Losar H Tablet 15'S

Introduction About LOSAR H TABLET

Losar H Tablet is a prescription medicine formulated for effective blood pressure management in adults. It contains a unique combination of Losartan and Hydrochlorothiazide, two proven ingredients that help lower high blood pressure, improve blood circulation, and support overall heart health.

Losar H Tablet can be taken with or without food, preferably at the same time every day, for the best results. Your doctor will decide the correct dose based on your medical condition and response to management. As it contains a diuretic (water pill), it may increase urine output, so avoid taking it within four hours of bedtime to reduce sleep disturbances. Continue using this medicine regularly, even if you feel well, as high blood pressure often has no symptoms. Do not stop taking Losar H without your doctor’s advice, as this may increase your risk of heart attack or stroke.

Common side effects of Losar H Tablet include dizziness, tiredness, nausea, diarrhea, headache, decreased blood pressure, cough, weakness, upset stomach, and changes in taste. Frequent urination is not a side effect but a desired effect of hydrochlorothiazide, helping to control blood pressure. While most side effects are mild and uncommon, some may persist or require medical attention. Always read the medicine leaflet carefully and inform your doctor if you experience bothersome or lasting side effects. Your doctor may adjust your dose or suggest an alternative medication to better suit your needs.

Losar H Tablet is not recommended for use during pregnancy. Consult your doctor before taking this medicine if you have a history of kidney or liver problems, heart conditions, or diabetes. Avoid alcohol consumption while on this medication, as it can further lower blood pressure and increase the risk of side effects. Always follow your doctor’s advice for safe and effective use.

Uses Of LOSAR H TABLET

• Hypertension (high blood pressure)

Benefits of LOSAR H TABLET

1.Reduces high blood pressure (hypertension): Losar H Tablet combines Losartan and Hydrochlorothiazide to effectively lower elevated blood pressure by relaxing blood vessels and increasing urine output, which helps reduce the risk of heart attack, stroke, and other cardiovascular complications.

2. Reducing cardiovascular events: By controlling blood pressure, Losar H Tablet reduces the risk of serious heart-related problems such as heart attacks, strokes, and kidney damage.

3. Promotes healthy blood circulation: Losartan in the medication helps widen blood vessels, improving overall blood flow and supporting heart health.

4.Helps reduce fluid retention: Hydrochlorothiazide acts as a diuretic (water pill), promoting increased urination to eliminate excess salt and water from the body, thereby aiding blood pressure control.

5.Supports kidney function: Effective blood pressure management with Losar H Tablet helps protect kidney health, reducing the risk of kidney-related complications in hypertensive patients.

How LOSAR H TABLET Works

Losar H Tablet is a combination medicine containing Losartan and Hydrochlorothiazide, designed to effectively manage high blood pressure by targeting different pathways in the body.

Understanding the Mechanism of Losar H Tablet

• Losartan, an angiotensin II receptor blocker (ARB), works by selectively blocking angiotensin II type 1 (AT1) receptors in blood vessels. Angiotensin II is a hormone that normally causes blood vessels to constrict and raises blood pressure. By lowering angiotensin II from binding to these receptors, Losartan helps relax and widen the blood vessels, reducing resistance and lowering blood pressure. This mechanism also decreases the release of aldosterone, a hormone that promotes sodium and water retention, aiding further in blood pressure control.
• Hydrochlorothiazide, a thiazide diuretic, supports blood pressure reduction by increasing urine production. It promotes the removal of excess salt (sodium) and water from the body through the kidneys. This decrease in fluid volume helps reduce the workload on the heart and lowers blood pressure.

Role of Losartan and Hydrochlorothiazide in Blood Pressure Support

1. Vascular relaxation: Losartan blocks the angiotensin II receptor, leading to relaxation and dilation of blood vessels for improved blood flow.
2. Fluid balance: Hydrochlorothiazide increases urination to remove excess salt and water, reducing blood volume and pressure.
3. Heart and kidney protection: Combined blood pressure control with this dual action helps protect the heart and kidneys from damage linked to hypertension.

