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Introduction About LOTEGATE EYE DROPS
LOTEGATE EYE DROPS is a combination of Gatifloxacin and Loteprednol which belongs to the group of medicines called Antibiotics and Corticosteroids respectively. It is used to manage eye inflammation and/or infection following eye surgery.
LOTEGATE EYE DROPS is for ophthalmic use only. Instil few drops of the medicine into the affected eye(s). Do not touch the tip of the dropper with your eye or other body surface to avoid contamination. If you wear soft contact lenses, remove the lens before applying LOTEGATE EYE DROPS and wait for at least 15 minutes before reinsertion.
Before using LOTEGATE EYE DROPS inform your doctor if you have glaucoma or any bleeding problems. You must also inform your doctor if you have any eye infections as a precaution.
LOTEGATE EYE DROPS is not recommended for use in pregnant women and in breastfeeding women unless considered necessary by the physician. The most common side effects of using LOTEGATE EYE DROPS are blurred vision, eye irritation or burning sensation. Consult your doctor if any of these side effect worsens.
Uses Of LOTEGATE EYE DROPS
- Manage and manages post-operative eye inflammation and infection
How LOTEGATE EYE DROPS Works
LOTEGATE EYE DROPS contains two medicines namely gatifloxacin and Loteprednol. Gatifloxacin is an antibacterial agent. When applied topically on the eyes, it kills the susceptible bacteria that causes eye infection.
Loteprednol is a corticosteroid medication. It blocks the release of certain chemicals in the body (such as prostaglandins) that causes eye pain, inflammation and swelling. Collectively, they act together and manages eye pain, inflammation and/or infection that can occur following eye surgeries.
How to use LOTEGATE EYE DROPS
Use LOTEGATE EYE DROPS as advised by your physician. It is for ophthalmic use only.
Wash your hands before application. Tilt your head slightly backwards and place the tip of the container close to your eyes. Gently pull your lower eyelid and instil few drops of the medicine as directed by your physician.
Close your eyes and gently press the inner corner of your eye for 2 minutes. Repeat the same for the other eye if required.
Do not touch the tip of the container with your eyes, eyelids or areas around your eyes or fingers, to avoid contamination. After applying LOTEGATE EYE DROPS, leave a time gap of at least 5 minutes before applying other eye drops or ointment.
If you wear soft contact lenses, remove the lens before applying LOTEGATE EYE DROPS and wait for at least 15 minutes before reinsertion. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
Side Effects Of LOTEGATE EYE DROPS
Common
- burning and stinging of the eyes
- redness, itching and watering of eyes or eyelids
- eye discomfort
- eye pain or irritation
- discharge from eyes
- dry eyes
- skin redness
- blurred vision, headache
- changes in taste
Uncommon
- abnormal vision
- swelling of the eyes
- light sensitivity
- tiredness, running nose and sore throat
Rare
- migraine
- spinning sensation
- numbness
- chills, fever and pain, cough
- urinary tract infection
- skin rash or itching, dry skin
- diarrhoea, nausea, vomiting
- weight gain
Stop using LOTEGATE EYE DROPS and contact your doctor immediately if you experience any of the following side effects:
- severe eye pain, redness, irritation and vision changes
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, throat or tongue causing difficulty in breathing or swallowing)
- signs of breast cancer (presence of lumps in breast, skin dimpling in breast and changes in the nipple)
- involuntary muscle contraction
- nervousness, ringing sound in the ears
- chest pain
How To Manage Side Effects
Burning or stinging of eyes:
Wash your eyes with plain cold water. Place an ice pack on your eye to ease the irritation. Avoid straining your eyes by looking at mobile phones, laptops or television. Wear protective eyeglasses while going outdoors.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Blurred vision:
Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
Warning & Precautions

Pregnancy
LOTEGATE EYE DROPS is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before using it.

Breastfeeding
LOTEGATE EYE DROPS is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, inform your doctor before using it.

Driving and Using Machines
Do not drive or operate any machines if you experience blurred vision after using LOTEGATE EYE DROPS. Wait, until your vision becomes clear.

Allergy
Do not use LOTEGATE EYE DROPS if you are allergic to Gatifloxacin, Loteprednol, other quinolones (such as moxifloxacin) or non-steroidal anti-inflammatory medicines (such as aspirin).

