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Introduction About LEUPROSTA 11.25MG INJECTION(DEPOT)
LEUPROSTA 11.25MG INJECTION(DEPOT) contains Leuprolide which belongs to the group of medicines called Gonadotropin Releasing Hormone (GnRH) Agonist. It is used to manage endometriosis, relieving pain and reducing endometriotic lesions. It is also used for preoperative hematologic improvement in women having fibroids (abnormal growth in uterus) induced anaemia for whom hormonal suppression is considered necessary for three months. It is also used in children to manage central precocious puberty (CPP).
Endometriosis is a chronic disease in which a tissue like the uterus lining grows outside the uterus, resulting in pain and/or infertility. It is characterized by symptoms such as pain during periods, pelvic pain, pain associated with sexual intercourse, painful urination, fatigue, depression, bloating and nausea.
Central precocious puberty (CPP) is the early onset of sexual characteristics in girls (generally earlier than 8 years) and boys (generally earlier than 9 years of age in boys) due to activation of pubertal pituitary gonadotropins. It may result in diminished adult height.
Do not receive LEUPROSTA 11.25MG INJECTION(DEPOT) if you are allergic to Leuprolide acetate, GnRH or GnRH agonist analogs.
Before receiving this medicine, inform your doctor if you have liver impairment, kidney impairment or undiagnosed abnormal uterine bleeding.
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use in pregnant and breastfeeding women. It is not recommended for use in children and adolescents (below 18 years) for endometriosis and fibroids.
It is not recommended for use in children (below 2 years) for central precocious puberty (CPP). It is not recommended for use in elderly patients (above 65 years). Consult your doctor before receiving.
The common side effects associated with the use of LEUPROSTA 11.25MG INJECTION(DEPOT) are hot flashes, sweating, general pain, headache, gastrointestinal disorders, swelling due to water retention, nausea, vomiting, reduced libido and dizziness. Consult your doctor if any of these side effects worsens.
Uses Of LEUPROSTA 11.25MG INJECTION(DEPOT)
It is used:
- to manage endometriosis, relieving pain and reducing endometriotic lesions
- for preoperative hematologic improvement in women having fibroids (abnormal growth in uterus) induced anaemia for whom hormonal suppression is considered necessary for three months
- to manage central precocious puberty (children)
How LEUPROSTA 11.25MG INJECTION(DEPOT) Works
LEUPROSTA 11.25MG INJECTION(DEPOT) contains Leuprolide that works by blocking the secretion of gonadotropin releasing hormone (GnRH) following an initial stimulation, resulting in suppression of ovarian and testicular steroidogenesis (process of synthesis of steroid hormones), thereby relieving the symptoms associated with increased levels of sex hormones.
How to use LEUPROSTA 11.25MG INJECTION(DEPOT)
LEUPROSTA 11.25MG INJECTION(DEPOT) will be administered to you only by a doctor or a nurse intramuscularly (into the muscle). Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LEUPROSTA 11.25MG INJECTION(DEPOT)
Common
- hot flashes/sweating
- general pain
- headache
- infection
- gastrointestinal disorders
- swelling due to water retention
- respiratory disorders
- urinary disorders
- shrinking of testicles
- impotence
- reduced libido
- injection site reactions including abscess
- dilation of blood vessels
- acne
- seborrhoea (a scaly condition of scalp)
- rash including erythema multiforme (a condition causing red patches)
- emotional lability
- vaginitis (swelling of vagina)
- vaginal bleeding
- abnormal vaginal discharge
- extreme tiredness or weakness
- nausea, vomiting
- weight gain or loss
- hirsutism (abnormal hair growth in females)
- joint disorder
- muscle pain
- dizziness
- nervousness
- neuromuscular disorders
- paraesthesia (sensation of burning & stinging)
- skin reactions
- breast changes or pain
Rare
Stop receiving LEUPROSTA 11.25MG INJECTION(DEPOT) and contact your doctor if you experience any of the following side effects:
- signs of pituitary apoplexy such as sudden headache, visual changes, vomiting, weakened eye muscles, altered mental status, sudden loss of heart function
How To Manage Side Effects
Headache:
Take rest and plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the condition persists for long or gets worsened.
Dizziness:
Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol or smoking. Consult your doctor if the condition persists for long or gets worsened.
Nausea and Vomiting:
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Warning & Precautions
Pregnancy
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use during pregnancy as it may increase the risk of pregnancy complications such as early pregnancy loss and foetal harm. Consult your doctor before receiving.
Breastfeeding
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use in breastfeeding women because it is not known whether it can pass through milk. Consult your doctor before receiving.
