Levipil 250mg Tablet 10'S

Introduction About LEVIPIL 250MG TABLET

Levipil 250mg Tablet contains Levetiracetam, an anticonvulsant medication widely used to manage epilepsy and various types of seizures. It is effective in controlling partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures. By stabilizing electrical activity in the brain and preventing abnormal nerve impulses, it helps reduce the frequency and severity of seizures, thereby improving the quality of life for patients living with epilepsy. This medication can be prescribed alone or in combination with other anticonvulsants depending on the patient’s condition.

Levipil 250mg is ideal for adult patients diagnosed with epilepsy who require consistent seizure management. It is also prescribed for adolescents in certain cases, though paediatric and geriatric use should follow specific medical guidance. Patients with kidney or heart conditions should use this medication with caution, and it is important to inform your healthcare provider of these conditions before starting treatment. The tablet should be swallowed whole with water and can be taken with or without food. Consistent daily dosing at the same time each day is essential for maintaining steady blood levels and efficacy.

Important precautions include careful use during pregnancy, only when clearly necessary as advised by a doctor, and it is not recommended during breastfeeding due to increased risk of side effects in infants. Patients should avoid alcohol consumption during treatment and refrain from driving or operating machinery if experiencing drowsiness or dizziness after taking this tablet. Allergies to levetiracetam or any tablet components are contraindications, and sudden discontinuation of the medicine without medical advice could trigger seizures.

Common side effects that patients may experience include sleepiness, dizziness, headache, irritability, mood changes, and decreased appetite, mostly occurring in the initial weeks after starting treatment and usually diminishing over time. If severe reactions or behavioural changes occur, consultation with a healthcare professional is crucial. Regular monitoring by a doctor, including kidney function tests, ensures the safe and effective use of Levipil 250mg Tablet while managing epilepsy symptoms.

Uses Of LEVIPIL 250MG TABLET

• Epilepsy (seizures)

Benefits of LEVIPIL 250MG TABLET

Levipil 250mg for Seizure

Levipil 250mg Tablet is an effective antiepileptic medication primarily used to manage seizures. It works by slowing down the abnormal electrical signals in the brain that cause seizures, helping to reduce their frequency and severity. It is commonly prescribed for different types of seizures, including partial-onset, myoclonic, and generalized tonic-clonic seizures. Regular use as prescribed can help patients maintain better control over seizure activity and improve their overall quality of life.

Levipil 250mg for Abnormal Brain Activity

Levipil 250mg targets abnormal brain activity by modulating synaptic neurotransmission. Its active ingredient, levetiracetam, binds to synaptic vesicle protein 2A (SV2A), which is involved in the release of neurotransmitters. This unique mechanism helps inhibit excessive nerve firing associated with epileptic seizures without interfering with normal brain function. By stabilizing electrical activity in the brain, Levipil helps prevent hypersynchronous bursts that underlie epilepsy and other neurological disturbances.

Levipil 250mg for Brain Health

While Levipil 250mg is primarily an anticonvulsant, its regulation of synaptic activity can indirectly support overall brain health by reducing seizure-induced neuronal damage. Controlling seizures prevents injury and cognitive decline caused by frequent seizures. By improving neuronal stability, Levipil may help patients maintain better mental function and reduce seizure-related disruptions in daily life. It is part of comprehensive epilepsy management aimed at ensuring healthier brain function over time.

How LEVIPIL 250MG TABLET Works

Levipil 250mg Tablet Mechanism of Action

Levipil 250mg tablet contains levetiracetam, which works by binding to a specific protein in the brain called synaptic vesicle protein 2A (SV2A). This protein plays a key role in the release of neurotransmitters, the chemicals responsible for transmitting signals between nerve cells. By binding to SV2A, Levipil modulates neurotransmitter release, reducing the abnormal electrical activity that leads to seizures. Unlike many other antiepileptic drugs, it does not broadly inhibit nerve signalling but selectively prevents hypersynchronous bursts of electrical activity associated with epilepsy, making it effective with fewer side effects.

