Liofen 10mg Tablet 10'S

Introduction About LIOFEN 10MG TABLET

Liofen 10mg Tablet is an effective muscle relaxant that supports improved muscle flexibility and helps relieve muscle spasticity symptoms such as stiffness, spasms, and discomfort. It is commonly recommended for individuals experiencing neurological conditions such as spinal cord injury, multiple sclerosis, and other nerve-related disorders to enhance mobility and comfort.

Liofen 10mg Tablet can be taken with or without food. It is recommended to use the lowest effective dose for the shortest duration necessary to manage your symptoms. For optimal results, take this medicine consistently as prescribed and avoid missing doses, as irregular use may reduce its effectiveness.

Common side effects of Liofen 10mg Tablet may include fatigue, weakness, drowsiness, dizziness, nausea, vomiting, tiredness, sleepiness, weak limbs, muscle pain, constipation, diarrhoea, dry mouth, nightmares, confusion, hallucination, breathing difficulties, vision problems, urge to pass urine (urinary frequency or retention), feeling unsteady or shaky, feeling faint due to low blood pressure (hypotension), skin rash, sweating and increased liver enzymes (requires monitoring). If these symptoms persist or worsen, it is important to consult your doctor. Your healthcare provider can recommend strategies to helps to reduce or minimize these side effects for your comfort and safety.

Before taking Liofen 10mg Tablet, inform your doctor about any existing medical conditions or health concerns. Additionally, disclose all other medications or supplements you are currently taking. Pregnant or breastfeeding women should seek medical advice before using this medicine to ensure safety for both mother and baby.

Uses Of LIOFEN 10MG TABLET

• Muscle flexibility and relieve symptoms of muscle spasticity associated with neurological conditions.

Benefits of LIOFEN 10MG TABLET

1. Relieves Muscle Stiffness and Spasms:
   Liofen 10mg Tablet acts as a muscle relaxant by calming nerve signals in the spinal cord, effectively reducing muscle stiffness, spasms, and discomfort caused by neurological disorders.
2. Improves Muscle Flexibility and Movement:
   By relaxing tight muscles, it enhances muscle flexibility and coordination, helping patients regain better control and ease in daily movements.
3. Supports Neurological Health:
   Commonly prescribed for conditions like spinal cord injury, multiple sclerosis, and cerebral palsy, Liofen helps manage muscle spasticity associated with nerve-related disorders.
4. Consistent Symptom Management with Regular Use:
   Taking the medication as prescribed ensures sustained relief from muscle spasticity symptoms, supporting improved mobility and quality of life.
5. Well-Tolerated Under Medical Supervision:
   Liofen 10mg Tablet is generally safe when used according to medical advice, with most side effects being mild and manageable.

How LIOFEN 10MG TABLET Works

Liofen 10mg Tablet is a muscle relaxant that works by acting on the brain and spinal cord to relieve muscle stiffness and spasms. It helps relax tight muscles, reduce pain, and improve muscle movement for better daily functioning.

Mechanism of Action: Liofen 10mg Tablet

Liofen contains Baclofen, which targets the GABA-B receptors in the central nervous system. By activating these receptors, it reduces excessive nerve signaling that causes muscle spasms, leading to improved muscle relaxation.

Baclofen and GABA-B Receptor Activation

Baclofen acts as an agonist at GABA-B receptors in the spinal cord and brain. This activation inhibits the release of excitatory neurotransmitters while stimulating inhibitory signals, resulting in the reduction of muscle spasticity and increased comfort.

Role of Liofen 10mg Tablet in Muscle Relaxation

Liofen helps ease muscle rigidity and spasticity by blocking overactive nerve impulses that cause muscle tightness. This results in smoother muscle function and enhanced coordination.

Neurotransmitter Modulation by Liofen 10mg Tablet

The medicine modulates neurotransmitters by decreasing excitatory signals and enhancing inhibitory nerve activity. This balance restores muscle control and reduces spasm frequency and severity.

Understanding Nerve Signal Inhibition

Liofen inhibits nerve activity involved in muscle contraction reflexes at the spinal level, calming hyperactive muscles and supporting better mobility and pain relief.

How to use LIOFEN 10MG TABLET

Take Liofen 10mg Tablet exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water. It can be taken with or without food. Do not crush, chew, or break the tablet. Maintain a consistent dosing schedule for best results.

Dosage Guidance for Liofen 10mg Tablet

The usual starting dose for adults is 5mg three times a day, which your doctor may gradually increase based on your response and tolerance. The maximum recommended dose is typically 80mg per day. Dosage for children should be determined by a healthcare professional.

How to Administer Liofen 10mg Tablet

Take the tablet at the same time every day to maintain an even level in your system. Follow your doctor’s instructions closely. If you are using the medicine for long-term therapy, regular follow-ups are important to monitor its effectiveness and adjust dosage if needed.

