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Introduction About LUPRIDE DEPOT 7.5MG INJECTION
LUPRIDE DEPOT 7.5MG INJECTION contains Leuprolide which belongs to the group of medicines called Gonadotropin Releasing Hormone (GnRH) agonist. It is used for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer. It is also used in children to manage central precocious puberty (CPP).
Advanced prostatic cancer is the cancer (abnormal cell multiplication and differentiation) that originates in the prostate gland and spreads to the other parts of the body. It is characterized by the symptoms such as painful urination, decreased urine pressure, blood in the semen, bone pain, leg swelling, and weakness.
Central precocious puberty (CPP) is the early onset of sexual characteristics in girls (generally earlier than 8 years) and boys (generally earlier than 9 years of age in boys) due to activation of pubertal pituitary gonadotropins. It may result in diminished adult height.
Do not receive LUPRIDE DEPOT 7.5MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs.
Before receiving this medicine, inform your doctor if you have liver impairment, kidney impairment, congenital long QT syndrome, congestive heart failure, frequent electrolyte abnormalities, metastatic vertebral lesions, urinary tract obstruction, or diabetes.
Before receiving this medicine, inform your doctor if you have history of seizures, epilepsy, cerebrovascular disorders, or central nervous system anomalies/tumours.
LUPRIDE DEPOT 7.5MG INJECTION is not recommended for use in pregnant women, breastfeeding women, and children (below 2 years). It should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving.
The common side effects associated with the use of LUPRIDE DEPOT 7.5MG INJECTION are hot flashes/sweating, general pain, headache, infection, gastrointestinal disorders, swelling due to water retention, and respiratory disorders. Consult your doctor if any of these side effects worsens.
Uses Of LUPRIDE DEPOT 7.5MG INJECTION
It is used:
- for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer
- to manage central precocious puberty (CPP)
How LUPRIDE DEPOT 7.5MG INJECTION Works
LUPRIDE DEPOT 7.5MG INJECTION contains Leuprolide works by blocking the secretion of gonadotropin releasing hormone (GnRH) following an initial stimulation, resulting in suppression of ovarian and testicular steroidogenesis (process of synthesis of steroid hormones), thereby relieving the symptoms associated with increased levels of sex hormones.
How to use LUPRIDE DEPOT 7.5MG INJECTION
LUPRIDE DEPOT 7.5MG INJECTION will be administered to you only by a doctor or a nurse intramuscularly (into the muscle). Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LUPRIDE DEPOT 7.5MG INJECTION
Common
- hot flashes/sweating
- general pain
- headache
- infection
- gastrointestinal disorders
- swelling due to water retention
- respiratory disorders
- urinary disorders
- shrinking of testicles
- impotence
- reduced libido
- injection site reactions including abscess
- dilation of blood vessels
- acne
- seborrhoea (scaly condition of scalp)
- rash including erythema multiforme (a condition causing red patches)
- emotional lability
- vaginitis, abnormal vaginal discharge or vaginal bleeding
Rare
Stop receiving LUPRIDE DEPOT 7.5MG INJECTION and contact your doctor if you experience any of the following side effects:
- signs of pituitary apoplexy such as sudden headache, visual changes, vomiting, weakened eye muscles, altered mental status, sudden loss of heart function
How To Manage Side Effects
Headache:
Take rest and plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the condition persists for long or gets worsened.
Warning & Precautions
Pregnancy
LUPRIDE DEPOT 7.5MG INJECTION is not recommended for use during pregnancy. Consult your doctor before receiving.
Breastfeeding
LUPRIDE DEPOT 7.5MG INJECTION is not recommended for use in breastfeeding women as it is not known whether it can pass through milk. Consult your doctor before receiving.
Kidney
LUPRIDE DEPOT 7.5MG INJECTION should be used with caution in patients with renal impairment. Consult your doctor before receiving.
Liver
LUPRIDE DEPOT 7.5MG INJECTION should be used with caution in patients with hepatic impairment. Consult your doctor before receiving.
Allergy
Do not receive LUPRIDE DEPOT 7.5MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs, or to any of the other ingredients of this medicine.
Heart Disease
LUPRIDE DEPOT 7.5MG INJECTION should be used with caution in patients with congenital long QT syndrome and congestive heart failure only if clearly necessary. Consult your doctor before receiving.
Others
Before receiving LUPRIDE DEPOT 7.5MG INJECTION, inform your doctor if you:
- have frequent electrolyte abnormalities
- have metastatic vertebral lesions
- have urinary tract obstruction
- have diabetes
- have history of seizures
- have history of cerebrovascular disorders
- have history of central nervous system anomalies or tumours
Use in pediatrics:
LUPRIDE DEPOT 7.5MG INJECTION is not recommended for use in children (below 2 years). Consult your doctor before receiving.
Use in geriatrics:
LUPRIDE DEPOT 7.5MG INJECTION should be used with caution in elderly patients (above 65 years). Consult your doctor before receiving.
Interactions
A. Drug-Drug Interactions:
Before receiving LUPRIDE DEPOT 7.5MG INJECTION, inform your doctor, if you are taking any of the following medicine:
- medicines that prolong the QT interval (Ex. haloperidol, amiodarone, erythromycin)
Overdosage:
LUPRIDE DEPOT 7.5MG INJECTION will be administered to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity, increased scratching, and irritation at the site of injection.
Synopsis
| Drug | : | Leuprolide |
| Pharmacological Category | : | Gonadotropin Releasing Hormone (GnRH) Agonist |
| Therapeutic Indication | : | Palliative management for advanced prostatic cancer, Central precocious puberty |
| Dosage Forms | : | Injection, Injection depot |
More Information
- Keep LUPRIDE DEPOT 7.5MG INJECTION out of reach of children
- Store below 30°C
FAQs About LUPRIDE DEPOT 7.5MG INJECTION
What LUPRIDE DEPOT 7.5MG INJECTION is used for?
LUPRIDE DEPOT 7.5MG INJECTION for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer. It is also used in children to manage central precocious puberty (CPP). Consult your doctor before receiving.
What side effects are seen with LUPRIDE DEPOT 7.5MG INJECTION?
The common side effects associated with the use of LUPRIDE DEPOT 7.5MG INJECTION are hot flashes/sweating, general pain, headache, infection, gastrointestinal disorders, swelling due to water retention, and respiratory disorders. Consult your doctor if any of these side effects worsens.
Who should avoid receiving LUPRIDE DEPOT 7.5MG INJECTION?
Do not receive LUPRIDE DEPOT 7.5MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs. It is not recommended for use in pregnant women, breastfeeding women, and children (below 2 years). Consult your doctor before receiving.
Is LUPRIDE DEPOT 7.5MG INJECTION safe to use in children?
LUPRIDE DEPOT 7.5MG INJECTION is not recommended for use in children (below 2 years) because safety and effectiveness of this medicine have not been established in this population. Consult your doctor before receiving.
Is LUPRIDE DEPOT 7.5MG INJECTION safe to use in pregnant and breastfeeding women?
LUPRIDE DEPOT 7.5MG INJECTION is not recommended for use during pregnancy as it may increase the risk for pregnancy loss. It is also not recommended for use in breastfeeding women as it is not known whether it can pass through milk. Consult your doctor before receiving.
What is the method of receiving LUPRIDE DEPOT 7.5MG INJECTION?
LUPRIDE DEPOT 7.5MG INJECTION will be given to you only by a doctor or a nurse intramuscularly (into the muscle). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
What happens if you take more LUPRIDE DEPOT 7.5MG INJECTION than your required dose?
LUPRIDE DEPOT 7.5MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity, increased scratching, and irritation at the site of injection.
Is LUPRIDE DEPOT 7.5MG INJECTION safe to use in heart patients?
LUPRIDE DEPOT 7.5MG INJECTION should be used with caution in patients with congenital long QT syndrome and congestive heart failure only if clearly necessary. Consult your doctor before receiving.
References
1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 243.
2. Dallas V. Swayzer, Valerie Gerriets. Leuprolide. NIH. National Library of Medicine. National Centre for Biotechnology Information. StatPearls. October 2015. [Accessed on 29th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK551662/
3. AbbVie Inc. FDA (Food and Drug Administration). [Revised in June 2014] [Accessed on 29th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020517s036_019732s041lbl.pdf
4. Dailymed. ELIGARD- leuprolide acetate. [Revised in April 2019] [Accessed on 29th November 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b78d1919-9dee-44fa-90f9-e0a26d32481d&audience=consumer
5. Abbott Laboratories. FDA (Food and Drug Administration). [Revised in August 2011] [Accessed on 29th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020263s036lbl.pdf
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