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Introduction About LUMATE AT TABLET
LUMATE AT TABLET is a combination of Artemether and Lumefantrine which belongs to the group of medicines called Antimalarials. It is used in infants, children and adults for the management of acute uncomplicated malaria (mosquito borne disease with symptoms of fever with chills, tiredness, nausea, vomiting, stomach pain) caused by a parasite called plasmodium falciparum.
LUMATE AT TABLET should be used with caution in patients with severe liver or kidney problems or if the patient feels worse or unwell to eat and drink.
LUMATE AT TABLET is not recommended for use in patients having severe type of malarial infection affecting the lungs, kidney or brain, heart condition such as changes in the heart rhythm, slow heartbeat or severe heart disease and low levels of electrolytes such as potassium or magnesium in the blood.
LUMATE AT TABLET is generally not recommended for use during the first trimester of pregnancy and it should be used with caution during the second and third trimester of pregnancy and breast-feeding women only if advised by the doctor.
LUMATE AT TABLET should be used with caution in children and your child’s doctor may adjust the dose depending upon child’s age and body weight.
The most common side effects of taking LUMATE AT TABLET are headache, dizziness, vomiting, stomach pain, nausea, muscle pain and loss of appetite. Consult your doctor if any of the side effects worsen.
Uses Of LUMATE AT TABLET
- Manage acute uncomplicated malarial infections (caused by plasmodium falciparum) in infants, children and adults
How LUMATE AT TABLET Works
LUMATE AT TABLET effectively manages malarial infections, where artemether effectively kills the malarial parasites by binding to haem (part of molecules that contains iron which is toxic to malarial parasites) which is produced during the breakdown of haemoglobin. Lumefantrine works by binding to hemin where it manages the formation of a toxic malarial pigment called hemozoin, thereby it manages malarial infection. In addition to this artemether and lumefantrine blocks nucleic acid and protein synthesis in parasite that damages the parasitic cell membrane of plasmodium falciparum which leads to the death of parasite. Thus, it helps in managing the malarial infection.
How to use LUMATE AT TABLET
Take LUMATE AT TABLET exactly as advised by your doctor.
For Tablet, Capsule: Swallow LUMATE AT TABLET with a glass of water. This medicine should be taken with food or drinks rich in fat such as milk. Crush the medicine into powder if your child is unable to swallow the whole medicine.
For Dispersible Tablet: Disperse LUMATE AT TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution.
Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of the disease condition.
Side Effects Of LUMATE AT TABLET
Common
- headache, dizziness
- nausea, vomiting
- stomach pain
- diarrhea
- muscle or joint pain
- difficulty to sleep
- loss of appetite
- cough
- fast heartbeat
- general weakness, tiredness
- involuntary muscle spasms
- abnormal walking (in children above 12 years)
- tingling sensation or numbness of hand and feet
- rashes or itching in the skin
- disturbance in heart rhythm (prolonged QTc interval)
Uncommon
- sleepiness
- decreased skin sensitivity
- inability to coordinate movements
Rare
- allergic reactions
Stop taking LUMATE AT TABLET and contact your doctor immediately if you experience any of the following side effects:
- swelling of the face, lips, tongue or throat with difficulty in breathing and swallowing
- skin condition with large fluid filled blisters (bullous eruption)
How To Manage Side Effects
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom does not improve.
Nausea and vomiting:
Stick to simple meals while taking this medicine. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom does not improve.
Diarrhea:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom does not improve.
Tiredness:
Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
LUMATE AT TABLET is generally not recommended for use during the first trimester of pregnancy. It should be used with caution during second and third trimester of pregnancy only if considered clearly necessary. Consult your doctor before taking LUMATE AT TABLET.
Breastfeeding
LUMATE AT TABLET should be taken with caution in breast feeding women only if considered clearly necessary. Consult your doctor before taking LUMATE AT TABLET.
Driving and Using Machines
Do not drive or operate any machines if you experience dizziness, sleepiness or weakness after taking LUMATE AT TABLET.
Kidney
LUMATE AT TABLET is not recommended for use in patients having severe type of malarial infection affecting the kidneys. It should be taken with caution in patients with severe kidney problems. Consult your doctor before taking LUMATE AT TABLET.
Liver
LUMATE AT TABLET should be taken with caution in patients with severe liver problems. Consult your doctor before taking LUMATE AT TABLET.
Allergy
Do not take LUMATE AT TABLET if you are allergic to Artemether, Lumefantrine or any other ingredients of this medicine.
Lungs
LUMATE AT TABLET is not recommended for use in patients having malaria with pulmonary edema or severe type of malarial infection affecting the lungs. Consult your doctor before taking it.
Heart Disease
LUMATE AT TABLET is not recommended for use in patients with severe heart disease or with heart diseases such as slow heartbeat, changes in the rhythm or rate of the heartbeat or family history of death due to heart problems or born with heart problems. LUMATE AT TABLET should be taken with caution in patients with variations in ECG (prolongation of QTc interval). Consult doctor before taking LUMATE AT TABLET.
Others
LUMATE AT TABLET is not recommended for use if you have:
- severe type of malarial infection that has affected the brain
- low levels of electrolytes such as potassium or magnesium in blood
Before taking LUMATE AT TABLET, inform your doctor if you:
- infected with both the plasmodium falciparum and plasmodium vivax parasites
- feeling worse or if you feel too unwell to eat and drink
Use in pediatrics
LUMATE AT TABLET should be given with caution in children as the dosages of LUMATE AT TABLET vary in children according to their body weight. So, consult a paediatrician before you give this medicine to your child.
