Livial Tablet 28'S
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Introduction About LIVIAL TABLET
LIVIAL TABLET contains Tibolone which belongs to the group of medicines called Steroids. LIVIAL TABLET is used in postmenopausal women to provide relief from symptoms that occur after menopause.
LIVIAL TABLET is also used in post-menopausal women to manage osteoporosis which occurs after menopause, generally characterized by symptoms such as weak and fragile bones.
LIVIAL TABLET is not recommended for use in patients allergic to Tibolone. It is also not recommended for use in patients who have/had/suspected of breast/endometrial cancer or thrombosis (blood clot in vein). The medicine is also not indicated for use in patients who suffer from unusual vaginal bleeding, unmanageed endometrial hyperplasia (excessive thickening of the womb lining), lung disease (such as pulmonary embolism), heart disease (such as heart attack/heart block), and/or liver disease (such as benign liver tumor).
Before taking LIVIAL TABLET, inform your doctor if you have fibroids (non-cancerous growths inside womb), endometriosis (growth of womb lining outside womb)/endometrial hyperplasia (excessive growth of the womb lining), and/or suffer from epilepsy, otosclerosis (disease that affects eardrum and hearing), and/or lung problems (such as asthma).
LIVIAL TABLET is not recommended for use in pregnant and breast-feeding women since it is intended to be used only in postmenopausal women. The medicine is also not recommended for use in children and adolescents since it is indicated for use only in postmenopausal women. It is advised to be used with caution in elderly women (aged 60 years and above) after consulting the doctor since the medicine may increase the risk of heart disease in elderly patients.
The most common side effects of taking LIVIAL TABLET are breast pain, stomach/pelvic pain, unusual hair growth, vaginal bleeding/spotting, vaginal problems (such as increased secretions, itching, and/or irritation), thickening of uterus/cervix lining, and/or weight gain. Consult your doctor if any of these symptoms worsens.
Uses Of LIVIAL TABLET
- Provides relief from symptoms that occur menopause in postmenopausal women
- Prevents osteoporosis in post-menopausal women
How LIVIAL TABLET Works
LIVIAL TABLET works by substituting loss of estrogen (female sex hormone responsible for ovulation) production in postmenopausal women which helps in managing the occurrence of menopausal symptoms (such as hot flashes, night sweats, and/or vaginal problems) and bone loss (followed by menopause) thus providing relief from menopausal symptoms in affected women.
How to use LIVIAL TABLET
Take LIVIAL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LIVIAL TABLET
Common
- breast pain
- stomach/pelvic pain
- unusual hair growth
- vaginal bleeding/spotting
- vaginal problems (such as more secretions, itching, irritation, and/or thrush)
- thickening of lining of uterus or cervix
- weight gain
Uncommon
- signs of fluid retention such as swelling in arms/legs
- stomach upset
- acne
- painful nipples, feeling uncomfortable in breasts
- vaginal infections
Rare
- itchy skin
Stop taking LIVIAL TABLET and contact your doctor immediately if you experience any of the following side effects:
- suspected of breast cancer/endometrial cancer
- unexplained vaginal bleeding
- signs of endometrial hyperplasia (excessive thickening of the womb lining) such as heavy menstrual bleeding, anemia, bleeding between menstrual periods
- thrombosis (blood clot in a vein) such as deep venous thrombosis
- signs of blood clot such as painful swelling & redness of the legs, sudden chest pain, and/or difficulty in breathing
- signs of liver disease such as yellowing of skin or whites of eyes (jaundice)
- signs of high blood pressure such as headache, tiredness, and/or dizziness
- migraine-like headaches (happening for the first time)
Warning & Precautions
Pregnancy
LIVIAL TABLET is not recommended for use during pregnancy and in women planning for pregnancy since it is intended to be used only in postmenopausal women. Consult your doctor before taking the medicine and stop the medicine immediately if you become pregnant or think you may be pregnant.
Breastfeeding
LIVIAL TABLET is not recommended for use in breastfeeding women as it is intended to be used only in postmenopausal women. Consult your doctor before taking LIVIAL TABLET.
Driving and Using Machines
LIVIAL TABLET is unlikely to affect your ability to drive/operate machines. Consult your doctor before taking the medicine.
Kidney
LIVIAL TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking LIVIAL TABLET.
Liver
LIVIAL TABLET is not recommended for use in patients with/history of liver disease (such as benign liver tumor) and in patients who have abnormal liver function. Consult your doctor before taking LIVIAL TABLET.
Allergy
Do not take LIVIAL TABLET if you are allergic to Tibolone, and/or any other ingredients of this medicine.