Neuronal Activity Stabilization

Levipil stabilizes neuronal activity by preventing excessive firing of nerve cells that cause seizures. It does this by modulating vesicle release during nerve signal transmission, which helps maintain normal communication between neurons and inhibits abnormal excitation. This selective action on synaptic vesicle dynamics helps reduce seizure frequency without disturbing normal brain functions. Additionally, Levipil’s influence on calcium channels and modulation of neurotransmitter systems further supports its role in maintaining balanced neuronal activity and protecting brain health.

How to use LEVIPIL 250MG TABLET

How to Take Levipil 250mg Tablet

• Take Levipil 250mg tablet exactly as prescribed by your doctor.
• Swallow the tablet whole with a full glass of water; do not chew, crush, or break it.
• You can take it with or without food based on your comfort.
• Try to take the medicine at the same times each day to maintain consistent blood levels.
• If taking twice daily, space doses evenly, for example, morning and evening.
• Do not stop or change the dose without consulting your healthcare provider to avoid seizure worsening.

Levipil 250mg Tablet Dosage

• The usual starting dose for adults and adolescents (16 years and older) is 250 mg twice daily.
• Your doctor may gradually increase the dose based on your response and tolerance, typically up to 1000 mg or more per day if needed.
• Dosage adjustments may be necessary in patients with kidney impairment or other health considerations.
• Children under 16 use different dosing and should follow paediatric specialist recommendations.
• Always follow the dosage instructions provided by your healthcare professional and do not self-adjust.
• Consistent adherence to the prescribed dosage is key to effective seizure control.

What if I forgot to take LEVIPIL 250MG TABLET

• Take the missed dose as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose.
• Do not take a double dose to make up for the missed one.
• Never take two doses at the same time as this may increase the risk of side effects.
• Try to maintain a consistent dosing schedule to maximize the medicine’s effect.
• If you frequently miss doses, consider setting reminders or alarms to help you remember.
• If you are uncertain about what to do after missing a dose, consult your doctor or pharmacist for advice.

Overdose

If you or someone else accidentally takes an extra dose of Levipil 250mg tablet, seek medical advice immediately or go to the nearest hospital. Signs of an overdose may include extreme sleepiness, increased aggression or agitation, difficulty breathing, and reduced alertness. Prompt medical attention is crucial to manage these symptoms effectively.

Side Effects Of LEVIPIL 250MG TABLET

Common side effects of Levipil 250mg tablet:

• inflammation of the nose and throat, respiratory problems, cough
• somnolence, headache
• depression, aggression, anxiety, insomnia, nervousness, irritability
• balance disorder
• dizziness, tiredness
• tremor (involuntary trembling), forgetfulness,
• vertigo (sensation of rotation or spinning)
• abdominal pain, diarrhoea, indigestion, vomiting, nausea, loss of appetite
• changes in body weight
• tingling and numbness
• hair loss

When to Seek Medical Attention?

Stop taking this medicine and inform your doctor immediately if you experience any of the following side effects:

• signs of sudden decrease of kidney function (low urine volume, tiredness, nausea, vomiting, confusion, and swelling in the legs, ankles, or feet)
• signs of serious mental changes that can be symptoms of encephalopathy (confusion, sleepiness, loss of memory, forgetfulness, abnormal behaviour, involuntary or uncontrolled movements)
• abnormal thoughts, feeling irritable, or reacting more aggressively
• aggravation (worsening) of epilepsy

How To Manage Side Effects

Headache

• Stay Hydrated: Dehydration is a common cause of headaches. Drink enough water throughout the day and avoid skipping meals.
• Cold or Warm Compress: Apply a cold pack on the forehead for migraine-type headaches, or a warm compress on the neck and back of the head for tension headaches.
• Ginger Tea: Ginger may reduce headache-related inflammation and nausea. Drinking ginger tea or inhaling ginger steam may help.
• Peppermint Oil: Applying diluted peppermint oil to the temples and forehead may relax muscles and ease tension headaches.
• Caffeine (in moderation): A small amount of tea or coffee can sometimes relieve headache symptoms but avoid excess as it can worsen headaches.
• Rest in a Quiet, Dark Room: For migraine headaches, lying down in a calm, dark environment may ease discomfort.
• Massage: Gently massaging the temples, neck, and shoulders helps relieve muscle tension that contributes to headaches.
• Proper Sleep: Maintain a regular sleep schedule, as both lack of sleep and oversleeping can trigger headaches.
• Stress Reduction: Try yoga, meditation, or breathing exercises to relax the mind and body, reducing stress-related headaches.
• Limit Screen Time: Long hours on computers or mobiles may cause eye strain headaches. Follow the 20-20-20 rule (look at something 20 feet away for 20 seconds every 20 minutes).