What Happens When You Take Losar H Tablet?

When taken regularly, Losar H Tablet lowers blood pressure by easing vascular tension and promoting fluid removal, which reduces strain on the cardiovascular system. This results in healthier circulation, lower risks of heart attacks, strokes, and kidney complications associated with uncontrolled hypertension.

Angiotensin Receptor Blockade Explained

Losartan specifically targets the angiotensin II type 1 receptor, stopping angiotensin II from causing blood vessel narrowing and aldosterone release. This selective blockade reduces the hormone’s blood pressure-raising effects, leading to sustained vascular relaxation and decreased sodium retention. The action of Losartan reduces peripheral resistance and helps maintain balanced blood circulation.

How Losar H Supports Vascular Relaxation and Fluid Balance

Through the complementary actions of Losartan and Hydrochlorothiazide, Losar H Tablet relaxes blood vessels and removes excess fluids effectively. This combined mechanism reduces blood pressure safely while supporting kidney function and cardiovascular health.

How to use LOSAR H TABLET

• Take Losar H Tablet exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water. Do not chew, crush, or break the tablet to ensure proper absorption and effectiveness.
• You can take Losar H with or without food, but try to take it at the same time every day to maintain consistent blood levels and optimal blood pressure control.
• The usual starting dose for adults is 1 tablet once daily, but your doctor may adjust this based on your condition and response. Do not exceed the prescribed dose.

Recommended Dosage and Administration Guidelines

• Follow your doctor’s instructions carefully for dosage and duration. Typical doses range up to 100 mg of losartan and 25 mg of hydrochlorothiazide daily.
• Losar H is usually taken once a day, but the timing can be adjusted by your doctor depending on your health status.
• Avoid taking the medicine too close to bedtime (within 4 hours) as hydrochlorothiazide may increase urination and disrupt sleep.

How to Take Losar H Tablet Safely

• Maintain a consistent dosing schedule to get the maximum benefit from the medication.
• Avoid alcohol while taking Losar H, as it can further lower blood pressure and increase side effects.
• Inform your doctor if you have kidney or liver problems, heart conditions, or diabetes before starting the medication.
• Always consult your healthcare provider before stopping or changing the dose to reduce complications like increased risk of heart attack or stroke.

When and How Often Should You Take Losar H?

• Take Losar H Tablet once daily, preferably at the same time each day to maintain effective blood pressure control.
• Your doctor may start you on a lower dose and increase it gradually if needed.

Tips for Remembering Your Losar H Dosing Schedule

• Set a daily alarm or reminder on your phone to take your medicine at the same time each day.
• Incorporate taking the tablet into an established daily routine such as after brushing your teeth or having breakfast.
• Use a pill organizer to keep track of your doses and avoid missing any.

General Precautions While Using Losar H Tablet

• Take Losar H regularly, even if you feel well, since high blood pressure often has no symptoms but could lead to serious health risks if unmanaged.
• Inform your doctor about any side effects or if you experience symptoms like dizziness, persistent cough, or unusual fatigue.
• Avoid sudden changes in position (like standing up too quickly) to reduce dizziness caused by lowered blood pressure.
• Keep the medication out of reach of children and store it in a cool, dry place away from light and moisture.

What if I forgot to take LOSAR H TABLET

• If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose.
• In that case, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one, as this may cause low blood pressure or other side effects.

Side Effects Of LOSAR H TABLET

Like all medicines, Losar H Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Losar H Tablet are:

• Dizziness
• Tiredness
• Nausea
• Diarrhea
• Headache
• Decreased blood pressure
• Cough
• Weakness
• Upset stomach
• Changes in taste

When to consult your doctor?

