M Cold CZ Tablet 10'S

Introduction About M COLD CZ TABLET

M COLD CZ TABLET is a combination of Cetirizine and Phenylephrine which belongs to the group of medicines called Anti-allergics and Nasal Decongestants respectively. It is indicated for the relief of symptoms of nasal congestion and allergic rhinitis.

M COLD CZ TABLET is not recommended for use in patients with coronary artery disease, impaired liver function and severely increased blood pressure. M COLD CZ TABLET should be used with caution in patients who have spinal cord lesion, prostatic hyperplasia (enlarged prostate), epilepsy and Raynaud’s syndrome.

M COLD CZ TABLET should be used with caution in pregnant women only if advised by the doctor and it is not recommended for use in breast feeding women. This medicine is not recommended for use in children (below 12 years of age).

The side effects of taking M COLD CZ TABLET are diarrhea, general discomfort, abnormal physical weakness, rash and itching. Talk with your doctor if any of the symptoms worsen or does not improve.    

Uses Of M COLD CZ TABLET

• Relieves symptoms of nasal congestion and allergic rhinitis

How M COLD CZ TABLET Works

M COLD CZ TABLET helps in relieving the symptoms of nasal congestion and allergic rhinitis where Cetirizine is a H1 receptor antagonist that works by blocking the action of a chemical messenger (histamine) responsible for runny nose, watery eyes and sneezing. It also has an anti-inflammatory action. Phenylephrine is a decongestant which acts by narrowing the small blood vessels providing temporary relief from congestion or stuffiness in the nose.

How to use M COLD CZ TABLET

Always take M COLD CZ TABLET as directed by your physician. Take this medicine with or without food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration of M COLD CZ TABLET for you depending upon your age, body weight and disease condition. Do not stop taking M COLD CZ TABLET without informing your doctor.  

Side Effects Of M COLD CZ TABLET

How To Manage Side Effects

Diarrhoea:

Drink lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Consult your doctor if the symptom does not improve.

Skin itching:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Avoid sun exposure or UV rays as it may sensitize your skin. Use sunscreen and protective clothing when going outdoor. Regularly moisturize your skin after consulting the doctor. Consult your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

M COLD CZ TABLET should be used with caution in pregnant women only if considered clearly necessary. Consult with your doctor for advice before taking M COLD CZ TABLET.

Breastfeeding

M COLD CZ TABLET is not recommended for use in breast-feeding women as it passes through the breast milk. Consult with your doctor for advice before taking M COLD CZ TABLET.

Alcohol

Consumption of alcohol is not recommended during management with M COLD CZ TABLET.

Kidney

Dose adjustment of M COLD CZ TABLET is needed in patients having moderate or severe kidney disease. Consult with your doctor for advice before taking M COLD CZ TABLET.

Liver

M COLD CZ TABLET is not recommended for use in patients with liver dysfunction. Consult with your doctor for advice before taking M COLD CZ TABLET.

Allergy

Do not take M COLD CZ TABLET if you are allergic to Cetirizine and Phenylephrine or hydroxyzine.

Heart Disease

M COLD CZ TABLET is not recommended for use in patients having heart diseases such as coronary artery disease (disease of the major blood vessels of the heart). Consult with your doctor for advice before taking M COLD CZ TABLET.

Interactions

A. Drug–Drug Interactions:

Before taking M COLD CZ TABLET inform to your doctor, if you are taking any of these medicines:

• monoamine oxidase inhibitors such as isocarboxazid, tricyclic antidepressants such as amitriptyline, nortriptyline (used to manage depression)
• digoxin, vasodilators such as hydralazine, minoxidil, beta blockers such as propranolol (used to manage heart problems)
• pseudoephedrine, sympathomimetic amines such as xylometazoline (used to relieve nasal congestion)
• theophylline (used to manage asthma)

Overdosage:

If you or anyone else accidentally take too much of M COLD CZ TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of M COLD CZ TABLET includes irritability, restlessness, palpitations, high blood pressure, difficulty in urination, nausea, vomiting, thirst, convulsions, confusion, diarrhoea, dizziness, tiredness, headache, general discomfort, dilated pupils, itching, sedation, sleepiness, altered consciousness, fast heart rate, tremor and urinary retention.

Synopsis

More Information

• Keep M COLD CZ TABLET out of reach of children
• Store at room temperature

FAQs About M COLD CZ TABLET

What is M COLD CZ TABLET and why is it given?

M COLD CZ TABLET is a combination of Cetirizine and Phenylephrine which belongs to the group of medicines called Anti-allergics and Nasal Decongestants. It is indicated for the relief of symptoms of nasal congestion and allergic rhinitis.

Can M COLD CZ TABLET be given to pregnant and breast-feeding women?

M COLD CZ TABLET should be used with caution in pregnant women only if considered clearly necessary. It is not recommended for use in breast-feeding women as it passes through the breast milk. Consult with your doctor for advice before taking M COLD CZ TABLET.

Is M COLD CZ TABLET safe to use in children?

M COLD CZ TABLET should not be used in children below 12 years of age as it does not allow for appropriate dose adaptation. Consult with your child’s doctor for advice before administration of M COLD CZ TABLET to your child.

How does M COLD CZ TABLET work?

M COLD CZ TABLET helps in relieving the symptoms of nasal congestion and allergic rhinitis where Cetirizine is a H1 receptor antagonist that works by blocking the action of a chemical messenger (histamine) responsible for runny nose, watery eyes and sneezing. It also has an anti-inflammatory action. Phenylephrine is a decongestant which acts by narrowing the small blood vessels providing temporary relief from congestion or stuffiness in the nose.

What to do If I forget to take M COLD CZ TABLET?

You should take M COLD CZ TABLET immediately when you remember. If it is time for your next dose skip the dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.

References

1. KD. Tripathi. Autacoids and Related Drugs, Adrenergic System and Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 166 & 135.

2. Evan Richards; Michael J. Lopez; Christopher V. Maani. NIH National Library of Medicine, National center for biotechnology information. Bookshelf. Phenylephrine. May 2022. [Accessed on 20th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK534801/

3. Aasim Naqvi; Valerie Gerriets. NIH National Library of Medicine, National center for biotechnology information. Bookshelf. Cetirizine. November 2021. [Accessed on 20th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK549776/

4. N Hutton, M H Wilson, E D Mellits, R Baumgardner, L S Wissow, C Bonuccelli, N A Holtzman, C DeAngelis. Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trial. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 1991. [Accessed on 20th June 2022] https://pubmed.ncbi.nlm.nih.gov/1670783/

5. Eli O Meltzer, Fernan Caballero, Leonard M Fromer, John H Krouse, Glenis Scadding. Treatment of congestion in upper respiratory diseases. NIH National Library of Medicine, National center for biotechnology information. Pubmed central. April 2010. [Accessed on 20th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866555/

6. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2019]. [Accessed on 20th June 2022] https://www.medicines.org.uk/emc/files/pil.8399.pdf

7. Phenylephrine hydrochloride tablet. DailyMed; National Library of Medicine; National Institute of Health. [Revised in March 2014]. [Accessed on 20th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8eec9d31-5f60-49bb-a427-e8163c9c8078

8. Cipla Ltd. Alerid D Tablets. Ciplamed (Cetirizine hydrochloride + Phenylephrine hydrochloride). Ciplamed [Revised in November 2013]. [Accessed on 20th June 2022] https://www.ciplamed.com/content/alerid-d-tablets

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 12 Dec 2022 | 06:10 PM(IST)