Nausea And Vomiting

• Stay Hydrated: Sip clear fluids such as water, fruit juices, and oral rehydration solutions slowly throughout the day to replenish lost fluids and prevent dehydration.
• Eat Small, Bland Meals: Consume 6-8 small meals rather than large ones; opt for bland foods like crackers, toast, rice, noodles, and clear soups while avoiding greasy or spicy foods.
• Avoid Strong Odors and Triggers: Minimize exposure to cooking smells, perfumes, air fresheners, and other strong scents, as these can worsen nausea.
• Use Anti-Nausea Medications: Take antiemetic medications as prescribed by healthcare providers at the earliest signs of nausea, not waiting until symptoms worsen.
• Try Non-Medical Remedies: Use ginger ale, peppermint tea, or ginger-based foods; other supportive techniques include fresh air, relaxation, or distraction like watching TV or listening to music.
• Remain Upright After Eating: Avoid lying down immediately after meals; sit up and move gently to reduce the risk of worsening nausea and vomiting

Warning & Precautions

Pregnancy

Consult your doctor

 Levipil 250mg tablet should be used during pregnancy only if clearly deemed necessary by your healthcare provider.

Breastfeeding

Contraindicated

 Use of Levipil 250mg tablet is not recommended during breastfeeding due to the increased possibility of side effects in the nursing infant.

Driving and Using Machines

Use with Caution

 If you experience drowsiness or sleepiness after taking this medicine, avoid driving or operating any machinery.

Alcohol

Consult your doctor

You should consult your doctor about alcohol consumption while on this medication, but it is generally advised to avoid alcohol during treatment.

Kidney

Use with Caution

Use Levipil 250mg tablet with caution if you have any kidney problems, and follow dosing advice provided by your doctor closely.

Allergy

Contraindicated

Do not take this medicine if you have a known allergy to levetiracetam or any other components of the tablet.

Heart Disease

Use with Caution

 If you have a history of irregular heart rhythm or heart disease, use Levipil with caution and under medical supervision.

Use In Pediatrics

Consult your doctor

 Levipil 250mg tablet is generally not recommended as a sole medication in children and adolescents under 16 years; however, it may be prescribed in combination with other medicines. Dosage will be determined based on the patient’s age, weight, and condition.

Use In Geriatrics

Use with Caution

Caution is advised when using Levipil 250mg tablet in elderly patients. Follow the dosing instructions given by the healthcare professional carefully.

Other Warnings for LEVIPIL 250MG TABLET

Before taking this medicine, tell your doctor if you:

• have salt imbalance

Safety Advice

• Do not use Levipil after the expiration date printed on the packaging to ensure safety and effectiveness.
• Always swallow the tablet whole; do not crush, chew, or break the tablet as it may affect how the medicine works.
• Avoid sudden changes in dosage without consulting your healthcare provider, as abrupt withdrawal can increase seizure risk.
• Inform your doctor of any other medications, supplements, or herbal products you are taking to prevent possible interactions.
• Report any signs of infection such as fever, sore throat, or unusual tiredness, as Levipil may affect your immune system.
• If you experience unusual skin rashes or allergic symptoms, seek medical help immediately as it may require urgent attention.
• For patients undergoing dialysis, supplemental doses may be necessary since Levipil is removed during the treatment.