Kidney
LEUPROSTA 11.25MG INJECTION(DEPOT) should be used with caution in patients with renal impairment. Consult your doctor before receiving.
Liver
LEUPROSTA 11.25MG INJECTION(DEPOT) should be used with caution in patients with hepatic impairment. Consult your doctor before receiving.
Allergy
Do not receive LEUPROSTA 11.25MG INJECTION(DEPOT) if you are allergic to Leuprolide, GnRH, GnRH agonist analogs or to any of the other ingredients of this medicine.
Others
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use if you:
- undiagnosed abnormal uterine bleeding
Before receiving LEUPROSTA 11.25MG INJECTION(DEPOT), inform your doctor if you:
- have history of depression
Use in pediatrics:
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use in children and adolescents (below 18 years) for endometriosis and fibroids. It is not recommended for use in children (below 2 years) for central precocious puberty (CPP). Consult your doctor before receiving.
Use in geriatrics:
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use in elderly patients (above 65 years). Consult your doctor before receiving.
Interactions
A. Drug-Drug Interactions
Before receiving LEUPROSTA 11.25MG INJECTION(DEPOT), inform your doctor, if you are taking prescription, non-prescription and herbal supplements.
Overdosage:
LEUPROSTA 11.25MG INJECTION(DEPOT) will be administered to you only by a doctor or nurse in a hospital and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity and irritation at the site of injection.
Synopsis
| Drug | : | Leuprolide |
| Pharmacological Category | : | Gonadotropin Releasing Hormone (GnRH) Agonist |
| Therapeutic Indication | : | Endometriosis, Fibroids, Central precocious puberty |
| Dosage Forms | : | Injection, Injection depot |
More Information
- Keep LEUPROSTA 11.25MG INJECTION(DEPOT) out of reach of children
- Store between 2°C - 8°C
FAQs About LEUPROSTA 11.25MG INJECTION(DEPOT)
What LEUPROSTA 11.25MG INJECTION(DEPOT) is used for?
It is used to manage endometriosis, relieving pain and reducing endometriotic lesions. It is also used for preoperative hematologic improvement in women having fibroids (abnormal growth in uterus) induced anaemia for whom hormonal suppression is considered necessary for three months. It is also used in children to manage central precocious puberty (CPP).
What side effects are seen with LEUPROSTA 11.25MG INJECTION(DEPOT)?
The common side effects associated with the use of LEUPROSTA 11.25MG INJECTION(DEPOT) are hot flashes/sweating, general pain, headache, gastrointestinal disorders, swelling due to water retention, nausea, vomiting, reduced libido and dizziness. Consult your doctor if any of these symptoms worsens.
Who should avoid receiving LEUPROSTA 11.25MG INJECTION(DEPOT)?
Do not receive LEUPROSTA 11.25MG INJECTION(DEPOT) if you are allergic to Leuprolide, GnRH or GnRH agonist analogs. It is not recommended for use during pregnancy and breastfeeding. LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use in children and adolescents (below 18 years) for endometriosis and fibroids. Consult your doctor before receiving.
Is LEUPROSTA 11.25MG INJECTION(DEPOT) safe to use in children?
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use in children and adolescents (below 18 years) for endometriosis and fibroids. It is not recommended for use in children (below 2 years) for central precocious puberty (CPP). Consult your doctor before receiving.
Is LEUPROSTA 11.25MG INJECTION(DEPOT) safe to use in elderly patients?
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use in elderly patients (above 65 years) as this medicine has not been studied in this population. Consult your doctor before receiving.
Is LEUPROSTA 11.25MG INJECTION(DEPOT) safe to use in breastfeeding women?
LEUPROSTA 11.25MG INJECTION(DEPOT) is not recommended for use in breastfeeding women because it is not known whether it can pass through milk. Consult your doctor before receiving.
What happens if you take more LEUPROSTA 11.25MG INJECTION(DEPOT) than your required dose?
LEUPROSTA 11.25MG INJECTION(DEPOT) will be given to you only by a doctor or nurse in a hospital and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity and irritation at the site of injection.
References
1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 243.
2. Dallas V. Swayzer, Valerie Gerriets. Leuprolide. NIH. National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. October 2015. [Accessed on 30th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK551662/
3. Abbott Laboratories. FDA (Food and Drug Administration). [Revised in August 2011] [Accessed on 30th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020263s036lbl.pdf
4. Abbott Laboratories. FDA (Food and Drug Administration). [Revised in January 2012] [Accessed on 30th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020708s033lbl.pdf
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