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INTRODUCTION ABOUT LIORESAL
LIORESAL contains Baclofen which belongs to the group of medicines called Muscle relaxants. It is used to manage muscle spasms caused due to cerebral palsy, multiple sclerosis, stroke or due to any other nerve or spinal cord disorders.
Before taking LIORESAL inform your doctor if you have diabetes, hypertension or any problems with your lung, liver, kidney or heart. You must also inform your doctor if you have fits, problems in urination, any mental illness or a previous history of alcoholism or drug abuse.
LIORESAL should not be used in pregnant or breastfeeding women unless considered necessary by the physician. During management with LIORESAL, your doctor will periodically monitor your health condition through several blood tests and urine tests to avoid the risk of unwanted side effects.
LIORESAL may causes excessive sleepiness. Therefore, restrict yourself from engaging into hazardous activities that requires complete alertness. Do not drive or handle any heavy tools or machines. Also, avoid consumption of alcohol as it may make you feel more drowsy.
The most common side effects of taking LIORESAL are drowsiness, confusion, weakness and feeling unsteady or shaky. Consult your doctor if any of the symptoms worsen. You must also inform your doctor immediately if you feel extremely sad or depressed along with thoughts of committing suicide after taking LIORESAL.
USES OF LIORESAL
- Manage muscle spasms (painful muscle contractions)
HOW LIORESAL WORKS
LIORESAL is a muscle relaxant. It acts by increasing the effects of certain chemical messengers (such as GABA) in the spinal cord that induces muscle relaxation. As a result, it manages muscle twitching, relieves pain caused due to muscle spasms and improves muscle movement.
DIRECTIONS FOR USE
Take LIORESAL as advised by your physician. Shake well before use. It is preferably taken with food or milk to avoid nausea.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Do not stop taking LIORESAL without consulting your doctor as it may cause withdrawal symptoms such as muscle spasms, increased muscle tightness, fast heart rate, fever, confusion, hallucinations, mood changes, mental disorders, feeling attacked or persecuted or convulsions (fits).
SIDE EFFECTS OF LIORESAL
COMMON
- nausea, vomiting
- tiredness, sleepiness
- weak limbs, muscle pain
- constipation, diarrhoea, dry mouth
- lack of sleep, nightmares
- confusion, hallucination
- breathing difficulties
- vision problems
- urge to pass urine
- feeling unsteady or shaky
- feeling faint due to low blood pressure
- skin rash, sweating
- increased liver enzymes
RARE
- numbness or tingling in hands or feet
- change in sense of taste
- slurred or slow speech
- sexual problems in men, such as impotence
- convulsions (fits)
Stop taking LIORESAL and inform your doctor immediately if you experience any of the following side effects such as:
- feeling extremely depressed with thoughts of harming or killing themselves (suicidal thoughts)
- uncontrollable muscle spasms affecting the eyes, head, neck or body
- fainting or seizures (fits)
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take LIORESAL with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Sleepiness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling sleepy. Do not consume excessive alcohol, as it could aggravate your sleepiness. Consult your doctor if your sleepiness worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
LIORESAL is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
BREASTFEEDING
LIORESAL should be used with caution in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you feel drowsy, dizzy or problems with your vision after taking LIORESAL.
ALCOHOL
Avoid consumption of alcohol while taking LIORESAL as it may make you feel dizzier or drowsier.
KIDNEY
LIORESAL should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
LIVER
LIORESAL should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take LIORESAL if you are allergic to Baclofen.
LUNGS
LIORESAL should be used with caution in patients with lung problems. Therefore, consult your doctor before taking it.
HEART DISEASE
LIORESAL should be used with caution in patients with heart problems. Therefore, consult your doctor before taking it.
OTHERS
LIORESAL is not recommended for use if you:
- have ever had a stomach ulcer
Before taking LIORESAL, inform your doctor if you:
- have or ever had stroke in the past
- have epilepsy (fits)
- have any mental illness
- have high blood pressure
- have Parkinson’s disease (shaking, stiffness and difficulty with walking or balance)
- have diabetes
- have postural problems caused due to muscle weakness
- have difficulties in passing urine
- are an alcoholic or have a history of drug abuse or dependence
- are scheduled for any surgery in the upcoming days
Use in pediatrics:
LIORESAL can be used in children and adolescents aged below 18 years if prescribed by the physician. However, consult your doctor for advice before taking it.
Use in geriatrics:
LIORESAL should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking LIORESAL, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to relax muscles (Ex. tizanidine)
- medicines used to manage mood disorders or depression (Ex. lithium, amitriptyline)
- medicines used to manage high blood pressure (Ex. diltiazem)
- medicines used for pain management (Ex. ibuprofen, morphine)
- medicines used to manage Parkinson’s disease (Ex. levodopa or carbidopa)
- medicines used to manage allergies (Ex. promethazine)
- medicines used to induce sleep (Ex. temazepam)
- medicines used to manage fits (Ex. carbamazepine)
B. Drug-Food interactions:
LIORESAL can be taken with food or milk.
Overdosage:
If you or anyone else accidentally took more LIORESAL, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include increased drowsiness, difficulties in breathing, feeling faint, muscle weakness, confusion, hallucinations, fits, low blood pressure, slow heartbeat, nausea, vomiting, diarrhoea, excessive saliva production or reflex problems, etc.
SYNOPSIS
| Drug | : | Baclofen |
| Pharmacological Category | : | γ-Aminobutyric acid (GABA) mimetic |
| Therapeutic Indication | : | Muscle Spasms |
| Dosage Forms | : | Tablet, Capsule, Liquid |
MORE INFORMATION
- Keep LIORESAL out of reach of children
- Store LIORESAL below 25°C
FAQs ABOUT LIORESAL
What is the use of LIORESAL?