• Severe allergic reactions: Symptoms such as swelling of the face, lips, tongue or throat, difficulty breathing, hives, or rash.
• Extreme dizziness or fainting: Signs of very low blood pressure that may cause you to feel lightheaded, confused, or weak.
• Signs of kidney problems: Swelling of feet, ankles or legs, decreased urination, unusual tiredness, chest pain, or difficulty breathing.
• Signs of severe muscle weakness or cramps: electrolyte imbalances like low or high potassium levels.
• Signs of vision changes or eye pain: Sudden trouble seeing or eye redness that could point to glaucoma or other serious eye conditions.
• Signs of chest pain or abnormal heart rhythms: Irregular, slow, or rapid heartbeat, palpitations, or chest discomfort
• Signs of seizures or confusion

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or Lie Down: If you feel dizzy, sit down, or lie down immediately to reduce falling. Keep your head still and close your eyes if needed.
• Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
• Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
• Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
• Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Sip Clear Liquids: Drink small sips of clear fluids like water, ginger ale, or herbal teas (ginger or peppermint are particularly helpful). Avoid drinking too much at once, which can worsen nausea.
• Eat Small, Bland Meals: Similar to stomach pain, eat light foods like crackers, toast, or bananas. Avoid greasy, spicy, or rich foods until you feel better.
• Get Fresh Air: Sometimes a little fresh air can help alleviate nausea. Take a short walk or sit near an open window.
• Use Acupressure: Applying gentle pressure to the P6 acupressure point on your wrist (located about two finger widths below the wrist crease, between the two tendons) may help reduce nausea.
• Avoid Strong Odors: Strong smells (like perfumes, cooking odors, or cigarette smoke) can trigger or worsen nausea, so it is best to avoid them if you can.

Warning & Precautions

Pregnancy

Contraindicated

Losar H is not recommended during pregnancy and should be avoided if you are more than 3 months pregnant, as it may cause serious harm to your baby. Always consult your doctor before using Losar H if you are pregnant or planning to become pregnant.

Breastfeeding

Contraindicated

Losar H is not recommended for breastfeeding mothers. Your doctor may suggest an alternative management if you wish to breastfeed. Consult your doctor before starting this medicine.

Driving and Using Machines

Use with Caution

Do not drive or operate machinery if Losar H affects your alertness, causes dizziness, or impairs your ability to focus.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking Losar H, as it can worsen your condition and increase the medication's blood pressure-lowering effects and side effects.

Kidney

Consult your doctor

Losar H is not recommended for patients with severe kidney impairment or those not producing urine. Use with caution if you have renal artery stenosis, a single functioning kidney, or recent kidney transplant. Consult your doctor before use.

Liver

Consult your doctor

Losar H is not recommended for severe liver impairment and should be used cautiously in patients with mild to moderate liver problems. Your doctor may adjust the dose accordingly. Consult your doctor before taking LOSAR H.

Allergy

Contraindicated

Do not take Losar H if you are allergic to Losartan or Hydrochlorothiazide, or any sulfonamide-derived substances (such as other thiazides or certain antibacterial drugs like co-trimoxazole).

Lungs

Use with Caution

LOSAR H should be used with caution in patients with asthma or if you previously experienced breathing or lung issues from hydrochlorothiazide. Consult your doctor before taking LOSAR H.

Heart Disease

Use with Caution

LOSAR H should be used with caution if you have heart problems (such as heart failure, atherosclerosis (narrowing of the arteries), angina pectoris, aortic or mitral valve stenosis (narrowing of valves of the heart) or hypertrophic cardiomyopathy (thickening of heart muscle)). Consult your doctor before taking LOSAR H.

Use In Pediatrics

Contraindicated

Losar H Tablet is not recommended for use in children and adolescents under 18 years of age. Always consult your pediatrician for appropriate advice and alternative management for children with hypertension.

Use In Geriatrics

Use with Caution

Elderly patients (aged 65 years and above) should use Losar H Tablet with caution. Age-related changes in kidney or liver function may affect how the medicine works, so it is important to consult your doctor before starting this medication.

Other Warnings for LOSAR H TABLET

Before taking LOSAR H, inform your physician if you:

• Have or had skin cancer.
• Are on a low-sodium or low-potassium diet.
• Have severe vomiting or diarrhea affecting your fluid balance.
• Autoimmune disorders such as systemic lupus erythematosus (causing skin rashes, fever, joint pain).
• Need anesthesia for upcoming surgery.
• Are scheduled for parathyroid function testing.
• Have primary hyperaldosteronism (excess aldosterone secretion by adrenal glands).

Who should not take [GBNKEYWORD

LOSAR H is not recommended for use if you have:

• Unmanageably low sodium or potassium levels in blood (hyponatremia or hypokalemia).
• Unmanageably high calcium levels in the blood (hypercalcemia).
• Gout or a history of elevated uric acid levels.
• Diabetes combined with impaired kidney function when managed with blood pressure medications containing aliskiren.

Diet and Lifestyle Advice

1.How can Losar H Tablet be safely incorporated into daily life, including guidance on managing side effects, staying hydrated, dietary recommendations, and overall lifestyle adjustments?

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Losar H Tablet:

1.Lithium (used for certain mental health conditions):
Interaction: Losar H Tablet can increase lithium levels in the blood.
Effects: Higher risk of lithium toxicity, which may cause tremors, confusion, nausea, and irregular heartbeat.
Management: Your doctor may avoid this combination or monitor lithium and electrolyte levels closely if both medicines are necessary.

2.Potassium supplements or potassium-containing salt substitutes:
Interaction: Losar H Tablet may increase potassium levels; combined use with potassium supplements increases risk of hyperkalemia (high potassium).
Effects: Hyperkalemia symptoms include muscle weakness, irregular heartbeat, and potentially serious heart issues.
Management: Avoid potassium supplements or salt substitutes unless your doctor advises otherwise; regular monitoring of potassium levels is recommended.

3.Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), e.g., ibuprofen, naproxen:
Interaction: NSAIDs can reduce the blood pressure-lowering effect of Losar H and increase risk of kidney damage.
Effects: Reduced efficacy of blood pressure control; potential worsening of kidney function.
Management: Use NSAIDs cautiously; your doctor may monitor kidney function and blood pressure more closely or suggest alternative pain relief.

4.Other blood pressure medicines including ACE inhibitors, ARBs, or aliskiren:
Interaction: Combining with similar drugs can increase risks of low blood pressure, high potassium, and kidney damage.
Effects: Hypotension (very low blood pressure), hyperkalemia, and kidney impairment symptoms.
Management: Avoid using with aliskiren especially if diabetic or with kidney problems; careful dose adjustment and monitoring are essential if combinations are required.

5.Diuretics and other water pills:
Interaction: Using multiple diuretics can amplify effects, causing excessive fluid loss and electrolyte imbalances.
Effects: Dehydration, electrolyte disturbances such as low sodium or potassium, dizziness, and weakness.
Management: Use under strict medical supervision with periodic blood tests to check electrolytes and kidney function.

Drug - Food interaction

1.Grapefruit and Grapefruit Juice:
Interaction: Grapefruit juice may interfere with the metabolism of Losartan, potentially increasing its blood levels.
Effects: This can increase side effects such as low blood pressure, dizziness, or kidney problems.
Management: Avoid consuming grapefruit or grapefruit juice while taking Losar H Tablet.

2.Potassium-Rich Foods (e.g., Bananas, Oranges):
Interaction: Hydrochlorothiazide can lower potassium levels, while Losartan may increase potassium. Eating too many potassium-rich foods may cause an imbalance.
Effects: Risk of either hyperkalemia (high potassium) or hypokalemia (low potassium), leading to muscle weakness, irregular heartbeat, or cardiac issues.
Management: Consult your doctor about your potassium intake; your potassium levels may need regular monitoring. Avoid sudden dietary changes with high potassium foods without medical advice.

3.Alcohol:
Interaction: Alcohol can enhance the blood pressure-lowering effects of Losar H Tablet.
Effects: Increased risk of dizziness, fainting, low blood pressure (hypotension), and impaired coordination.
Management: It is advisable to avoid or limit alcohol consumption while using Losar H Tablet to reduce side effects.