Tips for Safe Administration and Storage

Store Liofen 10mg Tablet at room temperature, away from moisture and heat. Keep it out of reach of children and pets. Avoid alcohol while taking this medicine as it may increase drowsiness and dizziness. Consult your doctor before making any changes to your medication routine.

Dosage Titration and Adjustment

Your doctor may start you on a low dose and gradually increase it to find the smallest effective dose that controls your symptoms with minimal side effects. Dose adjustments may be necessary for people with kidney or liver problems.

Advice for Missed Dose and Overdose

If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to catch up. In case of overdose, seek immediate medical attention, as symptoms may include severe drowsiness, weakness, or difficulty breathing.

Side Effects Of LIOFEN 10MG TABLET

Like all medicines, Liofen 10mg Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Liofen 10mg Tablet are:

• Fatigue
• Weakness
• Drowsiness
• Dizziness
• Nausea
• Vomiting
• Tiredness
• Sleepiness
• Weak limbs
• Muscle pain
• Constipation
• Diarrhoea
• Dry mouth
• Nightmares
• Confusion
• Hallucination
• Breathing difficulties
• Vision problems
• Urge to pass urine (urinary frequency or retention)
• Feeling unsteady or shaky
• Feeling faint due to low blood pressure (hypotension)
• Skin rash
• Sweating

When to consult your doctor?

• Severe allergic reactions such as swelling of the lips, mouth, throat, or tongue
• Difficulty breathing, wheezing, or shortness of breath
• Chest pain or rapid, irregular heartbeat
• Extreme drowsiness or difficulty staying awake
• Unconsciousness or fainting spells
• Seizures or convulsions
• Sudden confusion, severe dizziness, or trouble speaking
• Severe skin rash, blistering, or peeling
• Blue or pale lips, fingernails, or skin (signs of low oxygen)
• Difficulty swallowing or tight throat sensation
• Unusual muscle stiffness or weakness leading to inability to move
• Breathing difficulties during sleep (sleep apnea symptoms)
• Yellowing of the skin or eyes (signs of liver problems)

How To Manage Side Effects

Constipation

• Increase Fiber Intake: Eat high-fiber foods such as fruits, vegetables, and whole grains to support regular bowel movements.
• Stay Hydrated: Drink plenty of fluids, especially water, to help soften stools and reduce constipation.
• Physical Activity: Engage in regular, gentle exercise to stimulate digestion and improve bowel function.
• Avoid Laxative Overuse: Use laxatives only if recommended by your doctor to minimize dependency.
• Consult Your Doctor: If constipation lasts more than a few days or causes severe discomfort, talk to your healthcare provider for further advice.

Diarrhea

• Stay Hydrated: Drink plenty of clear fluids like water, oral rehydration solutions, or clear broths to replace lost fluids and reduce dehydration.
• Eat Light, Simple Foods: Choose bland foods such as bananas, rice, toast, or applesauce. Avoid fatty, spicy, or high-fiber foods until your symptoms improve.
• Rest: Give your body time to recover by resting as much as possible.
• Avoid Dairy and Caffeine: These can sometimes make diarrhea worse, so limit milk, cheese, coffee, and caffeinated drinks until you feel better.
• Monitor Symptoms: If diarrhea lasts more than a couple of days, becomes severe, or is accompanied by symptoms like fever, blood in the stool, or dehydration (such as dizziness or decreased urination), contact your doctor.

Dizziness Or Drowsiness

• Stay Safe: Avoid driving, operating heavy machinery, or performing any activities that require full alertness until you know how Liofen affects you.
• Rest and Hydrate: Sit or lie down if you feel dizzy to reduce the chance of falls. Drink plenty of water to stay hydrated and help reduce dizziness.
• Monitor Symptoms: If dizziness persists, worsens, or is accompanied by fainting or severe headache, contact your doctor promptly.
• Avoid Alcohol: Consuming alcohol while taking Liofen may increase dizziness and drowsiness, so it should be avoided.

Nausea And Vomiting

• Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
• Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
• Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
• Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Monitoring required

LIOFEN 10MG TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.

Breastfeeding

Use with Caution

LIOFEN 10MG TABLET should be used with caution in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines if you feel drowsiness, dizziness, or problems with your vision after taking LIOFEN 10MG TABLET.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking LIOFEN 10MG TABLET as it may make you feel dizzier or drowsier.

Kidney

Use with Caution

LIOFEN 10MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

Liver

Use with Caution

LIOFEN 10MG TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take LIOFEN 10MG TABLET if you are allergic to Baclofen.

Lungs

Use with Caution

LIOFEN 10MG TABLET should be used with caution in patients with lung problems. Therefore, consult your doctor before taking it.

Heart Disease

Use with Caution

LIOFEN 10MG TABLET should be used with caution in patients with heart problems. Therefore, consult your doctor before taking it.

