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Introduction About LINTRAN 600MG INFUSION
LINTRAN 600MG INFUSION contains Linezolid which belongs to the group of medicines called Antibiotics. It is used to manage bacterial infections like pneumonia (nosocomial and community-acquired pneumonia), complicated and uncomplicated skin and soft tissue infections caused by susceptible bacteria. It is also used to manage vancomycin-resistant enterococcus faecium infections, including cases with concurrent bacteremia (viable bacteria in the blood).
Bacterial infections are caused by the multiplication of specific harmful strains of bacteria anywhere in the body. It is generally characterized by fever, child and sweats, swollen lymph nodes, sudden pain or its worsening, unexplained tiredness, headache, skin flushing or discomfort, nausea, vomiting, diarrhoea or stomach pain.
Before receiving LINTRAN 600MG INFUSION, inform your doctor if you have liver, kidney or heart problems, mental health problems (such as maniac depression, schizoaffective disorder) overactive thyroid, anaemia or low blood sodium levels (hyponatremia), history of seizures, diarrhoea or if you are prone to get an infection.
During management with LINTRAN 600MG INFUSION, your doctor might perform regular blood tests to monitor your blood count and your eyesight if you receive LINTRAN 600MG INFUSION for more than 28 days.
LINTRAN 600MG INFUSION is not recommended for use in pregnant women unless advised by the doctor and it is not recommended for use in breastfeeding women. LINTRAN 600MG INFUSION is not recommended for use in children and adolescents (under 18 years of age) and it should be used with caution in elderly patients (aged 65 years and above).
The most common side effects of receiving LINTRAN 600MG INFUSION are headache, dizziness, nausea, vomiting, diarrhoea, metallic taste in the mouth and indigestion. Inform your doctor if any of the side effects worsen.
Uses Of LINTRAN 600MG INFUSION
Manages bacterial infections like:
- pneumonia (nosocomial and community-acquired)
- complicated and uncomplicated skin and soft tissue infections
- vancomycin-resistant enterococcus faecium infections
How LINTRAN 600MG INFUSION Works
LINTRAN 600MG INFUSION works by binding to and inhibiting bacterial enzymes required in DNA synthesis, thus interrupting DNA replication and managing bacterial cell multiplication.
How to use LINTRAN 600MG INFUSION
LINTRAN 600MG INFUSION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration of LINTRAN 600MG INFUSION for you depending on your age, body weight, severity and type of the infection.
Side Effects Of LINTRAN 600MG INFUSION
Common
- vaginal or oral thrush (fungal infection)
- headache, dizziness
- metallic taste in the mouth
- diarrhoea, nausea, vomiting, localized or general stomach pain, constipation, indigestion
- difficulty in sleeping
- increased blood pressure
- anaemia (low red blood cells)
- altered sugar levels
Uncommon
- tingling sensation or feeling numb
- swollen, sore or discoloured tongue
- dry mouth
- frequent urination
- chills
- feeling thirsty
- increased sweating
- kidney failure
- abdominal bloating
- increased or decreased heart rate
- pain and inflammation at the injection site and around
- weakness, sensory changes
- inflammation of the vagina or genital area (women)
Rare
- superficial tooth discolouration
Inform your doctor immediately if you experience any of the following side effects while receiving LINTRAN 600MG INFUSION:
- severe skin disorder and allergic reactions (sign includes swelling particularly around the face and neck, wheezing, difficulty breathing, raised purple rash due to inflammation of blood vessels, red sore skin and flaking, rash and itching)
- vision problems (like blurred vision, changes in colour vision, difficulty in seeing detail or a restricted field of vision)
- severe diarrhoea with blood or mucus (it may develop into complications which are life-threatening)
- repeated nausea or vomiting, abdominal pain or rapid breathing
- fits or seizures or serotonin syndrome (signs include agitation, confusion, mental disturbance, rigidity, shaking, incoordination, seizure, rapid heart rate and severe breathing problems)
- unexplained bleeding or bruising
- changes in the numbers of specific blood cells which may lead to infection (signs of infection include fever, sore throat, mouth ulcers and tiredness)
- inflammation of the pancreas
- transient ischaemic attacks (temporary disturbance of the flow of blood to the brain causing short-term symptoms such as loss of vision, leg and arm weakness, slurring of speech and loss of consciousness)
- ringing in the ears (tinnitus)
- new or worsening myelosuppression (fewer blood cells due to bone marrow suppression)
- syndrome of inappropriate antidiuretic hormone secretion (SIADH) causing confusion, sleepiness, generalized weakness and respiratory failure
How To Manage Side Effects
Nausea or vomiting:
Stick to simple meals while receiving this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.