4.Salt Intake (Sodium):
Interaction: High dietary sodium can reduce the effectiveness of Losar H Tablet in controlling blood pressure.
Effects: Poor blood pressure control, increased cardiovascular risk.
Management: Follow a low-sodium diet as recommended by your doctor while taking this medicine.

Synopsis

More Information

FAQs About LOSAR H TABLET

Q: What is Losar H Tablet used for?

A: Losar H Tablet is primarily used to manage high blood pressure (hypertension). It combines Losartan and Hydrochlorothiazide to relax blood vessels and reduce fluid retention, helping to lower elevated blood pressure and reduce the risk of heart attack, stroke, and kidney complications.

Q: How should I take Losar H Tablet?

A: Take Losar H Tablet exactly as prescribed by your doctor, usually once daily with or without food. Try to take it at the same time each day. Avoid taking it within four hours of bedtime to reduce frequent urination at night.

Q: What are the common side effects of Losar H Tablet?

A: Common side effects include dizziness, tiredness, headache, nausea, upset stomach, cough, weakness, and changes in taste. Frequent urination is an expected effect due to hydrochlorothiazide and not a side effect.

Q: Can I take Losar H Tablet during pregnancy or breastfeeding?

A: Losar H Tablet is not recommended during pregnancy, especially after the first three months, as it may harm the unborn baby. It is also not advised during breastfeeding. Consult your doctor for alternative managements.

Q: What should I avoid while taking Losar H Tablet?

A: Avoid alcohol as it can increase side effects and lower blood pressure further. Also avoid potassium supplements or salt substitutes unless advised by your doctor. Grapefruit juice should be avoided as it may interfere with medicine metabolism.

Q: Who should not take Losar H Tablet?

A: Losar H is not recommended if you have severe kidney or liver impairment, allergy to Losartan or Hydrochlorothiazide, severely low sodium or potassium levels, gout, or certain heart conditions. Always inform your doctor about your medical history before starting this medicine.

Q: What should I do if I miss a dose of Losar H Tablet?

A: Take the missed dose as soon as you remember, unless it is near your next scheduled dose. Do not double the dose to make up for a missed one. Continue with your regular dosing schedule.

Q: Can Losar H Tablet affect my ability to drive or use machines?

A: Yes, Losar H Tablet may cause dizziness or drowsiness. Avoid driving or operating machinery if you feel unsteady after taking the medicine.

Q: Is Losar H Tablet easy to use daily?

A: Yes. It is taken once a day, with or without food, making it simple to fit into your daily routine.

Q: Who should consider Losar H Tablet?

A: Adults with high blood pressure, especially if other managements have not worked well, may benefit. Always consult your doctor first.

Q: Are there general tips for safe use?

A: Drink enough water, do not stop the medicine suddenly, and visit your doctor regularly to monitor blood pressure and overall health.

References

1. KD. Tripathi. Drugs Affecting Renin-Angiotensin System and Plasma Kinins. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 506 & 559.

2. Randa Hilal-Dandan. Renin and Angiotensin. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 738.

3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2305-2308.

4. Merck Sharp & Dohme Corp. A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in May 2017] [Accessed on 12th August 2025] 

5. J H MacKay, K E Arcuri, A I Goldberg, S M Snapinn, C S Sweet. Losartan and low-dose hydrochlorothiazide in patients with essential hypertension. A double-blind, placebo-controlled trial of concomitant administration compared with individual components. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 1996. [Accessed on 12th August 2025] 

6. L M Ruilope , R L Simpson, J Toh, K E Arcuri, A I Goldberg, C S Sweet. Controlled trial of losartan given concomitantly with different doses of hydrochlorothiazide in hypertensive patients. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 1996. [Accessed on 12th August 2025] 

7. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 12th August 2025] 

8. Merck Sharp & Dohme Corp. U.S. Food & Drug Administration. [Revised in March 2013] [Accessed on 12th August 2025] 

Useful Diagnostic Tests

• Kidney function test

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 14 Aug 2025 | 09:35 AM(IST)