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Introduction About LOZAT 50MG TABLET
LOZAT 50MG TABLET is used to manage mild to moderate hypertension. It also used to manage hypertensive patients with left ventricular hypertrophy and nephropathy in type 2 diabetic patients. It contains Losartan which belongs to the group of medicines called Antihypertensive agents. It blocks the effects of Angiotensin II (substance produced in your body which causes narrowing of blood vessels), which leads to relaxation of blood vessels resulting in low blood pressure in affected individuals.
LOZAT 50MG TABLET is not recommended for use in patients allergic to losartan. It is also not recommended for use in patients with severely impaired liver function and kidney function. Before taking the medicine, inform your doctor if you have a history of angioedema and/or suffering from excessive vomiting/diarrhoea, primary hyperaldosteronism kidney problems. LOZAT 50MG TABLET is not recommended for use in early pregnancy and must not be taken when a woman is more than 3 months pregnant since it may cause serious harm to the baby if used after 3-months of pregnancy. It is not known whether the medicine is excreted in human milk, hence consult your doctor before taking the medicine.
It is not recommended for use in children under 6 years of age. The most common side effects are dizziness, general weakness, tiredness, low blood sugar, changes in kidney function (associated with signs such as decreased urine output, edema, shortness of breath) and/or anaemia. Consult your doctor if any of these symptoms worsens.
Uses Of LOZAT 50MG TABLET
It is used to manage:
- mild to moderate hypertension
- hypertensive patients with left ventricular hypertrophy
- nephropathy in type 2 diabetic patients
How LOZAT 50MG TABLET Works
LOZAT 50MG TABLET blocks the effects of Angiotensin II (substance produced in your body which causes narrowing of blood vessels), which leads to relaxation of blood vessels resulting in low blood pressure in affected individuals.
How to use LOZAT 50MG TABLET
- Take LOZAT 50MG TABLET as advised by your physician
- Swallow the medicine with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LOZAT 50MG TABLET
Common Side Effects of LOZAT 50MG TABLET:
- dizziness, general weakness, tiredness
- low blood pressure orthostatic hypotension
- signs of low blood sugar such as fast heartbeat, shaking, sweating and/or hunger
- signs of changes in kidney function such as decreased urine output, oedema, shortness of breath
- abdominal pain, constipation, diarrhoea
Stop taking LOZAT 50MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of severe allergic reactions such as rash, itching, swelling of the face, lips, mouth/throat that may cause difficulty in swallowing or breathing
Warning & Precautions
Pregnancy
ContraindicatedLOZAT 50MG TABLET is not recommended in early pregnancy and must not be taken when more than 3 months pregnant, as it may cause serious harm to the baby if used after 3 months of pregnancy.
Breastfeeding
Consult your doctorIt is not known whether the medicine is excreted in human milk, hence consult your doctor before taking the medicine.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy or drowsy after taking LOZAT 50MG TABLET.
Kidney
Consult your doctorLOZAT 50MG TABLET is not recommended for use in patients with impaired kidney function. It should be taken with caution in patients with narrowing of blood vessels to one or both the kidneys and in patients who had recently received kidney transplant.
Liver
Consult your doctorLOZAT 50MG TABLET is not recommended for use in patients with severely impaired liver function. It should be used with caution in patients having impaired liver function.
Allergy
ContraindicatedDo not take LOZAT 50MG TABLET if you are allergic to Losartan and/or any other ingredients of this medicine.
Heart Disease
Use with CautionLOZAT 50MG TABLET should be taken with caution in patients having heart failure, problems in heart valve and heart muscle, cardiac arrythmia (irregular and fast heartbeat), coronary heart disease.
Use In Pediatrics
Consult your doctorLOZAT 50MG TABLET is not recommended for use in children under 6 years of age and also in children suffering from kidney and/or liver problems. The medicine is recommended for used in children and adolescents (aged 6 to 18 years) after consulting the doctor.
Use In Geriatrics
Use with CautionLOZAT 50MG TABLET should be used with caution in patients (aged above 75 years).
Others
LOZAT 50MG TABLET is not recommended for use if you have:
- diabetes and managed with blood pressure lowering medicine containing aliskiren
Before taking LOZAT 50MG TABLET, inform your doctor if you:
- have a history of angioedema (swelling of the face, lips, throat and/or tongue)
- suffer from excessive vomiting/diarrhoea leading to extreme loss of fluid and/or salt in your body
- suffer from primary hyperaldosteronism (a syndrome associated with increased secretion of aldosterone hormone)
- suffer from cerebrovascular disease (caused by a reduced blood circulation to the brain)
- salt-restricted diet
Interactions
A. Drug-Drug Interactions:
Before taking LOZAT 50MG TABLET, inform your doctor if you are taking any of the following medicine:
- diuretics (Ex. furosemide, bumetanide)
- potassium-sparing diuretics (Ex. amiloride, triamterene, spironolactone)
- angiotensin converting enzyme inhibitors (Ex. enalapril, lisinopril, ramipril)
- aliskiren
- beta blockers (Ex. atenolol, propranolol, carvedilol)
- Anticoagulants (Ex. heparin)
- Antibiotics (Ex. trimethoprim)
- potassium supplements and potassium-containing salt substitutes
- antidepressants (Ex. citalopram, fluoxetine, paroxetine)
- antipsychotic agents (Ex. haloperidol, thioridazine)
- skeletal muscle relaxants (Ex. baclofen)
- cytoprotectants (Ex. amifostine)
- cox-2 inhibitors (Ex. meloxicam, etodolac)
- Antimanic agents (Ex. lithium)
Overdosage:
If you or anyone else accidentally take too much of LOZAT 50MG TABLET, consult your doctor immediately or visit the nearby hospital. The most common symptoms of overdose are low blood pressure, fast heartbeat and slow heartbeat.
