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Introduction About LUPIBOSE
LUPIBOSE contains Bosentan which belongs to the group of medicines called Endothelin receptor antagonists. LUPIBOSE is used to manage pulmonary arterial hypertension in affected individuals which is a disease that occurs due to high blood pressure in blood vessels that carry blood from heart to the lungs.
LUPIBOSE is also used in adults to reduce digital ulcers (sores on the fingers and toes) that occurs due to scleroderma which is a chronic disease that cause skin to become thick and hard.
LUPIBOSE is not recommended for use in patients allergic to Bosentan. It is also not recommended for use in patients suffering from liver problems.
Before taking LUPIBOSE, inform your doctor if you are planning to father a child, and/or have kidney problems (such as impaired renal function).
LUPIBOSE is generally not recommended for use during pregnancy and in women planning for pregnancy since the medicine may cause harm to the unborn child. It is also not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breastmilk.
LUPIBOSE is recommended for use in children and adolescents (aged 1 year and above) to manage only pulmonary hypertension and is not indicated for use to manage systemic sclerosis and digital ulcer disease in affected children. The medicine is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking LUPIBOSE are headache, oedema (swelling of legs & ankles), flushing/redness of skin, diarrhoea, low blood pressure, and/or nasal congestion. Consult your doctor if any of these symptoms worsen.
Uses Of LUPIBOSE
- Manage pulmonary artery hypertension
- Manage digital ulcers (that occurs due to scleroderma) in affected individuals
How LUPIBOSE Works
LUPIBOSE works by blocking the action of endothelin-1 hormone (chemical that cause vasoconstriction) which leads to relaxation and widening of blood vessel wall resulting in reduced pressure on the blood vessel wall and managing pulmonary hypertension in affected individuals.
How to use LUPIBOSE
Take LUPIBOSE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LUPIBOSE
Common
- headache
- oedema (swelling of legs & ankles)
- flushed appearance/redness of skin
- signs of hypersensitivity reactions (immune mediated allergic reaction) such as skin inflammation, itching, and/or rashes
- gastroesophageal reflux disease (acid reflux)
- diarrhoea
- syncope (fainting)
- palpitations (fast/irregular heartbeats)
- low blood pressure
- nasal congestion
Rare
- signs of anaphylactic reaction (life threatening allergic reaction) such as skin rash, nausea, difficulty in breathing, and/or shock
- cirrhosis/scarring of the liver
- liver failure.
Stop taking LUPIBOSE and consult your doctor immediately if you experience any of the following side effects:
- signs of abnormal/impaired liver function such as nausea, fever, pain in the stomach, jaundice (yellowing of the skin/whites of eyes), dark-coloured urine, itching, lethargy/fatigue, and/or flu-like symptoms such as joint & muscle pain with fever
How To Manage Side Effects
Headache:
If LUPIBOSE causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking LUPIBOSE. If it lasts more than a week or becomes severe, then consult your doctor.
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult your doctor if the symptom worsens.
Warning & Precautions
Pregnancy
LUPIBOSE is generally not recommended for use during pregnancy and in women planning for pregnancy since the medicine may cause harm to the unborn child. Women of child-bearing potential should use effective contraceptive measures to manage accidental pregnancy while in management with LUPIBOSE. Consult your doctor before taking the medicine.
Breastfeeding
LUPIBOSE is not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breastmilk. Consult your doctor before taking the medicine.
Driving and Using Machines
Do not drive/operate any machines if you feel dizzy or experience blurred vision after taking LUPIBOSE.
Kidney
LUPIBOSE should be used with caution in patients with kidney problems such as impaired renal function. Consult your doctor before taking the medicine.
Liver
LUPIBOSE is not recommended for use in patients with liver problems. Consult your doctor before taking the medicine.
Allergy
Do not take LUPIBOSE if you are allergic to Bosentan, and/or any other ingredients of the medicine.
Others
Before taking LUPIBOSE, inform your doctor if you:
- are planning to father a child (since this medicine may lower the sperm count).
Use in Paediatrics:
LUPIBOSE is recommended for use in children and adolescents (aged 1 year and above) to manage only pulmonary hypertension. It is not recommended for use to manage systemic sclerosis and ongoing digital ulcer disease in affected children. Consult your doctor before administering the medicine to the child.
Use in Geriatrics:
LUPIBOSE should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking the medicine.
Interactions
A. Drug-Drug interactions:
Before taking LUPIBOSE, inform your doctor if you are taking any of the following medicine:
- ciclosporin A (used after transplants and to manage psoriasis)
- sirolimus, tacrolimus (medicines used after transplants to manage organ rejection)
- glibenclamide (used to manage diabetes)
- rifampicin (use to manage tuberculosis)
- fluconazole, ketoconazole (medicines used to manage fungal infections)
- nevirapine (used to manage HIV infection)
- warfarin (used to manage blood clots)
- other medicine used to manage pulmonary hypertension (Ex. sildenafil, tadalafil)
- simvastatin (used to manage hypercholesterolaemia)
- hormonal contraceptives (used to manage pregnancy)
Overdosage:
If you or anyone else accidentally take too much of LUPIBOSE, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
Synopsis
| Drug | : | Bosentan |
| Pharmacological Category | : | Endothelin receptor antagonists |
| Therapeutic Indication | : | Pulmonary artery hypertension, Digital ulcers (due to scleroderma) |
| Dosage Forms | : | Tablet |
More Information
- Keep LUPIBOSE out of reach of children
- Do not store LUPIBOSE above 30 °C
FAQs About LUPIBOSE
What is LUPIBOSE used for?
LUPIBOSE is used to manage pulmonary arterial hypertension in affected individuals which is a disease that occurs due to high blood pressure in blood vessels that carry blood from heart to the lungs. It is also used in adults to reduce digital ulcers (sores on the fingers and toes) that occurs due to scleroderma which is a chronic disease that cause skin to become thick and hard in affected individuals.
What are the side effects of taking LUPIBOSE?
The most common side effects of taking LUPIBOSE are headache, oedema (swelling of legs & ankles), flushing/redness of skin, diarrhoea, low blood pressure, and/or nasal congestion. Contact your doctor if any of these symptoms worsen.
How LUPIBOSE works?
LUPIBOSE works by blocking the action of endothelin-1 hormone (chemical that cause vasoconstriction) which leads to relaxation and widening of blood vessel wall resulting in reduced pressure on the blood vessel wall and managing pulmonary hypertension in affected individuals.
How LUPIBOSE should be taken?
Take LUPIBOSE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Can LUPIBOSE be used in pregnant women?
No, LUPIBOSE is generally not recommended for use during pregnancy and in women planning for pregnancy since the medicine may cause harm to the unborn child. Women of child-bearing potential should use effective contraceptive measures to manage accidental pregnancy while in management with LUPIBOSE. Consult your doctor before taking the medicine.
References
1. Angela Cheng-Lai, James Nawarskas, William H. Frishman. Vasodilators. Current Cardiovascular Drugs. Fourth edition. 2005. Page – 327.
2. J Dingemanse, P L M van Giersbergen. Influence of severe renal dysfunction on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. NIH National Library of Medicine. National Center for biotechnology information. PubMed.gov. July 2002. [Accessed on 29th April 2022] https://pubmed.ncbi.nlm.nih.gov/12139208/
3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in September 2022] [Accessed on 29th April 2022] https://www.medicines.org.uk/emc/files/pil.8409.pdf
Useful Diagnostic Tests
- Echocardiogram
- Right heart catheterization
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