine. February 2020. [Accessed on 4th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034635/
3. Chiang, Tsung-Ta, Hung-Jen Tang, Cheng-Hsun Chiu, Te-Li Chen, Mao-Wang Ho, Chen-Hsiang Lee, Wang-Huei Sheng and Ya-Sung Yang.Antimicrobial activities of cefoperazone-sulbactam in comparison to cefoperazone against clinical organisms from medical centers in Taiwan. Journal of Medical Sciences. December 2016. [Accessed on 4th June 2022] https://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2016;volume=36;issue=6;spage=229;epage=233;aulast=Chiang;aid=JMedSci_2016_36_6_229_196365
4. Pfizer Limited. Electronic Medicines Compendium (EMC). [Revised in April 2020] [Accessed on 4th June 2022] https://labeling.pfizer.com/ShowLabeling.aspx?id=14800#:~:text=mEq)%20per%20gram.-,Sulbactam%20is%20an%20off%2Dwhite%20crystalline%20powder%20which%20is%20highly,(1.5%20mEq)%20per%20gram.
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
- Bacterial culture test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 12 Nov 2022 | 06:26 PM(IST)