Diet and Lifestyle Advice

• Balanced diet: Include nutrient-rich foods like whole grains, fresh fruits, vegetables, lean proteins, and healthy fats to support overall brain health.
• Adequate hydration: Drink enough water throughout the day to reduce tiredness, dizziness, or headache sometimes linked with seizure medicines.
• Avoid sleep deprivation: Maintain a consistent sleep schedule, as poor sleep can trigger seizures in sensitive individuals.
• Stress management: Practice relaxation techniques such as meditation, yoga, or breathing exercises to reduce seizure triggers.
• Caffeine caution: Limit excess tea, coffee, and energy drinks, as they may interfere with sleep and affect seizure control.
• Regular exercise: Engage in moderate physical activity like walking or yoga, which helps improve mood, sleep quality, and overall well-being.
• Avoid abrupt medication changes: Never stop or adjust Levipil dose suddenly without medical guidance, as it may worsen seizures.
• Routine check-ups: Attend regular follow-ups with your doctor to monitor medicine effectiveness and side effects.

1. Levipil 250mg and Torleva 250mg (both Levetiracetam brands) relate in terms of effectiveness and safety:

2. Levipil 250mg better tolerated than older antiepileptic medicines like Carbamazepine or Phenytoin

Drug - Drug interaction

1. Other Antiepileptic Drugs (Carbamazepine, Phenytoin, Valproate, etc.)

• Interaction: These older drugs may slightly alter blood levels of Levetiracetam or themselves, though not clinically significant in most cases.
• Management: Monitor seizure control and side effects if used in combination; dose adjustments are rarely needed.

2. CNS Depressants (Alcohol, Benzodiazepines, Antihistamines, Sleep medicines)

• Interaction: May increase drowsiness, dizziness, and reduced alertness when taken with Levipil.
• Management: Avoid alcohol, limit sedative use, and use caution when driving or operating machinery.

3. Methotrexate

• Interaction: Co-administration may reduce methotrexate clearance, leading to increased methotrexate levels and toxicity.
• Management: Monitor methotrexate blood levels closely; adjust dose if required under doctor’s supervision.

4. Oral Contraceptives (Ethinylestradiol + Levonorgestrel)

• Interaction: Unlike some older antiepileptics, Levetiracetam does not reduce contraceptive effectiveness.
• Management: No adjustment needed, but patients should inform their doctor if breakthrough bleeding occurs.

5. Warfarin (and other anticoagulants)

• Interaction: Levetiracetam does not significantly alter warfarin activity, but rare reports suggest minor changes in INR.
• Management: Regular INR monitoring is recommended when starting or stopping Levetiracetam.

6. Digoxin & Propranolol

• Interaction: Studies show no significant changes in blood levels of these medicines when combined with Levetiracetam.
• Management: No special action needed; monitor clinical response.

Drug - Food interaction

1. High-Fat Meals

• Interaction: May delay the absorption of Levetiracetam slightly but does not reduce overall effectiveness.
• Management: Can be taken with or without food; taking with meals may help reduce stomach upset

 2. Caffeine (coffee, tea, energy drinks)

• Interaction: Excess caffeine may interfere with sleep and trigger seizures in sensitive individuals, potentially reducing medicine effectiveness
• Management: Limit caffeine intake and maintain good sleep hygiene.

3. Grapefruit or Grapefruit Juice

• Interaction: Unlike some seizure medicines, Levipil is not affected by grapefruit juice because it does not depend on liver enzyme metabolism.
• Management: No restriction required, but moderation is always advised.

4.  Herbal Supplements (e.g., St. John’s Wort, Ginkgo biloba)

• Interaction: May increase nervous system side effects like irritability, mood changes, or dizziness.
• Management: Avoid combining with such herbal remedies unless approved by a doctor.

Synopsis

More Information

FAQs About LEVIPIL 250MG TABLET

References

1. K.D. Tripathi. Antiepileptic Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 420.

2. Bassel Abou-Khalil. Levetiracetam in the treatment of epilepsy. NIH National Library of Medicine, National Centre for Biotechnology Information. PubMed Central. [Revised in June 2008]. [Accessed on 4th September 2025]  

3. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in February 2025] [Accessed on 4th September 2025] 

Useful Diagnostic Tests

• Kidney Function test (KFT)
• Liver function test (LFT)

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 08 Sep 2025 | 10:04 AM(IST)