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Introduction About LOPOX TABLET
LOPOX TABLET contains Loperamide which belongs to the group of medicines called Antidiarrheals. It is used to manage acute attacks of diarrhea (in adults and children over 12 years of age) and acute episodes of diarrhea associated with irritable bowel syndrome (group of symptoms that affects the digestive system such as abdominal cramps, gas, bloating and diarrhea) (in adults aged 18 years and over).
Before taking LOPOX TABLET, inform your doctor if you have liver disease, acquired immunodeficiency syndrome (AIDS), low body fluids and salts (due to diarrhea), intolerance to certain sugars and if you have a history of intolerance to certain sugars such as lactose.
LOPOX TABLET is not recommended for use in pregnant and breast-feeding women. It is not recommended for use in children (less than 12 years of age) and it should be used with with caution in children (above 12 years of age) for short-term diarrhea.
LOPOX TABLET should be used with caution in elderly patients with severe diarrhea (due to increased risk of low body fluids and salts), consult your doctor before taking this medicine. The most common side effects of taking LOPOX TABLET are headache, constipation, flatulence and nausea. Consult your doctor immediately if any of the side effects worsen.
Uses Of LOPOX TABLET
- To manage acute attacks of diarrhea (in adults and children over 12 years of age)
- Manage acute episodes of diarrhea associated with irritable bowel syndrome (in adults aged 18 years and over)
How LOPOX TABLET Works
LOPOX TABLET acts by decreasing the muscle contraction and fluid secretion, resulting in longer stomach and intestinal transit time and increased absorption of fluids and electrolytes from the gastrointestinal tract. Thus, helps to manage diarrhoea by slowing down the overactive bowel.
How to use LOPOX TABLET
Take LOPOX TABLET as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LOPOX TABLET
Common
- constipation
- nausea
- flatulence
- headache
Uncommon
- dizziness, drowsiness
- stomach pain or discomfort
- dry mouth
- vomiting
- indigestion
- rash
Rare
- abnormal increase in muscle tension
- smaller pupils
- bloated tummy, tiredness
- severe itching
- skin rashes with the formation of wheals
Stop taking LOPOX TABLET and contact your doctor immediately if you experience any of the following side effects:
- bloated tummy which may be due to enlargement of the large intestine, which may cause constipation, bloating and tenderness of the stomach or fever (megacolon or toxic megacolon)
- allergic reaction which causes swelling of the face, throat or tongue, difficulty in breathing or dizziness
- severe skin, mouth, eyes and genital blisters (Steven-Johnson's Syndrome or toxic epidermal necrolysis)
- fever, ill feeling, itching, joint pain, multiple skin lesions (erythema multiforme)
- swelling of the deeper skin layers caused by a building up of fluid (angioedema)
- decreased level of consciousness or loss of consciousness (passing out, feeling faint or less alert)
- difficulties in co-ordinating movement
- difficulties in passing urine
- severe constipation, blockage of the bowl
How To Manage Side Effects
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If the symptom does not improve, consult your doctor.
Dry Mouth
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
Headache
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Stick to simple meals while taking this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Stomach Pain
Try to take rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.
Warning & Precautions
Pregnancy
ContraindicatedLOPOX TABLET is not recommended for use in pregnant women. Consult with your doctor before taking LOPOX TABLET if you are pregnant or planning to have a baby.
Breastfeeding
ContraindicatedLOPOX TABLET is not recommended for use in breast feeding women as small amount of this medicine may pass into the breast milk. Consult your doctor before taking LOPOX TABLET.
Driving and Using Machines
Use with CautionDo not drive or use machines while taking LOPOX TABLET as it may cause dizziness, tiredness, drowsiness, reduced alertness, fainting or passing out. Consult your doctor before taking LOPOX TABLET.
Liver
Use with CautionLOPOX TABLET should be used with caution in patients with liver disease. Consult your doctor before taking LOPOX TABLET.
Allergy
ContraindicatedDo not take LOPOX TABLET if you are allergic to loperamide or any other ingredients of this medicine.
Use In Pediatrics
Consult your doctorLOPOX TABLET is not recommended for use in children (less than 12 years of age). It is used with caution in children (above 12 years of age) for short-term diarrhea. Consult child’s doctor for advice.
Use In Geriatrics
Use with CautionLOPOX TABLET should be used with caution in elderly patients with severe diarrhea (due to increased risk of low body fluids and salts). Consult your doctor before taking LOPOX TABLET.
