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Introduction About LOXOF OZ TABLET
LOXOF OZ TABLET is a combination of Levofloxacin and Ornidazole which belongs to the group of medicines called Antibiotics and Anthelminthics respectively. It is used in the management of various bacterial infections such as gastrointestinal infections, chest infections and urinary tract infections. It can also be used in the management of protozoal infections (parasitic infections).
Avoid consumption of alcohol while taking LOXOF OZ TABLET because it might aggravate your existing symptoms. [ GBNKEYWORD] is not recommended for use if you have or ever had epilepsy (fits) or tendon problems such as (tendonitis). LOXOF OZ TABLET should be used with caution in patients having liver, kidney and heart problems. Consult your doctor before taking it. LOXOF OZ TABLET is not recommended for use in pregnant and breast-feeding women.
LOXOF OZ TABLET is not recommended for use in children and adolescents (under 18 years of age). It should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it. The most common side-effects of taking LOXOF OZ TABLET are nausea, vomiting, diarrhoea, dizziness, headache and sleeping problems. Ask for your doctor’s advise if any of these worsen or doesn’t improve.
Uses Of LOXOF OZ TABLET
It is used to manages:
- Gastrointestinal infections
- Chest infections
- Urinary tract infections
- Other bacterial and protozoal infections (parasitic infections)
How LOXOF OZ TABLET Works
LOXOF OZ TABLET works by inhibiting the growth of bacteria which are responsible for causing various infections in the body. It inhibits the synthesis of bacterial enzymes which can cause damage to the structure of DNA leading to cell death. Thus, it effectively manages different types of infections caused by microorganisms. Also, it works against the parasites which are responsible for causing various infections in the body. It inhibits the synthesis of protein and manages the activation of free radicals and arrests the growth of parasites.
How to use LOXOF OZ TABLET
Take LOXOF OZ TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. You can take LOXOF OZ TABLET with meals or at any time during the meals. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LOXOF OZ TABLET
Common
- Sleeping problems
- Headache
- dizziness
- Nausea
- vomiting
- Diarrhoea
Uncommon
- Candidiasis (fungal infection)
- Shortness of breath
- Anxiety
- Confusion
- nervousness
- Sleepiness
- Trembling
- vertigo (spinning feeling)
- Loss of appetite
- stomach pain
- indigestion
- Constipation
- flatulence
- Skin rash
- severe itching or hives
- increased sweating
- Painful joints and muscles
- General weakness
- Dry mouth
Rare
- Hypersensitivity reactions
- Hallucination
- paranoia (mental illness)
- Abnormal dreams and nightmares
- Paraesthesia (tingling sensation in hands and feet)
- Blurred vision
- Ringing in ears
- Decreased blood pressure, rapid heartbeat
- Muscle weakness
- Kidney failure
- Fever
Stop taking LOXOF OZ TABLET and contact your doctor immediately if you experience any of the following side effects:
- Signs of severe intestinal problems (such as watery diarrhoea with blood, stomach cramps and high temperature)
- Inflammation and pain in tendons and ligaments
- Fits (convulsions)
How To Manage Side Effects
Constipation
Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals and drink plenty of water. Exercise regularly (such as daily walk). If this does not help, consult your doctor for receiving alternate management for constipation.
Diarrhea
Drink lot of fluids such as water to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom did not improve.
Dry Mouth
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Take LOXOF OZ TABLET with or immediately after food. Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom does not improve.
Stomach Pain
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ContraindicatedLOXOF OZ TABLET is not recommended for use in pregnant women or women who are planning to become pregnant. Consult your doctor before taking LOXOF OZ TABLET.
Breastfeeding
ContraindicatedLOXOF OZ TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking LOXOF OZ TABLET.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy, sleepy, spinning feeling, changes in your vision, inability to concentrate or coordinate things, fits, tremor, rigidity and temporary loss of consciousness after taking LOXOF OZ TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking LOXOF OZ TABLET because it may aggrevate your existing symptoms.
Kidney
Use with CautionLOXOF OZ TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking LOXOF OZ TABLET.
Liver
Use with CautionLOXOF OZ TABLET should be taken with caution in patients with liver disease. Consult your doctor before taking LOXOF OZ TABLET.
Allergy
ContraindicatedDo not take LOXOF OZ TABLET if you are allergic to Levofloxacin and Ornidazole
Heart Disease
Use with CautionLOXOF OZ TABLET should be taken with caution in patients who have or ever had a family history of prolonged QT interval, slow heart rhythm, heart failure or weak heart, history of heart attack, aortic aneurysm or large vessel peripheral aneurysm ( enlargement or bulging of large blood vessels of the heart), heart valve regurgitation ( leaking of heart valves), congenital heart valve disease or aortic dissection, vascular disorders such as Takayasu arteritis, giant cell arteritis, bechet’s disease, high blood pressure and endocarditis (infection of the heart). Consult your doctor before taking LOXOF OZ TABLET.