Lungs
LOTEGATE EYE DROPS should be used with caution in patients who previously developed asthma while using any non-steroidal anti-inflammatory drugs. Therefore, consult your doctor before application.
Others
LOTEGATE EYE DROPS is not recommended for use if you:
- have any bacterial, fungal or viral infections in the eye
Before using LOTEGATE EYE DROPS inform your doctor if you:
- have glaucoma
- have any bleeding problems
Use in pediatrics:
LOTEGATE EYE DROPS is generally not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before application.
Use in geriatrics:
LOTEGATE EYE DROPS should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before application.
Interactions
A. Drug-Drug interactions:
Before using LOTEGATE EYE DROPS, inform your doctor if you are taking any of the following medicines such as:
- anticholinergics (used to manage a variety of conditions such as gastrointestinal cramps, muscular spasms, urge incontinence or asthma) such as baclofen, prazosin, dicyclomine
- medicines used to manage glaucoma (such as timolol)
Overdosage:
If you or anyone else accidentally used more LOTEGATE EYE DROPS, rinse your eye with warm water. If still irritation persists, consult your doctor.
Synopsis
Drug | : | Gatifloxacin, Loteprednol |
Pharmacological Category | : | Fluroquinolones, Topical Corticosteroids |
Therapeutic Indication | : | Prevents post operative eye infection and inflammation |
Dosage Forms | : | Eye drops |
More Information
- Keep LOTEGATE EYE DROPS out of reach of children
- Store LOTEGATE EYE DROPS at room temperature
FAQs About LOTEGATE EYE DROPS
Can the use of LOTEGATE EYE DROPS cause blurred vision?
Yes. LOTEGATE EYE DROPS may cause blurred vision after application in some individuals, although not everybody gets them. If your vision becomes blur, close your eyes for some time and rest. Do not strain your eyes by looking at mobile phones, laptops or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
Can I use other eye medicines while using LOTEGATE EYE DROPS?
Avoid concomittant use of any eye medicines while using LOTEGATE EYE DROPS without consulting your doctor.
How to use LOTEGATE EYE DROPS?
Use LOTEGATE EYE DROPS as advised by your physician. It is for ophthalmic use only. Instil few drops of the medicine into the affected eye(s). Close your eyes and press the corner of your eye with your finger for a minute. Repeat the same for the other eye if required.
What is the use of LOTEGATE EYE DROPS?
LOTEGATE EYE DROPS is a prescription medicine used to manage eye inflammation and/or infection following eye surgery.
How long does it take for [GBNKRYWORD] to work?
It may take around 10-15 minutes for LOTEGATE EYE DROPS to start showing its effects. However, this period may vary from person-to-person depending upon the dose that is administered.
What are the side effects of LOTEGATE EYE DROPS?
LOTEGATE EYE DROPS is generally safe and well tolerated. It may cause blurred vision, eye irritation or burning sensation in some individuals. Contact your doctor if they trouble you.
Can I use LOTEGATE EYE DROPS while wearing contact lenses?
If you wear soft contact lenses, remove the lens before applying LOTEGATE EYE DROPS and wait for at least 15 minutes before reinsertion.
Can I stop using LOTEGATE EYE DROPS without consulting my doctor?
Do not stop using LOTEGATE EYE DROPS without consulting your doctor, as the symptoms may reappear once again. If you think that you are feeling better or if you wish to stop using LOTEGATE EYE DROPS, contact your doctor for advice.
Can I drive or ride a bike after using LOTEGATE EYE DROPS?
Do not drive if you experience blurred vision after using LOTEGATE EYE DROPS.
What if I miss a dose of LOTEGATE EYE DROPS?
If you missed a dose of LOTEGATE EYE DROPS, apply it as soon as you remember. However, if it is time for next dose, skip the missed dose and use the regular dose. Do not use a double dose of LOTEGATE EYE DROPS to compensate the missed dose.
How LOTEGATE EYE DROPS works?
LOTEGATE EYE DROPS blocks the release of certain chemicals in the body (such as prostaglandins) that causes eye pain, inflammation and swelling. It also kills the susceptible bacteria that causes eye infection. Therefore, it manages eye pain, inflammation and/or infection that occurs following eye surgeries.
References
1. KD. Tripathi. Autacoids and related drugs. Sulfonamides, Cotrimoxazole and Quinolones. Essentials of Medical Pharmacology. 7th Edition. 2013. Page –714.
2. Clyde Schultz. Gatifloxacin Ophthalmic Solution for Treatment of Bacterial Conjunctivitis: Safety, Efficacy and Patient Perspective. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed central. July 2012. [Accessed on 22nd December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619660/
3. Michael Amon and Massimo Busin. Loteprednol etabonate ophthalmic suspension 0.5 %: efficacy and safety for postoperative anti-inflammatory use. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed central. June 2012. [Accessed on 22nd December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459083/
4. Akorn. GATIFLOXACIN solution/ drops. Dailymed.com. [Revised in March 2022]. [Accessed on 22nd December 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=14312de6-67d4-4de2-854c-ef764090dd83
5. Dr. Gerhard Mann chem.-pharm. Fabrik GmbH. Electronic Medicines Compendium (EMC). [Revised in August 2022]. [Accessed on 22nd December 2022] https://www.medicines.org.uk/emc/files/pil.6212.pdf
6. Allergan India Private Limited. Zylopred Eye drops. Gatifloxacin and Loteprednol Ophthalmic solution. [Accessed on 22nd December 2022] https://allergan-web-cdn-prod.azureedge.net/allerganindia/allerganindia/media/allergan-india/products/zylopred.pdf
7. Central Drugs Standard Control Organization. Gatifloxacin 0.3% + Loteprednol Etabonate 0.5% + Benzalkonium Chloride 0.01% w/v Opthalmic suspension. May 2011. [Accessed on 22nd December 2022] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf