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Introduction About LOX 5% OINMENT
LOX 5% OINMENT contains Lignocaine which belongs to the group of medicines called Local Anesthetic agents. It causes numbness of body parts at sites where it has been applied. It is used for temporary relief of pain and discomfort associated with skin abrasions, sun burns, insect bites, sore nipples, hemorrhoids (piles), anal fissures, bed sores and shingles or cold sores (pain skin rash or blisters around the mouth due to viral infections).
It can also be used to relieve pain following circumcision in children (a surgery that removes the foreskin from human penis) and can be used to soothe itching around the rectum, anus (pruritus ani), or female genitalia (vulva).
It also relieves pain caused due to oral sores and can numb the mouth and throat prior to any dental procedures (such as scaling or denture fixing).
It acts as an anesthetic lubricant for catheterization, intubation and for other diagnostic procedures (such as proctoscopy, rectoscopy, cystoscopy, gastroscopy, bronchoscopy, esophagoscopy etc.)
If you are managed with LOX 5% OINMENT in your oral cavity, avoid oral foods or chewing gums for at least 60 minutes or until sensation comes back in your mouth. This is because you may experience trouble in swallowing or accidentally bite your tongue or cheek muscles during this period.
Before using LOX 5% OINMENT inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any infections or injuries at the site of application as a precaution.
LOX 5% OINMENT can be used in pregnant and breastfeeding women if considered necessary. It is generally safe and well tolerated without any major side effects. However, if you experience any skin rash or irritation in the application site or feel drowsy consult your doctor for advice.
Uses Of LOX 5% OINMENT
It causes numbness and provides temporary relief of pain, itching and discomfort associated with:
- skin abrasions, sun burns, insect bites, sore nipples
- shingles, bed sores and cold sores
- hemorrhoids (piles), anal fissures, pruritus ani (itching of anus)
- pruritus vulvae (itching of female genitalia)
- circumcision (a surgery that removes the foreskin from human penis) in children
- oral sores and dental procedures (such as scaling or denture fixing)
- invasive procedures (such as insertion of catheters or intubation tubes)
- diagnostic procedures (such as proctoscopy, rectoscopy, cystoscopy, gastroscopy, bronchoscopy, esophagoscopy etc.)
How LOX 5% OINMENT Works
LOX 5% OINMENT is a local anesthetic agent. It reduces pain sensation and causes numbness of body parts by blocking the flow of certain ions (sodium ions) through the nerves that causes pain sensation. As a result, it limits the transfer of pain signals from the peripheral part of the body (i.e., face, hands, legs, abdomen, pelvis, genitals or where the medicine has been applied) to the brain which ultimately leads to loss of sensation.
How to use LOX 5% OINMENT
LOX 5% OINMENT should be used under proper medical supervision. It is administered by the physician at the region where anesthesia is required. However, it can also be self-administered by the patients if instructed by the doctor.
Take a small quantity of LOX 5% OINMENT and apply on the required areas. Avoid contact of LOX 5% OINMENT with your eyes.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, health condition and sites where numbness is required in the body.
Side Effects Of LOX 5% OINMENT
Rare
Consult your doctor immediately if you experience any of the following after using LOX 5% OINMENT:
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, throat, or tongue causing difficulty in breathing or swallowing)
- dizziness or drowsiness, confusion, shortness of breath, ringing in the ears, blurred vision, slow heartbeat, feeling faint, nervousness, unusual sweating, trembling or seizures
- signs of methemoglobinemia (such as pale, grey, or bluish discoloration of the skin, headache, abnormal or irregular heartbeat, dizziness, and tiredness etc.)
Warning & Precautions
Pregnancy
LOX 5% OINMENT can be used in pregnant women if considered necessary. However, consult your doctor for advice before using it.
Breastfeeding
LOX 5% OINMENT can be used in breastfeeding women if considered necessary. However, consult your doctor for advice before using it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if your ability is affected by LOX 5% OINMENT.
Kidney
LOX 5% OINMENT should be used with caution in patients with kidney diseases. Therefore, consult your doctor before application.
Liver
LOX 5% OINMENT should be used with caution in patients with liver diseases. Therefore, consult your doctor before application.
Allergy
Talk to your doctor before using LOX 5% OINMENT if you are allergic to lignocaine or to any other amide local anesthetics (Ex. bupivacaine).
Heart Disease
LOX 5% OINMENT should be used with caution in patients with heart diseases (such as heart block, or an abnormal or very slow heartbeat). Therefore, consult your doctor before application.
Others
Before using LOX 5% OINMENT inform your physician if you:
- have any open wounds, injuries, or infections at the site of application
- have porphyria (a rare inherited blood disorder)
- have epilepsy (fits)
- have or have a family history of malignant hyperthermia (dangerous rise in body temperature)
Use in pediatrics:
LOX 5% OINMENT can be used in children and adolescents aged above 2 years after consulting your physician. It is not recommended for use in children aged below 2 years. Therefore, consult your doctor for advice.
Use in geriatrics:
LOX 5% OINMENT should be used with caution in the elderly patients. Therefore, consult your doctor for advice.
Interactions
A. Drug-Drug interactions:
Before using LOX 5% OINMENT inform your doctor if you are taking any of the following medicines such as:
- mexiletine, amiodarone (used to manage uneven heartbeat)
- cimetidine (a medicine used to manage stomach ulcers)
- beta-blockers such as atenolol, propranolol, bisoprolol (used to manage high blood pressure)
- nitrates (such as nitric oxide, nitroglycerin) used to improve blood flow
- other local anesthetic agents (such as bupivacine, proparacaine, ropivacine, mepivacaine, prilocaine, procaine, tetracaine)
- antibiotics (used to manage bacterial infections) such as PABA, nitrofurantoin, dapsone, sulfasalazine
- anticancer medicines (used to manage cancer) such as cyclophosphamide, ifosfamide, hydroxyurea, flutamide, rasburicase
- antimalarial agents (used to manage malarial infection) Ex. chloroquine, primaquine, quinine
- anti-epileptic agents (used to manage fits) Ex. phenytoin, sodium valproate, phenobarbital
- metoclopramide (a medicine used to manage nausea and vomiting)
Overdosage:
If you or anyone else applied excessive LOX 5% OINMENT, wipe off the excess with a paper towel or tissue paper. If your child or anyone else accidentally swallowed LOX 5% OINMENT, contact your doctor immediately or visit a nearby hospital immediately as it may lead to severe decrease in low blood pressure.
Synopsis
| Drug | : |
Lignocaine |
| Pharmacological Category | : |
Amide Local Anesthetics |
| Therapeutic Indication | : |
Local anesthesia |
| Dosage Forms | : |
Injection, Gel, Cream, Ointment, Jelly, Topical Solution, Spray, Oral solution, Plaster |
More Information
- Keep LOX 5% OINMENT out of reach of children
- Store LOX 5% OINMENT at room temperature
FAQs About LOX 5% OINMENT
How long will it take for LOX 5% OINMENT to induce numbness?
It may take around 3-5 minutes for LOX 5% OINMENT to create numbness. However, this period may vary from person-to-person based on the dose and amount of LOX 5% OINMENT that is administered.
How long does the effects of LOX 5% OINMENT lasts long in the body?
The effects of LOX 5% OINMENT may last from 20-30 up to 1 hour after application. However, the recovery period may vary from person-to-person based on the dose and amount of the LOX 5% OINMENT applied.
What is the use of LOX 5% OINMENT?
LOX 5% OINMENT is used to cause temporary numbness of body parts. It provides pain relief during skin abrasions, sun burns, insect bites, sore nipples, hemorrhoids (piles), anal fissures, bed sores, shingles or cold sores, circumcision and oral sores. It can also be used to soothe itching around the rectum, anus or vulva and helps in the easy fix of catheters and intubation tubes. It also acts as an anesthetic lubricant for various diagnostic procedures.
How to use LOX 5% OINMENT?
LOX 5% OINMENT should be used under proper medical supervision. It is usually administered by the physician prior to the surgical or diagnostic procedures. However, it may also be self-administered by the patients if instructed by the doctor for temporary pain relief. Take a small quantity of LOX 5% OINMENT and apply on the required areas. Avoid contact of LOX 5% OINMENT with your eyes.
Can LOX 5% OINMENT be used in children?
LOX 5% OINMENT can be used in children and adolescents aged above 2 years after consulting your physician. It is not recommended for use in children aged below 2 years. Therefore, consult your doctor for advice.
Can you drink water after using LOX 5% OINMENT?
Avoid eating foods or drinking water or other fluids after applying LOX 5% OINMENT as it may reduce its anesthetic effects.
How often can we use LOX 5% OINMENT?
LOX 5% OINMENT should be used as instructed by the doctor. Your doctor will decide the duration of therapy for you depending upon your age, body weight, health condition and sites where numbness is required in the body.
Can LOX 5% OINMENT be used in infants?
LOX 5% OINMENT is not recommended for use in children aged below 2 years. Therefore, consult your doctor for advice.
Will LOX 5% OINMENT cause sleepiness?
LOX 5% OINMENT may cause sleepiness when used more than the recommended dosage. It may also happen if you apply this medicine more frequently within a shorter duration. In such cases, consult your doctor for advice.
Can I have food after applying LOX 5% OINMENT in the mouth?
Avoid consuming food while your mouth and throat are numb or for at least 60 minutes after using LOX 5% OINMENT as you may experience trouble in swallowing during this period. This may also involve the risk of biting your cheeks or tongue.
What if I have accidental exposure of LOX 5% OINMENT to the eye?
Use lukewarm water to gently wash the outer surface of the eye in case of accidental contact with LOX 5% OINMENT. If the discomfort in the eye persists, contact your doctor, or visit a nearby hospital immediately.
What to do if I forget to take a dose of LOX 5% OINMENT?
If you miss to apply a dose of LOX 5% OINMENT, apply it as soon as you remember. If it is time for the next dose, skip the missed dose and apply the next time at regular times. Do not apply excessive amount of LOX 5% OINMENT to compensate the missed dose.
References
1. KD. Tripathi. Drugs acting on peripheral (somatic) nervous system. Essentials of medical pharmacology. 8th Edition. 2019. Page – 392.
2. Natasha Beg, Thierry Vancaillie, Alan Hewitt, Julie Eggermont, Georgina Armstrong. NIH National Library of Medicine, National center for biotechnology information. Lignocaine gel in minimally invasive surgery - A pilot cohort, August 2010. [Accessed on 26th September 2022] https://pubmed.ncbi.nlm.nih.gov/20716268/
3. Lidocaine Ointment. NIH. National Library of Medicine. Dailymed.com. [Revised in July 2022]. [Accessed on 26th September 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=88ca9cba-0c4a-482f-b502-ceefdb1bfbcd
4. Merckle GmbH. Teva.uk. [Revised in February 2022]. [Accessed on 26th September 2022] https://products.tevauk.com/mediafile/id/52082.pdf
5. Aspen Pharmacare Australia Pty Ltd. Xylocaine 5% ointment. [Revised in February 2018]. [Accessed on 26th September 2022] https://www.aspenpharma.com.au/wp-content/uploads/PICMI/CMI/CMI_XylocaineOintment.pdf
6. Pharmacy Retailing (NZ) Limited. Medsafe. [Revised in January 2018] Accessed on 26th September 2022] https://www.medsafe.govt.nz/profs/Datasheet/x/Xylocainejelly.pdf
7. Aspen Pharmacare Australia. Xylocaine 2% Jelly. [Accessed on 26th September 2022] https://www.xylocaine.com.au/jelly/
8. Aspen Pharmacare Australia. Xylocaine 5% Ointment. [Accessed on 26th September 2022] https://www.xylocaine.com.au/ointment/
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