Use In Pediatrics
ContraindicatedLOXOF OZ TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionLOXOF OZ TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
Others
LOXOF OZ TABLET is not recommended for use if you:
- Have ever had epilepsy (fits)
- Have ever had tendon problems such as (tendonitis)
Before taking LOXOF OZ TABLET, inform your doctor if you:
- Have or had any damage to brain due to stroke or any injury to brain
- Have glucose -6-phosphate dehydrogenase deficiency (an inherited disease causing deficiency of an enzyme called glucose -6-phosphate dehydrogenase in the body)
- Have or ever had mental health problems
- Have connective tissue disorders (such as marfan syndrome, ehlers-danlos syndrome and turner syndrome)
- Have sjogren’s disease or myasthenia gravis (autoimmune disorder)
- Have salt imbalances in the body (such as potassium or magnesium)
- Have diabetes (high blood sugar)
- Are experiencing rapid onset of shortness of breath
- Have multiple sclerosis (chronic condition affecting the brain)
Interactions
A. Drug-Drug interactions:
Before taking LOXOF OZ TABLET, inform your doctor if you are taking any of the following medicines:
- Corticosteroids (medicines used to manage inflammation) Ex. prednisolone
- Warfarin (used to manage clotting of blood)
- Theophylline (used to manage asthma)
- NSAIDS (medicines used to manage pain and inflammation) Ex. ibuprofen, fenbufen
- Cyclosporine (used to manage organ rejection during organ transplantation)
- Cimetidine (used to manage acidity)
- Probenecid (used to manage gout)
- Anti-arrhythmics (medicines used to manage abnormal heart rhythm) Ex. quinidine, hydroquinidine, disopyramide, sotalol, dofetilide, ibutilideamiodarone)
- Antidepressants (used to manage depression) Ex. amitriptyline, imipramine
- Antipsychotics (used to manage mental disorders) Ex. risperidone, quetiapine
- Macrolide antibiotics (used to manage bacterial infections) Ex. erythromycin, azithromycin, clarithromycin
- Lithium (used to manage mood disorders)
- Antiepileptics (medicines used to manage fits) Ex. phenytoin, phenobarbital
- Vecuronium bromide (medicine used as a general anaesthetic agent during surgeries)
Overdosage:
If you or anyone else accidentally take too much of LOXOF OZ TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of LOXOF OZ TABLET includes fits, confusion, dizziness, less conscious, tremor, heart problems leading to irregular heartbeats, nausea and burning stomach.
Synopsis
| Drug | : | Levofloxacin, Ornidazole |
| Pharmacological Category | : | Fluoroquinolone, Nitroimidazole |
| Therapeutic Indication | : | Bacterial, Protozoal infections |
| Dosage Forms | : | Tablet, Syrup, Oral Suspension |
More Information
Storage
- Keep LOXOF OZ TABLET out of reach of children
- Store at room temperature
FAQs About LOXOF OZ TABLET
Q: What dietary changes should I follow while taking LOXOF OZ TABLET?
A: While taking LOXOF OZ TABLET alcohol must not be taken for at least 3 days after stopping this medicine. You can stick on to normal foods and take LOXOF OZ TABLET during meals or anytime between meals.
Q: Does LOXOF OZ TABLET cause diarrhoea?
A: Yes, LOXOF OZ TABLET may cause diarrhoea. To manage this effect, drink lot of fluids such as water or fruit juice to avoid dehydration. Do not consume LOXOF OZ TABLET on your own without consulting your doctor.
Q: How does LOXOF OZ TABLET work?
A: LOXOF OZ TABLET works by inhibiting the growth of bacteria which are responsible for causing various infections in the body. It inhibits the synthesis of bacterial enzymes which can cause damage to the structure of DNA leading to cell death. Thus, it effectively manages different types of infections caused by microorganisms. Also, it works by killing the parasites which are responsible for causing various infections in the body. It inhibits the synthesis of protein and manages the activation of free radicals and arrests the growth of parasites.
Q: What is LOXOF OZ TABLET used for?
A: LOXOF OZ TABLET is used in the management of various bacterial infections such as gastrointestinal infections, chest infections and urinary tract infections. It can also be used in the management of protozoal infections (parasitic infections).
Q: Is LOXOF OZ TABLET recommended for children?
A: LOXOF OZ TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice to select a suitable alternative medicine to manage the infection.
References
1. KD Tripathi. Antimicrobial Drugs, Anti-amoebic and Other Antiprotozoal Drugs Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 764 & 897.
2. Bush N, Sharma V, Chandrahasan K, Patil AN. Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge. NIH National Library of Medicine, National center for biotechnology information. [Accessed on 8th January 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491762/
3. Elara Pharma services Limited. Electronic Medicines Compendium (EMC) [Revised in January 2021] [Accessed on 8th January 2022] https://www.medicines.org.uk/emc/files/pil.12130.pdf
4. Teva Pharma (New Zealand) Limited. [Revised in October 2018] [Accessed on 8th January 2022] https://www.medsafe.govt.nz/profs/datasheet/a/arrowornidazoletab.pdf
5. Leeford. levelfox-oz tablet (Levofloxacin & Ornidazole). [Accessed on 8th January 2022] https://www.leeford.in/product/1022/levelfox-oz-tablets
Useful Diagnostic Tests
- Complete blood count
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