Headache:
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress-free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.
Dizziness:
Lie down until the dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid intake of caffeine and its related products. If dizziness does not improve or worsen, inform your doctor.
Diarrhoea:
Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heating pad on your stomach. Inform your doctor if the symptom does not improve.
Constipation:
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. If this does not help, inform your doctor to receive alternate management for constipation.
Warning & Precautions
Pregnancy
LINTRAN 600MG INFUSION is not recommended for use in pregnant women unless advised by the doctor. Consult your doctor before receiving LINTRAN 600MG INFUSION.
Breastfeeding
LINTRAN 600MG INFUSION is not recommended for use in breastfeeding women as it passes into the breast milk and may affect the baby. Consult your doctor before receiving LINTRAN 600MG INFUSION.
Driving and Using Machines
Do not drive or operate any machines if you experience dizziness or problems with your eyesight after receiving LINTRAN 600MG INFUSION.
Alcohol
Avoid consumption of alcohol (especially draught beers and wine) while receiving LINTRAN 600MG INFUSION.
Kidney
LINTRAN 600MG INFUSION should be used with caution in patients with kidney problems especially if the patient is on dialysis. Consult your doctor before receiving LINTRAN 600MG INFUSION.
Liver
LINTRAN 600MG INFUSION should be used with caution in patients with liver problems. Consult your doctor before receiving LINTRAN 600MG INFUSION.
Allergy
Do not receive LINTRAN 600MG INFUSION if you are allergic to Linezolid or any other ingredients of this medicine.
Heart Disease
LINTRAN 600MG INFUSION should be used with caution in patients with high blood pressure. Consult your doctor before receiving LINTRAN 600MG INFUSION.
Others
Before receiving LINTRAN 600MG INFUSION, inform your doctor if you:
- have an overactive thyroid
- have adrenal glands tumor (phaeochromocytoma) or carcinoid syndrome (tumors of the hormone system causing diarrhoea, flushing of the skin and wheezing)
- have mental disorders such as manic depression, schizoaffective disorder, mental confusion or other mental problems
- bruise and bleed easily
- have a history of low blood sodium levels
- are anaemic (low red blood cells)
- are prone to getting infections
- have a history of seizures
- have diarrhoea
Use in pediatrics:
LINTRAN 600MG INFUSION is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
LINTRAN 600MG INFUSION should be used with caution in elderly patients (aged 65 years and above) due to the greater risk of developing blood dyscrasias (a condition which affects the blood, bone marrow or lymph tissue). Consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving LINTRAN 600MG INFUSION, inform your doctor if you are taking any of the following medicines:
- medicines used to manage cold or flu (Ex. pseudoephedrine, phenylpropanolamine)
- medicines used to manage asthma (Ex. salbutamol, terbutaline, fenoterol)
- medicines used to manage depression (Ex. clomipramine, amitriptyline, doxepin, citalopram, dosulepin, fluoxetine, fluvoxamine, imipramine, lofepramine, paroxetine and sertraline), monoamine oxidase inhibitors (MAOIs) (used to manage depression or parkinson’s disease) (Ex. phenelzine, isocarboxazid, selegiline, moclobemide)
- medicines used to manage migraines (Ex. sumatriptan, zolmitriptan)
- medicines used to manage sudden, severe allergic reactions (Ex. adrenaline (epinephrine))
- medicines that increase blood pressure (Ex. noradrenaline (norepinephrine), dopamine and dobutamine)
- pethidine (used to manage moderate to severe pain)
- buspirone (used to manage anxiety disorders)
- warfarin (used to stop blood clotting)
- rifampicin (used to manage bacterial infections)
B. Drug-Food interaction:
Avoid eating large amounts of mature cheese, yeast extracts or soya bean extracts (Ex. soy sauce) while receiving LINTRAN 600MG INFUSION as it may react with a substance called tyramine which is naturally present in some foods and cause an increase in blood pressure.