LIORESAL is used to manage muscle spasms caused due to cerebral palsy, multiple sclerosis, stroke or due to any other nerve or spinal cord disorders.
How LIORESAL works?
LIORESAL is a muscle relaxant. It acts by increasing the effects of certain chemical messengers (such as GABA) in the spinal cord that induces muscle relaxation. As a result, it manages muscle twitching, relieves pain caused due to muscle spasms and improves muscle movement.
How to take LIORESAL?
Take LIORESAL as advised by your physician. Shake well before use. It is preferably taken with meals or milk to avoid nausea.
What is the best time to take LIORESAL?
LIORESAL can be taken during bedtime or while performing activities such as washing, dressing and shaving etc. However, your doctor will decide the best time to take LIORESAL.
Can I stop taking LIORESAL once I started feeling better?
No. Do not stop taking LIORESAL without consulting your doctor as it may make your symptoms re-appear once again or can cause withdrawal symptoms such as increased muscle tightness, fast heart rate, fever, confusion, hallucinations or fits.
Can I take LIORESAL daily?
Take LIORESAL as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take LIORESAL every day or not.
Will taking a higher dose of LIORESAL be more effective?
No. Taking a higher dose of LIORESAL will not be effective rather it would be making you drowsier. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
What to do if I forgot to take a dose of LIORESAL?
If you forgot to take a dose of LIORESAL, take it as soon as you remember. However, if it is time for the next dose of LIORESAL, skip the missed dose and take the next one regularly. Do not take a double dose of LIORESAL to compensate the missed ones. Consult your doctor for advice.
What are the side effects of LIORESAL?
The most common side effects of taking LIORESAL are drowsiness, confusion, weakness and feeling unsteady or shaky. Consult your doctor if any of the symptoms worsen.
Is LIORESAL safe to use in children?
LIORESAL can be used in children and adolescents aged below 18 years if prescribed by the physician. However, consult your doctor for advice before taking it.
What precautions do I need to follow while taking LIORESAL?
Patients taking LIORESAL must inform their doctor about their pre-existing disease conditions like stomach ulcers, kidney, heart or liver problems. Patients should also inform if they have diabetes, hypertension, fits, any mental illness, history of alcoholism or if they are pregnant or breast-feeding. Avoid alcohol consumption. Consult your doctor immediately if you feel extremely depressed with thoughts of committing suicide after taking LIORESAL.
Who should not take LIORESAL?
LIORESAL not recommended for use in patients who are allergic to baclofen. It is also not suitable for use in patients with stomach ulcer or during pregnancy. Therefore, consult your doctor for advice.
Does LIORESAL make me feel sleepy?
LIORESAL may causes excessive sleepiness. Therefore, restrict yourself from engaging into hazardous activities that requires complete alertness. Do not drive or handle any heavy tools or machines. Also, avoid consumption of alcohol as it may make you feel more drowsy. Consult your doctor if sleepiness worsens.
Can I consume alcohol while taking LIORESAL?
Avoid consumption of alcohol while taking LIORESAL as it might make you feel dizzier and drowsier.
Is LIORESAL safe to use in diabetic patients?
LIORESAL may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking LIORESAL as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
Can LIORESAL be taken during pregnancy?
LIORESAL should be used during pregnancy only if considered necessary by the physician. Therefore, consult your doctor before taking it.
Can the use of LIORESAL affect the liver?
Yes. LIORESAL may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Can the use of LIORESAL affect my sexual life?
LIORESAL may rarely cause problems in erection and ejaculation in some individuals. Consult your doctor if it troubles you.
REFERENCES
1. KD. Tripathi. Drugs Acting on Peripheral (Somatic) Nervous System. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 358.
2. Shirin Ghanavatian; Armen Derian. Baclofen. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2022. [Accessed on 12th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK526037/
3. Yang He, PhD,1 Janice E. Brunstrom-Hernandez, MD,2 Liu Lin Thio, MD, PhD,2 Shellie Lackey, RN,3 Deborah Gaebler-Spira, MD,4,5 Maxine M. Kuroda, PhD, MPH,5 Elaine Stashinko, PhD, RN,6 Alexander H. Hoon, Jr., MD, MPH,6 Jilda Vargus-Adams, MD,7 Richard D. Stevenson, MD,8 Stephanie Lowenhaupt, RN, CCRC,9 John F. McLaughlin, MD,10 Ana Christensen, MPH,10 Nienke P. Dosa, MD, MPH,11 Maureen Butler, BSN,12 Aloysia Schwabe, MD,13 Christina Lopez, CCRP,14 Desiree Roge, MD,15 Diane Kennedy, RN, PhD, CCRC,15 Ann Tilton, MD,16 Linda E. Krach, MD,17 Andrew Lewandowski, PhD,18 Hongying Dai, PhD,19 Andrea Gaedigk, PhD,20 J. Steven Leeder, PharmD, PhD,20 and William J. Jusko, PhD1. Population Pharmacokinetics of Oral Baclofen in Paediatric Patients with Cerebral Palsy. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2022. [Accessed on 12th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992203/
4. Thame Laboratories. Health Products Regulatory Authority (HPRA). [Revised in October 2021] [Accessed on 12th November 2022] https://www.hpra.ie/img/uploaded/swedocuments/4eae8f99-a32a-4e7a-9d22-5061d1590226.pdf
5. Central Pharma (Contract packing) Limited. Electronic Medicines Compendium (EMC). [Revised in August 2019] [Accessed on 12th November 2022] https://www.medicines.org.uk/emc/files/pil.3345.pdf
USEFUL DIAGNOSTIC TESTS
- Random Blood Sugar (RBS)
- Liver Function Test (LFT)
AUTHOR DETAILS