Synopsis
| Drug | : | Losartan |
| Pharmacological Category | : | Angiotensin II receptor antagonists |
| Therapeutic Indication | : | Hypertension, Hypertensive patients with left ventricular hypertrophy, Neuropathy in type 2 diabetic patient |
| Dosage Forms | : | Tablet |
More Information
FAQs About LOZAT 50MG TABLET
Q: What is LOZAT 50MG TABLET used for?
A: LOZAT 50MG TABLET is primarily used to manage high blood pressure (hypertension). It is also prescribed to protect the kidneys in people with diabetes and to reduce the risk of stroke in individuals with heart disease. By lowering blood pressure, Losartan helps reduce complications such as heart attacks, strokes, and kidney damage.
Q: How does LOZAT 50MG TABLET works?
A: LOZAT 50MG TABLET belongs to a class of drugs called angiotensin II receptor blockers (ARBs). It works by relaxing blood vessels, making it easier for blood to flow. It blocks the action of angiotensin II, a natural substance that tightens blood vessels and increases blood pressure. By preventing this tightening, Losartan lowers blood pressure and reduces strain on the heart.
Q: What is the best time to take LOZAT 50MG TABLET?
A: LOZAT 50MG TABLET is usually taken once a day, with or without food. It is often recommended to take it at the same time each day to maintain consistent blood levels. Some people prefer taking it in the morning to avoid nighttime urination, while others may take it at night if it causes dizziness or tiredness during the day. Consult your doctor for personalized advice.
Q: How many doses of Losartan can be taken in a day?
A: Most people take one dose of Losartan daily, though the dose may vary depending on the condition being treated. For example, the typical starting dose for hypertension is 50 mg once a day, but it can be adjusted to 25–100 mg based on your response. Taking more than the prescribed dose can cause excessive blood pressure lowering, so always follow your doctor’s instructions.
Q: Can LOZAT 50MG TABLET be used during pregnancy?
A: No, Losartan is not safe to use during pregnancy. It can harm the developing baby, especially during the second and third trimesters, potentially leading to kidney problems or developmental issues. If you are pregnant or planning to conceive, inform your doctor immediately to switch to a safer alternative.
Q: Can LOZAT 50MG TABLET control blood pressure effectively?
A: Yes, Losartan is highly effective in controlling high blood pressure when taken as prescribed. However, its effectiveness depends on factors such as adhering to the prescribed dose, maintaining a healthy diet, limiting salt intake, and incorporating regular exercise into your routine. Regular blood pressure monitoring is also essential.
Q: Who should not use Losartan?
A: Losartan should not be used by individuals who are pregnant or breastfeeding, have severe kidney or liver disease, are allergic to Losartan or its ingredients, have low blood potassium or sodium levels. Consult your doctor if you have any underlying medical conditions or are taking other medications.
Q: What are the common side effects of Losartan?
A: The most common side effects of Losartan include dizziness, fatigue, nasal congestion, and back pain. Some people may also experience diarrhoea or high potassium levels (hyperkalemia). If any side effects persist or worsen, seek medical attention.
Q: Is Losartan safe?
A: Losartan is generally considered safe when taken as prescribed by a doctor. Regular monitoring of blood pressure, kidney function, and potassium levels is recommended to ensure safety, especially in individuals with pre-existing kidney or liver conditions. Always inform your doctor about any other medications or supplements you are using.
Q: Can LOZAT 50MG TABLET be taken on an empty stomach or before food?
A: Yes, LOZAT 50MG TABLET can be taken with or without food. Food does not significantly affect the absorption of the medication, so you can take it at a time that suits your routine. Ensure you drink plenty of water when taking the tablet.
Q: Is LOZAT 50MG TABLET safe for kidney patients?
A: Losartan is often prescribed to protect the kidneys, especially in diabetic patients. However, it may not be suitable for individuals with severe kidney impairment or those on dialysis. Regular monitoring of kidney function is essential to ensure its safe use in such cases.
Q: How long will it take for Losartan to work?
A: Losartan starts working within 1–2 hours of taking a dose, but its full blood pressure-lowering effect may take 3–6 weeks of consistent use. If you are using it for conditions like diabetic kidney disease, the benefits may take longer to show, requiring regular follow-ups with your doctor.
Q: Can I stop taking Losartan once my blood pressure is controlled?
A: No, you should not stop taking Losartan without consulting your doctor. High blood pressure is a chronic condition, and stopping the medication abruptly can cause blood pressure to rise again, increasing the risk of complications. Your doctor may adjust your dose or recommend lifestyle changes to complement the treatment.
References
1. KD. Tripathi. Drugs Affecting Renin-Angiotensin System and Plasma Kinins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 506
2. Sana Mulla; Waqas J. Siddiqui. Losartan. NIH National Library of Medicine. National Center for Biotechnology Information. July 2022. [Accessed on 11th May 2022] click here
3. Merck Sharp & Dohme Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 11th May 2022] click here
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