Others
LOPOX TABLET is not recommended for use if you have:
- flare-up of ulcerative colitis (inflammatory bowel disease) which leads to abdominal pain, bloody diarrhoea, fever and weight loss.
- severe diarrhoea after taking antibiotics (accompanied with watery or bloody diarrhoea)
- constipation, bowel blockage or stomach bloating
- bacterial infection of the small intestine and colon (caused by bacteria such as salmonella, shigella and campylobacter)
- inflammation of the colon after taking antibiotics (associated with watery or bloody diarrhoea)
- acute (short-lived) dysentery, the symptoms include blood in your stools and high temperature
Before taking LOPOX TABLET, inform your doctor if you have:
- acquired immunodeficiency syndrome (AIDS)
- low body fluids and salts (due to diarrhea)
- intolerance to certain sugars
- history of drug abuse
- loss of appetite or weight loss
- difficulty or pain in passing urine
- fever or recently passed blood from the bowel
Interactions
A. Drug-drug interactions:
Before taking LOPOX TABLET, inform your doctor if you are taking any of the following medicines:
- gemfibrozil (used to manage high cholesterol levels)
- quinidine (used to manage abnormal heart rhythm)
- ritonavir (used to manage HIV infection)
- itraconazole, ketoconazole (used to manage fungal infections)
- oral desmopressin (used in the management of diabetes insipidus)
- other antidiarrheal preparations such as bismuth subsalicylate (used to manage diarrhea)
Over dosage:
If you or anyone else accidentally take too much of LOPOX TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose includes, increased heart rate, irregular heartbeat, muscle stiffness, uncoordinated movements, drowsiness, difficulty urinating or weak breathing.
Synopsis
| Drug | : | Loperamide |
| Pharmacological Category | : | Antidiarrheals |
| Therapeutic Indication | : | Diarrhoea |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep LOPOX TABLET out of reach of children
- Store LOPOX TABLET at room temperature
FAQs About LOPOX TABLET
Q: What is LOPOX TABLET used for?
A: LOPOX TABLET is used to manage acute attacks of diarrhea (in adults and children over 12 years of age) and acute episodes of diarrhea associated with irritable bowel syndrome (group of symptoms that affects the digestive system such as abdominal cramps, gas, bloating, diarrhea) (in adults aged 18 years and over).
Q: What are the common side effects of LOPOX TABLET?
A: The most common side effects of taking LOPOX TABLET are headache, constipation, flatulence and nausea. Consult your doctor immediately if any of the side effects worsen
Q: Can LOPOX TABLET be used in breast-feeding women?
A: LOPOX TABLET is not recommended for use in breast feeding women as small amount of this medicine may pass into the breast milk. Consult your doctor before taking LOPOX TABLET.
Q: Can I drive or operate machines after taking LOPOX TABLET?
A: Do not drive or use machines while taking LOPOX TABLET as it may cause dizziness, tiredness, drowsiness, reduced alertness, fainting or passing out. Consult your doctor for advice before taking LOPOX TABLET.
Q: Is LOPOX TABLET safe to use in elderly patients?
A: LOPOX TABLET should be used with caution in elderly patients with severe diarrhea (due to increased risk of low body fluids and salts). Consult your doctor before taking LOPOX TABLET.
References
1. K.D. Tripathi. Loperamide. Drugs for constipation and diarrhoea. Essentials of medical pharmacology. Seventh edition. 2013. Page-664.
2. Baker DE. Loperamide: a pharmacological review. NIH National Library of Medicine; National centre for biotechnology information. Pubdmed.gov. 2007 [Accessed on 16th September 2022] https://pubmed.ncbi.nlm.nih.gov/18192961/
3. Sahi N, Nguyen R, Santos C. Loperamide. NIH National Library of Medicine; National centre for biotechnology information. [Revised in May 2022] [Accessed on 16th September2022] https://www.ncbi.nlm.nih.gov/books/NBK557885/
4. Tillomed Laboratories Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 16th September 2022] https://www.medicines.org.uk/emc/files/pil.11853.pdf
5. Cipla (EU) Limited. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed 16th September 2022] https://www.medicines.org.uk/emc/product/10287/smpc#gref
Useful Diagnostic Tests
- Stool culture
- Complete blood count
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