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Introduction About LUPRIDE 22.5MG INJECTION(DEPOT)
LUPRIDE 22.5MG INJECTION(DEPOT) contains Leuprolide which belongs to the group of medicines called Gonadotropin Releasing Hormone (GnRH) Agonist. It is used for palliative management (relieving symptoms and minimising the associated suffering) of advanced prostatic cancer. Advanced prostatic cancer is a cancer (abnormal cell multiplication and differentiation) that originates in the prostate gland and spreads to the other parts of the body. It is characterized by the symptoms such as painful urination, decreased urine pressure, blood in the semen, bone pain, leg swelling, and weakness.
Do not receive LUPRIDE 22.5MG INJECTION(DEPOT) if you are allergic to Leuprolide, GnRH, GnRH agonist analogs. Before receiving the medicine, inform your doctor if you have liver impairment, kidney impairment, congenital long QT syndrome, congestive heart failure, frequent electrolyte abnormalities, metastatic vertebral lesions, urinary tract obstruction, or diabetes. Before receiving this medicine, inform your doctor if you have a history of seizures, epilepsy, cerebrovascular disorders, or central nervous system anomalies/tumours. LUPRIDE 22.5MG INJECTION(DEPOT) is not recommended for use in pregnant women, breastfeeding women, and children.
It should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving. The most common side effects associated with the use of LUPRIDE 22.5MG INJECTION(DEPOT) are general pain, reactions at the site of injection, hot flashes/sweating, gastrointestinal disorders, joint disorders, shrinking of testes, urinary disorders, infections in upper respiratory tract, and fatigue. Consult your doctor if any of these side effects worsens.
Uses Of LUPRIDE 22.5MG INJECTION(DEPOT)
- Used for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer
How LUPRIDE 22.5MG INJECTION(DEPOT) Works
LUPRIDE 22.5MG INJECTION(DEPOT) contains Leuprolide which works by blocking the secretion of gonadotropin releasing hormone (GnRH) following an initial stimulation, resulting in suppression of ovarian and testicular steroidogenesis (process of synthesis of steroid hormones), thereby relieving the symptoms associated with increased testosterone levels in advanced prostatic cancer.
How to use LUPRIDE 22.5MG INJECTION(DEPOT)
LUPRIDE 22.5MG INJECTION(DEPOT) will be administered to you only by a doctor or a nurse intramuscularly (into the muscle) or subcutaneously (under the skin). Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LUPRIDE 22.5MG INJECTION(DEPOT)
Common
- hot flashes, sweating
- general pain in the body
- pain at the site of injection
- gastrointestinal disorders
- respiratory disorders
- urinary disorders
- shrinking of testicles
- extreme weakness
- headache
- joint disorders
- dizziness
- neuromuscular disorders
- skin reactions
- flu-syndrome
- dehydration
- muscle pain
- sensation of pins and needles
- lethargy
- constipation
- sinus headache
- influenza-like illness including influenza, nasopharyngitis, nasal congestion, upper respiratory tract infection, rhinorrhea, and viral upper respiratory tract infection
- cough
- hemorrhagic cystitis
- high blood pressure
- rash
- urinary tract infection
- cystitis (an inflammatory condition of bladder)
- decreased haemoglobin
- increased frequency of urination in night
- peripheral/pitting oedema (swelling in legs and feet due to water retention)
- itching
- hair loss
- pain in testicles
- clamminess
- breast enlargement in males
- reduced libido
Stop receiving LUPRIDE 22.5MG INJECTION(DEPOT) and contact your doctor if you experience any of the following side effects:
- COPD (chronic obstructive pulmonary disease)
- coronary artery disease (heart disease) is characterized by angina (chest pain)
- cerebrovascular accident/transient ischemic attack (life-threatening events related to impaired heart function)
- pneumonia (a life-threatening lung disease)
- second primary neoplasm (cancer) including basal cell carcinoma, lung neoplasm, bladder transitional cell carcinoma, malignant melanoma, squamous cell carcinoma, non-Hodgkin’s lymphoma
How To Manage Side Effects
Constipation
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.
Dizziness Or Drowsiness
Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for long or gets worsens.
Headache
Take rest and plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching the screen for a long time. Consult your doctor if the condition persists for long or gets worsens.
Warning & Precautions
Pregnancy
ContraindicatedLUPRIDE 22.5MG INJECTION(DEPOT) is not recommended for use during pregnancy. Consult your doctor before receiving the medicine.
Breastfeeding
ContraindicatedLUPRIDE 22.5MG INJECTION(DEPOT) is not recommended for use in breastfeeding women as it can pass through milk. Consult your doctor before receiving the medicine.
Driving and Using Machines
Use with CautionDo not receive LUPRIDE 22.5MG INJECTION(DEPOT) if you are allergic to Leuprolide, GnRH, GnRH agonist analogs, or to any of the other ingredients of this medicine.
Kidney
Use with CautionLUPRIDE 22.5MG INJECTION(DEPOT) should be used with caution in patients with renal impairment. Consult your doctor before receiving the medicine.
Liver
Use with CautionLUPRIDE 22.5MG INJECTION(DEPOT) should be used with caution in patients with hepatic impairment. Consult your doctor before receiving the medicine.
Heart Disease
Monitoring requiredLUPRIDE 22.5MG INJECTION(DEPOT) should be used with caution in patients with congenital long QT syndrome and congestive heart failure only if clearly necessary. Consult your doctor before receiving.
Use In Pediatrics
ContraindicatedLUPRIDE 22.5MG INJECTION(DEPOT) is not recommended for use in children. Consult your doctor before receiving.
Use In Geriatrics
Use with CautionLUPRIDE 22.5MG INJECTION(DEPOT) should be used with caution in elderly patients (above 65 years). Consult your doctor before receiving the medicine.
Others
Before receiving LUPRIDE 22.5MG INJECTION(DEPOT), inform your doctor if you:
- have frequent electrolyte abnormalities
- have metastatic vertebral lesions
- have urinary tract obstruction
- have diabetes
- have a history of epilepsy
- have a history of cerebrovascular disorders
- have a history of central nervous system anomalies or tumours
Interactions
A. Drug-Drug Interactions:
Before receiving LUPRIDE 22.5MG INJECTION(DEPOT), inform your doctor, if you are taking any of the following medicine:
- medicines that prolong the QT interval (Ex. haloperidol, amiodarone, erythromycin)
Overdosage:
LUPRIDE 22.5MG INJECTION(DEPOT) will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity, and increased scratching.
Synopsis
| Drug | : | Leuprolide |
| Pharmacological Category | : | Gonadotropin Releasing Hormone (GnRH) Agonist |
| Therapeutic Indication | : | Palliative management for advanced prostatic cancer |
| Dosage Forms | : | Injection, Injection depot |
More Information
Storage
- Keep LUPRIDE 22.5MG INJECTION(DEPOT) out of reach of children
- Store between 2-8°C
FAQs About LUPRIDE 22.5MG INJECTION(DEPOT)
Q: What LUPRIDE 22.5MG INJECTION(DEPOT) is used for?
A: LUPRIDE 22.5MG INJECTION(DEPOT) for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer. Consult your doctor before receiving.
Q: What side effects are seen with LUPRIDE 22.5MG INJECTION(DEPOT)?
A: The most common side effects associated with the use of LUPRIDE 22.5MG INJECTION(DEPOT) are general pain, reactions at the site of injection, hot flashes/sweating, gastrointestinal disorders, joint disorders, shrinking of testes, urinary disorders, infections in the upper respiratory tract, and fatigue. Consult your doctor if any of these symptoms worsens.
Q: Who should avoid receiving LUPRIDE 22.5MG INJECTION(DEPOT)?
A: Do not receive LUPRIDE 22.5MG INJECTION(DEPOT) if you are allergic to leuprolide, GnRH, GnRH agonist analogs. It is not recommended for use in pregnant women, breastfeeding women, and children. Consult your doctor before receiving.
Q: Is LUPRIDE 22.5MG INJECTION(DEPOT) safe to use in children?
A: LUPRIDE 22.5MG INJECTION(DEPOT) is not recommended for use in children because the safety and effectiveness of this medicine have not been established in this population. Consult your doctor before receiving.
Q: Is LUPRIDE 22.5MG INJECTION(DEPOT) safe to use in pregnant and breastfeeding women?
A: LUPRIDE 22.5MG INJECTION(DEPOT) is not recommended for use during pregnancy as it may increase the risk for pregnancy loss. It is also not recommended for use in breastfeeding women as it can pass through milk. Consult your doctor before receiving.
Q: What happens if you take more LUPRIDE 22.5MG INJECTION(DEPOT) than your required dose?
A: LUPRIDE 22.5MG INJECTION(DEPOT) will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity, and increased scratching.
Q: Is LUPRIDE 22.5MG INJECTION(DEPOT) safe to use in heart patients?
A: LUPRIDE 22.5MG INJECTION(DEPOT) should be used with caution in patients with congenital long QT syndrome and congestive heart failure only if clearly necessary. Consult your doctor before receiving.
References
1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page-243.
2. Dallas V. Swayzer, Valerie Gerriets. Leuprolide. NIH. National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. October 2015. [Accessed on 28th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK551662/
3. AbbVie Inc. FDA (Food and Drug Administration). [Revised in June 2014] [Accessed on 28th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020517s036_019732s041lbl.pdf
4. Dailymed. ELIGARD- leuprolide acetate. [Revised in April 2019] [Accessed on 28th November 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b78d1919-9dee-44fa-90f9-e0a26d32481d&audience=consumer
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