Use in geriatrics
LUMATE AT TABLET can be used in elderly patients. However, consult your doctor before taking this medicine.
Interactions
A. Drug – drug interactions:
Before taking LUMATE AT TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to manage heart rhythm problems (Ex. Flecainide, metoprolol)
- medicines used to manage depression (Ex. imipramine, amitriptyline, clomipramine, St. John’s wort)
- medicine used to manage leprosy or tuberculosis (Ex. rifampicin)
- medicines used to manage bacterial infections (EX. fluroquinolones such as ciprofloxacin, levofloxacin, macrolide antibiotics like azithromycin, erythromycin)
- medicines used to manage fungal infection (Ex. ketoconazole, fluconazole, itraconazole)
- medicines used to manage allergy (Ex. terfenadine, astemizole)
- medicine used to manage stomach disturbance (Ex. cisapride)
- medicines used to manage fits (Ex. carbamazepine, phenytoin)
- medicines used to manage malaria (Ex. atovaquone/proguanil, chloroquine)
- medicines used to manage HIV infection (Ex. indinavir, ritonavir)
- medicine used to manage pregnancy (Ex. Ethinyl estradiol)
B. Drug – Food interactions
Drink grapefruit juice with caution while taking LUMATE AT TABLET as it may interact with this medicine.
Overdosage:
If you or anyone else accidentally take too much of LUMATE AT TABLET, consult your doctor immediately or visit a nearby hospital.
Synopsis
| Drug | : | Artemether, Lumefantrine |
| Pharmacological Category | : | Antimalarials |
| Therapeutic Indication | : | Manages acute uncomplicated malaria |
| Dosage Forms | : | Tablet, Dispersible tablet, Injection, Syrup, Oral suspension, Dry Syrup |
More Information
- Keep LUMATE AT TABLET out of reach of children
- Store LUMATE AT TABLET at room temperature
FAQs About LUMATE AT TABLET
What is LUMATE AT TABLET used for?
LUMATE AT TABLET is used in infants, children and adults for the management of acute uncomplicated malaria (mosquito born disease with symptoms of fever with chills, tiredness, nausea, vomiting, stomach pain) caused by a parasite called plasmodium falciparum.
Does LUMATE AT TABLET helps to manage malaria?
LUMATE AT TABLET is not used to manage malaria. It is only used to manage malarial infection caused by a parasite called plasmodium falciparum. Consult your doctor for advice before taking this medicine.
Is LUMATE AT TABLET safe to use in pregnant women?
LUMATE AT TABLET is generally not recommended for use during the first trimester of pregnancy. It should be used with caution during second and third trimester of pregnancy only if considered clearly necessary. Consult your doctor before taking LUMATE AT TABLET.
Can LUMATE AT TABLET be used in patients with kidney problems?
LUMATE AT TABLET is not recommended for use in patients having severe type of malarial infection affecting the kidneys. It should be taken with caution in patients with severe kidney problems. Consult your doctor before taking LUMATE AT TABLET.
Does LUMATE AT TABLET cause diarrhea?
Yes, LUMATE AT TABLET may cause diarrhea in some individuals. To manage this effect, drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom does not improve.
References
1. KD Tripathi. Antimalarial drugs. Essentials of Medical Pharmacology. Eighth edition. 2019. Page: 875-77.
2. Stephan Ehrhardt, Christian G Meyer. Artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria. NIH. National Library of medicine. National center for Biotechnology Information. PubMed central. October 2009. [Accessed on 3rd November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762439/
3. Novartis Pharmaceuticals. Pharmacokinetics, Safety, Tolerability and Efficacy of a New Artemether-lumefantrine Dispersible Tablet in Infants and Neonates <5 kg Body Weight With Acute Uncomplicated Plasmodium Falciparum Malaria (CALINA). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in March 2020] [Accessed on 3rd November 2022] https://clinicaltrials.gov/ct2/show/NCT04300309
4. Novartis Ireland Limited. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 3rd November 2022] https://www.medicines.org.uk/emc/files/pil.1628.pdf
5. Ajanta Pharma Ltd. Food and Drugs Authority (FDA).[Revised in February 2018] [Accessed on 3rd November 2022] https://fdaghana.gov.gh/img/smpc/Artefan%20(Artemether-Lumefantrine%2060mg-360mg)%20Tablets.pdf
6. Ajanta Pharma Ltd. Artefan 80/480 (Artemether and Lumefantrine). [Revised in March 2019] [Accessed on 3rd November 2022] https://extranet.who.int/pqweb/sites/default/files/MA130part3.pdf
7. Ajanta Pharma Ltd. Artefan 40/240 (Artemether and Lumefantrine). [Revised in March 2019] [Accessed on 3rd November 2022] https://extranet.who.int/pqweb/sites/default/files/MA128part3.pdf
8. Getz pharma ltd. Artheget (Artemether + Lumefantrine). [Accessed on 3rd November 2022] https://getzpharma.com/wp-content/uploads/2016/07/Artheget-Range-Leaflet-Pakistan.pdf
9. Cipla Ltd. Lumet 80 Tablets (Artemether + Lumefantrine). CiplaMed. [Revised in October 2013] [Accessed on 3rd November 2022] https://ciplamed.com/content/lumet-80-tablets
Useful Diagnostic Tests
- Peripheral Smear for Malaria
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