Overdosage:
LINTRAN 600MG INFUSION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Linezolid |
| Pharmacological Category | : | Oxazolidinone antibiotic |
| Therapeutic Indication | : |
Pneumonia, Skin infections, Vancomycin-resistant enterococcus faecium infections |
| Dosage Forms | : |
Tablet, Dispersible Tablet, Injection, Infusion, Dry Syrup, Syrup, Oral suspension |
More Information
StoreLINTRAN 600MG INFUSION below 25°C
FAQs About LINTRAN 600MG INFUSION
Can LINTRAN 600MG INFUSION be used in infants?
No, LINTRAN 600MG INFUSION is used for adults and it is not recommended for children and adolescents below 18 years of age. Your child’s doctor will select a suitable alternative therapy for your child to manage the specific infection.
Can LINTRAN 600MG INFUSION be used during pregnancy?
LINTRAN 600MG INFUSION is not recommended for use in pregnant women unless advised by the doctor. Consult your doctor before receiving LINTRAN 600MG INFUSION if you are pregnant or planning to get pregnant.
Is LINTRAN 600MG INFUSION safe to use in patients with kidney problems?
LINTRAN 600MG INFUSION should be used with caution in patients with kidney problems especially if the patient is on dialysis. Your doctor may monitor your kidney function test regularly to manage any unusual effects. Consult your doctor before receiving LINTRAN 600MG INFUSION.
What are the common side effects of LINTRAN 600MG INFUSION?
The most common side effects of receiving LINTRAN 600MG INFUSION are headache, dizziness, nausea, vomiting, diarrhea, metallic taste in the mouth, localized or general stomach pain, constipation, altered sugar levels, vaginal or oral fungal infection, indigestion, etc. Inform your doctor if any of the side effects worsen.
How is LINTRAN 600MG INFUSION administered?
LINTRAN 600MG INFUSION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion over a period of 30 to 120 minutes. Your doctor will decide the correct dose and duration of LINTRAN 600MG INFUSION for you depending on your age, severity and type of the infection.
References
1. KD. Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics; Urinary Antiseptics. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 807.
2. Seyed Mohammad Reza Hashemian, Tayebeh Farhadi and Mojdeh Ganjparvar. Linezolid: a review of its properties, function and use in critical care. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. June 2018 [Accessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014438/
3. Abed Zahedi Bialvaei, Mohammad Rahbar, Mehdi Yousefi, Mohammad Asgharzadeh, Hossein Samadi Kafil. Linezolid: a promising option in the treatment of Gram-positives. Journal of Antimicrobial Chemotherapy. February 2017 [Accessed on 29th August 2022] https://academic.oup.com/jac/article/72/2/354/2629138
4. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 29th August 2022] https://www.medicines.org.uk/emc/files/pil.12567.pdf
5. Pfizer Limited. Zyvox (Linezolid). [Revised in November 2021] [Accessed on 29th August 2022] https://labeling.pfizer.com/ShowLabeling.aspx?format=PDF&id=649
Useful Diagnostic Tests
- Completed Blood Count (CBC)
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