Use In Pediatrics

Consult your doctor

LIOFEN 10MG TABLET can be used in children and adolescents aged below 18 years if prescribed by the physician. However, it is not suitable for use in children weighing below 33kg of body weight. Therefore, consult your doctor for advice.

Use In Geriatrics

Use with Caution

LIOFEN 10MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.

Other Warnings for LIOFEN 10MG TABLET

Before taking Liofen 10mg Tablet, inform your doctor if you:

• A history of stroke or transient ischemic attack (TIA).
• Epilepsy or any seizure disorders.
• Any diagnosed mental health conditions.
• High blood pressure (hypertension).
• Parkinson’s disease, characterized by shaking, stiffness, or difficulty with walking and balance.
• Diabetes or blood sugar management issues.
• Difficulty in passing urine or urinary retention problems.
• A history of alcohol use disorder, drug abuse, or dependence.
• Upcoming surgery scheduled in the near future.

Who should not take [GBNKEYWORD

Liofen 10mg Tablet is not recommended for use if you:

• Have ever experienced a stomach ulcer or gastrointestinal bleeding.

Drug - Drug interaction

Inform your physician if you are taking any of the following medications before starting Liofen 10mg Tablet:

1. Muscle Relaxants and CNS Depressants (e.g., Diazepam, Alprazolam, Morphine)
Interaction: Liofen may increase the sedative effects of other central nervous system (CNS) depressants.
Effects: Enhanced drowsiness, dizziness, respiratory depression, and impaired coordination.
Management: Avoid activities requiring full alertness such as driving. Use medications cautiously under doctor supervision, with possible dose adjustments.

2. Antihypertensive Medications (e.g., Amlodipine)
Interaction: Combined use may lower blood pressure excessively.
Effects: Increased risk of hypotension, dizziness, and fainting.
Management: Monitor blood pressure regularly and inform your doctor of any symptoms like dizziness or lightheadedness.

3. Opioids (e.g., Codeine, Morphine)
Interaction: Liofen can potentiate the effects of opioids.
Effects: Increased risk of respiratory depression, sedation, and low blood pressure.
Management: Use opioid and Liofen combination only under strict medical supervision with careful dose adjustments.

4. Antidepressants (e.g., Amitriptyline, Lithium)
Interaction: May increase muscle weakness or CNS effects due to additive action.
Effects: Enhanced drowsiness, confusion, and muscle relaxation effects.
Management: Close monitoring for adverse reactions; doses may need adjustment.

5. Anti-Parkinson Drugs (e.g., Levodopa)
Interaction: Possible alteration in effectiveness when combined with Liofen.
Effects: Changes in muscle control or spasticity symptoms.
Management: Doctor may adjust dosages or monitor symptoms carefully.

Drug - Food interaction

1. Food:

• There are no known significant food interactions with Liofen 10mg Tablet. It can be taken with or without food.
• Taking the tablet with food may help reduce stomach irritation or nausea associated with the medication.

2. Alcohol:

• Interaction: Alcohol can increase the nervous system side effects of Liofen, such as dizziness, drowsiness, and difficulty concentrating.
• Effects: Enhanced sedation, impaired coordination, and increased risk of accidents.
• Management: Avoid alcohol consumption while taking Liofen 10mg Tablet to minimize these risks.

3. Caffeine (Coffee, Tea):

• There are no specific food interaction reports with caffeine. However, if Liofen causes insomnia, limiting caffeine intake in the evening may help improve sleep quality.

Synopsis

More Information

What should be expected when using Liofen, and how can it be effectively integrated with other therapies or lifestyle changes?

FAQs About LIOFEN 10MG TABLET

References

1. KD. Tripathi. Drugs Acting on Peripheral (Somatic) Nervous System. Essentials of Medical Pharmacology. Seventh edition. 2013. Page-358.

2. Shirin Ghanavatian; Armen Derian. Baclofen. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2022. [Accessed on 18th August 2025] 

3. Per Ertzgaard, MD, Claudia Campo, MS and Alessandra Calabrese, PhD. FFICACY AND SAFETY OF ORAL BACLOFEN IN THE MANAGEMENT OF SPASTICITY: A RATIONALE FOR INTRATHECAL BACLOFEN. Journal of Rehabilitation Medicine. January 2017. [Accessed on 18th August 2025] 

4. Camber Pharmaceuticals, Inc. Baclofen Tablet. Dailymed.com. [Revised in October 2021]. [Accessed on 18th August 2025] 

5. Central Drugs Standard Control Organisation. Baclofen tablets. Baclofen ER Capsule 10 mg/50 mg (Additional Strength). Baclofen E.R capsule (30mg). [Accessed on 18th August 2025] 

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Liver Function Test (LFT)

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Srikar Modepu - MBBS, MD (Diabetology)

Last updated on 20 Aug 2025 | 09:35 AM(IST)