Lungs
LIVIAL TABLET is not recommended for use in patients with lung disease such as pulmonary embolism (blood clot in lungs). It should be used with caution in patient with other lung problems such as asthma. Consult your doctor before taking LIVIAL TABLET.
Heart Disease
LIVIAL TABLET is not recommended for use in patients with heart disease such as heart attack/heart block. Consult your doctor before taking the medicine.
Others
LIVIAL TABLET is not recommended for use if you:
- have/had/suspected of breast cancer
- have/suspected of endometrium cancer
- have unusual vaginal bleeding
- suffer from unmanageed endometrial hyperplasia (excessive thickening of the womb lining)
- have/had thrombosis (blood clot in a vein) such as deep venous thrombosis
- have blood clotting disorder such as protein C/protein S/antithrombin deficiency
- have/recently had blood clots in arteries such as stroke
- suffer from inherited porphyria (rare blood disorder)
Before taking LIVIAL TABLET, inform your doctor if you:
- have fibroids (non-cancerous growths) inside womb
- suffer from endometriosis (growth of womb lining outside womb) or have a history of endometrial hyperplasia (excessive growth of the womb lining)
- have an increased risk of developing blood clots
- have an increased risk of developing estrogen-sensitive cancer such as mother, sister/ grandmother who has/had breast cancer
- suffer from high blood pressure, diabetes, gallstones, migraine/severe headaches
- suffer from systemic lupus erythematosus (disease of the immune system that affects many organs of the body)
- suffer from epilepsy
- otosclerosis (disease affecting eardrum and hearing)
- are scheduled for any surgery
Use in Pediatrics:
LIVIAL TABLET is not recommended for use in children and adolescents since it is intended to be used only in postmenopausal women.
Use in Geriatrics:
LIVIAL TABLET should be used with caution in elderly women (aged 60 years and above) due to increased risk of developing heart disease. Consult your doctor before taking LIVIAL TABLET.
Interactions
A. Drug-Drug Interactions:
Before applying LIVIAL TABLET, inform your doctor, if you are applying any of the following medicine:
- medicines used to manage blood clotting (Ex. warfarin)
- medicines used to manage epilepsy (Ex. phenobarbital, phenytoin, carbamazepine)
- medicines used to manage tuberculosis (Ex. rifampicin)
- St John’s Wort (herbal medicine used to manage depression)
Overdosage:
If you or anyone else accidentally takes too much of LIVIAL TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, vomiting, and/or vaginal bleeding.
Synopsis
| Drug | : | Tibolone |
| Pharmacological Category | : | Steroids |
| Therapeutic Indication | : | Provides relief from symptoms after menopause, Prevents osteoporosis (after menopause) |
| Dosage Forms | : | Tablet |
More Information
- Keep LIVIAL TABLET out of reach of children
- Store LIVIAL TABLET at room temperature
FAQs About LIVIAL TABLET
Q. What is LIVIAL TABLET used for?
A. LIVIAL TABLET is used in postmenopausal women to provide relief from symptoms that occur after menopause. It is also used in post-menopausal women to manage osteoporosis which occurs after menopause, generally characterized by symptoms such a s weak and fragile bones.
Q. What are the common side effects of taking LIVIAL TABLET?
A. The most common side effects of taking LIVIAL TABLET are breast pain, stomach/pelvic pain, unusual hair growth, vaginal bleeding/spotting, vaginal problems (such as increased secretions, itching, and/or irritation), thickening of uterus/cervix lining, and/or weight gain. Consult your doctor if any of these symptoms worsens.
Q. How LIVIAL TABLET is taken?
A. Take LIVIAL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Q. What happens if LIVIAL TABLET is taken more than its required dosage?
A. If you or anyone else accidentally takes too much of LIVIAL TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, vomiting, and/or vaginal bleeding.
Q. How LIVIAL TABLET works?
A. LIVIAL TABLET works by substituting loss of estrogen (female sex hormone responsible for ovulation) production in postmenopausal women which helps in managing the occurrence of menopausal symptoms (such as hot flashes, night sweats, and/or vaginal problems) and bone loss (followed by menopause) thus providing relief from menopausal symptoms in affected women.
References
1. KD Tripathi. Estrogens, Progestins and Contraceptives. Essentials of Medical Pharmacology. seventh edition.2013. Page-311.
2. Helenius J Kloosterboer. Tissue-selectivity: the mechanism of action of tibolone. NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. August 2004. [Accessed on 2nd January 2023] https://pubmed.ncbi.nlm.nih.gov/15337246/
3. Strides Pharma UK Ltd. Electronic Medicines Compendium (EMC). [Revised in November 2022] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.14366.pdf
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